Xylocaine

(Lidocaine)

ApprovedSmall molecule

Lidocaine is a local anesthetic used to numb specific areas of the body to prevent pain during medical procedures or to relieve minor skin irritation and pain. It works by blocking nerve signals in the area where it's applied.[2] Xylocaine is currently approved and in use across 181 indications[4].[1]

Xylocaine is one of 2289 small molecule programs targeting Peripheral Nerve Injury. It is currently in Approved.

181

Indications

657

Total Trials

Active Trials

2,288

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Peripheral Nerve InjuryActive, not recruiting

Plantar FasciitisActive, not recruiting

Premature BirthApproved

ContraceptionApproved

Myofascial Pain SyndromeApproved

ArrhythmiaActive, not recruiting

Muscle SpasmActive, not recruiting

DysuriaApproved

Chondromalacia PatellaeActive, not recruiting

Spasmodic DystoniaApproved

Peripheral Nerve InjuryApproved

Active, not recruiting

Plantar FasciitisPreclinical

Active, not recruiting

Premature BirthApproved

Approved

ContraceptionApproved

Approved

Myofascial Pain SyndromeApproved

Approved

ArrhythmiaPreclinical

Active, not recruiting

Muscle SpasmApproved

Active, not recruiting

DysuriaApproved

Approved

Chondromalacia PatellaePreclinical

Active, not recruiting

Spasmodic DystoniaApproved

Approved

Showing 10 of 171 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Xylocaine

MMEDRx USA, Inc.

Approved

3 2

Tecentriq

Roche

Preclinical

36 3

Nolvadex

SSan Diego Pacific Oncology & Hematology Associates

Preclinical

78 4

DATROWAY

Daiichi Sankyo

Preclinical

4 5

MS Contin

Merck & Co.

Preclinical

2 6

Zolymbus

AbbVie

Preclinical

1 7

Lupron

EEastern Cooperative Oncology Group

Preclinical

5 8

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 9

Recentin

NNational Cancer Institute (NCI)

Preclinical

2 10

Effexor

WWyeth-Lederle Vaccines

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

N/ARecruiting

Scoliosis

NCT06451562

Q4 2026

Post-ApprovalRecruiting

Study completion

NCT06045936

Q2 2027

Phase 2Recruiting

Immune Response

NCT07432399

N/ARecruiting

Post Operative Pain

NCT06405776

Q3 2027

Phase 2Recruiting

Subarachnoid Hemorrhage

NCT07294118

Clinical

Trials by Indication[1]

Lidocaine17 trials

Perioperative Protective Effects of Lidocaine

Terminated·UUniversity Hospital Muenster·Phase 2/3·NCT00413127·78 enrolled

The Impact of Pain Scores on Intrauterine Lidocaine Versus Normal Saline Infusion at the Time of IUD Placement

Completed·WWomen's Health Care Clinic, Torrance, California·Phase 4·NCT01311102·40 enrolled

Comparison of Two Lidocaine Administration Techniques

Completed·UUniversity of Chicago·Phase 4·NCT01330134·481 enrolled

Show 14 more trials

The Optimal Timing of the Initiation of Esophagogastroduodenoscopy After Oral Lidocaine Spray

Recruiting·NNational Cheng-Kung University Hospital·N/A·NCT06497296·160 enrolled

Relationship Between Lidocaine and Serum Orphanin FQ (N/OFQ)

Unknown status·SSecond Hospital of Shanxi Medical University·Phase 4·NCT05899127·80 enrolled

Topical Lidocaine on the Cervix and Intra-Cervical Prior to Insertion of Intrauterine Devices

Unknown status·UUniversity of Tennessee·N/A·NCT01192490·210 enrolled

Clinical Outcomes Maxilla: Buffered 1% Lidocaine vs. Non-buffered 2% Lidocaine

Completed·UUniversity of North Carolina, Chapel Hill·N/A·NCT02747186·24 enrolled

Buffered Lidocaine for Reducing Pain in Patients Undergoing Prostate Biopsy, BURN Trial

Completed·UUniversity of Washington·Phase 1/2·NCT06661902·350 enrolled

Buffered Lidocaine in Paracervical Blocks

Completed·UUniversity of Hawaii·Phase 4·NCT03107754·98 enrolled

Role of LIDOCAINE IN Pediatric Cochlear Implant Surgery

Completed·WWahba bakhet·Phase 4·NCT04194294·70 enrolled

Contrast of Buffered Vs. Unbuffered Lidocaine in Bone Marrow Biopsies

Completed·OOhio State University Comprehensive Cancer Center·N/A·NCT00456872·49 enrolled

Lidocaine in ERAS for FESS

Completed·—·Phase 2·NCT03047070·43 enrolled

Clinical Outcomes of Buffered vs. Non-Buffered Lidocaine

Completed·UUniversity of North Carolina, Chapel Hill·N/A·NCT02620683·23 enrolled

Pain on Injection of Propofol: a Comparison of Lidocaine and Alkalinized Lidocaine

Completed·IInonu University·Phase 4·NCT01773044·300 enrolled

Articaine vs Lidocaine for Pediatric Dental Procedures

Withdrawn·—·Phase 4·NCT03318952

Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT02240628·76 enrolled

Lidocaine and Food Intake

Completed·MMaastricht University Medical Center·Phase 4·NCT03227900·26 enrolled

Intravenous Lidocaine16 trials

Effect of Perioperative Intravenous Lidocaine Infusion and Magnesium Infusion on the Functional Recovery After General Anesthesia in the Patients Undergoing Thyroid Surgery

