Naropin

(Ropivacaine)

ApprovedSmall molecule

Ropivacaine is a local anesthetic used to numb specific areas of the body during surgery, dental procedures, or to relieve pain after certain medical procedures.[2] Naropin is currently approved and in use across 80 indications[4].[1]

Naropin is one of 822 small molecule programs targeting Total Knee Arthroplasty. It is currently in Approved.

Indications

507

Total Trials

Active Trials

821

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Total Knee ArthroplastyCompleted

Coronary Artery BypassActive, not recruiting

Type 2 DiabetesActive, not recruiting

Femoral Neck FractureActive, not recruiting

HypospadiasActive, not recruiting

Adductor Canal BlockUnknown status

ParalysisApproved

Neuropathic PainActive, not recruiting

Muscle WeaknessActive, not recruiting

Childhood CancerActive, not recruiting

Total Knee ArthroplastyApproved

Completed

Coronary Artery BypassApproved

Active, not recruiting

Type 2 DiabetesApproved

Active, not recruiting

Femoral Neck FractureApproved

Active, not recruiting

HypospadiasApproved

Active, not recruiting

Adductor Canal BlockApproved

Unknown status

ParalysisApproved

Approved

Neuropathic PainPreclinical

Active, not recruiting

Muscle WeaknessPreclinical

Active, not recruiting

Childhood CancerPreclinical

Active, not recruiting

Showing 10 of 78 indications

Competition

Competitive Landscape

348 competitors in Prostate Cancer

#DrugCompanyPhaseTrials

Naropin

FFresenius Kabi USA, LLC

Approved

507 2

Antiandrogen Therapy

UUniversity of Washington

Phase 3

10 3

Xaluritamig

Amgen

Phase 3

4 4

Radium-223

Bayer

Phase 3

6 5

Gallium Ga 68 Gozetotide

MMayo Clinic

Phase 3

3 6

Androgen Deprivation Treatment

MMedical University of Vienna

Phase 3

1 7

Antibiotic Prophylaxis

AAssistance Publique - Hôpitaux de Paris

Phase 3

1 8

Trexall

Jazz Pharmaceuticals

Preclinical

—9

Botox

VVitae Pharmaceuticals Inc., an Allergan affiliate

Preclinical

1 10

Duragesic

CCephalon

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

N/ARecruiting

Postoperative Analgesia

NCT07209345

N/ANot yet recruiting

Tachycardia

NCT06953661

Post-ApprovalRecruiting

Liposomal Bupivacaine

NCT05972018

Q2 2027

Post-ApprovalRecruiting

Dexmedetomidine

NCT07316166

Post-ApprovalNot yet recruiting

Regional Anesthesia

NCT06054750

Q4 2027

Post-ApprovalRecruiting

Cardiac Surgery

NCT07116343

Clinical

Trials by Indication[1]

Total Knee Arthroplasty9 trials

Does Continuous Adductor Canal Nerve Block Improve the Quality of Recovery for Outpatient Total Knee Arthroplasty Patients?

Completed·OOttawa Hospital Research Institute·N/A·NCT03038425·81 enrolled

Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty

Completed·PPoznan University of Medical Sciences·Phase 4·NCT06470204·60 enrolled

Pre vs Post Block in Total Knee Arthroplasty (TKA)

Completed·UUniversity of Miami·Phase 4·NCT05974501·84 enrolled

Show 6 more trials

Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty

Completed·NNational University Hospital, Singapore·Phase 3·NCT02954484·116 enrolled

Comparing Exparel & Ropivacaine for Pain Relief in Total Knee Arthroplasty

Unknown status·—·N/A·NCT02607579·200 enrolled

The Analgesic Effect of Combined Nerve Block and Systemic High Dose Glucocorticoid After Total Knee Arthroplasty.

Completed·RRegionshospitalet Silkeborg·Phase 4·NCT02374008·74 enrolled

Continuous Versus Intermittent Sciatic Block for Total Knee Arthroplasty

Completed·KKreiskrankenhaus Dormagen·Phase 4·NCT01843153·140 enrolled

Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

Completed·—·Phase 4·NCT00562627·102 enrolled

Exparel Use in Adductor Canal Block After Total Knee Arthroplasty

Completed·SSt. Luke's Hospital, Pennsylvania·Phase 3·NCT04910165·100 enrolled

Nerve Block8 trials

Ultrasound Guided Supraclavicular Nerve Block

Completed·TThe Cleveland Clinic·Phase 3·NCT00825786·103 enrolled

Phase I Study of Ropivacaine, Clonidine, and Betamethasone Combination for Sciatic Nerve Block in the Popliteal Region

Completed·PPHARMAFINA·Phase 1·NCT06781632·12 enrolled

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair

Completed·—·N/A·NCT03041935·90 enrolled

Show 5 more trials

Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT02740127·52 enrolled

Popliteal Sciatic Nerve Block: Intraneural or Extraneural?

