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Other/Sinus Surgery

Sinus Surgery

6

Pipeline Programs↗

6

Active Trials↗

3

Companies Involved↗

Sinus Surgery is an early-stage landscape with 6 programs across 3 companies. 1 program is in Phase 3.

Intelligence

Pipeline Metrics

Competitive Density

34/100

Pipeline Velocity

11/100

Mech. Concentration

33/100

Completion Rate

75/100

Attrition Rate

18/100

Pipeline

Programs by Phase

Preclinical4

Bacitracin

Healthpoint

Guanfacine

Promius Pharma, LLC

Phentolamine

Life Extension Foundation Inc.

Esmolol

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Phase 11

Tranexamic Acid

J Molner

Phase 2

No programs

Phase 31

Magnesium SO4

Hospital de Base

Approved

No programs

Analysis

Trial Status

39

clinical trials

Completed21 · 54%

Withdrawn5 · 13%

Unknown status5 · 13%

Not yet recruiting4 · 10%

Terminated2 · 5%

Recruiting1 · 3%

Other1 · 3%

Clinical Trials

Trial Activity

39 trials

Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score

Recruiting·—·Phase 1·NCT06725732·90 enrolled

Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery

Active, not recruiting·TThe Second People's Hospital of Huai'an·Phase 1/2·NCT06457100·60 enrolled

Anti-IL-5 Therapy With Simple Polypectomy Versus Extended Endoscopic Sinus Surgery for CRSwNP

Not yet recruiting·EEye & ENT Hospital of Fudan University·Phase 4·NCT07200336·360 enrolled

Opioid Sparing Effect of Sphenopalatine Ganglion Block in Functional Endoscopic Sinus Surgery: a Randomized Controlled Clinical Trial.

Not yet recruiting·—·Phase 4·NCT06752525·60 enrolled

Magnesium Sulfate Versus Lidocaine as Additives to Dexmedetomidine for Cough Suppression After Functional Endoscopic Sinus Surgery

Not yet recruiting·—·Phase 3·NCT07213037·102 enrolled

Pre-operative Phentolamine Vs Intraoperative Esmolol Efficacy for Hypotensive Anesthesia in Functional Endoscopic Sinus Surgery

Not yet recruiting·—·N/A·NCT06620991·60 enrolled

Auricular Neuromodulation and Surgical Conditions During Functional Endoscopic Sinus Surgery

Completed·IIcahn School of Medicine at Mount Sinai·Preclinical·NCT06662422·20 enrolled

Nasal Desmopressin Versus Oral Bisoprolol for Controlling Bleeding During Endoscopic Sinus Surgery

Completed·ZZagazig University·Phase 2·NCT05430048·100 enrolled

Pain Control Following Sinus Surgery

Completed·SStanford University·Phase 4·NCT03783702·118 enrolled

Adrenaline Solution Irrigation and Bleeding During Sinus Surgery

Completed·JJordan University of Science and Technology·Phase 1·NCT04551703·60 enrolled

Comparison of Metoprolol and Tramadol With Remifentanil in Endoscopic Sinus Surgery

Completed·RRecep Tayyip Erdogan University·Phase 4·NCT02484859·88 enrolled

Guanfacine for PONV and Pain After Sinus Surgery

Completed·VVanderbilt University Medical Center·N/A·NCT02882854·84 enrolled

Triamcinolone Packing Following Endoscopic Sinus Surgery

Completed·UUniversity of California, Los Angeles·N/A·NCT04841343·22 enrolled

Esmolol vs. Labetalol in Endoscopic Sinus Surgery

Completed·TThe University of Texas Medical Branch, Galveston·Phase 2·NCT03661346·28 enrolled

The Use of Antibiotic Sinonasal Rinse After Sinus Surgery

Completed·UUniversity of Miami·Phase 4·NCT02218307·68 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)