Completed·YYonsei University·N/A·NCT02018276·135 enrolled

Intravenous Lidocaine to Supress of Cough Reflex During Anesthesia Emergence

Unknown status·—·Phase 3·NCT03805282·132 enrolled

Functional Restoration After Abdominal and Pelvic Laparoscopic Surgery: Effect of Perioperative Intravenous Lidocaine

Completed·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT00982618·60 enrolled

Show 13 more trials

Pilot Study of Effect of Intravenous Lidocaine on Propofol Requirement in Facial Plastic Surgery

Completed·—·Phase 4·NCT02597140·40 enrolled

Intravenous Lidocaine and Acute Rehabilitation

Completed·TThe Cleveland Clinic·Phase 4·NCT00330941·45 enrolled

Intravenous Lidocaine Randomized Comparative Effectiveness Trial

Completed·MMontefiore Medical Center·Phase 4·NCT03300674·154 enrolled

The Effect of Intravenous Lidocaine on Normal Sensation and Pain in Healthy Volunteers

Completed·UUniversity of Alabama at Birmingham·N/A·NCT00657358·22 enrolled

Effect of Perioperative Intravenous Lidocaine on Opioid Consumption and Pain After Laparoscopic Totally Extraperitoneal Inguinal Hernioplasty

Completed·—·Phase 4·NCT02601651·64 enrolled

Effect of Intravenous Lidocaine on the Tolerability of Early Oral Feeding After Laparoscopic Colorectal Surgery

Completed·KKangbuk Samsung Hospital·N/A·NCT01346917·77 enrolled

Perioperative Intravenous Lidocaine or Epidural Anesthesia on Outcomes in Complex Spine Surgery

Completed·TThe Cleveland Clinic·N/A·NCT00840996·116 enrolled

Effect of Intravenous Lidocaine, Used to Attenuate Pain With Propofol Injection, on Defibrillation Threshold Testing

Terminated·—·Phase 1/2·NCT03117166·19 enrolled

Intravenous Lidocaine for Cystectomy Procedures

Completed·—·N/A·NCT02924480·50 enrolled

Intravenous Lidocaine and Quality of Recovery After Cesarean Delivery

Withdrawn·NNorthwestern University·N/A·NCT02257346

Intravenous Lidocaine Infusion in the Management of Post-operative Pain in Colorectal Patients

Withdrawn·—·Phase 1/2·NCT01836614

Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT00236249·110 enrolled

Safety Profile of IntRAvenous Lidocaine Use in Coelioscopic Bariatric Surgery

Completed·HHospices Civils de Lyon·Phase 3·NCT02525016·50 enrolled

Local Anesthetic5 trials

Effects of Epidural Local Anesthetics on Propofol Induction

Completed·FFirst Hospital of China Medical University·Phase 4·NCT02000973·80 enrolled

The Effect of Local Anesthetic Volume Within the Adductor Canal on Quadriceps Function Evaluated by Electromyography

Completed·UUlrik Grevstad·Phase 4·NCT02344589·20 enrolled

Local Anesthetics for Pain Reduction Prior to IV Line Placement

Completed·—·Phase 4·NCT01759459·150 enrolled

Show 2 more trials

Effects of Intravenous Local Anesthetic on Bowel Function After Colectomy

Completed·UUniversity of Virginia·Phase 3·NCT00600158·45 enrolled

Comparing the Efficacy of Local Anesthetics in Mohs Surgery

Unknown status·OOttawa Hospital Research Institute·N/A·NCT03871478·105 enrolled

Treatment5 trials

Lidocaine and Triamcinolone vs Saline Trigger Point Injection for Treatment of Chronic Abdominal Wall Pain

Withdrawn·TTemple University·Phase 4·NCT02748395

Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch

Completed· Astellas logo

Astellas·Phase 4·NCT01416116·122 enrolled

To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo.

Unknown status·HHospital Universitari de Bellvitge·Phase 3·NCT03676556·46 enrolled

Show 2 more trials

Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia

Completed·UUniversité de Sherbrooke·N/A·NCT01455350·212 enrolled

LIMIT Trial - Lidocaine With Intramuscular Injection of Benzathine Penicillin G for Treponema Pallidum Treatment

Recruiting·WWashington University School of Medicine·Phase 3·NCT06391125·48 enrolled

Lidocaine Infusion5 trials

Lidocaine Infusion in Radical Cystectomy

Completed·—·Phase 2·NCT03047057·57 enrolled

Intrauterine Lidocaine Infusion for Essure Sterilization Procedures

Completed·OOregon Health and Science University·Phase 4·NCT00613834·58 enrolled

Continuous Lidocaine Infusion Via Closed Chest Drainage Tube for Pain Control After Thoracoscopic Partial Lung Resection

Unknown status·QQilu Hospital of Shandong University·N/A·NCT05901389·456 enrolled

Show 2 more trials

The Effect of Intrauterine Lidocaine Infusion and Oral Tramadol on Pain During Diagnostic Office Hysteroscopy

Completed·—·Phase 4·NCT03701984·156 enrolled

Intra-operative Lidocaine Infusion in Preventing CPSP Post VATs

Unknown status·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 4·NCT02862769·120 enrolled

