Xylocaine

(Lidocaine)

ApprovedSmall molecule

Lidocaine is a local anesthetic used to numb specific areas of the body to prevent pain during medical procedures or to relieve minor skin irritation and pain. It works by blocking nerve signals in the area where it's applied.[2] Xylocaine is currently approved and in use across 164 indications[4].[1]

Xylocaine is one of 1573 small molecule programs targeting Treatment. It is currently in Approved.

164

Indications

669

Total Trials

Active Trials

1,572

Competitors

146

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

TreatmentWithdrawn

Randomized Controlled TrialCompleted

Intravenous LidocaineCompleted

Limb Pain, PhantomRecruiting

SclerodermaApproved

PharyngitisApproved

Osteoarthritis, KneeApproved

Shoulder Impingement SyndromeApproved

Overactive BladderApproved

PulpitisApproved

TreatmentApproved

Withdrawn

Randomized Controlled TrialPhase 3

Completed

Intravenous LidocaineApproved

Completed

Limb Pain, PhantomApproved

Recruiting

SclerodermaApproved

Approved

PharyngitisApproved

Approved

Osteoarthritis, KneeApproved

Approved

Shoulder Impingement SyndromeApproved

Approved

Overactive BladderApproved

Approved

PulpitisApproved

Approved

Showing 10 of 154 indications

Competition

Competitive Landscape

332 competitors in Treatment

#DrugCompanyPhaseTrials

Xylocaine

MMEDRx USA, Inc.

Approved

13 2

Biltricide

Bayer

Preclinical

3 3

Dexilant

Takeda

Preclinical

2 4

Theo-Dur

Pfizer

Preclinical

1 5

Hivid

CConrado Roberto Hoffmann Filho

Preclinical

6 6

Valium

Akero Therapeutics

Preclinical

2 7

Intuniv

PPromius Pharma, LLC

Preclinical

1 8

Barhemsys

Tibotec Pharmaceuticals, Ireland

Preclinical

1 9

Norpramin

VValidus Pharmaceuticals

Preclinical

1 10

Lotemax

PPharmos

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalRecruiting

Study completion

NCT06045936

Phase 3Not yet recruiting

Functional Endoscopic Sinus Surgery

NCT07213037

Q1 2027

Post-ApprovalRecruiting

Intravenous Lidocaine

NCT06795100

N/ARecruiting

Osteoarthritis

NCT07245121

Q2 2027

N/AActive, not recruiting

Lidocaine Infusion

NCT04840511

Q4 2029

N/ARecruiting

Obesity

NCT03756961

Clinical

Trials by Indication[1]

Lidocaine16 trials

Clinical Outcomes of Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine

Completed·UUniversity of North Carolina, Chapel Hill·N/A·NCT02708433·23 enrolled

Perioperative Protective Effects of Lidocaine

Terminated·UUniversity Hospital Muenster·Phase 2/3·NCT00413127·78 enrolled

Comparison of Two Lidocaine Administration Techniques

Completed·UUniversity of Chicago·Phase 4·NCT01330134·481 enrolled

Show 13 more trials

Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain

Terminated·WWake Forest University Health Sciences·Phase 2/3·NCT04356352·33 enrolled

Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation

Completed·SSheba Medical Center·Phase 4·NCT02097017·134 enrolled

Use of Lidocaine in Rapid Sequence Induction

Completed·UUniversity of Athens·N/A·NCT01238718·76 enrolled

Intrauterine Lidocaine for Laminaria

Completed·UUniversity of North Carolina, Chapel Hill·Phase 1·NCT01541293·72 enrolled

Does Topical Lidocaine Decrease Sweat During Exercise in the Heat?

Completed·—·N/A·NCT05379283·10 enrolled

A Comparison of Pain Severity on Injection of MCT/LCT Propofol Between Lidocaine 20 mg, 40 mg, and Without Lidocaine.

Completed·PPrince of Songkla University·N/A·NCT01345981·210 enrolled

Clinical Outcomes Maxilla: Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine

Completed·UUniversity of North Carolina, Chapel Hill·N/A·NCT02747186·24 enrolled

The Optimal Timing of the Initiation of Esophagogastroduodenoscopy After Oral Lidocaine Spray

Recruiting·NNational Cheng-Kung University Hospital·N/A·NCT06497296·160 enrolled

Buffered Lidocaine for Reducing Pain in Patients Undergoing Prostate Biopsy, BURN Trial

Completed·UUniversity of Washington·Phase 1/2·NCT06661902·350 enrolled

Buffered Lidocaine in Paracervical Blocks

Completed·UUniversity of Hawaii·Phase 4·NCT03107754·98 enrolled

Role of LIDOCAINE IN Pediatric Cochlear Implant Surgery

Completed·WWahba bakhet·Phase 4·NCT04194294·70 enrolled

Topical Lidocaine for Needle Insertion and Injection Pain

Completed·NNew York School of Regional Anesthesia·N/A·NCT03206320·30 enrolled

Clinical Outcomes Mandible: Buffered 1% vs. Non-Buffered 1% Lidocaine

Completed·UUniversity of North Carolina, Chapel Hill·Phase 4·NCT03127943·24 enrolled

Intravenous Lidocaine15 trials

Effect of Perioperative Intravenous Lidocaine Infusion and Magnesium Infusion on the Functional Recovery After General Anesthesia in the Patients Undergoing Thyroid Surgery

Completed·YYonsei University·N/A·NCT02018276·135 enrolled

Perioperative Intravenous Lidocaine Infusion for Patients Undergoing Laparoscopic and Open Pancreatectomies

Completed·MMayo Clinic·Phase 4·NCT02623803·48 enrolled

Intravenous Lidocaine Randomized Comparative Effectiveness Trial

Completed·MMontefiore Medical Center·Phase 4·NCT03300674·154 enrolled

Show 12 more trials

Continuous Nerve Block Block vs Combination of Single Block Plus Intravenous Lidocaine for Postoperative Pain.

