Bupivacaine liposome

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Postoperative AnalgesiaAnalgesiaCognitive DisorderTotal Knee Replacement

24 competitors in Postoperative Analgesia

#DrugCompanyPhaseTrials

1

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Approved

152

Duragesic

CCephalon

Approved

43

Decadron

AAspen Global Incorporated

Approved

44

Nubain

AAultman Health Foundation

Approved

35

Celebrex

PPhiladelphia Eye Associates

Approved

16

EXPAREL

Pacira Pharmaceuticals, Inc

Approved

27

Intrathecal Morphine

Pacira Pharmaceuticals, Inc

Phase 3

58

Bupivacaine Only

Pacira Pharmaceuticals, Inc

Phase 3

39

Advil

KKenvue Brands

Phase 2

210

Bupivacaine liposome

Pacira Pharmaceuticals, Inc

Phase 3

1Show 10 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Liposomal Bupivacaine7 trials

Liposomal Bupivacaine With Dexamethasone for Foot Surgery

Enrolling by invitation·RRothman Institute Orthopaedics·Phase 4·NCT06465992·126 enrolled

Standard Bupivacaine vs Liposomal Bupivacaine in Colorectal Patients

Terminated·IInova Health Care Services·Phase 4·NCT03638635·63 enrolled

A Study of Loco-Regional Liposomal Bupivacaine Injection

Terminated·MMayo Clinic·Phase 4·NCT05992896·2 enrolled

Show 4 more trials

Efficacy of Extended-Release Liposomal Bupivacaine for Post-Partum Pain Management Following Obstetrical Laceration

Completed·WWalter Reed National Military Medical Center·N/A·NCT03152877·120 enrolled

Utility of Liposomal Bupivacaine Transversus Abdominal Plane Block for Open Myomectomy

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT04272086·140 enrolled

Liposomal Bupivacaine Pharmacokinetic Study After Median Sternotomy Incision Infiltration in a Pediatric Cardiac Surgery

Terminated·NNicklaus Children's Hospital f/k/a Miami Children's Hospital·Phase 1·NCT04685421·15 enrolled

Exparel Versus Bupivacaine in Post-operative Pain Control Following Bilateral Third Molar Extractions: A Single-blind Randomized Clinical Trial

Completed·CCase Western Reserve University·Approved·NCT06547255·100 enrolled

Total Knee Arthroplasty3 trials

Intraoperative Liposomal Bupivacaine Injection in Primary Total Knee Arthroplasty

Withdrawn·UUnited States Naval Medical Center, San Diego·Phase 2/3·NCT02341079

Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty

Completed·Pacira Pharmaceuticals, Inc·Phase 3·NCT05139030·167 enrolled

Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block With EXPAREL in Total Knee Arthroplasty

Completed·Pacira Pharmaceuticals, Inc·Phase 3·NCT02713178·232 enrolled

Postoperative Pain Control2 trials

Postoperative Pain Control With Lipossomic Extended Release Bupivacaine

Unknown status·UUniversity of Tennessee·Phase 1/2·NCT03560362·50 enrolled

Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine

Recruiting·—·N/A·NCT06471348·128 enrolled

Hip Fracture2 trials

Hip Fracture Exparel Administration Trial Capsule During Hemiarthroplasty

Completed·MMaimonides Medical Center·Phase 4·NCT03502018·50 enrolled

The Effect of Bupivacaine Liposome Preemptive Analgesia on Postoperative Pain and Delirium in Elderly Patients Undergoing Hip Fracture Surgery

Not yet recruiting·NNanjing First Hospital, Nanjing Medical University·Phase 4·NCT07066111·40 enrolled

Bupivacaine2 trials

Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection

Completed·TTriHealth Inc.·N/A·NCT02299349·70 enrolled

Extended Delivery of Bupivacaine Study in Herniorrhaphy

Completed·HHeron Therapeutics·Phase 4·NCT04102267·32 enrolled

23 more indications

Postsurgical Analgesia1 trial

Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction

Completed·Pacira Pharmaceuticals, Inc·Phase 3·NCT02517905·166 enrolled

Total Knee Replacement1 trial

Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement

Not yet recruiting·HHuazhong University of Science and Technology·Phase 4·NCT06653621·144 enrolled

Arthroscopic Shoulder Surgery1 trial

Interscalene Single Shot With Plain Bupivacaine Versus Liposomal Bupivacaine for Arthroscopic Shoulder Surgery