117 more indications

Neuropathic Pain4 trials

NS1209 and Lidocaine in Patients With Peripheral Neuropathic Pain

Completed·—·Phase 2·NCT00258622·18 enrolled

Lidocaine Patch in Treating Cancer Patients With Neuropathic Pain After Surgery

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT00058357·30 enrolled

Randomized Controlled Trial of Efficacy and Safety of Local Anesthetics and Steroids for Chronic Peripheral Post-traumatic Neuropathic Pain

Completed·UUniversity Health Network, Toronto·Phase 3·NCT03009500·3 enrolled

Show 1 more trial

Impact of 5% Lidocaine Medicated Plaster on Allodynic Symptoms of Localized Neuropathic Pain After Knee Surgery

Completed·UUniversity Hospital, Clermont-Ferrand·Phase 2·NCT02763592·37 enrolled

Concentration4 trials

Minimum Anaesthesia Concentration of Lidocaine Required for Sciatic Popliteal Block

Unknown status·—·Phase 4·NCT03613974·50 enrolled

Effect of Different Concentrations of Lidocaine in Relieving Pain in Wide Awake Hand Surgery Using Tumescence

Completed·KKing Edward Medical University·Phase 1·NCT04692896·90 enrolled

The Effects of Different Clonidine Concentrations on Axillary Brachial Plexus Block With 1,5% Lidocaine

Completed·UUniversidade Federal do Rio de Janeiro·Phase 2·NCT01620112·60 enrolled

Show 1 more trial

Endovenous Lidocaine and Serum Cytokines Concentration

Completed·UUniversidade Federal de Santa Maria·Phase 4·NCT02363699·44 enrolled

Anesthesia4 trials

Topical Lidocaine Anesthesia for Nasopharyngeal Sampling

Completed·—·N/A·NCT04885777·50 enrolled

Is it Possible to Replace Fentanyl in Anesthesia for Minor Procedures?

Completed·—·N/A·NCT03806374·120 enrolled

Epidural Anesthesia With Chloroprocaine Versus Lidocaine

Completed·JJinling Hospital, China·Phase 4·NCT02287870·120 enrolled

Show 1 more trial

Anesthesia Lumbar Puncture In Children

Unknown status·—·N/A·NCT02590705·200 enrolled

Post Operative Pain3 trials

Comparison of the Effect of Lidocaine Infusion Applied at Different Doses During Lumbar Spinal Surgery on Hemodynamics and Postoperative Pain

Unknown status·—·N/A·NCT05936190·80 enrolled

Are There Differences in Postoperative Pain Between Bupivacaine and Lidocaine for Carpal Tunnel Release?

Completed·HHospital Italiano de Buenos Aires·N/A·NCT05697276·82 enrolled

Effect of Lidocaine on Postoperative Pain and Long-term Survival in Elderly Patients Undergoing Colorectal Surgery

Recruiting·WWest China Hospital·N/A·NCT06405776·276 enrolled

Hemodynamic Response3 trials

Attenuation of the Hemodynamic Response to Double-lumen Endotracheal Intubation With Nebulized Lidocaine

Unknown status·RRenJi Hospital·Phase 4·NCT05850702·92 enrolled

The Effects of Lidocaine and Magnesium Sulphate on the Attenuation of the Hemodynamic Response to Tracheal Intubation

Completed·HHospital de Base·Phase 4·NCT02359370·49 enrolled

The Effects of Lidocaine and Esmolol on Attenuation of Hemodynamic Response to Orotracheal Intubation

Unknown status·HHospital de Base·Phase 4·NCT03612492·80 enrolled

Pain Control3 trials

Lidocaine Spray Plus Oral Celecoxib for Pain Control During Hysterosalpingography

Completed·—·N/A·NCT04505657·150 enrolled

Pain Control in Pediatric Oncology: Utility of EMLA Cream vs Lidocaine Injection in Lumbar Punctures

Completed·—·Phase 4·NCT04003012·10 enrolled

Study On Lidocaine Vs. Placebo Pain Control During Transrectal Ultrasound Guided Prostate Biopsy

Completed·CCorewell Health East·N/A·NCT00441532·50 enrolled

Midazolam3 trials

Efficacy of Topical Lidocaine to Decrease Discomfort With Intranasal Midazolam Administration

Completed·UUniversity of Alabama at Birmingham·N/A·NCT02396537·77 enrolled

Does Use of Topical Lidocaine in EGD Reduce Amount of IV Midazolam and Fentanyl Required and Shorten Recovery Time

Unknown status·—·N/A·NCT02620501·106 enrolled

PREMIX vs PREMED Intranasal Lidocaine and Midazolam

Completed·—·Phase 2·NCT03054844·55 enrolled

Laparoscopic Cholecystectomy3 trials

Intravenous Lidocaine for Laparoscopic Cholecystectomy

Completed·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT01062906·80 enrolled

Synergistic Effect of Intravenous Lidocaine on Anesthetic Induction and Emergence in Patients Undergoing Laparoscopic Cholecystectomy or Gynecological Surgery

Enrolling by invitation·GGeneral Hospital of Ningxia Medical University·N/A·NCT07193836·195 enrolled

Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy

Unknown status·HHvidovre University Hospital·Phase 4·NCT00209885·60 enrolled

Randomized Controlled Trial3 trials

Does Injection Site Matter? A Randomized Controlled Trial to Evaluate Efficacy of Knee Intraarticular Injections on Improval of Patient Reported Outcomes.

Completed·UUniversity of Puerto Rico·Phase 4·NCT02176304·60 enrolled

Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine in Labor Epidural Analgesia.