Terminated·JJeremy Kearns·Phase 4·NCT04208516·17 enrolled

Intravenous Lidocaine to Supress of Cough Reflex During Anesthesia Emergence

Unknown status·—·Phase 3·NCT03805282·132 enrolled

Pharmacokinetic Study of Intravenous Lidocaine in Young and Elderly Patients

Recruiting·RRennes University Hospital·Phase 4·NCT06795100·64 enrolled

Perioperative Intravenous Lidocaine in Liver Surgery

Completed·LLund University Hospital·Phase 2/3·NCT05153785·124 enrolled

Serum Opiorphin Level After Intraoperative Intravenous Lidocaine Infusion

Completed·—·Phase 1·NCT03502395·80 enrolled

Effect of Intravenous Lidocaine on the Tolerability of Early Oral Feeding After Laparoscopic Colorectal Surgery

Completed·KKangbuk Samsung Hospital·N/A·NCT01346917·77 enrolled

Perioperative Intravenous Lidocaine or Epidural Anesthesia on Outcomes in Complex Spine Surgery

Completed·TThe Cleveland Clinic·N/A·NCT00840996·116 enrolled

Intravenous Lidocaine for Cystectomy Procedures

Completed·—·N/A·NCT02924480·50 enrolled

Intravenous Lidocaine and Quality of Recovery After Cesarean Delivery

Withdrawn·NNorthwestern University·N/A·NCT02257346

Intravenous Lidocaine Infusion in the Management of Post-operative Pain in Colorectal Patients

Withdrawn·—·Phase 1/2·NCT01836614

PK Intravenous Lidocaine Infusion

Terminated·—·Phase 1·NCT02241096·2 enrolled

Investigation of the Effect of Intravenous Lidocaine Infusion on Postoperative Pain Treatment and Bowel Function in Robotic Bowel Surgery

Completed·OOdense University Hospital·Phase 4·NCT03044808·60 enrolled

Sedation7 trials

Impact of Topical Pharyngeal Anesthetics on Discharge of the Patients When Used in Conjunction With Propofol Sedation in Routine EGD's

Completed·BBassett Healthcare·Phase 4·NCT02507440·100 enrolled

Efficacy of IV Lidocaine at Alleviating Pain Associated With Propofol Infusion in Pediatric Patients Undergoing Sedation

Completed·—·Phase 4·NCT00786916·109 enrolled

Usefulness of Lidocaine as Topical Pharyngeal Anaesthesia in Esophagogastroduodenoscopy Under Sedation With Propofol

Completed·HHospital Universitario Infanta Cristina·Phase 4·NCT01489891·120 enrolled

Show 4 more trials

Effects of Intravenous Lidocaine During Sedation for Colonoscopy.

Completed·UUniversity of Liege·Phase 4·NCT02784860·40 enrolled

Decreasing Propofol Injection Pain by Pre-Treatment With Lidocaine in Pediatric Procedural Sedation

Terminated·—·N/A·NCT02512783·171 enrolled

General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke

Completed·RRennes University Hospital·Phase 3·NCT02822144·351 enrolled

Interscalene Nerve Block vs. Sedation for Shoulder Dislocation Reduction

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT03041506·90 enrolled

Local Anesthesia5 trials

Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients

Completed·UUniversity of California, San Francisco·Phase 4·NCT01622296·20 enrolled

MEOPA Versus Local Anesthesia for Analgesia During Chorionic Villus Sampling.

Completed·HHospital St. Joseph, Marseille, France·Phase 4·NCT02573987·192 enrolled

Bupivacaine Versus Lidocaine Local Anesthesia

Completed·UUniversity of British Columbia·Phase 4·NCT01751347·135 enrolled

Show 2 more trials

Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia

Terminated·UUniversity of Nebraska·Phase 4·NCT02647892·70 enrolled

Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children

Terminated·UUniversity of Colorado, Denver·N/A·NCT01628874·66 enrolled

Neuropathic Pain5 trials

NS1209 and Lidocaine in Patients With Peripheral Neuropathic Pain

Completed·—·Phase 2·NCT00258622·18 enrolled

Lidocaine Patch in Treating Cancer Patients With Neuropathic Pain After Surgery

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT00058357·30 enrolled

Randomized Controlled Trial of Efficacy and Safety of Local Anesthetics and Steroids for Chronic Peripheral Post-traumatic Neuropathic Pain

Completed·UUniversity Health Network, Toronto·Phase 3·NCT03009500·3 enrolled

Show 2 more trials

Lidocaine IV Injection With Different Doses for Patients With Neuropathic Pain After Mastectomy

Completed·—·N/A·NCT07475520·30 enrolled

Long Term Outcome After Serial Lidocaine Infusion in Peripheral Neuropathic Pain

Completed·MMahidol University·Phase 3·NCT02217267·29 enrolled

110 more indications

Lidocaine Infusion5 trials

The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping

Active, not recruiting·TThe Catholic University of Korea·N/A·NCT04840511·60 enrolled

Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy

Terminated·WWashington University School of Medicine·Phase 2·NCT05017246·110 enrolled

Lidocaine Infusion for Propofol Dose Reduction in ERCP Procedure

Unknown status·IIuliu Hatieganu University of Medicine and Pharmacy·Phase 1·NCT05274984·100 enrolled

Show 2 more trials

Lidocaine Infusion for Postthoracotomy Pain Syndrome

Unknown status·GGuangzhou First People's Hospital·N/A·NCT03666299·72 enrolled

Systemic Effects of Lidocaine Infusion for TAP Block Catheter

Completed·UUniversity of Alberta·N/A·NCT03971708·80 enrolled

Local Anesthetic4 trials

The Utility of Long-acting Local Anesthetic Agents in Reducing Post-operative Opioid Requirements Following Rhinoplasty

Completed·OOur Lady of the Lake Hospital·Phase 1·NCT04377204·5 enrolled

Effects of Intravenous Local Anesthetic on Bowel Function After Colectomy

Completed·UUniversity of Virginia·Phase 3·NCT00600158·45 enrolled

Local Anesthetics for Pain Reduction Prior to IV Line Placement

Completed·—·Phase 4·NCT01759459·150 enrolled

Show 1 more trial

Comparing the Efficacy of Local Anesthetics in Mohs Surgery

Unknown status·OOttawa Hospital Research Institute·N/A·NCT03871478·105 enrolled

Laparoscopic Cholecystectomy4 trials

Intravenous Lidocaine for Laparoscopic Cholecystectomy

Completed·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT01062906·80 enrolled

