Magnesium SO4

Phase 3Small molecule

HHospital de Base

Magnesium SO4 is one of 104 small molecule programs targeting Cesarean Section. It is currently in Phase 3.

Indications

Total Trials

Active Trials

103

Competitors

Pipeline

Status by Indication[3][1]

Indication

Cesarean SectionActive, not recruiting

Atrial FibrillationActive, not recruiting

Muscle RelaxationRecruiting

Functional Endoscopic Sinus SurgeryNot yet recruiting

IntravenousNot yet recruiting

Cesarean SectionPreclinical

Active, not recruiting

Atrial FibrillationPreclinical

Active, not recruiting

Muscle RelaxationPhase 3

Recruiting

Functional Endoscopic Sinus SurgeryPhase 3

Not yet recruiting

IntravenousPhase 3

Not yet recruiting

Competition

Competitive Landscape

137 competitors in Atrial Fibrillation

#DrugCompanyPhaseTrials

Magnesium SO4

HHospital de Base

Phase 3

2 2

Calquence

AstraZeneca

Preclinical

1 3

Rituxan

Coumadin

3 5

Brukinsa

BBeOne Medicines

Preclinical

1 6

Imbruvica

PPharmacyclics LLC.

Preclinical

1 7

Versed

CConrado Roberto Hoffmann Filho

Preclinical

1 8

Ondexxya

UUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology

Preclinical

1 9

Romazicon

CConrado Roberto Hoffmann Filho

Preclinical

1 10

Statin

Bristol-Myers Squibb

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Phase 3Not yet recruiting

Dexmedetomidine

NCT07326397

Clinical

Trials by Indication[1]

Mastectomy3 trials

SAP Block to Reduce Post Mastectomy Pain

Completed·SSuez Canal University·N/A·NCT03810209·40 enrolled

Effect of Infusion of Lidocaine, Magnesium and Remifentanil Perioperatively in Patients Undergoing Mastectomy

Completed·HHospital de Base·Phase 4·NCT02309879·120 enrolled

Magnesium Sulphate to Bupivicaine in Serratus Anterior Plane Block in Modified Radical Mastectomy

Unknown status·—·Phase 2/3·NCT04429893·80 enrolled

Sedation3 trials

Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery

Completed·KKasr El Aini Hospital·Phase 2·NCT03854812·32 enrolled

Magnesium Sulphate Versus Fentanyl for Conscious Sedation in CSDH

Completed·KKasr El Aini Hospital·Phase 2·NCT03548493·34 enrolled

Goal Directed Propofol Sedation With Magnesium Sulphate Versus Dexmedetomidine for ERCP Procedure

Completed·TTheodor Bilharz Research Institute·Phase 3·NCT02684019·60 enrolled

Agitation2 trials

Efficacy of Intraoperative Magnesium Sulphate vs Dexmedetomidine on Emergence Agitation in Pediatric Patients

Completed·—·N/A·NCT06977425·60 enrolled

Dexmedetomidine Versus Magnesium Infusion in Reducing Agitations in Pediatric Patients Undergoing Adenotonsillectomy

Unknown status·—·N/A·NCT05164627·40 enrolled

Magnesium Sulfate2 trials

Dexmedetomidine Versus Magnesium Sulfate Infusion During Spinal Anesthesia

Completed·—·Phase 3·NCT03640390·60 enrolled

Magnesium Sulfate in Combination With Dexmedetomidine As Adjuvants to Levobupivacaine

Completed·—·Phase 1·NCT04498351·130 enrolled

Asthma2 trials

Comparasion of Efficacy of Nebulized With Intravenous Magnesium Sulphate in Children With Asthma

Completed·SSaima Khatoon·Phase 4·NCT04497766·148 enrolled

Randomized Controlled Trial of Intravenous Magnesium Sulfate Versus Terbutaline for Children in the Management of Acute Exacerbation of Asthma

Completed·MMuhammad Aamir Latif·Phase 3·NCT06626620·120 enrolled

37 more indications

Atrial Fibrillation2 trials

Atrial Fibrillation and Neuropathic Pain After Thoracotomy and Continuous Application of Magnesium Sulphate.