Not yet recruiting·HHadassah Medical Organization·Phase 4·NCT06302257·60 enrolled

Efficacy of Triamcinolone-Lidocaine Mix in Trigger Points Injection of Masseter Muscle: Double-blinded, Randomized Controlled Trial

Not yet recruiting·—·Phase 2/3·NCT07445191·30 enrolled

Bupivacaine3 trials

Incidence of TNS After Intrathecal Lidocaine v.s Bupivacaine

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·N/A·NCT03862287·160 enrolled

Determination of the Effective Volume of 0.125% Bupivacaine-fentanyl 5mcg/mL in Labour Epidurals

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT01972269·80 enrolled

Bupivacaine Versus Lidocaine on Inflammatory Regulation

Completed·—·Phase 4·NCT01060774·11 enrolled

Prevention3 trials

The Prevention of Pain Associated With Rocuronium Injection

Completed·SSuleyman Demirel University·Phase 4·NCT02524743·150 enrolled

Amiodarone for the Prevention of Reperfusion Ventricular Fibrillation

Completed·MMayo Clinic·N/A·NCT00587483·342 enrolled

Surgery Prevention by Transforaminal Injection of Epidural Steroids for Cervical Radicular Pain

Completed·OOrthoCarolina Research Institute, Inc.·Phase 4·NCT02226159·65 enrolled

Total Hip Arthroplasty2 trials

Treatment of Postoperative Pain After Total Hip Arthroplasty Using Intravenous Lidocaine Infusion

Withdrawn·LLoma Linda University·Phase 1/2·NCT01108562

Spinal Anesthesia in Total Hip Arthroplasty

Terminated·TThomas L Bradbury·Phase 4·NCT02818894·135 enrolled

Neuralgia2 trials

Dysport in Post-Surgical Neuralgia

Completed· Ipsen logo

Ipsen·Phase 2·NCT03663101·16 enrolled

Therapeutic Effects Analysis of Pudendal Nerve Infiltrations After 3 Months, in Patients Suffering of Pudendal Neuralgia

Completed·NNantes University Hospital·Phase 4·NCT00851513·202 enrolled

Pain Perception2 trials

Pain Perception During Vulvar Biopsy

Terminated·—·Phase 4·NCT03654417·37 enrolled

Pain Perception: Lidocaine Rate/Temp/Buffer

Active, not recruiting·NNorthwestern University·N/A·NCT02823002·26 enrolled

Nerve Block2 trials

Onset and Duration of Forearm Nerve Blockade

Completed·NNew York School of Regional Anesthesia·Phase 4·NCT03649763·36 enrolled

Ilioinguinal Nerve Block in Transcatheter Aortic Valve Implantation

Unknown status·—·Phase 4·NCT05220813·88 enrolled

Peripheral Neuropathy2 trials

A Randomized, Double-blind, Placebo- and Active-controlled Study of the Electric Current Effects of ABT-639 on the Spontaneous Activity of Pain Sensory Receptors in Patients With Diabetic Peripheral Neuropathy

Completed· AbbVie logo

AbbVie·Phase 2·NCT01589432·39 enrolled

Lidocaine for Diabetic Peripheral Neuropathy

Completed·WWashington University School of Medicine·N/A·NCT02363803·34 enrolled

Postoperative Pain Management2 trials

Intravenous Lidocaine and Postoperative Pain Management

Unknown status·—·Phase 4·NCT02997215·80 enrolled

Comparison of the Effectiveness of Intraoperative Intravenous Lidocaine and Intravenous Remifentanil in Postoperative Pain Management in Laparoscopic Cholecystectomy

Completed·—··NCT07312877·138 enrolled

Mastectomy2 trials

Infusion of Dexmedetomidine Versus Lidocaine in Management of Acute Postoperative Pain After Modified Radical Mastectomy

Completed·—·N/A·NCT06974656·40 enrolled

Analgesic Effect of Perioperative Systemic Lidocaine in Patients Undergoing Unilateral Mastectomy Surgery

Terminated·NNorthwestern University·Phase 4·NCT00913003·22 enrolled

Sedation2 trials

Interscalene Nerve Block vs. Sedation for Shoulder Dislocation Reduction

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT03041506·90 enrolled

Analgesia From Conscious Sedation Versus Paracervical Block for Manual Vacuum Aspiration

Completed·DDarlington-Peter Chibuzor Ugoji·Phase 4·NCT06539143·81 enrolled

Immune Response2 trials

Effect of Perioperative Lidocaine or High-Dose Dexamethasone on Immune Response in Colon Cancer Surgery (PILDI Study)

Recruiting·IInstitute of Oncology Ljubljana·Phase 2·NCT07432399·100 enrolled

Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patients Undergoing Surgery for Colon Cancer - the PILDI Study

Recruiting·IInstitute of Oncology Ljubljana·Phase 2·NCT06923787·100 enrolled

Safety and Efficacy2 trials

Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort

Completed·LLumara Health, Inc.·Phase 2·NCT00590590·105 enrolled

Safety and Efficacy of Lidocaine Infiltration in Suction Assisted Lipectomy

Unknown status·—·Phase 3·NCT00591487·60 enrolled

Cardiac Arrest1 trial

Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia

Completed·UUniversity of Washington·Phase 3·NCT01401647·3,024 enrolled

Fibromyalgia1 trial

Lidocaine on Manifestations of Fibromyalgia

Completed·FFederal University of São Paulo·Phase 1·NCT00991848·30 enrolled

Hemodynamic Stability1 trial

Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients

Withdrawn·WWashington University School of Medicine·Phase 1·NCT03177252

Scoliosis1 trial

Effect of Regional Anesthesia or Intravenous Infusion of Lidocaine on Morphine Use After Scoliosis Repair Surgery