Lidocaine and Analgesia After Laparoscopic Cholecystectomy

Completed·LLarissa University Hospital·N/A·NCT03620591·98 enrolled

Comparison of Effect on Quality of Recovery Outcome Between Systemic Lidocaine and Dexamethasone in Patients Undergoing Laparoscopic Cholecystectomy

Terminated·YYonsei University·N/A·NCT02224170·8 enrolled

Show 1 more trial

Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy

Unknown status·HHvidovre University Hospital·Phase 4·NCT00209885·60 enrolled

Treatment4 trials

Evaluation of Topical Liposomal Lidocaine and Oral Sucrose for Treatment of Pain in Newborns Undergoing Venipuncture

Completed·TThe Hospital for Sick Children·Phase 3·NCT00519207·330 enrolled

Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch

Completed· Astellas logo

Astellas·Phase 4·NCT01416116·122 enrolled

To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo.

Unknown status·HHospital Universitari de Bellvitge·Phase 3·NCT03676556·46 enrolled

Show 1 more trial

Fractional Ablative Laser Treatment for Skin Grafts

Completed·WWake Forest University Health Sciences·N/A·NCT04176705·9 enrolled

Anesthesia4 trials

Topical Lidocaine Anesthesia for Nasopharyngeal Sampling

Completed·—·N/A·NCT04885777·50 enrolled

Is it Possible to Replace Fentanyl in Anesthesia for Minor Procedures?

Completed·—·N/A·NCT03806374·120 enrolled

Epidural Anesthesia With Chloroprocaine Versus Lidocaine

Completed·JJinling Hospital, China·Phase 4·NCT02287870·120 enrolled

Show 1 more trial

Intravitreal Injection Anesthesia - Comparison of Different Topical Agents

Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·N/A·NCT01224847·92 enrolled

Bupivacaine3 trials

Efficacy of Repeated Locoregional Anesthetics Blocks With Bupivacaine in Patients Suffering of Chronic Dentoalveolar Pain.

Unknown status·UUniversity Hospital, Clermont-Ferrand·Phase 2·NCT04207411·50 enrolled

Lidocaine Versus Bupivacaine in Ambulatory Continuous Block With Elastomeric Pump

Completed·PPontificia Universidad Catolica de Chile·Phase 4·NCT02121119·70 enrolled

Incidence of TNS After Intrathecal Lidocaine v.s Bupivacaine

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT03862287·160 enrolled

Post Operative Pain3 trials

Effect of Local Anesthesia on Postoperative Pain Following Sacrospinous Ligament Fixation

Unknown status·HHartford Hospital·N/A·NCT02890199·30 enrolled

Comparison of the Effect of Lidocaine Infusion Applied at Different Doses During Lumbar Spinal Surgery on Hemodynamics and Postoperative Pain

Unknown status·—·N/A·NCT05936190·80 enrolled

Are There Differences in Postoperative Pain Between Bupivacaine and Lidocaine for Carpal Tunnel Release?

Completed·HHospital Italiano de Buenos Aires·N/A·NCT05697276·82 enrolled

Analgesia3 trials

Preemptive Analgesia for Postlaminectomy

Completed·HHarran University·Phase 4·NCT00656526·40 enrolled

Combination Analgesia for Neonatal Circumcision

Completed·—·Phase 3·NCT02990364·70 enrolled

Lidocaine Analgesia For Removal Of Wound Vac Dressings

Completed·UUniversity of Utah·N/A·NCT01126359·11 enrolled

Fibromyalgia3 trials

Lidocaine on Manifestations of Fibromyalgia

Completed·FFederal University of São Paulo·Phase 1·NCT00991848·30 enrolled

Potential Role of Intravenous Lidocaine Versus Intravenous Ketamine for Pain Management in Fibromyalgia Patients

Unknown status·—·Phase 4·NCT06184958·75 enrolled

Lidocaine on Pain Relief and IL and Substance P in Fibromyalgia

Unknown status·FFederal University of São Paulo·Phase 3·NCT01391598·40 enrolled

Randomized Controlled Trial3 trials

Does Injection Site Matter? A Randomized Controlled Trial to Evaluate Efficacy of Knee Intraarticular Injections on Improval of Patient Reported Outcomes.

Completed·UUniversity of Puerto Rico·Phase 4·NCT02176304·60 enrolled

Ondansetron As a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial

Recruiting·EEmory University·Phase 2·NCT05378113·120 enrolled

Efficacy of Triamcinolone-Lidocaine Mix in Trigger Points Injection of Masseter Muscle: Double-blinded, Randomized Controlled Trial

Not yet recruiting·—·Phase 2/3·NCT07445191·30 enrolled

Shoulder pain3 trials

Sphenopalatine Ganglion Block to Treat Shoulder Pain After Laparoscopic Surgery

Unknown status·RRabin Medical Center·N/A·NCT04101019·76 enrolled

Subacromial Corticosteroid Injection for Hemiplegic Shoulder Pain

Completed·MMetroHealth Medical Center·Phase 2·NCT00597766·28 enrolled

Sphenopalatine Ganglion Block to Treat Shoulder Pain After Thoracotomy

Completed·NNYU Langone Health·Phase 1·NCT02733393·2 enrolled

Adductor Canal Block2 trials

Continuous Adductor Canal Block With a New Catheter - Primary Placement and Secondary Repositioning

Completed·KKai Henrik Wiborg Lange·N/A·NCT02657603·16 enrolled

Location of Injection of Local Anesthetics in the Adductor Canal Block

Completed·WWomen's College Hospital·N/A·NCT02554864·108 enrolled

Cancer Pain2 trials

Efficacy of Lidocaine Versus Placebo in Palliative Care Patients With Opioid-refractory Cancer Pain With Neuropathic Component: a Multicenter, Prospective, Double-blind Randomized Placebo-controlled Study.