Completed·UUniversity of Southern California·Phase 4·NCT03638960·40 enrolled

Perioperative Pain1 trial

Prospective RCT Comparing Perioperative Pain

Completed·RRothman Institute Orthopaedics·N/A·NCT03253198·156 enrolled

Local Infiltration1 trial

Efficacy Between Serratus Plane Block And Local Infiltration In Vats

Terminated·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT03642457·65 enrolled

Surgical1 trial

Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain

Enrolling by invitation·RRutgers, The State University of New Jersey·Phase 2/3·NCT06077422·150 enrolled

Orthognathic Surgery1 trial

Bupivacaine Liposomal Injectable Suspension, Pain and Narcotic Use After Elective Orthognathic Surgery

Withdrawn·—·Phase 4·NCT03318757

Adult1 trial

A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B301

Terminated·Pacira Pharmaceuticals, Inc·Phase 4·NCT01507220·2 enrolled

Thoracoscopic Surgery1 trial

A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery

Recruiting·JJiangsu HengRui Medicine Co., Ltd.·Phase 2·NCT06529432·96 enrolled

Efficacy1 trial

Efficacy, Safety, and Pharmacokinetics of Brachial Plexus Block With EXPAREL in Shoulder Surgery

Completed·Pacira Pharmaceuticals, Inc·Phase 3·NCT02713230·156 enrolled

Nerve Block1 trial

Phase 3, Sciatic Nerve Block With EXPAREL for Subjects Undergoing Bunionectomy

Completed·Pacira Pharmaceuticals, Inc·Phase 3·NCT05157841·185 enrolled

Pain Management1 trial

Improving Pain Management After Total Shoulder Replacement Using Bupivacaine Liposome

Withdrawn·UUniversity of Massachusetts, Worcester·Phase 4·NCT04134442

Tics1 trial

Evaluate the Pharmacokinetics and Safety of EXPAREL® Following Subcutaneous Administration in Healthy Chinese Subjects

Completed·NNuance Pharma (shanghai) Co., Ltd·Phase 1·NCT04158102·20 enrolled

Post Cesarean Analgesia1 trial

ESP Block for Post Cesarean Analgesia

Completed·—·Phase 4·NCT05664958·150 enrolled

Joint1 trial

Comparing Post-Op Narcotic Usage in Patients Receiving Periarticular Exparel vs. Standard Periarticular Joint Inj

Completed·UUniversity of California, Irvine·Phase 4·NCT02682498·38 enrolled

Dexamethasone1 trial

Comparison of Exparel to Bupivacaine With Dexamethasone in TAP Block

Terminated·—·Phase 4·NCT02179892·9 enrolled

Rib Fracture1 trial

Liposomal Bupivacaine Intercostal Nerve Block vs Thoracic Epidural for Regional Analgesia in Multiple Rib Fractures

Unknown status·CChadrick Evans·Phase 4·NCT03574376·258 enrolled

Post Operative Pain1 trial

The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery

Completed·—·Phase 4·NCT02052557·51 enrolled

Postoperative Analgesia1 trial

Efficacy and Safety of Liposomal Bupivacaine Under ERAS Concept for Postoperative Analgesia of Ultrasound-Guided QLB in Gynecologic Laparoscopic Patients: A Randomized, Single-blind, Active-Controlled Clinical Study

Unknown status·TTianjin Medical University General Hospital·N/A·NCT06288841·200 enrolled

Excretion1 trial

Exparel PK and Breast Milk Excretion

Completed·UUniversity of Minnesota··NCT03526419·30 enrolled

Analgesia1 trial

A Real World Study on Local Infiltration of Bupivacaine Liposome Injection for Acute Postoperative Pain After Pediatric Orthopedic Surgery

Recruiting·JJiangsu HengRui Medicine Co., Ltd.·Approved·NCT06344091·232 enrolled

Hip Fractures1 trial

Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial): A Pragmatic Multi-arm, Adaptive, Open Label, Multicenter Randomized Controlled Platform Trial to Assess the Effect of Different Enhanced Anesthesia Technique in Perioperative Neurocognitive Function, as Compared to Standard Anesthesia Care in the Elderly Patients Undergoing Hip Fracture

Recruiting·SSecond Affiliated Hospital of Wenzhou Medical University·Preclinical·NCT06452147·1,860 enrolled

Unspecified1 trial

Evaluation of LB in THA

Completed·OOSF Healthcare System··NCT03341104·173 enrolled

Details

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