Recruiting·—·N/A·NCT06451562·105 enrolled

Caesarean Section1 trial

Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine

Completed·—·Phase 4·NCT02274974·160 enrolled

Postoperative Pain Control1 trial

Perioperative Lidocaine Administration in Thoracoscopic Surgery for Improved Postoperative Pain Control

Completed·UUniversity Hospital, Basel, Switzerland·Phase 3·NCT03677817·113 enrolled

Chronic pain1 trial

Lidocaine-Ketamine for Management of Chronic Pain

Unknown status·HHamilton Health Sciences Corporation·N/A·NCT03249025·72 enrolled

Pain1 trial

Pupillometry - Future of Objective Pain Reaction Measurement While Unconscious

Completed·UUniversity of Warmia and Mazury·N/A·NCT04000126·90 enrolled

Prospective1 trial

Analgesic Effect of Illiohypogastic & Ilioinguinal Nerve Block in TAVR - TF (Prospective Randomized Study)

Recruiting·—·Phase 1/2·NCT06362915·52 enrolled

Preoperative1 trial

Comparing Efficacy Preoperative Nebulized: Ketamine , Mgspo4 ,and Lidocaine In Attenuating Endotracheal Sore Throat

Completed·ZZagazig University·Phase 3·NCT03729973·100 enrolled

Perioperative Pain Control1 trial

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

Unknown status·UUniversity of Illinois College of Medicine at Peoria·Phase 4·NCT02958566·80 enrolled

Laparotomy1 trial

Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy

Completed·—·Phase 4·NCT06772727·149 enrolled

Female1 trial

Cystoscopy in Females: Is There a Difference Between Rigid and Flex Cystoscopy, and Does it Require Local Anasthesia?

Completed·—·N/A·NCT03210038·120 enrolled

Rotator Cuff Tear1 trial

Comparison of Strength and Constant Score Pre- and Post-Subacromial Injection for Full Thickness Rotator Cuff Tears

Withdrawn·RRush University Medical Center·N/A·NCT02693444

General Anesthesia1 trial

Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia

Unknown status·IIsfahan University of Medical Sciences·Phase 4·NCT01417572·30 enrolled

Bowel Surgery1 trial

A Pain Study Comparing Two Commonly Used Medications to Treat Pain After Bowel Surgery

Completed·—·N/A·NCT02849678·68 enrolled

Septic Shock1 trial

Lidocaine as an Adjuvant for Ketamine in Induction of Anesthesia in Septic Shock Patients

Unknown status·—·Phase 3·NCT03640468·36 enrolled

Intravenous1 trial

Intravenous Infusion of Lidocaine in Colonoscopy

Unknown status·SShandong University·Phase 4·NCT04439786·50 enrolled

Sternotomy1 trial

Percutaneous Ketamine Versus Lidocaine for Mid-Sternotomy

Unknown status·TTel-Aviv Sourasky Medical Center·Phase 4·NCT00822419·75 enrolled

GAN1 trial

Sphenopalatine Ganglion Blocks RCT

Completed·UUniversity of California, San Francisco·Phase 4·NCT03666663·10 enrolled

Pain and Discomfort1 trial

TAmoxifen Versus LIdocaine Cream. A Randomized Clinical Trial for Reducing Pain and Discomfort During Mammography

Unknown status·UUniversidade Federal de Goias·Phase 2/3·NCT02801786·450 enrolled

IUD1 trial

Paracervical Block Versus No Paracervical Block During IUD Insertion

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT02904915·50 enrolled

Prostatectomy1 trial

Spinal Morphine in Robotic Assisted Radical Prostatectomy

Completed·MMaasstad Hospital·Phase 4·NCT02924974·160 enrolled

Renal Colic1 trial

Treatment of Renal Colic in the Emergency Departement (ED).

Completed·UUniversity of Monastir·Phase 2·NCT03199924·600 enrolled

Abortion1 trial

Paracervical Block in First Trimester Surgical Abortions

Completed·JJohns Hopkins University·Phase 2/3·NCT00617097·50 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Quality of Recovery Following Opioids Free Anaesthesia in Laparoscopic Sleeve Gastrectomy

Completed·—·N/A·NCT04285255·103 enrolled

Skin1 trial

Determine the Effect of AZD3161,Injected Intradermally, on Quantitative Sensory Testing Variables in Normal and Ultraviolet-C (UVC) Exposed Skin in Healthy Volunteers

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01240148·26 enrolled

Pompe Disease1 trial

Re-administration of Intramuscular AAV9 in Patients With Late-Onset Pompe Disease

Completed·UUniversity of Florida·Phase 1·NCT02240407·2 enrolled

Functional Endoscopic Sinus Surgery1 trial

Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Functional Endoscopic Sinus Surgery

Recruiting·—·N/A·NCT06848764·40 enrolled

Hysterectomy1 trial

Lidocaine Infusion on Optic Nerve Sheath Diameter in Laparoscopic Hysterectomy in Trendelenburg Position