Completed·AASST Gaetano Pini-CTO·Phase 4·NCT01987128·88 enrolled

Abdominal Wall Nerve Blockade: A Comparison With Local Port Site Injection as Well as Between the Use of Ultrasound and Laparoscopy to Guide Placement

Withdrawn·MMarcus Malek·N/A·NCT02945696

A Study Comparing Continuous Sciatic Nerve Block to Single Shot Sciatic Nerve Block

Terminated·NNorthwestern University·Phase 4·NCT01615939·17 enrolled

Dorsal Penile Nerve Block for Rigid Cystoscopy in Men

Completed·WWest China Hospital·N/A·NCT02502487·258 enrolled

Adductor Canal Block6 trials

Adductor Canal Blockade vs Femoral Nerve Blockade on Muscle Strength, Mobility and Pain After TKA

Completed·UUniversity Hospital, Gentofte, Copenhagen·Phase 4·NCT01922596·50 enrolled

Location of Injection of Local Anesthetics in the Adductor Canal Block

Completed·WWomen's College Hospital·N/A·NCT02554864·108 enrolled

High Versus Low Adductor Canal Block

Unknown status·CCarilion Clinic·Phase 4·NCT04155983·140 enrolled

Show 3 more trials

Comparing Ropivacaine Adductor Canal Blockade by Surgeon Versus Anesthesiologist

Unknown status·RRothman Institute Orthopaedics·Phase 4·NCT03864588·164 enrolled

Magnesium Sulfate in Adductor Canal Blocks

Completed·QQueen's University·Phase 4·NCT02581683·130 enrolled

Addition of Clonidine to Ropivacaine in Adductor Canal Block

Unknown status·UUniversity of Vermont·Phase 4·NCT03057015·80 enrolled

Erector Spinae Plane Block5 trials

Ultrasound-guided Erector Spinae Plane Blocks

Completed·MMayo Clinic·Phase 1·NCT04916691·40 enrolled

Erector Spinae Plane Block (ESPB): in Patients Undergoing Surgery Through a Flank or Anterior Subcostal Incision.

Terminated·MMilton S. Hershey Medical Center·Phase 4·NCT03691935·20 enrolled

Erector Spinae Plane Block With Ropivacaine for Major Upper Abdominal Surgery

Unknown status·—·Phase 3·NCT04702685·50 enrolled

Show 2 more trials

Effect of Ultrasound-guided Erector Spinae Plane Block on Postoperative Pain and Sleep Quality of Infants With Congenital Pulmonary Cystic Disease After Thoracoscopic Surgery

Recruiting·LLei Xiaoming·N/A·NCT06498583·40 enrolled

Erector Spinae Plane Block and Pain Management in Cardiac Surgery

Completed·VVinmec Healthcare System·N/A·NCT03541837·40 enrolled

Ropivacaine5 trials

Ropivacaine After Sternotomy

Completed·KKuopio University Hospital·Phase 4·NCT02449486·90 enrolled

Preemptive Analgesia in Children Using Caudal Epidural Ropivacaine

Terminated·LLoma Linda University·N/A·NCT00616577·26 enrolled

The Minimum Effective Volume of Ropivacaine in Ultrasound-guided Supraclavicular Block

Completed·HHuazhong University of Science and Technology·N/A·NCT02512471·114 enrolled

Show 2 more trials

Ropivacaine Pharmacokinetics in ESP Blocks

Completed·TThomas Jefferson University··NCT04807504·20 enrolled

Pain Relief by Intra-Peritoneal Ropivacaine During Gynecological Laparoscopy

Completed·—·Phase 3·NCT00433316·40 enrolled

106 more indications

Dexmedetomidine5 trials

Duration of Analgesia With Dexmedetomidine and Ropivacaine in Brachial Plexus Block

Withdrawn·UUniversity of Florida·Phase 4·NCT03385967

Does Perineural Dexmedetomidine Prolong Duration of a Nerve Block?