Unknown status·AAssistance Publique Hopitaux De Marseille·Phase 3·NCT02137954·200 enrolled

Radiofrequency and Chemical Neurolysis of Thoracic Splanchnic Nerve for Abdominal Cancer Pain

Unknown status·SSouth Egypt Cancer Institute·N/A·NCT03063112·79 enrolled

Nerve Block2 trials

Ilioinguinal Nerve Block in Transcatheter Aortic Valve Implantation

Unknown status·—·Phase 4·NCT05220813·88 enrolled

Onset and Duration of Forearm Nerve Blockade

Completed·NNew York School of Regional Anesthesia·Phase 4·NCT03649763·36 enrolled

Postoperative Recovery2 trials

The Effect of Perioperative Lidocaine Intravenous Infusion on Postoperative Recovery After Spine Surgery.

Unknown status·SSheba Medical Center·Phase 4·NCT02762656·60 enrolled

Effect of Perioperative Intravenous Lidocaine Infusion on Postoperative Recovery in Patients Undergoing Arthroscopic Rotator Cuff Repair Under General Anesthesia

Completed·YYonsei University·N/A·NCT04061057·98 enrolled

Efficacy2 trials

Efficacy Study of Topical Application of Lidacaine Spray Prior to IUD Insertion

Unknown status·—·Phase 4·NCT01496105·200 enrolled

An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA

Completed·CCentrexion Therapeutics·Phase 3·NCT03661996·854 enrolled

Prevention2 trials

Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated With Medium-/Long-chain Triglycerides

Completed·YYangzhou University·N/A·NCT04008433·31 enrolled

Pain Prevention During Propofol Infusion in Pediatric: Hypnoanalgesia of the Hand Versus Lidocaine.

Completed·UUniversity Hospital, Toulouse·Phase 4·NCT03453723·100 enrolled

Osteoarthritis2 trials

Perineural Prolotherapy in Chronic Knee Osteoarthritis Pain.

Recruiting·NNational and Kapodistrian University of Athens·N/A·NCT07245121·60 enrolled

Intra-Articular 0.5 % Lidocaine Injection for Osteoarthritis

Completed·HH. Evren Eker·Phase 4·NCT02632565·52 enrolled

Pain Perception2 trials

Pain Perception During Vulvar Biopsy

Terminated·—·Phase 4·NCT03654417·37 enrolled

Pain Perception: Lidocaine Rate/Temp/Buffer

Active, not recruiting·NNorthwestern University·N/A·NCT02823002·26 enrolled

Concentration2 trials

Effect of Different Concentrations of Lidocaine in Relieving Pain in Wide Awake Hand Surgery Using Tumescence

Completed·KKing Edward Medical University·Phase 1·NCT04692896·90 enrolled

The Effects of Different Clonidine Concentrations on Axillary Brachial Plexus Block With 1,5% Lidocaine

Completed·UUniversidade Federal do Rio de Janeiro·Phase 2·NCT01620112·60 enrolled

Peripheral Neuropathy2 trials

A Randomized, Double-blind, Placebo- and Active-controlled Study of the Electric Current Effects of ABT-639 on the Spontaneous Activity of Pain Sensory Receptors in Patients With Diabetic Peripheral Neuropathy

Completed· AbbVie logo

AbbVie·Phase 2·NCT01589432·39 enrolled

Lidocaine for Diabetic Peripheral Neuropathy

Completed·WWashington University School of Medicine·N/A·NCT02363803·34 enrolled

Cesarean Section1 trial

Effect of Lidocaine Infusion on Neuraxial Opioid-induced Pruritus After Cesarean Section

Completed·—·N/A·NCT06225323·136 enrolled

Obesity1 trial

Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery

Recruiting·GGöteborg University·N/A·NCT03756961·220 enrolled

General Anesthesia1 trial

Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia

Recruiting·—·Phase 3·NCT06979141·300 enrolled

Hematoma1 trial

Hematoma Block as an Adjunct to Procedural Sedation for Forearm Fracture Reduction

Terminated·RRhode Island Hospital·Phase 4·NCT00763880·89 enrolled

Orthopedic Surgery1 trial

How Lidocaine Affects Outcomes In Orthopedic Surgery Patients

Withdrawn·—·Phase 4·NCT01179100

Scoliosis1 trial

Effect of Regional Anesthesia or Intravenous Infusion of Lidocaine on Morphine Use After Scoliosis Repair Surgery

Recruiting·—·N/A·NCT06451562·105 enrolled

Hand Surgery1 trial

Effects of Systemic or Adjunct Tramadol Addition to Lidocaine Used for IVRA in Patients Undergoing Hand Surgery

Completed·—·Phase 3·NCT02658721·60 enrolled

Quadratus Lumborum Block1 trial

Analgesic Efficacy of Ultrasound Guided Quadratus Lumborum Block During ESWL

Completed·—·Phase 4·NCT03080363·40 enrolled

Laparotomy1 trial

Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy

Completed·—·Phase 4·NCT06772727·149 enrolled

Knee Arthroscopy1 trial

Spinal Anaesthesia for Knee Arthroscopy: Does Lignocaine Shorten the Effect of Bupivacaine

Completed·—·Phase 4·NCT01245868·60 enrolled

Rotator Cuff Tear1 trial

Comparison of Strength and Constant Score Pre- and Post-Subacromial Injection for Full Thickness Rotator Cuff Tears

Withdrawn·RRush University Medical Center·N/A·NCT02693444

Pain1 trial

Pupillometry - Future of Objective Pain Reaction Measurement While Unconscious

Completed·UUniversity of Warmia and Mazury·N/A·NCT04000126·90 enrolled

Caesarean Section1 trial

Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine

Completed·—·Phase 4·NCT02274974·160 enrolled

Preoperative1 trial

Comparing Efficacy Preoperative Nebulized: Ketamine , Mgspo4 ,and Lidocaine In Attenuating Endotracheal Sore Throat