Completed·TTanta University·N/A·NCT05690087·66 enrolled

Osteoarthritis1 trial

Intra-Articular 0.5 % Lidocaine Injection for Osteoarthritis

Completed·HH. Evren Eker·Phase 4·NCT02632565·52 enrolled

Arthritis1 trial

Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb Joint

Terminated·UUniversity of Missouri-Columbia·Phase 4·NCT01045694·8 enrolled

Antibiotic1 trial

Cefazolin-Lidocaine Combination Solution to Reduce Antibiotic Pain

Unknown status·UUniversity Health Network, Toronto·Phase 4·NCT02324166·54 enrolled

Tendinopathy1 trial

Treatment for Achilles Tendinopathy

Unknown status·UUniversity of Calgary·Phase 2/3·NCT00835939·17 enrolled

Blood Pressure1 trial

Decision Support for Intraoperative Low Blood Pressure

Completed·VVanderbilt University Medical Center·N/A·NCT02726620·22,435 enrolled

Cognitive Dysfunction1 trial

Lidocaine on Early Cognitive Dysfunction in Shoulder Arthroscopy

Unknown status·—·Phase 2·NCT04634656·80 enrolled

Cancer Pain1 trial

Radiofrequency and Chemical Neurolysis of Thoracic Splanchnic Nerve for Abdominal Cancer Pain

Unknown status·SSouth Egypt Cancer Institute·N/A·NCT03063112·79 enrolled

Pilonidal sinus1 trial

Sacrococcygeal Local Anesthesia With Different Doses of Clonidine for Pilonidal Sinus Surgery

Unknown status·MMakassed General Hospital·N/A·NCT02539693·60 enrolled

ESS1 trial

Block Pressor Response to Intubation

Unknown status·—·N/A·NCT05659212·102 enrolled

Intravitreal Injections1 trial

Cryoanesthesia for Intravitreal Injections

Completed·UUniversity of Michigan·Phase 1/2·NCT02872012·23 enrolled

Hypersensitivity1 trial

Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain

Unknown status·TThe Hospital for Sick Children·Phase 3·NCT01503060·352 enrolled

Total Knee Replacement1 trial

Intravenous Lidocaine in Total Knee Replacement

Completed·TThe University of Hong Kong·Phase 4·NCT03597776·62 enrolled

Double-blind1 trial

Intrauterine Anesthesia in Operative, Awake, Office Hysteroscopy. A Randomized Double-blind Placebo-controlled Trial

Completed·—·N/A·NCT05610371·100 enrolled

Postoperative Quality of Recovery1 trial

Effect of Perioperative Intravenous Lidocaine on Postoperative Quality of Recovery in Patients Undergoing Spine Surgery

Withdrawn·—·Phase 2·NCT01930877

Perioperative Analgesia1 trial

Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery

Terminated·—·Phase 3·NCT04176419·30 enrolled

Colon Surgery1 trial

Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine

Completed·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 2·NCT01155440·60 enrolled

Supraclavicular Brachial Plexus Block1 trial

Ultrasound-guided Supraclavicular Brachial Plexus Blockade

Terminated·UUniversity of Manitoba·N/A·NCT00523055·10 enrolled

Shoulder pain1 trial

Sphenopalatine Ganglion Block to Treat Shoulder Pain After Thoracotomy

Completed·NNYU Langone Health·Phase 1·NCT02733393·2 enrolled

Postoperative Recovery1 trial

Effect of Perioperative Intravenous Lidocaine Infusion on Postoperative Recovery in Patients Undergoing Arthroscopic Rotator Cuff Repair Under General Anesthesia

Completed·YYonsei University·N/A·NCT04061057·98 enrolled

Epidural Analgesia1 trial

A Comparison of Epidural Analgesia: Continuous Infusion Versus Programmed Intermittent Boluses

Completed·FFundación Santa Fe de Bogota·N/A·NCT02510287·128 enrolled

Erector Spinae Plane Block1 trial

Erector Spinae Plane Block Versus Perioperative Intravenous Lidocaine for Thoracotomy

Completed·—·N/A·NCT04221880·60 enrolled

Endovascular Thrombectomy1 trial

General Anesthesia for Endovascular Thrombectomy; A Pilot Study.

Completed·UUniversity of Saskatchewan··NCT02639806·34 enrolled

Laparoscopic Appendectomy1 trial

Intravenous Lidocaine in Children Undergoing Laparoscopic Appendectomy

Completed·MMedical University of Warsaw·Phase 4·NCT03886896·74 enrolled

Cervical Cancer1 trial

The Effect of Intravenous Lidocaine on THBS2 and Angiogenic Factors Expression in Women Undergoing Cervical Cancer Surgery

Unknown status·GGeneral Hospital of Ningxia Medical University·N/A·NCT05560035·60 enrolled

Irritable Bowel Syndrome1 trial

Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome

Completed·UUS Department of Veterans Affairs·Phase 2·NCT00108446

Rib Fracture1 trial

Ketamine vs Lidocaine in Traumatic Rib Fractures

Active, not recruiting·BBrittany Hoyte·Phase 4·NCT04781673·74 enrolled

Surgical Field1 trial

Lidocaine Versus Esmolol for Optimizing Surgical Field Visibility

Completed·ZZagazig University·Phase 2·NCT04260685·70 enrolled

Atrial Fibrillation1 trial

Workflow Optimization During Pulse Field Ablation for Atrial Fibrillation

Not yet recruiting·NNational Taiwan University Hospital·Phase 4·NCT07354217·60 enrolled

Steroid Injection1 trial

Does Adding Lidocaine to Corticosteroid Injections Reduce Pain Intensity in Hand Surgery