Completed·ZZealand University Hospital·Phase 2·NCT02488473·21 enrolled

Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve Block

Unknown status·FFayoum University Hospital·N/A·NCT05897307·90 enrolled

Show 2 more trials

Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine

Recruiting·RRhode Island Hospital·Phase 4·NCT07316166·120 enrolled

Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve (PECS) Block

Recruiting·FFayoum University·Phase 4·NCT06636578·90 enrolled

Labor Analgesia4 trials

Epidural Dexamethasone for Labor Analgesia: the Effects on Ropivacaine Consumption and Labour Outcome

Withdrawn·—·Phase 3·NCT02857465

Intermittent Ropivacaine Bolus for Epidural Labor Analgesia

Completed·PPierre and Marie Curie University··NCT02809742·500 enrolled

Comparison of PIEB vs CEI for Labor Analgesia

Completed·—·Phase 4·NCT02949271·179 enrolled

Show 1 more trial

Labor Analgesia With Ropivacaine and Clonidine

Completed·UUPECLIN HC FM Botucatu Unesp··NCT00626977·32 enrolled

Total Hip Arthroplasty4 trials

Effect of Local Infiltration Analgesia in Total Hip Arthroplasty

Completed·HHvidovre University Hospital·Phase 4·NCT00968955·120 enrolled

Effect of Nervus Cutaneous Femoris Lateralis-Blockade on Moderate Pain Responders After Total Hip Arthroplasty

Completed·DDaniel Hägi-Pedersen·Phase 4·NCT02344264·60 enrolled

Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty

Completed·CCorewell Health East·Phase 4·NCT02658149·100 enrolled

Show 1 more trial

Total Hip Arthroplasty: Multiple Blocks by UltraSound

Unknown status·—·N/A·NCT01276925·81 enrolled

Mastectomy4 trials

Pre-op Paravertebral Blocks to Decrease Post-op Pain Following Mastectomy With Immediate Tissue Expander (TE) Reconstruction

Terminated·JJohns Hopkins University·Phase 3·NCT02161705·18 enrolled

Continues Cicatricial Perfusion of Ropivacaine Versus Placebo After Mastectomy : Rehabilitation After Treatment

Terminated·IInstitut Paoli-Calmettes·Phase 3·NCT02525211·59 enrolled

Ultrasound-guided Serratus Plane Block for the Quality of Recovery After Modified Radical Mastectomy

Completed·FFujian Provincial Hospital·Phase 4·NCT02691195·72 enrolled

Show 1 more trial

Regional Anesthesia and Partial Mastectomy

Completed·—·N/A·NCT04824599·60 enrolled

Liposomal Bupivacaine4 trials

Liposomal Bupivacaine in Rotator Cuff Repair

Completed·UUniversity of Alabama at Birmingham·Phase 4·NCT03738696·64 enrolled

TAP Block Catheters vs Liposomal Bupivacaine for Pain Control After Colorectal Surgery

Completed·UUniversity of California, Davis·Phase 4·NCT03080142·86 enrolled

Liposomal Bupivacaine/Bupivacaine in Rectus Sheath Blocks Versus Ropivacaine in Rectus Sheath Blocks And Catheters

Recruiting·HHartford Hospital·Phase 4·NCT05972018·14 enrolled

Show 1 more trial

Liposomal Bupivacaine vs Ropivacaine for TAPBs

Recruiting·SSun Yat-sen University·Phase 3·NCT06430112·74 enrolled

Hip Fracture4 trials

Blind Fascia Iliaca Compartment Block Compared to Ultrasound-guided Femoral Nerve Block in Patients With Hip Fractures

Unknown status·UUniversity Hospital, Linkoeping··NCT05365555·100 enrolled

Single Shot Fascia Iliaca Block vs Femoral Nerve Block for Analgesia for Surgical Fixation of Hip Fractures

Completed·—·N/A·NCT02330302·30 enrolled

Continuous Fascia Iliaca Block for Acute Hip Fractures

Completed·UUniversity of Saskatchewan·Phase 4·NCT03588689·30 enrolled

Show 1 more trial

Influence of Standardized Perioperative Anesthetic, Analgesic Care on Outcome of Patients Undergoing Hip Fracture Surgeries

