VivoSeq
Gastroenterology

Ventral Hernia

15

Pipeline Programs↗

4

Active Trials↗

6

Companies Involved↗

Ventral Hernia is an emerging landscape with 15 programs across 6 companies. The most active players are AbbVie, Vitae Pharmaceuticals Inc., an Allergan affiliate, Citius Pharmaceuticals, Inc.. 3 therapies are approved with 3 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

43/100

Pipeline Velocity

11/100

Mech. Concentration

40/100

Completion Rate

56/100

Attrition Rate

27/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

AbbVie logo

AbbVie

3 programs

Phase 2V

Vitae Pharmaceuticals Inc., an Allergan affiliate

1 program

Phase 2C

Citius Pharmaceuticals, Inc.

1 program

Phase 3Merck & Co. logo

Merck & Co.

1 program

PreclinicalF

Fresenius Kabi Oncology Ltd.

1 program

PreclinicalAmgen logo

Amgen

1 program

Preclinical

Pipeline

Programs by Phase

Analysis

Trial Status

15

clinical trials

Completed5 · 33%
Withdrawn3 · 20%
Unknown status2 · 13%
Recruiting2 · 13%
Active, not recruiting2 · 13%
Terminated1 · 7%

Clinical Trials

Trial Activity

15 trials

Preoperative BOTOX® Injection for Large Ventral Hernia Repair
Recruiting·TThe Cleveland Clinic·Phase 4·NCT07220382·188 enrolled
A Phase 2 Double-Blind, Placebo-Controlled, Adaptive, Dose-Escalation Study to Evaluate the Safety and Efficacy of AGN-151607-DP (USAN: gemibotulinumtoxinA) for the Achievement of Primary Fascial Closure Without the Use of Component Separation Technique, in Subjects Undergoing Open Abdominal Ventral Hernia Repair
Recruiting·AbbVie logoAbbVie·Phase 2·NCT07226791·200 enrolled
Addition of Methocarbamol to Postoperative Multimodal Analgesic Regimen: A Prospective, Randomized Pilot Study
Active, not recruiting·PPrisma Health-Upstate·Approved·NCT05388929·164 enrolled
Feasibility and Efficacy of CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs: A Pilot Pragmatic Trial
Active, not recruiting·UUniversity of Florida·Preclinical·NCT06565546·100 enrolled
A Study Evaluating Intravenous (IV) MOA-728 for the Treatment of Postoperative Ileus (POI) in Participants After Ventral Hernia Repair
Completed·BBausch Health Americas, Inc.·Phase 3·NCT00528970·374 enrolled
Reducing INfection at the Surgical SitE With Antibiotic Irrigation During Ventral Hernia Repair (RINSE Trial)
Completed·PPrisma Health-Upstate·Phase 3·NCT03945357·250 enrolled
Does a Transabdominal Plane Block Decrease Patient Pain After Ventral Hernia Repair?
Completed·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT02007096·127 enrolled
Laparoscopic Ventral Hernia Repair With Elastomeric Pain Pump
Completed·UUniversity Hospitals Cleveland Medical Center·N/A·NCT00472134·100 enrolled
Preliminary Study of CA-008 (Vocacapsaicin) in Patients Undergoing Ventral Hernia Repair
Completed·—·Phase 1/2·NCT04774328·34 enrolled
Gastrointestinal Tract Recovery in Patients Undergoing Open Ventral Hernia Repair
Terminated·MMedical College of Wisconsin·N/A·NCT02379858·10 enrolled
Improving Pain Relief Following Laparoscopic Ventral Hernia Repair
Withdrawn·UUniversity of Auckland, New Zealand·N/A·NCT02785276
Systemic Lidocaine Infusion for Pain Control in Ventral Hernia
Withdrawn·CCarilion Clinic·Phase 3·NCT03484650
A Study to Evaluate Adverse Events and Effectiveness of OnabotulinumtoxinA in Participants Undergoing Open Abdominal Ventral Hernia Repair for the Achievement of Primary Fascial Closure Without the Use of Component Separation Technique
Withdrawn·AbbVie logoAbbVie·Phase 2·NCT05606757
Bupivicaine to Reduce Postoperative Pain in Laparoscopic Ventral Hernia Repair
Unknown status·—·N/A·NCT01530815·80 enrolled
Use of Mosquito Net Mesh for Ventral Hernia Repair
Unknown status·HHospital Central "Dr. Ignacio Morones Prieto"·N/A·NCT03324854·20 enrolled

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)