VivoSeq
Other

Tinnitus

39

Pipeline Programs↗

8

Active Trials↗

20

Companies Involved↗

Tinnitus is a moderately active landscape with 39 programs across 20 companies. The most active players are TO Pharmaceuticals, Novartis, Autifony Therapeutics Limited. 5 therapies are approved with 2 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

57/100

Pipeline Velocity

22/100

Mech. Concentration

14/100

Completion Rate

84/100

Attrition Rate

13/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

T

TO Pharmaceuticals

1 program

Phase 1Novartis logo

Novartis

1 program

Phase 2A

Autifony Therapeutics Limited

1 program

Phase 2R

Revance Therapeutics, Inc.

1 program

Phase 2I

Immunex

1 program

Phase 2Boehringer Ingelheim logo

Boehringer Ingelheim

1 program

Phase 2

Pipeline

Programs by Phase

Analysis

Modality Breakdown

98%

Small molecule

43 of 44 classified programs — the dominant modality here.

2%ALL OTHERSProtein / enzyme12%

Small molecule leads; the ring shows all 44 classified programs, each share of the total. Modality classified for 100% of 45 pipeline programs.

Analysis

Trial Status

54

clinical trials

Completed36 · 67%
Terminated5 · 9%
Recruiting4 · 7%
Unknown status3 · 6%
Not yet recruiting3 · 6%
Withdrawn2 · 4%
Other1 · 2%

Clinical Trials

Trial Activity

54 trials

TNF-α Treatment of Blast-Induced Tinnitus
Recruiting·WWayne State University·Phase 2·NCT04066348·88 enrolled
An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus
Recruiting·—·Phase 1·NCT04192773·40 enrolled
Noninvasive Therapeutic Hypothermia for Tinnitus
Recruiting·RRestorear Devices LLC·Preclinical·NCT07071480·40 enrolled
Mild Therapeutic Hypothermia for Tinnitus Management
Recruiting·RRestorear Devices LLC·Preclinical·NCT07017998·80 enrolled
Efficacy of Donepezil in Patients With Chronic Tinnitus
Active, not recruiting·UUniversity of Sao Paulo·Phase 4·NCT07153991·70 enrolled
The Effects of Conventional Therapy on Tinnitus, Disability, and Quality of Life in Patients With Tinnitus
Not yet recruiting·SSisli Hamidiye Etfal Training and Research Hospital·N/A·NCT07334002·30 enrolled
Efficacy and Safety of Acupuncture Versus Sham Acupuncture in the Treatment of Tinnitus: A Randomized Controlled Clinical Trial
Not yet recruiting·SShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University·Preclinical·NCT07700069·226 enrolled
Efficacy of Sound Therapy, Cognitive Behavioral Therapy and Their Combination in Management of Chronic Tinnitus
Not yet recruiting·SSohag University·Preclinical·NCT07665385·60 enrolled
Evaluating Possible Improvement in Tinnitus Severity After 28 Days Dosing of the Study Drug AUT00063 Compared to Placebo
Completed·AAutifony Therapeutics Limited·Phase 2·NCT02315508·91 enrolled
Sulodexide Efficacy in Chronic Idiopathic Subjective Tinnitus
Completed·SSt Joseph University, Beirut, Lebanon·Phase 2·NCT02737670·126 enrolled
Efficacy, Safety, Tolerability of Neramexane in Patients With Subjective Tinnitus
Completed·MMerz Pharmaceuticals GmbH·Phase 3·NCT00955799·455 enrolled
Action of Intra-auricular Topical Lidocaine on Tinnitus
Completed·UUniversity of Sao Paulo General Hospital·N/A·NCT05711641·32 enrolled
Repetitive Transcranial Magnetic Stimulation for Chronic Subjective Tinnitus
Completed·UUniversity Hospital Ostrava·N/A·NCT03425045·40 enrolled
An Open-Label Study Evaluating Brexanolone in Adults With Tinnitus
Completed·Supernus Pharmaceuticals, Inc. logoSupernus Pharmaceuticals, Inc.·Phase 2·NCT05645432·10 enrolled
Study of BGG492 in Patients With Chronic Subjective Tinnitus
Completed·Novartis logoNovartis·Phase 2·NCT01302873·96 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)