Bupivacaine liposome

Phase 3Small molecule

Pacira Pharmaceuticals, Inc

Bupivacaine liposome is one of 39 small molecule programs targeting Cognitive Disorder. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Cognitive DisorderActive, not recruiting

Postoperative AnalgesiaUnknown status

Total Knee ReplacementNot yet recruiting

Pediatric PatientsRecruiting

Cognitive DisorderPreclinical

Active, not recruiting

Postoperative AnalgesiaPreclinical

Unknown status

Total Knee ReplacementPhase 3

Not yet recruiting

Pediatric PatientsPhase 3

Recruiting

Competition

Competitive Landscape

23 competitors in Postoperative Analgesia

#DrugCompanyPhaseTrials

Precedex

MMcNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Approved

15 2

Decadron

AAspen Global Incorporated

Approved

4 3

Duragesic

CCephalon

Approved

4 4

Nubain

AAultman Health Foundation

Approved

3 5

Celebrex

PPhiladelphia Eye Associates

Approved

1 6

EXPAREL

Pacira Pharmaceuticals, Inc

Approved

2 7

Intrathecal Morphine

Pacira Pharmaceuticals, Inc

Phase 3

5 8

Bupivacaine Only

Pacira Pharmaceuticals, Inc

Phase 3

4 9

Bupivacaine liposome

Pacira Pharmaceuticals, Inc

Phase 3

1 10

Anrikefon

ZZhujiang Hospital

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalRecruiting

Pediatric Patients

NCT06344091

Phase 2Recruiting

Thoracoscopic Surgery

NCT06529432

Post-ApprovalNot yet recruiting

Hip Fracture

NCT07066111

Q3 2028

N/ARecruiting

Cognitive Disorder

NCT06452147

N/ARecruiting

Postoperative Pain Control

NCT06471348

Clinical

Trials by Indication[1]

Liposomal Bupivacaine7 trials

Standard Bupivacaine vs Liposomal Bupivacaine in Colorectal Patients

Terminated·IInova Health Care Services·Phase 4·NCT03638635·63 enrolled

Efficacy of Extended-Release Liposomal Bupivacaine for Post-Partum Pain Management Following Obstetrical Laceration

Completed·WWalter Reed National Military Medical Center·N/A·NCT03152877·120 enrolled

Liposomal Bupivacaine With Dexamethasone for Foot Surgery

Enrolling by invitation·RRothman Institute Orthopaedics·Phase 4·NCT06465992·126 enrolled

Show 4 more trials

Utility of Liposomal Bupivacaine Transversus Abdominal Plane Block for Open Myomectomy

Completed·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT04272086·140 enrolled

Liposomal Bupivacaine Pharmacokinetic Study After Median Sternotomy Incision Infiltration in a Pediatric Cardiac Surgery

Terminated·NNicklaus Children's Hospital f/k/a Miami Children's Hospital·Phase 1·NCT04685421·15 enrolled

A Study of Loco-Regional Liposomal Bupivacaine Injection

Terminated·MMayo Clinic·Phase 4·NCT05992896·2 enrolled

Exparel Versus Bupivacaine in Post-operative Pain Control Following Bilateral Third Molar Extractions: A Single-blind Randomized Clinical Trial

Completed·CCase Western Reserve University·Approved·NCT06547255·100 enrolled

Total Knee Arthroplasty3 trials

Intraoperative Liposomal Bupivacaine Injection in Primary Total Knee Arthroplasty

Withdrawn·UUnited States Naval Medical Center, San Diego·Phase 2/3·NCT02341079

Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT05139030·167 enrolled

Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block With EXPAREL in Total Knee Arthroplasty

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT02713178·232 enrolled

Bupivacaine2 trials

Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection

Completed·TTriHealth Inc.·N/A·NCT02299349·70 enrolled

Extended Delivery of Bupivacaine Study in Herniorrhaphy

Completed·HHeron Therapeutics·Phase 4·NCT04102267·32 enrolled

Hip Fracture2 trials

The Effect of Bupivacaine Liposome Preemptive Analgesia on Postoperative Pain and Delirium in Elderly Patients Undergoing Hip Fracture Surgery

Not yet recruiting·NNanjing First Hospital, Nanjing Medical University·Phase 4·NCT07066111·40 enrolled

Hip Fracture Exparel Administration Trial Capsule During Hemiarthroplasty

Completed·MMaimonides Medical Center·Phase 4·NCT03502018·50 enrolled

Postoperative Pain Control2 trials

Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine

Recruiting·—·N/A·NCT06471348·128 enrolled

Postoperative Pain Control With Lipossomic Extended Release Bupivacaine

Unknown status·UUniversity of Tennessee·Phase 1/2·NCT03560362·50 enrolled

23 more indications

Post Operative Pain1 trial

The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery

Completed·—·Phase 4·NCT02052557·51 enrolled

Arthroscopic Shoulder Surgery1 trial

Interscalene Single Shot With Plain Bupivacaine Versus Liposomal Bupivacaine for Arthroscopic Shoulder Surgery