Withdrawn·MMilton S. Hershey Medical Center·Phase 1·NCT06925789

Cesarean Section4 trials

Comparison of TAP, Anterior QL, or ESP Block for Elective Cesarean Section

Terminated·—·Phase 4·NCT03695172·12 enrolled

Ropivacaine Transversus Abdominis Plane Blocks for Cesarean Section Analgesia

Terminated·MMaimonides Medical Center·N/A·NCT02893423·51 enrolled

Ropivacaine Through Continuous Infusion Versus Epidural Morphine for Postoperative Analgesia After Emergency Cesarean Section

Completed·UUniversity Hospital, Grenoble·Phase 3·NCT02410317·101 enrolled

Show 1 more trial

The Effect of the Transversus Abdominis Plane Block to Postoperative Analgesia for Cesarean Section

Completed·GGia Dinh People Hospital·N/A·NCT03634111·60 enrolled

Regional Anesthesia4 trials

Testing Regional anesthesia Techniques For Up And Early Discharge Following Knee arthroplasty - a Feasibility Study

Not yet recruiting·MMcMaster University·Phase 4·NCT06054750·226 enrolled

Regional Anesthesia in Total Hip and Knee Arthroplasty

Unknown status·OOttawa Hospital Research Institute·Phase 4·NCT04257682·135 enrolled

Is Regional Anesthesia of the Hip Preferable Over Traditional Analgesia in the Acute Stage of the Management of Patients With a Fracture of the Hip

Terminated·LLandstinget i Värmland·Phase 4·NCT01593319·37 enrolled

Show 1 more trial

Regional Anesthesia in Pediatric Orthopaedic Patients

Completed·OOchsner Health System·Phase 2/3·NCT04669145·24 enrolled

Local Anesthetic3 trials

Initial Local Anesthetic Dose With Continuous Interscalene Analgesia

Completed·CCorewell Health East·N/A·NCT00672100·36 enrolled

Topical Formulations of Liposomal Local Anesthetics

Completed·UUniversity of Campinas, Brazil·Phase 1·NCT01054547·80 enrolled

Effects of Epidural Local Anesthetics on Propofol Induction

Completed·FFirst Hospital of China Medical University·Phase 4·NCT02000973·80 enrolled

Rectus Sheath Block3 trials

Analgesic Effects of US Bilateral Rectus Sheath Block for Laparoscopic GY Surgery

Completed·EEwha Womans University Mokdong Hospital·N/A·NCT02476799·60 enrolled

Ropivacaine With Clonidine For Pediatric Rectus Sheath Blocks- The Magic Combination

Terminated·MMihaela Visoiu·N/A·NCT02439281·50 enrolled

Ultrasound-guided Bilateral Rectus Sheath Block for Robotic Single-port Gynecologic Surgery

Completed·EEwha Womans University Mokdong Hospital·N/A·NCT02450084·60 enrolled

Quadratus Lumborum Block3 trials

Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Laparoscopic Hand-assisted Nephrectomy and Robot Assisted Partiel Nephrectomy

Completed·ZZealand University Hospital·Phase 4·NCT03571490·50 enrolled

Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section.

Completed·ZZealand University Hospital·Phase 4·NCT03068260·72 enrolled

Continous Quadratus Lumborum Block for Hepatic Surgery With Right Subcostal Incision

Terminated·CCui Xulei·N/A·NCT02914015·40 enrolled

Epidural Analgesia3 trials

A Comparison of Different Concentration Ropivacaine for Patient-controlled Epidural Analgesia

Unknown status·KKaohsiung Medical University Chung-Ho Memorial Hospital·Phase 1/2·NCT03195309·120 enrolled

Epidural Analgesia and Troubles of Fetal Cardiaq Rythm : Effect of the Systemic Transfer of Ropivacaine and Sufentanil

Completed·UUniversity Hospital, Rouen·Phase 4·NCT01686347·40 enrolled

Comparison of Programmed Intermittent Epidural Bolus With Continuous Epidural Infusion for Labor Epidural Analgesia

Unknown status·NNanjing Maternity and Child Health Care Hospital·N/A·NCT02873091·186 enrolled