Completed·ZZagazig University·Phase 3·NCT03729973·100 enrolled

Glioblastoma1 trial

Systemic and Local Levels of Lidocaine During Surgery for the Removal of Glioblastoma

Completed·UUniversity of California, Davis·Phase 1·NCT04716699·12 enrolled

Bowel Surgery1 trial

A Pain Study Comparing Two Commonly Used Medications to Treat Pain After Bowel Surgery

Completed·—·N/A·NCT02849678·68 enrolled

Postoperative Pain Control1 trial

Perioperative Lidocaine Administration in Thoracoscopic Surgery for Improved Postoperative Pain Control

Completed·UUniversity Hospital, Basel, Switzerland·Phase 3·NCT03677817·113 enrolled

Sternotomy1 trial

Percutaneous Ketamine Versus Lidocaine for Mid-Sternotomy

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 4·NCT00822419·75 enrolled

Pain and Discomfort1 trial

TAmoxifen Versus LIdocaine Cream. A Randomized Clinical Trial for Reducing Pain and Discomfort During Mammography

Unknown status·UUniversidade Federal de Goias·Phase 2/3·NCT02801786·450 enrolled

Total Hip Arthroplasty1 trial

Treatment of Postoperative Pain After Total Hip Arthroplasty Using Intravenous Lidocaine Infusion

Withdrawn·LLoma Linda University·Phase 1/2·NCT01108562

Postherpetic Neuralgia1 trial

Safety and Efficacy Study of KAI-1678 to Treat Pain in Subjects With Postherpetic Neuralgia

Completed·KKAI Pharmaceuticals·Phase 2·NCT01106716·23 enrolled

IUD1 trial

Paracervical Block Versus No Paracervical Block During IUD Insertion

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT02904915·50 enrolled

Female1 trial

Cystoscopy in Females: Is There a Difference Between Rigid and Flex Cystoscopy, and Does it Require Local Anasthesia?

Completed·—·N/A·NCT03210038·120 enrolled

Abortion1 trial

Paracervical Block in First Trimester Surgical Abortions

Completed·JJohns Hopkins University·Phase 2/3·NCT00617097·50 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Quality of Recovery Following Opioids Free Anaesthesia in Laparoscopic Sleeve Gastrectomy

Completed·—·N/A·NCT04285255·103 enrolled

Skin1 trial

Determine the Effect of AZD3161,Injected Intradermally, on Quantitative Sensory Testing Variables in Normal and Ultraviolet-C (UVC) Exposed Skin in Healthy Volunteers

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01240148·26 enrolled

Functional Endoscopic Sinus Surgery1 trial

Magnesium Sulfate Versus Lidocaine as Additives to Dexmedetomidine for Cough Suppression After Functional Endoscopic Sinus Surgery

Not yet recruiting·—·Phase 3·NCT07213037·102 enrolled

Prospective1 trial

Analgesic Effect of Illiohypogastic & Ilioinguinal Nerve Block in TAVR - TF (Prospective Randomized Study)

Recruiting·—·Phase 1/2·NCT06362915·52 enrolled

Pain Control1 trial

Lidocaine Spray Plus Oral Celecoxib for Pain Control During Hysterosalpingography

Completed·—·N/A·NCT04505657·150 enrolled

Safety and Efficacy1 trial

Safety and Efficacy Study of Lidocaine Mixed Hyaluronate on Nasolabial Folds Correction

Withdrawn·SSciVision Biotech Inc.·N/A·NCT02006173

Epidural1 trial

Comparative Trial Via Tranforaminal Approach Versus Epidural Catheter Via Interlaminar Approach

Completed·UUniversity of Utah·Phase 4·NCT03382821·120 enrolled

Arteriovenous Fistula1 trial

Anesthetic Effect of Ropivacaine on Local Infiltration Anesthesia in Arteriovenous Fistula Surgery

Active, not recruiting·TThe First People's Hospital of Lianyungang·Phase 4·NCT07259772·40 enrolled

Alpha-1 Antitrypsin Deficiency1 trial

Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD)

Completed·UUniversity of Florida··NCT01810458·109 enrolled

Tremor1 trial

Lidocaine Reduces Muscle Tremor is Beneficial for Intraoperative Recurrent Laryngeal Nerve Monitoring

Unknown status·—·N/A·NCT03530033·40 enrolled

Postoperative Analgesia1 trial

Longterm Postoperative Analgesia, Intravenous Lidocaine Infusion

Completed·—·Phase 2·NCT03030560·40 enrolled

Lung Cancer1 trial

Anesthesia in Flexible Bronchoscopy for Lung Cancer Diagnostic

Completed·—·Phase 4·NCT00440960

Analgesic1 trial

Different Analgesics Prior to Intrauterine Device (IUD) Insertion: Is There Any Evidence?

Unknown status·—·N/A·NCT02522130·200 enrolled

Epilepsy1 trial

Conscious Sedation for Epilepsy Surgery

Completed·MMenoufia University·N/A·NCT02988050·60 enrolled

Laparoscopic1 trial

Percutaneous Ketamine Versus Lidocaine or Placebo, for Post-Surgery Analgesia, in Patients Undergoing Laparoscopic Partial Lung Resection

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 4·NCT00822133·75 enrolled

Hyperalgesia1 trial

Effect of GSK1014802 on Electrical Hyperalgesia and Threshold Tracking in Healthy Subjects

Terminated· Biogen logo

Biogen·Phase 1·NCT00964288·16 enrolled

Inflammatory Cytokines1 trial

Intraoperative Lidocaine Infusion and Surgery-induced Release of Pro-inflammatory Cytokines After Abdominal Surgery

Unknown status·—·N/A·NCT05541640·60 enrolled

Endoscopic Sinus Surgeries1 trial

Lidocaine Infusion Versus Magnesium Infusion in Decreasing Fentanyl Requirements in Endoscopic Sinus Surgeries

Not yet recruiting·—·Phase 4·NCT06966102·156 enrolled

Oral ulcer1 trial

Evaluation of Low Level Laser Therapy and Lidocaine Versus Chlorhexidine for the Management of Traumatic Oral Ulcers in Children

Completed·NNational Research Centre, Egypt·N/A·NCT07138586·30 enrolled

Greater Occipital Nerve Block1 trial

Sphenopalatine Block Versus Greater Occipital Nerve Block in PDPH

Unknown status·—·N/A·NCT05235256·120 enrolled

Prostatectomy1 trial

Spinal Morphine in Robotic Assisted Radical Prostatectomy

Completed·MMaasstad Hospital·Phase 4·NCT02924974·160 enrolled

Renal Colic1 trial

Treatment of Renal Colic in the Emergency Departement (ED).