Completed·—·N/A·NCT02008747·100 enrolled

Magnesium Sulphate for Treatment of New Onset Atrial Fibrillation in Medical Intensive Care Unit Patient

Unknown status·MMahidol University·N/A·NCT01049464·128 enrolled

Asphyxia2 trials

Magnesium Sulphate in Perinatal Asphyxia

Completed·SSheri Kashmir Institute of Medical Sciences·Phase 3·NCT00553072·40 enrolled

Enhancing Neonatal Sucking Reflex: A Study on the Efficacy of Magnesium Sulphate in Severe Birth Asphyxia

Completed·RRESnTEC, Institute of Research·N/A·NCT06468475·80 enrolled

Erector Spinae Plane Block1 trial

Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia

Recruiting·—·N/A·NCT07139522·150 enrolled

Encephalopathy1 trial

Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy

Unknown status·SSajjad Rahman·Phase 3·NCT01646619·300 enrolled

Hand, Foot and Mouth Disease1 trial

Magnesium Sulphate for Severe Hand, Foot and Mouth Disease in Vietnam

Completed·OOxford University Clinical Research Unit, Vietnam·Phase 2·NCT01940250·26 enrolled

Myofascial Pain Dysfunction Syndrome1 trial

Lidocaine Versus Magnesium Sulphate in Management of Myofascial Pain Dysfunction Syndrome

Not yet recruiting·MMisr University for Science and Technology·Phase 2·NCT06595017·75 enrolled

Hypertension1 trial

Magnesium Sulphate Versus Lidocaine for Control of Emergence Hypertension

Unknown status·AAhmed Mohamed ELbadawy·Phase 1·NCT03566329·90 enrolled

Functional Endoscopic Sinus Surgery1 trial

Opioid Sparing Effect of Sphenopalatine Ganglion Block in Functional Endoscopic Sinus Surgery: a Randomized Controlled Clinical Trial.

Not yet recruiting·—·Phase 4·NCT06752525·60 enrolled

Oxytocin1 trial

Effect of Magnesium Sulphate Pre-exposure on Oxytocin-induced Contractility in Desensitized Human Myometrium - an in Vitro Study

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT02647268·26 enrolled

Pediatric1 trial

Role of Magnesium in Pediatric Cochlear Implant

Completed·WWahba bakhet·Phase 4·NCT03722940·66 enrolled

Hysterectomy1 trial

Intraperitoneal Bupivacaine With Magnesium or Nalbuphine for Postoperative Pain Control in Laparoscopic Hysterectomy

Completed·—·Phase 4·NCT03393572·80 enrolled

Preeclampsia1 trial

Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia

Completed·MMohamed Sayed Abdelhafez·Phase 4·NCT02699827·60 enrolled

Muscle Relaxation1 trial

Effect of MgSO4 Pretreatment on Muscle Relaxation

Recruiting·—·Phase 2/3·NCT05757999·100 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Opioid Free vs Opioid Based Anesthesia for Laparoscopic Sleeve Gastrectomy

Completed·MMedical University of Warsaw·Phase 4·NCT04260659·59 enrolled

Neuromuscular Block1 trial

The Effect of Magnesium Sulphate on the Time Course of Rocuronium Induced Neuromuscular Block

Completed·UUniversity Hospital, Geneva·Phase 4·NCT00405977·80 enrolled

ESS1 trial

Block Pressor Response to Intubation

Unknown status·—·N/A·NCT05659212·102 enrolled

Laparoscopic Cholecystectomy1 trial

Intraperitoneal Dexamethasone vs Dexamethasone Plus Magnesium Sulphate for Pain Relief in Laparoscopic Cholecystectomy

Unknown status·—·Phase 3·NCT03643666·75 enrolled

Hypospadias1 trial

Dexmedetomidine, Ketamine and Magnesium Sulphate in Caudal Block for Hypospadias Repair

Unknown status·KKafrelsheikh University·Phase 4·NCT05837000·75 enrolled

Intravenous1 trial

Intravenous Tramadol and Magnesium Sulphate for Prevention of Shivering

Not yet recruiting·—·Phase 4·NCT06612996·180 enrolled

Dexmedetomidine1 trial

Comparison Between Intrathecal Magnesium Sulphate & Dexmedetomidine in DHS

Not yet recruiting·—·Phase 3·NCT07326397·92 enrolled

Hypercoagulability1 trial

Magnesium Sulfate and Postoperative Hypercoagulability in Laparoscopic Gynecological Surgeries

Recruiting·MMarianna Mavromati·N/A·NCT06717490·60 enrolled

Adjuvant1 trial

Adenosine and Magnesium Sulphate as Adjuvants for PECS Block.

