VivoSeq
Other

Total Knee Replacement

0

Pipeline Programs↗

2

Active Trials↗

7

Companies Involved↗

Total Knee Replacement is an early-stage landscape with 0 programs across 7 companies. The most active players are Bayer, Takeda, Johnson & Johnson.

Intelligence

Pipeline Metrics

Competitive Density

10/100

Pipeline Velocity

11/100

Mech. Concentration

N/A

Completion Rate

88/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Bayer logo

Bayer

0 programs

PreclinicalTakeda logo

Takeda

0 programs

PreclinicalJohnson & Johnson logo

Johnson & Johnson

0 programs

PreclinicalA

AlgoRx Pharmaceuticals

0 programs

PreclinicalT

Tetherex Pharmaceuticals Corporation

0 programs

PreclinicalP

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

0 programs

Preclinical

Pipeline

Programs by Phase

No pipeline programs currently tracked for this disease.

Analysis

Trial Status

60

clinical trials

Completed46 · 77%
Unknown status6 · 10%
Terminated2 · 3%
Suspended2 · 3%
Not yet recruiting2 · 3%
Withdrawn2 · 3%

Clinical Trials

Trial Activity

60 trials

Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement
Not yet recruiting·HHuazhong University of Science and Technology·Phase 4·NCT06653621·144 enrolled
Boosting Venous Return After Knee Replacement: Effects of a Novel Circulatory Exercise on Early Postoperative Inflammation - A Randomized Controlled Trial
Not yet recruiting·AAssiut University·Preclinical·NCT07688642·68 enrolled
Efficacy and Safety of TAK-442 in Subjects Undergoing Total Knee Replacement
Completed·Takeda logoTakeda·Phase 2·NCT00641732·1,045 enrolled
Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?
Completed·NNew Lexington Clinic·N/A·NCT00492973·101 enrolled
The Use of Fibrin Sealant to Reduce Bleeding After Total Knee Replacement
Completed·UUniversity of Milan·N/A·NCT01816282·62 enrolled
Ultrasound-guided Adductor Canal Block for Total Knee Replacement
Completed·NNorthwestern University·Phase 4·NCT02100579·40 enrolled
Pre-operative Intravenous Steroid in Total Knee Replacement for Pain Relief and Recovery
Completed·QQueen Elizabeth Hospital, Hong Kong·Phase 4·NCT03082092·60 enrolled
Perioperative Iron With Erythropoietin in Bilateral Total Knee Replacement Arthroplasty (TKRA)
Completed·SSeoul National University Bundang Hospital·N/A·NCT01012063·54 enrolled
Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement
Completed·Johnson & Johnson logoJohnson & Johnson·Phase 3·NCT01094886·56 enrolled
Platelet Rich Plasma (PRP) in Total Knee Replacement
Completed·EExactech·Phase 4·NCT00826098·70 enrolled
The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)
Completed·HHospital for Special Surgery, New York·Phase 4·NCT02292082·111 enrolled
Safety and Activity of F14 for Management of Pain Following Total Knee Replacement
Completed·AArthritis Innovation Corporation·Phase 2·NCT03541655·20 enrolled
Safety and Efficacy of TeaRx Xa Factor Direct Inhibitor Versus Enoxaparin as a Venous Thromboembolic Events (VTE) Prevention Following Total Knee Replacement
Completed·TTeaRx LLC·Phase 2·NCT03088358·200 enrolled
A Trial of Intraoperative Fibrin Sealant on Postoperative Recovery After Total Knee Replacement
Completed·SSingapore General Hospital·Phase 4·NCT07455591·78 enrolled
Efficacy of Low-dose Intra-articular Tranexamic Acid in Total Knee Replacement
Completed·MMahidol University·N/A·NCT01850394·152 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)