Completed·UUniversity of Monastir·Phase 2·NCT03199924·600 enrolled

Propofol1 trial

the Effect of Spray on Propofol Injection Pain

Completed·TThe Catholic University of Korea·Phase 4·NCT02770690·90 enrolled

Breast Cancer1 trial

The Impact of Intravenous Anaesthesia on Angiogenesis in Patients With Breast Cancer (TIVA/TCI-BC)

Completed·IIuliu Hatieganu University of Medicine and Pharmacy·Phase 2·NCT02839668·120 enrolled

Local1 trial

Painless Local Anaesthesia With Bicarbonate Admixture

Completed·UUniversity of Zurich·Phase 2·NCT03238625·48 enrolled

Agitation1 trial

The Effect of Dexmedetomidine Versus Lidocaine on Emergence Agitation.

Not yet recruiting·FFayoum University·N/A·NCT07355049·80 enrolled

Post Operative Cognitive Dysfunction1 trial

Effect of Lidocaine in Antiarrhythmic Dosage on Postoperative Cognitive Dysfunction in Supratentorial Craniotomy Dysfunction in Supratentorial Craniotomy

Completed·—·Phase 2·NCT00975910·100 enrolled

Dexamethasone1 trial

Does Perineural Dexamethasone Increase the Duration of an Ulnar Nerve Block When Controlling for Systemic Effects?

Completed·ZZealand University Hospital·Phase 2·NCT04817982·16 enrolled

Radiculopathy1 trial

Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica)

Completed·—·Phase 1·NCT02644421·18 enrolled

Methylprednisolone1 trial

Preoperative Intraarticular Injection of Methylprednisolone in Patients Scheduled for Total Knee-arthroplasty

Completed·RRigshospitalet, Denmark·Phase 2·NCT02253966·48 enrolled

Remifentanil1 trial

Efficacy of Remifentanil Compared to Lidocaine on the Incidence of Coughing During Emergence of Anesthesia

Completed·—·N/A·NCT01026129·93 enrolled

Intravenous1 trial

Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain

Not yet recruiting·HHayatabad Medical Complex·N/A·NCT07422558·92 enrolled

Diabetic Polyneuropathy1 trial

Pharmacodynamic Study of BIIB095 and BIIB074 in Healthy Participants and Participants With Painful Diabetic Polyneuropathy

Withdrawn· Biogen logo

Biogen·Phase 1·NCT04106050

Spinal Cord Injury1 trial

Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial

Completed·—·Phase 2·NCT02218203·26 enrolled

Tenosynovitis1 trial

Anesthesia Tumescent for Surgical Management of Tenosynovitis.

Completed·IInstituto Mexicano del Seguro Social·N/A·NCT03914235·60 enrolled

Headache1 trial

A Double Blind Randomized Controlled of Placebo and Nebulized Lidocaine for Migraine Headache

Completed·—·N/A·NCT00287781·150 enrolled

Arthritis1 trial

Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb Joint

Terminated·UUniversity of Missouri-Columbia·Phase 4·NCT01045694·8 enrolled

Antibiotic1 trial

Cefazolin-Lidocaine Combination Solution to Reduce Antibiotic Pain

Unknown status·UUniversity Health Network, Toronto·Phase 4·NCT02324166·54 enrolled

Tendinopathy1 trial

Treatment for Achilles Tendinopathy

Unknown status·UUniversity of Calgary·Phase 2/3·NCT00835939·17 enrolled

Blood Pressure1 trial

Decision Support for Intraoperative Low Blood Pressure

Completed·VVanderbilt University Medical Center·N/A·NCT02726620·22,435 enrolled

Cognitive Dysfunction1 trial

Lidocaine on Early Cognitive Dysfunction in Shoulder Arthroscopy

Unknown status·—·Phase 2·NCT04634656·80 enrolled

Migraine1 trial

Intranasal Lidocaine to Treat Pediatric Migraine in the Emergency Department

Unknown status·NNew York City Health and Hospitals Corporation·Phase 3·NCT03576820·50 enrolled

ESS1 trial

Block Pressor Response to Intubation

Unknown status·—·N/A·NCT05659212·102 enrolled

Intravitreal Injections1 trial

Cryoanesthesia for Intravitreal Injections

Completed·UUniversity of Michigan·Phase 1/2·NCT02872012·23 enrolled

Hypersensitivity1 trial

Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain

Unknown status·TThe Hospital for Sick Children·Phase 3·NCT01503060·352 enrolled

Postoperative Quality of Recovery1 trial

Effect of Perioperative Intravenous Lidocaine on Postoperative Quality of Recovery in Patients Undergoing Spine Surgery

Withdrawn·—·Phase 2·NCT01930877

Perioperative Analgesia1 trial

Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery

Terminated·—·Phase 3·NCT04176419·30 enrolled

Postoperative Pain Management1 trial

Intravenous Lidocaine and Postoperative Pain Management

Unknown status·—·Phase 4·NCT02997215·80 enrolled

Supraclavicular Brachial Plexus Block1 trial

Ultrasound-guided Supraclavicular Brachial Plexus Blockade

Terminated·UUniversity of Manitoba·N/A·NCT00523055·10 enrolled

Erector Spinae Plane Block1 trial

Erector Spinae Plane Block Versus Perioperative Intravenous Lidocaine for Thoracotomy

Completed·—·N/A·NCT04221880·60 enrolled

Endovascular Thrombectomy1 trial

General Anesthesia for Endovascular Thrombectomy; A Pilot Study.

