Musculoskeletal

Scoliosis

26

Pipeline Programs↗

9

Active Trials↗

12

Companies Involved↗

Scoliosis is an emerging landscape with 26 programs across 12 companies. The most active players are Vitae Pharmaceuticals Inc., an Allergan affiliate, Revance Therapeutics, Inc., Viatris Specialty LLC. 9 therapies are approved with 6 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

52/100

Pipeline Velocity

19/100

Mech. Concentration

13/100

Completion Rate

87/100

Attrition Rate

6/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Revance Therapeutics, Inc.

1 program

Viatris Specialty LLC

1 program

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

1 program

Amring

1 program

Boehringer Ingelheim

1 program

Pipeline

Programs by Phase

Preclinical7

Lidocaine

MEDRx USA, Inc.

Remimazolam

Acacia Pharma Ltd

Plasmalyte

Seoul National University Hospital

Desmopressin Acetate

Teva

Spinal Orthoses

Istanbul Medipol University Hospital

Phase 1

No programs

Phase 24

Onabotulinumtoxina

Vitae Pharmaceuticals Inc., an Allergan affiliate

Magnesium

Spherium Biomed

Botulinum Toxin Type a

Revance Therapeutics, Inc.

Alphacalcidol

University of Ioannina

Phase 36

Methadone

Hikma Pharmaceuticals LLC

Gabapentin

Viatris Specialty LLC

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Magnesium Sulfate

Fresenius Kabi Oncology Ltd.

Narcotic Analgesics

Ain Shams University

Approved9

Tranexamic Acid

Amring

Clonidine

Boehringer Ingelheim

Bupivacaine

Innocoll

Clevidipine

Chiesi Farmaceutici S.p.A.

Propofol

Fresenius Kabi Oncology Ltd.

Analysis

Trial Status

32

clinical trials

Completed13 · 41%

Unknown status8 · 25%

Recruiting5 · 16%

Not yet recruiting3 · 9%

Terminated2 · 6%

Enrolling by invitation1 · 3%

Clinical Trials

Trial Activity

32 trials

Effect of Regional Anesthesia or Intravenous Infusion of Lidocaine on Morphine Use After Scoliosis Repair Surgery

Recruiting·—·N/A·NCT06451562·105 enrolled

The Role of VitD in Rehabilitation of Idiopathic Adolescent Scoliosis

Recruiting·UUniversity of Ioannina·Phase 2·NCT03582917·80 enrolled

Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery

Recruiting·PPeking University First Hospital·Phase 4·NCT06062550·312 enrolled

IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study

Recruiting·—·Phase 2/3·NCT07217873·120 enrolled

Body Structure and Capacity Evaluation of Adults With Scoliosis

Recruiting·UUniversity of Alberta·N/A·NCT05538871·108 enrolled

Small Study Comparing Two Pain Medicines in Teenagers for Pain Control After Scoliosis Corrective Surgery.

Not yet recruiting·UUniversity of Malaya·N/A·NCT07452705·114 enrolled

Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery

Not yet recruiting·PPeking Union Medical College Hospital·Phase 4·NCT07229495·171 enrolled

Psychometric Properties of the Turkish Version of the Staffordshire Adolescent Idiopathic Scoliosis Questionnaire (SQAIS)

Not yet recruiting·AAcibadem University·N/A·NCT07676019·100 enrolled

Prospective Pilot Study of Anterior Vertebral Body Tethering Using Zimmer Biomet Tether System or Dynesys System Components to Treat Pediatric Scoliosis

Enrolling by invitation·MMayo Clinic·Preclinical·NCT03506334·80 enrolled

IRB-HSR# 14145 R,S Methadone: Analgesia and Pharmacokinetics in Adolescents Undergoing Scoliosis Correction

Completed·UUniversity of Virginia·Phase 3·NCT01205256·11 enrolled

Kyphoscoliosis Surgery: Blood Conservation and Analgesia

Completed·MMansoura University·N/A·NCT03319563·52 enrolled

IV Lidocaine Analgesia in Pediatric Scoliosis Surgery

Completed·UUniversity of British Columbia·Phase 3·NCT04069169·48 enrolled

Dexmedetomidine Versus Magnesium Sulfate in Ultrasound Guided Bilateral Bi-level Erector Spinae Plane Block in Corrective Scoliosis Surgery

Completed·—·Phase 3·NCT05671081·60 enrolled

Use of Virtual Reality to Reduce Morphine Consumption in Adolescents Undergoing Scoliosis Surgery

Completed·UUniversity Hospital, Toulouse·N/A·NCT04892940·101 enrolled

Analgesic Effects of Gabapentin After Scoliosis Surgery in Children

Completed·TThe Hospital for Sick Children·Phase 3·NCT00684112·35 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)