Intraperitoneal3 trials

Intraperitoneal Local Anaesthetic in Bowel Surgery

Completed·RRoyal Adelaide Hospital·Phase 4·NCT02449720·86 enrolled

Intraperitoneal Local Anaesthetic in Colonic Surgery

Completed·UUniversity of Auckland, New Zealand·Phase 1·NCT00722709·60 enrolled

The Use of Intraperitoneal Ropivacaine in Bariatric Bypass Surgery

Completed·OOttawa Hospital Research Institute·Phase 3·NCT02154763·120 enrolled

Analgesic2 trials

Clinical Evaluation of the ReLeaf Analgesic Infusion Catheter & Wound Drain

Withdrawn·VVital 5, LLC·N/A·NCT02293525

Analgesic Effect of the QLB-3 for Patients Undergoing a Total Hip Surgery

Completed·—·N/A·NCT04555291·60 enrolled

Post Operative Pain2 trials

Septorhinoplasty Post-operative Pain Control With SPG Nerve Block

Completed·UUniversity of Florida·Phase 4·NCT05667324·50 enrolled

Adductor Canal Vs Adductor Canal Plus SPANK Block for Postoperative Pain in Knee Arthroplasty Surgery

Withdrawn·BBruce Ben-David·Phase 4·NCT04290442

Femoral Nerve Block2 trials

Clonidine in Femoral Nerve Block Surgery in Children

Withdrawn·NNationwide Children's Hospital·Phase 2·NCT01293149

Adductor Canal Versus Femoral Nerve Block for Analgesia Post Total Knee Arthroscopy

Unknown status·—·N/A·NCT02033603·30 enrolled

Video-Assisted Thoracoscopic Surgery2 trials

Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery.

Completed·—·Phase 4·NCT03809442·116 enrolled

VATS Block for Uniportal Video-assisted Thoracoscopic Surgery

Unknown status·TTaipei Medical University WanFang Hospital·N/A·NCT03083080·30 enrolled

Gastrectomy2 trials

Comparison of the Analgesic Effect Between Intrathecal Morphine and IV-fentanyl Patient Controlled Analgesia (ITM-IVPCA) and Epidural PCA (PCEA) in Patients Undergoing Gastrectomy -Randomized Allocation Study-

Completed·YYonsei University·Phase 4·NCT01234272·59 enrolled

Routine Irrigation With Ropivacaine vs. Lidocaine vs. Saline of Surgical Bed in Sleeve Gastrectomy

Unknown status·TThe Baruch Padeh Medical Center, Poriya·N/A·NCT02023684·90 enrolled

Ankle Fracture2 trials

Ropivacaine Versus Bupivacaine as Preemptive Analgesia in Surgical Site in Ankle Fracture Patients

Completed·IInstituto Mexicano del Seguro Social·Phase 3·NCT02949674·93 enrolled

Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures

Completed·UUniversity of Iowa·Phase 4·NCT02967172·100 enrolled

Pain Management2 trials

CT Evaluating the Efficacy of Pre-incisional Local Analgesia With Ropivacaine + Dexamethasone in Pain Management After Tonsillectomy

Completed·—·Phase 2·NCT05504967·115 enrolled

Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients

Completed·—·Phase 4·NCT07425678·62 enrolled

Local Anesthesia2 trials

WALANT Technique (Wide Awake Local Anesthesia No Tourniquet) for Carpal Tunnel Release.

Completed·CCMC Ambroise Paré·N/A·NCT04494100·60 enrolled

Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery

Completed·HHospital Universitari de Bellvitge·Phase 4·NCT01075646·225 enrolled

ACL2 trials

Costoclavicular vs Paracoracoid Approach to Infraclavicular Brachial Plexus Block: a Feasibility Study

Completed·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·N/A·NCT02657291·70 enrolled

MEV to Block the Posterior and Lateral Cords of the Infraclavicular Brachial Plexus

Completed·UUniversity Hospital of North Norway·Phase 4·NCT03329456·23 enrolled

Thoracic Paravertebral Block2 trials

Ultrasound-guided Thoracic Paravertebral Block Using Ropivacaine With/Without Dexamethasone in Elective Thoracotomy

Completed·TThe First Affiliated Hospital of Anhui Medical University·N/A·NCT02871193·68 enrolled

Thoracic Paravertebral Blocks in Open Nephrectomy

Completed·—·Phase 2·NCT03428633·60 enrolled

Total Shoulder Arthroplasty2 trials

Liposomal Bupivacaine in Total Shoulder Arthroplasty

Completed·HHenry Ford Health System·Phase 4·NCT02570022·57 enrolled

Pain Management After Total Shoulder Arthroplasty

Terminated·TThe Christ Hospital·Phase 4·NCT03219983·22 enrolled

Local Infiltration2 trials

Local Infiltration Versus Block Against Pains After High Tibial Osteotomy

Completed·NNorthern Orthopaedic Division, Denmark·Phase 4·NCT01537146·60 enrolled