Completed·UUniversity of Saskatchewan··NCT02639806·34 enrolled

Irritable Bowel Syndrome1 trial

Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome

Completed·UUS Department of Veterans Affairs·Phase 2·NCT00108446

Children1 trial

Pudendal Block Versus Penian Block For Circumcision In Children

Unknown status·UUniversité Libre de Bruxelles·N/A·NCT03046290·60 enrolled

Epidural Analgesia1 trial

A Comparison of Epidural Analgesia: Continuous Infusion Versus Programmed Intermittent Boluses

Completed·FFundación Santa Fe de Bogota·N/A·NCT02510287·128 enrolled

Laparoscopic Appendectomy1 trial

Intravenous Lidocaine in Children Undergoing Laparoscopic Appendectomy

Completed·MMedical University of Warsaw·Phase 4·NCT03886896·74 enrolled

Cervical Cancer1 trial

The Effect of Intravenous Lidocaine on THBS2 and Angiogenic Factors Expression in Women Undergoing Cervical Cancer Surgery

Unknown status·GGeneral Hospital of Ningxia Medical University·N/A·NCT05560035·60 enrolled

Surgical Field1 trial

Lidocaine Versus Esmolol for Optimizing Surgical Field Visibility

Completed·ZZagazig University·Phase 2·NCT04260685·70 enrolled

Vomiting1 trial

Intravenous Lidocaine in the Prevention of Postoperative Vomiting in Elective Tonsil Surgery

Completed·PPontificia Universidad Catolica de Chile·Phase 4·NCT01986309·92 enrolled

Trigeminal Neuralgia1 trial

The Effect of Intravenous Lidocaine on Trigeminal Neuralgia

Completed·PPain Relief & Palliative Care Center, Athens, Greece·N/A·NCT01955967·20 enrolled

Atrial Fibrillation1 trial

Workflow Optimization During Pulse Field Ablation for Atrial Fibrillation

Not yet recruiting·NNational Taiwan University Hospital·Phase 4·NCT07354217·60 enrolled

Tics1 trial

Anesthetics in Rhytidoplasty - A Comparison Study

Completed·MMercy Facial Plastic Surgery Center·N/A·NCT02410460·30 enrolled

Steroid Injection1 trial

Does Adding Lidocaine to Corticosteroid Injections Reduce Pain Intensity in Hand Surgery

Completed·UUniversity of Texas at Austin·N/A·NCT06188221·40 enrolled

Total Knee Arthroplasty1 trial

The Effect of Continuous Femoral Nerve Block With Modulation of Depth of Anesthesia on Prognosis of Patients Receiving Total Knee Arthroplasty

Unknown status·MMin Su·N/A·NCT02576015·380 enrolled

Interstitial Cystitis1 trial

Effect of Intravesical Lidocaine on Urodynamic and Symptomatic Parameters of Interstitial Cystitis

Withdrawn·NNorthwell Health·N/A·NCT00823030

Unspecified5 trials

A Study of Contralateral Limb Block

Recruiting·MMayo Clinic·Phase 4·NCT06045936·20 enrolled

Glenohumeral Cortisone Injection

Completed·UUniversity of Washington·Phase 2·NCT04216017·9 enrolled

Navigator vs Standard Needle Injection for Hip

Completed·CCartiva, Inc.·Phase 2·NCT02066844·40 enrolled

Show 2 more trials

A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin

Completed·—·N/A·NCT03587220·44 enrolled

Ability of Late Sodium or Calcium Current Block to Balance the ECG Effects of Potassium Current Block

Completed·FFood and Drug Administration (FDA)·Phase 1·NCT02308748·22 enrolled

Regulatory

FDA Approval Timeline[5]

Nov 19, 1948

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Dec 4, 1972

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

May 20, 1974

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jun 24, 1974

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jul 16, 1975

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Aug 28, 1975

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Aug 28, 1975

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Oct 9, 1975

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Feb 2, 1976

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

May 17, 1978

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Feb 27, 1979

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 26, 1979

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Apr 9, 1979

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Apr 9, 1979

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Aug 29, 1979

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Apr 17, 1980

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Dec 31, 1980

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Oct 1, 1981

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Oct 1, 1981

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE

NDA NDA017584

Jan 1, 1982

XYLOCAINE

NDA NDA013077

Jan 1, 1982

XYLOCAINE

NDA NDA014127

Jan 1, 1982

XYLOCAINE VISCOUS

NDA NDA009470

Jan 1, 1982

XYLOCAINE

NDA NDA008048

Jan 1, 1982

XYLOCAINE

NDA NDA008816

Jan 1, 1982

XYLOCAINE 1.5% W/ DEXTROSE 7.5%

NDA NDA016297

Jan 1, 1982

XYLOCAINE

NDA NDA014394

Jan 1, 1982

XYLOCAINE DENTAL

NDA NDA021380

Jan 1, 1982

XYLOCAINE 4% PRESERVATIVE FREE

NDA NDA010417

Jan 1, 1982

XYLOCAINE

NDA NDA006488

Jan 1, 1982

XYLOCAINE

NDA NDA010418

Jan 1, 1982

LIDOPEN

NDA NDA017549

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE

NDA NDA017702

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% IN PLASTIC CONTAINER

NDA NDA018388

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE 0.1% AND DEXTROSE 5% IN PLASTIC CONTAINER