Completed·MMenoufia University·N/A·NCT03344679·90 enrolled

Post Operative Pain1 trial

Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section

Completed·OOlakunle Ifeoluwa Makinde·N/A·NCT04539249·324 enrolled

Cardiac Surgery1 trial

Evaluation of the Role of Magnesium in Prevention of AF Post Cardiac Surgery

Completed·—·Phase 3·NCT06675500·130 enrolled

Treatment1 trial

Intubating Condition After Magnesium Pre-treatment

Completed·SSeoul National University Bundang Hospital·N/A·NCT01153256·168 enrolled

Randomized Controlled Trial1 trial

Magnesium Infusion for Pain Relief After Thoracotomy. A Randomized Controlled Trial.

Terminated·MMahidol University·Phase 4·NCT01261702·32 enrolled

Sugammadex1 trial

Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients

Completed·KKocaeli University·Phase 4·NCT01972659·80 enrolled

Cesarean Section1 trial

Analgesia After Cesarean Section

Completed·SSeoul National University Bundang Hospital··NCT01360060·503 enrolled

Oxygenation1 trial

Effect of Magnesium Sulphate Infusion on Lung Mechanics and Oxygenation in COPD Patients Undergoing Total Laryngeal

Completed·—·Phase 4·NCT03461328·40 enrolled

Preterm Birth1 trial

Magnesium Sulphate for Preterm Birth (MASP Study)

Completed·HHvidovre University Hospital·Phase 3·NCT01492608·560 enrolled

MPR1 trial

Improving Quality of Bier Block

Unknown status·—·Phase 2/3·NCT04393610·75 enrolled

Supraclavicular Brachial Plexus Block1 trial

Magnesium Sulphate in the Ultrasound-guided Supraclavicular Brachial Plexus Block

Completed·—·Phase 2·NCT02752334·60 enrolled

Lower Limb Orthopedic Surgery1 trial

Comparison of Postoperative Analgesic Effect of Intrathecal Magnesium and Fentanyl Added to Bupivacaine in Patients Undergoing Lower Limb Orthopedic Surgery

Completed·QQazvin University Of Medical Sciences·Phase 1/2·NCT01205997·90 enrolled

Seizure1 trial

Comparing Intravenous and Intramuscular Magnesium Sulphate for Preventing Seizure Recurrence in Women With Eclampsia

Completed·NNishtar Medical University·Phase 4·NCT06997575·200 enrolled

Hemodynamic Response1 trial

The Effects of Lidocaine and Magnesium Sulphate on the Attenuation of the Hemodynamic Response to Tracheal Intubation

Completed·HHospital de Base·Phase 4·NCT02359370·49 enrolled

Postoperative Analgesia1 trial

Pediatric Caudal Dexmedetomidine Enhances Postoperative Analgesia of Magnesium Sulphate in Lower Abdominal Surgeries

Unknown status·—·Phase 2/3·NCT02487355·120 enrolled

Abdominal Surgeries1 trial

Magnesium Sulfate as an Adjuvant to Caudal Bupivacaine in Lower Abdominal Surgeries in Paediatrics.

Unknown status·—·Phase 4·NCT03322878·90 enrolled

Sources

References

[1]
ClinicalTrials.gov — 51 trial records for Magnesium SO4. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Magnesium SO4 compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Magnesium SO4. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Hospital de Base company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: HHospital de Base

Magnesium SO4

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Trials by Indication[1]

Mastectomy3 trials

Sedation3 trials

Agitation2 trials

Magnesium Sulfate2 trials

Asthma2 trials

Atrial Fibrillation2 trials

Asphyxia2 trials

Erector Spinae Plane Block1 trial

Encephalopathy1 trial

Hand, Foot and Mouth Disease1 trial

Myofascial Pain Dysfunction Syndrome1 trial

Hypertension1 trial

Functional Endoscopic Sinus Surgery1 trial

Oxytocin1 trial

Pediatric1 trial

Hysterectomy1 trial

Preeclampsia1 trial

Muscle Relaxation1 trial

Laparoscopic Sleeve Gastrectomy1 trial

Neuromuscular Block1 trial

ESS1 trial

Laparoscopic Cholecystectomy1 trial

Hypospadias1 trial

Intravenous1 trial

Dexmedetomidine1 trial

Hypercoagulability1 trial

Adjuvant1 trial

Post Operative Pain1 trial

Cardiac Surgery1 trial

Treatment1 trial

Randomized Controlled Trial1 trial

Sugammadex1 trial

Cesarean Section1 trial

Oxygenation1 trial

Preterm Birth1 trial

MPR1 trial

Supraclavicular Brachial Plexus Block1 trial

Lower Limb Orthopedic Surgery1 trial

Seizure1 trial

Hemodynamic Response1 trial

Postoperative Analgesia1 trial

Abdominal Surgeries1 trial

References

Drug Info

Quick Facts

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