Placebo-controlled Evaluation of Ropivacaine Efficacy by Local Infiltrations

Completed·CCentre Leon Berard·N/A·NCT01194843·85 enrolled

Cesarean Delivery2 trials

Minimum Effective Dose of Ropivacaine for Spinal Anesthesia for Cesarean Delivery

Completed·SShanghai 6th People's Hospital·N/A·NCT02565303·60 enrolled

Efficacy of the Transversus Abdominus Plane (TAP) Block for Post-Cesarean Delivery Analgesia

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT00573963·100 enrolled

Lateral Femoral Cutaneous Nerve Block2 trials

Sensory Distribution of Lateral Femoral Cutaneous Nerve Block

Completed·ZZealand University Hospital·Phase 4·NCT02957903·20 enrolled

Preemptive Femoral & Lateral Femoral Cutaneous Nerve Blocks for THA Acute Pain

Terminated·RRush University Medical Center·N/A·NCT01997567·3 enrolled

Postoperative Analgesia2 trials

Postoperative Analgesia After Caesarean Section Under ALR: TAP Block Versus Catheter Scar Infiltration

Unknown status·AAssistance Publique Hopitaux De Marseille·Phase 3·NCT02184559·60 enrolled

Pre-emptive Scalp Infiltration With Low-dose Flurbiprofen and Ropivacaine for Postoperative Analgesia After Craniotomy

Recruiting·—·N/A·NCT07209345·216 enrolled

Caesarean Section2 trials

Chloroprocaine 3% - Epidural Anesthesia in Unplanned Caesarean Section

Terminated·SSintetica SA·Phase 3·NCT02919072·16 enrolled

Continuous Wound Infiltration for Diminution of Post-surgery Pain After Caesarean Section

Withdrawn·JJena University Hospital··NCT02828059

Bupivacaine2 trials

Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia

Completed·CCentro Cardiologico Monzino·Phase 4·NCT00552864·61 enrolled

Ropivacaine Versus Bupivacaine for Spinal Anaesthesia in Patients Undergoing Unilateral Lower Limb Surgery

Completed· AstraZeneca logo

AstraZeneca·Phase 3·NCT00358280·220 enrolled

Analgesic Efficacy2 trials

Postoperative Analgesic Efficacy of Continuous Wound Infusion After Laparoscopy

Unknown status·KKangbuk Samsung Hospital·N/A·NCT03645304·66 enrolled

The Analgesic Efficacy of Pericapsular Nerve Group (PENG) Block in Patients Undergoing Primary Total Hip Arthoplasty:

Recruiting·DDiakonie-Klinikum Stuttgart·N/A·NCT06557044·110 enrolled

Agitation2 trials

Effect of Infraorbital and Infratrochlear Nerve Block on Emergence Agitation in Patients Undergoing Septorhinoplasty

Unknown status·—·Phase 4·NCT02751268·66 enrolled

Scalp Nerve Block on Emergence Agitation

Completed·—·Phase 4·NCT02428283·44 enrolled

Analgesia2 trials

Local Analgesia to Prevent Pain in Patient Undergoing Removal of the Uterus Through Vaginal Route

Completed·—·Phase 4·NCT03099720·48 enrolled

Effect of Mode of Femoral Nerve Analgesia on Quadriceps Muscle Strength

Unknown status·SSeoul National University Hospital·N/A·NCT02007850·36 enrolled

Laparoscopic2 trials

A Study to Compare Laparoscopic to Echographic Assisted Transversus Abdominis Plane Block in Laparoscopic Colectomy

Completed·DDavide La Regina·N/A·NCT04575233·116 enrolled

TQL-block for Laparoscopic Hemicolectomy

Completed·ZZealand University Hospital·Phase 4·NCT03570541·69 enrolled

Interscalene Block2 trials

Effective Pain Management of Interscalene Blocks During Shoulder Surgery

Completed·TTriHealth Inc.·N/A·NCT02267044·76 enrolled

Ropivacaine Use in Interscalene Block; What is the Minimal Effective Analgesic Concentration (MEAC 90)

Unknown status·—·Phase 4·NCT04833296·45 enrolled

Postoperative Pain Control2 trials

Ultrasound-guided Selective Supraclavicular Nerve Block for Postoperative Pain Control in Pediatric Patients.

