VivoSeq
Other

Stomatitis

17

Pipeline Programs↗

2

Active Trials↗

9

Companies Involved↗

Stomatitis is an emerging landscape with 17 programs across 9 companies. The most active players are Merck & Co., Regeneron, Immunex. 5 therapies are approved with 4 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

44/100

Pipeline Velocity

11/100

Mech. Concentration

9/100

Completion Rate

78/100

Attrition Rate

17/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Merck & Co. logo

Merck & Co.

1 program

Phase 1Regeneron logo

Regeneron

1 program

Phase 1I

Immunex

1 program

Phase 2G

Glaxo Dba Glaxosmithkline

1 program

Phase 2Bristol-Myers Squibb logo

Bristol-Myers Squibb

2 programs

Phase 2Novartis logo

Novartis

1 program

Phase 3

Pipeline

Programs by Phase

Analysis

Modality Breakdown

63%

Small molecule

10 of 16 classified programs — the dominant modality here.

38%ALL OTHERSMonoclonal antibody213%Protein / enzyme213%Antibody–drug conjugate16%Vaccine16%

Small molecule leads; the ring shows all 16 classified programs, each share of the total. Modality classified for 94% of 18 pipeline programs.

Analysis

Trial Status

12

clinical trials

Completed7 · 58%
Terminated2 · 17%
Recruiting2 · 17%
Unknown status1 · 8%

Clinical Trials

Trial Activity

12 trials

Preventing Dato-DXd Associated Stomatitis With Dexamethasone Mouthwash, TROPION-DM
Recruiting·—·Phase 2·NCT06974604·60 enrolled
A Phase IV, Open-Label, Single-Arm Study of Prophylaxis for Datopotamab Deruxtecan-related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer (TROPION-SWISH)
Recruiting·AstraZeneca logoAstraZeneca·Approved·NCT07357597·100 enrolled
Hyaluronic Acid in Counteracting Aphthous Stomatitis
Completed·—·N/A·NCT04884464·49 enrolled
Should We Use Oral Valacyclovir in Acute Herpetic Gingivostomatitis in Children?
Completed·SSt. Justine's Hospital·Phase 2·NCT02738229·80 enrolled
Placebo Controlled, Dose Response, Safety and Immunogenicity Study of Vesicular Stomatitis Virus (VSV) Ebola Vaccine in Healthy Adults (V920-004)
Completed·Merck & Co. logoMerck & Co.·Phase 1·NCT02314923·513 enrolled
Clinical Trial on the Efficacy and Safety of Chining Decoction in the Treatment of Radiation Stomatitis
Completed·TTianjin Medical University Cancer Institute and Hospital·Phase 3·NCT02303197·70 enrolled
Topical Morphine for Stomatitis-related Pain Induced by Chemotherapy
Completed·—·Phase 4·NCT00357942·72 enrolled
Safety and Immunogenicity of Prime-Boost Vesicular Stomatitis Virus (VSV) Ebola Vaccine in Healthy Adults (V920-002)
Completed·Merck & Co. logoMerck & Co.·Phase 1·NCT02280408·39 enrolled
Immunogenicity of Recombinant Vesicular Stomatitis Vaccine for Ebola-Zaire (rVSV[Delta]G-ZEBOV-GP) for Pre-Exposure Prophylaxis (PREP) in People at Potential Occupational Risk for Ebola Virus Exposure
Completed·National Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT02788227·99 enrolled
Effectiveness of Topical Thalidomide to Treat Chronic Graft-Versus-Host-Disease Related Stomatitis
Terminated·National Institute of Nursing Research (NINR)·Phase 2·NCT00075023·10 enrolled
Dexamethasone in Reducing Everolimus-Induced Oral Stomatitis in Patients With Cancer
Terminated·Alliance for Clinical Trials in Oncology·Phase 3·NCT03839940·39 enrolled
Effects of Denture-Related Stomatitis on Blood Pressure in Denture Wearers
Unknown status·JJagiellonian University·N/A·NCT02166450·80 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)