Medrol

(methylprednisolone acetate)

ApprovedSmall molecule

Pfizer

Medrol is one of 132 small molecule programs targeting Dysphagia. It is currently in Approved.

Indications

Total Trials

Active Trials

131

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

DysphagiaActive, not recruiting

Carpal Tunnel SyndromeActive, not recruiting

SciaticaActive, not recruiting

KeloidActive, not recruiting

TendinitisActive, not recruiting

MigraineActive, not recruiting

Knee OsteoarthritisNot yet recruiting

Total Knee ReplacementCompleted

OsteoarthritisRecruiting

DysphagiaPreclinical

Active, not recruiting

Carpal Tunnel SyndromePreclinical

Active, not recruiting

SciaticaPreclinical

Active, not recruiting

KeloidPreclinical

Active, not recruiting

TendinitisApproved

Active, not recruiting

MigraineApproved

Active, not recruiting

Knee OsteoarthritisPreclinical

Not yet recruiting

Total Knee ReplacementPreclinical

Completed

OsteoarthritisPhase 3

Recruiting

Competition

Competitive Landscape

143 competitors in Osteoarthritis

#DrugCompanyPhaseTrials

Medrol

Pfizer

Approved

3 2

Toradol

Roche

Preclinical

1 3

Cataflam

Bayer Aspirin

Enbrel

2 6

Glucophage

EMD Serono

Preclinical

1 7

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Preclinical

1 8

Protonix

WWyeth-Lederle Vaccines

Preclinical

1 9

Catapres

Boehringer Ingelheim

Preclinical

1 10

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2028

PreclinicalNot yet recruiting

Knee Osteoarthritis

NCT07804199

Q4 2028

Phase 3Recruiting

Osteoarthritis

NCT07371572

Clinical

Trials by Indication[1]

Osteoarthritis3 trials

Intra-articular Injections of Platelet-rich Plasma, Hyaluronic Acid, or Corticosteroids for Knee Osteoarthritis

Unknown status·UUniversity of Wasit·Phase 3·NCT04980105·150 enrolled

The Efficacy and Safety of Intramuscular Methylprednisolone in Patients With Hand OsteoArthritis

Recruiting·SSint Maartenskliniek·Phase 3·NCT07371572·212 enrolled

Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis

Completed·EEdin Mešanović·Phase 4·NCT06717529·65 enrolled

Total Knee Replacement1 trial

Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?

Completed·NNew Lexington Clinic·N/A·NCT00492973·101 enrolled

Dysphagia1 trial

Effect of Topical Corticosteroids on Dysphagia in Anterior Cervical Discectomy and Fusion

Completed·HHospital for Special Surgery, New York·N/A·NCT02539394·128 enrolled

Keloid1 trial

Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids, Hypertrophic Scars)

Unknown status·TTel-Aviv Sourasky Medical Center·N/A·NCT04593706·40 enrolled

Sciatica1 trial

Transforaminal Epidural Injection in Acute Sciatica

Recruiting·CC.L.A.Vleggeert-Lankamp·N/A·NCT03924791·142 enrolled

10 more indications

Methylprednisolone1 trial

Subacromial Methylprednisolone Versus Ketorolac for Shoulder Impingement

Terminated·TThe University of Texas Medical Branch, Galveston·Phase 2·NCT03913702·1 enrolled

Corticosteroids1 trial

Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection

Completed·IIstituto Ortopedico Rizzoli·Phase 4·NCT01652495·44 enrolled

Low back pain1 trial

A Trial of Corticosteroids for Low Back Pain

Completed·MMontefiore Medical Center·Phase 3·NCT00290589·82 enrolled

RCT1 trial

Knee Injection RCT

Terminated·UUConn Health·Phase 4·NCT03694821·18 enrolled

Carpal Tunnel Syndrome1 trial

Local Injection of Ozone Versus Methylprednisolone Acetate in Carpal Tunnel Syndrome of Scleroderma Patients

Completed·—·N/A·NCT03742466·50 enrolled

Migraine1 trial

Corticosteroids for Acute Migraine in the Emergency Department

Completed·MMontefiore Medical Center·Phase 4·NCT02847494·220 enrolled

Suprascapular Nerve Block1 trial

Quality of Life and Pain With Infiltration or Suprascapular Nerve Block in Glenohumeral Arthirtis

Completed·IInstituto Mexicano del Seguro Social·Phase 3·NCT03794505·40 enrolled

Dexamethasone1 trial

Dexamethasone Versus Depo Medrol in Lumbar Epidurals

Terminated·SState University of New York - Upstate Medical University·N/A·NCT01397552·8 enrolled

Tendinitis of Shoulder1 trial

Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection: A Double Blind Controlled Study

Completed·NNantes University Hospital·Approved·NCT02403856·136 enrolled

Knee Osteoarthritis1 trial

Optimizing Home-Based Auricular Vagus Nerve Stimulation for Pain, Function, and Inflammation in Veterans With Knee Osteoarthritis: A Randomized Pilot Dose-Finding Study (AVAHCS) (F4845-C)

Not yet recruiting·VVA Office of Research and Development·Preclinical·NCT07804199·40 enrolled

Regulatory

FDA Approval Timeline[4]

Jan 1, 1982

MEDROL

NDA NDA018102

Jan 1, 1982

DEPO-MEDROL

NDA NDA011757

Jan 1, 1982

SOLU-MEDROL

NDA NDA011856

Jan 1, 1982

MEDROL ACETATE

NDA NDA012421

Jan 1, 1982

MEDROL

NDA NDA011153

Sources

References

[1]
ClinicalTrials.gov — 17 trial records for methylprednisolone acetate. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — methylprednisolone acetate compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for methylprednisolone acetate. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (NDA NDA018102). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Pfizer

Medrol

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2028

Q4 2028

Trials by Indication[1]

Osteoarthritis3 trials

Total Knee Replacement1 trial

Dysphagia1 trial

Keloid1 trial

Sciatica1 trial

Methylprednisolone1 trial

Corticosteroids1 trial

Low back pain1 trial

RCT1 trial

Carpal Tunnel Syndrome1 trial

Migraine1 trial

Suprascapular Nerve Block1 trial

Dexamethasone1 trial

Tendinitis of Shoulder1 trial

Knee Osteoarthritis1 trial

FDA Approval Timeline[4]

References

Drug Info

Quick Facts

Related News