NDA NDA018461

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE

NDA NDA018543

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE

NDA NDA017701

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE

NDA NDA017508

Mar 25, 1982

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jun 28, 1982

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jul 7, 1982

XYLOCAINE 5% W/ GLUCOSE 7.5%

NDA NDA010496

Jul 26, 1982

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jul 26, 1982

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 30, 1984

LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER

NDA NDA018967

Dec 3, 1984

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Dec 12, 1984

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jan 22, 1985

LIGNOSPAN STANDARD

NDA ANDA088390

Mar 22, 1985

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 22, 1985

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jul 9, 1985

LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% IN PLASTIC CONTAINER

NDA NDA018954

Jan 14, 1986

LIGNOSPAN FORTE

NDA ANDA088389

Jan 14, 1986

LIGNOSPAN STANDARD

NDA ANDA088390

Feb 22, 1986

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Feb 22, 1986

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Feb 27, 1986

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

May 19, 1986

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Aug 29, 1986

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Aug 29, 1986

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Nov 13, 1986

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Nov 13, 1986

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 16, 1987

LIGNOSPAN STANDARD

NDA ANDA088390

Mar 16, 1987

LIGNOSPAN FORTE

NDA ANDA088389

Mar 18, 1987

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jun 8, 1987

LIGNOSPAN FORTE

NDA ANDA088389

Jun 8, 1987

LIGNOSPAN STANDARD

NDA ANDA088390

Sep 11, 1987

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Sep 11, 1987

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Sep 16, 1987

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jan 19, 1988

XYLOCAINE PRESERVATIVE FREE

NDA NDA016801

May 5, 1988

LIGNOSPAN STANDARD

NDA ANDA088390

May 5, 1988

LIGNOSPAN FORTE

NDA ANDA088389

Dec 2, 1988

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Dec 2, 1988

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jul 11, 1989

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Oct 2, 1990

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 21, 1991

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 21, 1991

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jan 27, 1992

LIGNOSPAN STANDARD

NDA ANDA088390

Jan 27, 1992

LIGNOSPAN FORTE

NDA ANDA088389

Feb 3, 1992

LIGNOSPAN STANDARD

NDA ANDA088390

Apr 8, 1992

LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER

NDA NDA019830

May 11, 1992

LIGNOSPAN FORTE

NDA ANDA088389

May 12, 1992

LIGNOSPAN FORTE

NDA ANDA088389

May 12, 1992

LIGNOSPAN STANDARD

NDA ANDA088390

Feb 9, 1993

LIGNOSPAN FORTE

NDA ANDA088389

Feb 9, 1993

LIGNOSPAN STANDARD

NDA ANDA088390

Feb 18, 1993

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 23, 1993

LIGNOSPAN STANDARD

NDA ANDA088390

Mar 23, 1993

LIGNOSPAN FORTE

NDA ANDA088389

Apr 13, 1993

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Oct 20, 1993

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Aug 4, 1994

LIGNOSPAN STANDARD

NDA ANDA088390

Aug 4, 1994

LIGNOSPAN FORTE

NDA ANDA088389

Nov 21, 1994

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jul 11, 1995

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jul 18, 1995

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jan 3, 1996

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 4, 1996

LIGNOSPAN FORTE

NDA ANDA088389

Mar 4, 1996

LIGNOSPAN STANDARD

NDA ANDA088390

May 2, 1996

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

May 21, 1996

DENTIPATCH

NDA NDA020575

May 31, 1996

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Dec 8, 1997

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 6, 1998

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 19, 1999

LIDODERM

NDA NDA020612

May 26, 1999

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Apr 6, 2000

LIGNOSPAN STANDARD

NDA ANDA088390

Apr 6, 2000

LIGNOSPAN FORTE

NDA ANDA088389

Apr 6, 2000

LIGNOSPAN STANDARD

NDA ANDA088390

Apr 6, 2000

LIGNOSPAN FORTE

NDA ANDA088389

Dec 8, 2000

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Dec 14, 2000

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jul 17, 2002

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Oct 4, 2004

LIGNOSPAN STANDARD

NDA ANDA088390

Oct 4, 2004

LIGNOSPAN FORTE

NDA ANDA088389

Jun 29, 2007

LIGNOSPAN FORTE

NDA ANDA088389

Jun 29, 2007

LIGNOSPAN STANDARD

NDA ANDA088390

Aug 16, 2007

ZINGO

NDA NDA022114

Oct 7, 2008

AKTEN

NDA NDA022221

Sep 30, 2009

LIGNOSPAN FORTE

NDA ANDA088389

Feb 19, 2010

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Feb 13, 2013

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Feb 16, 2013

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Feb 20, 2013

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 28, 2013

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Apr 9, 2013

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jun 11, 2013

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jul 22, 2013

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Oct 29, 2013

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Dec 26, 2013

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 3, 2015

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Mar 17, 2016

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jul 28, 2017

LIGNOSPAN STANDARD

NDA ANDA088390

Jul 28, 2017

LIGNOSPAN FORTE

NDA ANDA088389

Dec 22, 2017

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Dec 22, 2017

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Feb 28, 2018

ZTLIDO

NDA NDA207962

Nov 2, 2018

LIGNOSPAN STANDARD

NDA ANDA088390

Nov 2, 2018

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Nov 2, 2018

LIGNOSPAN FORTE

NDA ANDA088389

Jun 8, 2021

LIGNOSPAN STANDARD

NDA ANDA088390

Jun 8, 2021

LIGNOSPAN FORTE

NDA ANDA088389

Oct 30, 2024

XYLOCAINE W/ EPINEPHRINE, XYLOCAINE

NDA NDA006488

Jun 27, 2025

LIGNOSPAN STANDARD

NDA ANDA088390

Jun 27, 2025

LIGNOSPAN FORTE

NDA ANDA088389

Sep 24, 2025

BONDLIDO

NDA NDA215029

Sources

References

[1]
ClinicalTrials.gov — 669 trial records for Lidocaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Xylocaine drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Lidocaine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Lidocaine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA215029). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Xylocaine. U.S. Food & Drug Administration.
[7]
SEC EDGAR — MEDRx USA, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Sodium Channel Alpha Subunit Blocker[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: MMEDRx USA, Inc.

Patent Landscape[6]

Patent Cliff

Oct 22, 2029

Earliest patent expiration — generic entry possible after this date

Patent #Expires

8759401Jul 24, 2026

8540665Oct 22, 2029

10765640May 10, 2031

9931403May 10, 2031

11278623May 10, 2031

7 more patents

9925264May 10, 2031

11786455May 10, 2031

11793766May 10, 2031

9283174May 10, 2031

10765749May 10, 2031

9358338Apr 27, 2035

9370622Sep 28, 2035