Completed·UUniversity of Texas at Austin·N/A·NCT06188221·40 enrolled

Vomiting1 trial

Intravenous Lidocaine in the Prevention of Postoperative Vomiting in Elective Tonsil Surgery

Completed·PPontificia Universidad Catolica de Chile·Phase 4·NCT01986309·92 enrolled

Local Anesthesia1 trial

Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia

Terminated·UUniversity of Nebraska·Phase 4·NCT02647892·70 enrolled

Trigeminal Neuralgia1 trial

The Effect of Intravenous Lidocaine on Trigeminal Neuralgia

Completed·PPain Relief & Palliative Care Center, Athens, Greece·N/A·NCT01955967·20 enrolled

Adductor Canal Block1 trial

Location of Injection of Local Anesthetics in the Adductor Canal Block

Completed·WWomen's College Hospital·N/A·NCT02554864·108 enrolled

Abdominal Surgery1 trial

Lidocaine and Ketamine in Abdominal Surgery

Terminated·TThe Cleveland Clinic·N/A·NCT00721110·64 enrolled

Quality of Recovery1 trial

Effect of Lidocaine and Esmolol to Improve the Quality of Recovery

Terminated·—·Phase 4·NCT01114997·32 enrolled

AIN1 trial

Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage

Terminated·AAlbert Einstein Healthcare Network·Phase 4·NCT01673061·21 enrolled

Dexamethasone1 trial

Perineural Low-dose Dexamethasone Added to Infraclavicular Block Anesthesia

Completed·FFoisor Orthopedics Clinical Hospital·Phase 3·NCT02698995·180 enrolled

Bronchoscopy1 trial

Non-anesthesiologist-administered Propofol During the Flexible Bronchoscopy

Completed·HHospital Universitario Dr. Jose E. Gonzalez·N/A·NCT02820051·102 enrolled

Pulmonary Hypertension1 trial

A Study of Stellate Ganglion Block and / or Reserpine in Group 2 Pulmonary Hypertension

Withdrawn·MMayo Clinic·Phase 1·NCT02684786

Dysmenorrhea1 trial

Efficacy and Safety Study of Lidocaine Vaginal Gel for Recurrent Dysmenorrhea (Painful Periods)

Completed·JJuniper Pharmaceuticals, Inc.·Phase 2·NCT00651313·81 enrolled

Opioid Free Anesthesia1 trial

OFA - Opioid Free Anesthesia

Unknown status·UUniversity of Parma·Phase 4·NCT03124082·64 enrolled

Adhesive Capsulitis of the Shoulder1 trial

A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses Standard of Care in Adhesive Capsulitis of the Shoulder

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT05844930·56 enrolled

Children1 trial

Optimization Lumbar Puncture In Children

Withdrawn·—·N/A·NCT02454894

Cesarean Delivery1 trial

Local Lidocaine Infiltration for Pain Management Post Cesarean Delivery.

Unknown status·SSoroka University Medical Center·N/A·NCT00737542

Magnesium Sulfate1 trial

Atracurium Mixed With Magnesium Sulfate Versus Atracurium Alone as Adjuvant to Lidocaine in IVRA

Completed·—·Phase 3·NCT02920905·75 enrolled

Gastrostomy1 trial

Trial Evaluating the Efficacy of the Combination of ROpivacaine With Reference XYlocaine in the Evaluation of Pain During the Installation of Percutaneous Radiological GASTrostomy

Terminated·—·Phase 2·NCT04250805·17 enrolled

Laryngospasm1 trial

The Effect of Intravenous Lidocaine on Post-extubation Laryngospasm

Terminated·KKing Saud University·N/A·NCT01445847·134 enrolled

Thoracic Paravertebral Block1 trial

Serratus Anterior Muscle Plane Block vsThoracic Paravertebral Block For Unilateral Mastectomies

Withdrawn·TThe University of Texas Health Science Center, Houston·Phase 4·NCT02822196

Cataract1 trial

Topical Jelly and Intracameral Anesthesia Versus Subtenon Anesthesia, in Cataract Surgery

Withdrawn·HHospital Italiano de Buenos Aires·Phase 4·NCT01344252

Subarachnoid Hemorrhage1 trial

Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage

Recruiting·TThe University of Texas Medical Branch, Galveston·Phase 2·NCT07294118·15 enrolled

Chronic Pelvic Pain1 trial

Lidocaine Injection and Ischemic Compression on Chronic Pelvic Pain Treatment

Terminated·UUniversity of Sao Paulo·Phase 4·NCT00628355·30 enrolled

Abdominal Surgeries1 trial

Adjuvant to General Anesthesia in Patients Undergoing Major Abdominal Surgeries

Unknown status·SSuez Canal University·Phase 4·NCT03600493·64 enrolled

Infiltration1 trial

Self-Reported Pain in Children Submitted to Single Infiltration of Articaine During Primary Molar Extraction

Completed·—·Phase 4·NCT05443009·76 enrolled

Gastroesophageal Reflux Disease1 trial

Impact of Blocking the Glossopharyngeal Nerve on Gastroesophageal Reflux Disease

Not yet recruiting·MMuhammad·N/A·NCT06304870·80 enrolled

Cardiac Surgery1 trial

Lidocaine For Neuroprotection During Cardiac Surgery

Completed·—·N/A·NCT00938964·550 enrolled

Function1 trial

Penile Fracture: A Comparison of Erectile Function After Immediate Repair Versus Delayed Repair

