IV lidocaine

Phase 3Small molecule

WWake Forest University Health Sciences

IV lidocaine is one of 112 small molecule programs targeting Cesarean Section. It is currently in Phase 3.

Indications

Total Trials

Active Trials

111

Competitors

Pipeline

Status by Indication[3][1]

Indication

Cesarean SectionActive, not recruiting

EndometriosisActive, not recruiting

TinnitusRecruiting

Lidocaine InfusionNot yet recruiting

Cesarean SectionPreclinical

Active, not recruiting

EndometriosisPreclinical

Active, not recruiting

TinnitusPhase 1

Recruiting

Lidocaine InfusionPhase 3

Not yet recruiting

Competition

Competitive Landscape

83 competitors in Cesarean Section

#DrugCompanyPhaseTrials

IV lidocaine

WWake Forest University Health Sciences

Phase 3

1 2

Fentanyl-Morphine

SSeoul National University Hospital

Phase 3

2 3

Acetaminophen/ibuprofen

SSeoul National University Hospital

Phase 3

1 4

Ondansetron, Dexamethasone

KKing Khaled Eye Specialist Hospital

Phase 3

1 5

Morphine - .

RRambam Health Care Campus

Phase 3

1 6

Sebacoyl Dinalbuphine Ester

LLumosa Therapeutics Co., Ltd.

Phase 3

1 7

Proamatine

Takeda

Preclinical

1 8

Dynastat

Pfizer

Preclinical

1 9

Duragesic

CCephalon

Preclinical

6 10

Versed

CConrado Roberto Hoffmann Filho

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Phase 2/3Not yet recruiting

Lidocaine Infusion

NCT07150481

Q4 2027

Phase 1Recruiting

Tinnitus

NCT04192773

Clinical

Trials by Indication[1]

Hemodynamic Response1 trial

Lidocaine in the Prevention of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation

Completed·—··NCT06107543·94 enrolled

Cesarean Section1 trial

Lidocaine Patch Versus Intravenous Lidocaine in Pain Relief After Cesarean Section

Unknown status·—·N/A·NCT04505644·180 enrolled

Lidocaine1 trial

IV Lidocaine in Pediatric AIS

Terminated·WWashington University School of Medicine·Phase 4·NCT03893318·15 enrolled

Erector Spinae Plane Block1 trial

Perioperative Use of Erector Spinae Plane Block (ESPB) and Intravenous Lidocaine Infusion in Anesthetic Management of Spinal Surgery in Children

Not yet recruiting·SSaint Petersburg State University, Russia·Phase 4·NCT06965933·68 enrolled

Lidocaine Infusion1 trial

Intraoperative Lidocaine Infusion

Not yet recruiting·—·Phase 2/3·NCT07150481·90 enrolled

7 more indications

Liposomal Bupivacaine1 trial

Pain Control in Colorectal Surgery: Liposomal Bupivacaine Block Versus Intravenous Lidociane

Completed·WWake Forest University Health Sciences·Phase 4·NCT04005859·61 enrolled

Intravenous Lidocaine1 trial

Lidocaine Patch Versus Intravenous Lidocaine in Pain Relief After Laparoscopy

Unknown status·—·N/A·NCT04506034·150 enrolled

Endometriosis1 trial

Effects of Intravenous Lidocaine on Endometriosis Pain

Completed·—·N/A·NCT01968694·20 enrolled

Tinnitus1 trial

An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus

Recruiting·—·Phase 1·NCT04192773·40 enrolled

Shoulder Arthroplasty1 trial

Opioid-Free Shoulder Arthroplasty

Completed·OOrthoCarolina Research Institute, Inc.·Phase 4·NCT03540030·86 enrolled

Injury1 trial

Perioperative Lidocaine Infusions for the Management of Pain From Burn Injury

Not yet recruiting·UUniversity of Washington·Phase 4·NCT06828601·20 enrolled

Hernia, Paraesophageal1 trial

Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo

Completed·WWake Forest University Health Sciences·Approved·NCT04096170·16 enrolled

Sources

References

[1]
ClinicalTrials.gov — 12 trial records for IV lidocaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — IV lidocaine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for IV lidocaine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Wake Forest University Health Sciences company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: WWake Forest University Health Sciences

IV lidocaine

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2027

Q4 2027

Trials by Indication[1]

Hemodynamic Response1 trial

Cesarean Section1 trial

Lidocaine1 trial

Erector Spinae Plane Block1 trial

Lidocaine Infusion1 trial

Liposomal Bupivacaine1 trial

Intravenous Lidocaine1 trial

Endometriosis1 trial

Tinnitus1 trial

Shoulder Arthroplasty1 trial

Injury1 trial

Hernia, Paraesophageal1 trial

References

Drug Info

Quick Facts

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