Completed·UUniversity of Southern California·Phase 4·NCT03638960·40 enrolled

Postsurgical Analgesia1 trial

Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT02517905·166 enrolled

Perioperative Pain1 trial

Prospective RCT Comparing Perioperative Pain

Completed·RRothman Institute Orthopaedics·N/A·NCT03253198·156 enrolled

Surgical1 trial

Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain

Enrolling by invitation·RRutgers, The State University of New Jersey·Phase 2/3·NCT06077422·150 enrolled

Orthognathic Surgery1 trial

Bupivacaine Liposomal Injectable Suspension, Pain and Narcotic Use After Elective Orthognathic Surgery

Withdrawn·—·Phase 4·NCT03318757

Adult1 trial

A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B301

Terminated· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT01507220·2 enrolled

Thoracoscopic Surgery1 trial

A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery

Recruiting·JJiangsu HengRui Medicine Co., Ltd.·Phase 2·NCT06529432·96 enrolled

Efficacy1 trial

Efficacy, Safety, and Pharmacokinetics of Brachial Plexus Block With EXPAREL in Shoulder Surgery

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT02713230·156 enrolled

Nerve Block1 trial

Phase 3, Sciatic Nerve Block With EXPAREL for Subjects Undergoing Bunionectomy

Completed· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 3·NCT05157841·185 enrolled

Pain Management1 trial

Improving Pain Management After Total Shoulder Replacement Using Bupivacaine Liposome

Withdrawn·UUniversity of Massachusetts, Worcester·Phase 4·NCT04134442

Tics1 trial

Evaluate the Pharmacokinetics and Safety of EXPAREL® Following Subcutaneous Administration in Healthy Chinese Subjects

Completed·NNuance Pharma (shanghai) Co., Ltd·Phase 1·NCT04158102·20 enrolled

Excretion1 trial

Exparel PK and Breast Milk Excretion

Completed·UUniversity of Minnesota··NCT03526419·30 enrolled

Pediatric Patients1 trial

A Study of Bupivacaine Liposome Injection in Local Analgesia of Pediatric Patients

Recruiting·JJiangsu HengRui Medicine Co., Ltd.·Phase 4·NCT06344091·232 enrolled

Post Cesarean Analgesia1 trial

ESP Block for Post Cesarean Analgesia

Completed·—·Phase 4·NCT05664958·150 enrolled

Joint1 trial

Comparing Post-Op Narcotic Usage in Patients Receiving Periarticular Exparel vs. Standard Periarticular Joint Inj

Completed·UUniversity of California, Irvine·Phase 4·NCT02682498·38 enrolled

Dexamethasone1 trial

Comparison of Exparel to Bupivacaine With Dexamethasone in TAP Block

Terminated·—·Phase 4·NCT02179892·9 enrolled

Rib Fracture1 trial

Liposomal Bupivacaine Intercostal Nerve Block vs Thoracic Epidural for Regional Analgesia in Multiple Rib Fractures

Unknown status·CChadrick Evans·Phase 4·NCT03574376·258 enrolled

Total Knee Replacement1 trial

Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement

Not yet recruiting·HHuazhong University of Science and Technology·Phase 4·NCT06653621·144 enrolled

Cognitive Disorder1 trial

Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)

Recruiting·SSecond Affiliated Hospital of Wenzhou Medical University·N/A·NCT06452147·1,860 enrolled

Postoperative Analgesia1 trial

Efficacy and Safety of Liposomal Bupivacaine Under ERAS Concept for Postoperative Analgesia of Ultrasound-Guided QLB in Gynecologic Laparoscopic Patients: A Randomized, Single-blind, Active-Controlled Clinical Study

Unknown status·TTianjin Medical University General Hospital·N/A·NCT06288841·200 enrolled

Local Infiltration1 trial

Efficacy Between Serratus Plane Block And Local Infiltration In Vats

Terminated·IIcahn School of Medicine at Mount Sinai·Phase 4·NCT03642457·65 enrolled

Unspecified1 trial

Evaluation of LB in THA

Completed·OOSF Healthcare System··NCT03341104·173 enrolled

Sources

References

[1]
ClinicalTrials.gov — 39 trial records for Bupivacaine liposome. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Bupivacaine liposome compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Bupivacaine liposome. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pacira Pharmaceuticals, Inc company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Pacira Pharmaceuticals, Inc

Bupivacaine liposome

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q3 2028

Trials by Indication[1]

Liposomal Bupivacaine7 trials

Total Knee Arthroplasty3 trials

Bupivacaine2 trials

Hip Fracture2 trials

Postoperative Pain Control2 trials

Post Operative Pain1 trial

Arthroscopic Shoulder Surgery1 trial

Postsurgical Analgesia1 trial

Perioperative Pain1 trial

Surgical1 trial

Orthognathic Surgery1 trial

Adult1 trial

Thoracoscopic Surgery1 trial

Efficacy1 trial

Nerve Block1 trial

Pain Management1 trial

Tics1 trial

Excretion1 trial

Pediatric Patients1 trial

Post Cesarean Analgesia1 trial

Joint1 trial

Dexamethasone1 trial

Rib Fracture1 trial

Total Knee Replacement1 trial

Cognitive Disorder1 trial

Postoperative Analgesia1 trial

Local Infiltration1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

Related News