Completed·MMinistry of Health, Jamaica·N/A·NCT03449940·46 enrolled

Juvenile Idiopathic Arthritis1 trial

Hip Denervation in Juvenile Idiopathic Arthritis With Hip Arthritis

Completed·SSohag University·Phase 3·NCT04775225·120 enrolled

Steroid1 trial

Corticosteroid and Lidocain Injections for Tennis Elbow

Completed·SShin Kong Wu Ho-Su Memorial Hospital·N/A·NCT02700906·60 enrolled

Satisfaction1 trial

Lidocaine Improves Satisfaction in Labiaplasty

Unknown status·KKaohsiung Medical University Chung-Ho Memorial Hospital·Phase 4·NCT05706987·80 enrolled

Gastrectomy1 trial

Routine Irrigation With Ropivacaine vs. Lidocaine vs. Saline of Surgical Bed in Sleeve Gastrectomy

Unknown status·TThe Baruch Padeh Medical Center, Poriya·N/A·NCT02023684·90 enrolled

Visceral Pain1 trial

Benefit of Lidocaine Perfusion in Cancer Related Visceral Pain Resistant to Morphinics

Unknown status·GGustave Roussy, Cancer Campus, Grand Paris·Phase 3·NCT00181012·100 enrolled

Spine Surgery1 trial

Peri-Operative Lidocane, Ketamine, or Lidocane and Ketamine Combination, Infusion for Patients Undergoing Spine Surgery

Completed·—·Phase 3·NCT01983020·46 enrolled

Aneurysm1 trial

Lidocaine and Perioperative Cytokine Levels in Blood and Cerebrospinal Fluid in Cerebral Aneurysm Patients

Unknown status·—·N/A·NCT03823482·40 enrolled

Flushing1 trial

The Value of Endocervical and Endometrial Lidocaine Flushing Before Office Hystroscopy

Unknown status·—·Phase 4·NCT03530488·250 enrolled

Postoperative Analgesia1 trial

Does Intraperitoneal Instillation of Lidocaine at Cesarean Delivery Improve Postoperative Analgesia?

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT02264795·204 enrolled

Unspecified1 trial

A Study of Contralateral Limb Block

Recruiting·MMayo Clinic·Phase 4·NCT06045936·20 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

XYLOCAINE 4% PRESERVATIVE FREE

NDA NDA010417

Jan 1, 1982

XYLOCAINE DENTAL

NDA NDA021380

Jan 1, 1982

XYLOCAINE 1.5% W/ DEXTROSE 7.5%

NDA NDA016297

Jan 1, 1982

XYLOCAINE

NDA NDA008816

Jan 1, 1982

XYLOCAINE

NDA NDA008048

Jan 1, 1982

XYLOCAINE VISCOUS

NDA NDA009470

Jan 1, 1982

XYLOCAINE

NDA NDA014127

Jan 1, 1982

XYLOCAINE

NDA NDA013077

Jan 1, 1982

XYLOCAINE

NDA NDA006488

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE

NDA NDA017508

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE

NDA NDA017701

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE

NDA NDA018543

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE 0.1% AND DEXTROSE 5% IN PLASTIC CONTAINER

NDA NDA018461

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% IN PLASTIC CONTAINER

NDA NDA018388

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE

NDA NDA017584

Jan 1, 1982

LIDOCAINE HYDROCHLORIDE PRESERVATIVE FREE

NDA NDA017702

Jan 1, 1982

LIDOPEN

NDA NDA017549

Jan 1, 1982

XYLOCAINE

NDA NDA010418

Jan 1, 1982

XYLOCAINE

NDA NDA014394

Jul 7, 1982

XYLOCAINE 5% W/ GLUCOSE 7.5%

NDA NDA010496

Mar 30, 1984

LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER

NDA NDA018967

Jul 9, 1985

LIDOCAINE HYDROCHLORIDE 0.2% IN DEXTROSE 5% IN PLASTIC CONTAINER

NDA NDA018954

Jan 19, 1988

XYLOCAINE PRESERVATIVE FREE

NDA NDA016801

Apr 8, 1992

LIDOCAINE HYDROCHLORIDE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER

NDA NDA019830

May 21, 1996

DENTIPATCH

NDA NDA020575

Mar 19, 1999

LIDODERM

NDA NDA020612

Aug 16, 2007

ZINGO

NDA NDA022114

Oct 7, 2008

AKTEN

NDA NDA022221

Feb 28, 2018

ZTLIDO

NDA NDA207962

Sep 24, 2025

BONDLIDO

NDA NDA215029

Sources

References

[1]
ClinicalTrials.gov — 657 trial records for Lidocaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Xylocaine drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Lidocaine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Lidocaine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA215029). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Xylocaine. U.S. Food & Drug Administration.
[7]
SEC EDGAR — MEDRx USA, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Sodium Channel Alpha Subunit Blocker[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: MMEDRx USA, Inc.

Patent Landscape[6]

Patent Cliff

Jul 24, 2026

Earliest patent expiration — generic entry possible after this date

Patent #Expires

8759401Jul 24, 2026

8540665Oct 22, 2029

10765640May 10, 2031

9931403May 10, 2031

11278623May 10, 2031

7 more patents

9925264May 10, 2031

11786455May 10, 2031

11793766May 10, 2031

9283174May 10, 2031

10765749May 10, 2031

9358338Apr 27, 2035

9370622Sep 28, 2035