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Other/Tinnitus

Tinnitus

11

Pipeline Programs↗

20

Active Trials↗

15

Companies Involved↗

Tinnitus is an emerging landscape with 11 programs across 15 companies.

Intelligence

Pipeline Metrics

Competitive Density

46/100

Pipeline Velocity

45/100

Mech. Concentration

50/100

Completion Rate

83/100

Attrition Rate

9/100

Pipeline

Programs by Phase

Preclinical9

Nicotine Polacrilex Gum

HALEON

Cilostazol

Otsuka

Prednisone

Roxane Laboratories

Syntocinon

Shana McCormack, MD

Distilled Water

GSK

Phase 11

IV Lidocaine

Wake Forest University Health Sciences

Phase 21

Trtl-913

Tortugas Neuroscience, Inc.

Phase 3

No programs

Approved

No programs

Analysis

Trial Status

76

clinical trials

Completed45 · 59%

Recruiting10 · 13%

Not yet recruiting8 · 11%

Terminated5 · 7%

Active, not recruiting2 · 3%

Withdrawn2 · 3%

Other4 · 5%

Clinical Trials

Trial Activity

76 trials

An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus

Recruiting·—·Phase 1·NCT04192773·40 enrolled

A Phase 2a, Randomized, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TRTL-913 in Healthy Adult Volunteers Under Fed Conditions (Part A), and an Open-Label Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Efficacy in Adults With Tinnitus (Part B)

Recruiting·TTortugas Neuroscience, Inc.·Phase 2·NCT07777549·100 enrolled

Deep Repetitive Transcranial Magnetic Stimulation in the Treatment of Tinnitus

Recruiting·UUniversity of Regensburg·Preclinical·NCT07885176·60 enrolled

BosSTENT ImpLant to trEat debilitatiNg Pulse-synchronous Tinnitus

Recruiting·SSonorous NV, Inc·Preclinical·NCT07070089·90 enrolled

Targeted Neurofeedback Training to Alleviate Tinnitus Distress

Recruiting·UUniversity of Illinois at Urbana-Champaign·Preclinical·NCT07788638·20 enrolled

Developing Tools and a Care Path for Somatosensory Tinnitus

Recruiting·VVA Office of Research and Development·Preclinical·NCT05434637·72 enrolled

Evaluation of the Safety and Feasibility of the VivaStent in Patients With Pulsatile Tinnitus Secondary to Ipsilateral Transverse-sigmoid Stenosis - The VivaStent Feasibility Study

Recruiting·VV-Flow 21·Preclinical·NCT07515781·15 enrolled

Mild Therapeutic Hypothermia for Tinnitus Management

Recruiting·RRestorear Devices LLC·Preclinical·NCT07017998·80 enrolled

Efficacy of Foot Reflexology and Transcutaneous Auricular Vagus Nerve Stimulation on Tinnitus in Non-Cancer Adult Populations

Recruiting·Tzu Chi University·Preclinical·NCT07711639·180 enrolled

Noninvasive Therapeutic Hypothermia for Tinnitus

Recruiting·RRestorear Devices LLC·Preclinical·NCT07071480·40 enrolled

Efficacy of Donepezil in Patients With Chronic Tinnitus

Active, not recruiting·UUniversity of Sao Paulo·Phase 4·NCT07153991·70 enrolled

Investigating EEG as a Biomarker for Tinnitus Improvement After Bimodal Stimulation

Active, not recruiting·UUniversity of Minnesota·Preclinical·NCT07158034·10 enrolled

The Effects of Conventional Therapy on Tinnitus, Disability, and Quality of Life in Patients With Tinnitus

Not yet recruiting·SSisli Hamidiye Etfal Training and Research Hospital·N/A·NCT07334002·30 enrolled

A Randomized, Double-Blind, Placebo-Controlled, Within-Subject Crossover Trial of a Single 4 mg Dose of Nicotine Polacrilex Gum on Auditory Oddball P3, Oddball Task Performance, and Resting-State EEG in Non-Smoking Adults With Chronic Tinnitus

Not yet recruiting·—·Preclinical·NCT07877701·20 enrolled

Efficacy Analysis of Transcutaneous Auricular Vagus Nerve Stimulation Combined With Tailor-Made Notched Music Therapy in the Treatment of Chronic Subjective Tinnitus: A Multicenter, Randomized, Double-Blind Controlled Clinical Trial

Not yet recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Preclinical·NCT07794462·444 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)