Completed·SSeoul National University Hospital·N/A·NCT05015907·50 enrolled

Post Operative Pain Control After Pediatric Hip Surgery

Terminated·SSeattle Children's Hospital·N/A·NCT03435692·42 enrolled

Dexamethasone2 trials

Interscalene Nerve Blocks With Ropivacaine Alone, With Dexamethasone, Plus Systemic Dexamethasone

Terminated·TThe Cleveland Clinic·N/A·NCT00519584·218 enrolled

A Comparison of Ropivacaine Alone Versus Combination of Dexamethasone and Clonidine for Block

Completed·UUniversity of Texas Southwestern Medical Center··NCT02151487·97 enrolled

Children1 trial

Pudendal Block Versus Penian Block For Circumcision In Children

Unknown status·UUniversité Libre de Bruxelles·N/A·NCT03046290·60 enrolled

Pectoral Nerve1 trial

Double-blind Study to Assess effectIveness of Pectoral Nerves Block After Breast Surgery on Piritramide Consumption

Completed·JJules Bordet Institute·Phase 3·NCT02655965·54 enrolled

Paralysis1 trial

Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block

Recruiting·—··NCT04209504·60 enrolled

Appendicitis1 trial

Ultrasound-guided Abdominal Wall Nerve Blockade in Laparoscopic Surgery for Acute Appendicitis.

Completed·—·N/A·NCT01825863·56 enrolled

Post-thoracotomy Pain1 trial

Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Thoracic Paravertebral Nerve Block for Chronic Post-thoracotomy Pain

Unknown status·—·Phase 4·NCT05175001·100 enrolled

Blood Pressure1 trial

Decision Support for Intraoperative Low Blood Pressure

Completed·VVanderbilt University Medical Center·N/A·NCT02726620·22,435 enrolled

Extremity1 trial

USG Brachial Plexus Block for Upper Extremity Surgery

Completed·JJens Borglum Neimann·N/A·NCT01993290·120 enrolled

Laparoscopic Cholecystectomy1 trial

Transmuscular Quadratus Lumborum Block for Laparoscopic Cholecystectomy

Withdrawn·JJens Borglum Neimann·N/A·NCT02225418

Tachycardia1 trial

Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome

Not yet recruiting·SStanford University·N/A·NCT06953661·20 enrolled

Gynecologic Surgery1 trial

Intraoperative Transversus Abdominis Plane Block for Gynecologic Surgery (GYNTAP)

Withdrawn·UUniversity of Mississippi Medical Center·Phase 3·NCT02506855

Ultrasound1 trial

Comparison Between Costoclavicular and Paracoracoid Ultrasound-guided Infraclavicular Block for Forearm Surgery

Unknown status·HHuazhong University of Science and Technology·N/A·NCT03279679·50 enrolled

Osteoarthritis1 trial

Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis

Completed·MMayo Clinic·Phase 4·NCT02576249·29 enrolled

Medication1 trial

Efficacy of Transversus Abdominis Plane Block Versus Local Injection of Pain Medication

Completed·LLiberman, Eric, D.O.·N/A·NCT02314104·220 enrolled

Hernia1 trial

Postsurgical Analgesia After Hernia Repair

Withdrawn·AAmacaThera Inc.·Phase 2·NCT06709612

Thoracic Outlet Syndrome1 trial

A Study of Paravertebral Block in Thoracic Outlet Syndrome

Enrolling by invitation·MMayo Clinic·Phase 4·NCT05544721·50 enrolled

Clavicle Fracture1 trial

Superficial Cervical Plexus Blockade for Clavicle Fracture Analgesia

Withdrawn·UUniversity of Alabama at Birmingham·Phase 3·NCT03187899

Postsurgical Pain Management1 trial

Phase 2/3 Study of TLC590 for Postsurgical Pain Management

Not yet recruiting·TTaiwan Liposome Company·Phase 2/3·NCT05161637·415 enrolled

Total Knee Replacement1 trial

Comparison of Continuous Femoral Nerve Block and Adductor Canal Block After Total Knee Replacement Therapy

Completed·PPhilipps University Marburg·N/A·NCT02125903·44 enrolled

Femur Fracture1 trial

Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures

Completed·UUniversity of Iowa·Phase 4·NCT02793947·102 enrolled

Type 2 Diabetes1 trial

Evaluation of Block Duration in Type 2 Diabetes Patients

Completed·PPierre and Marie Curie University·Phase 4·NCT01704612·70 enrolled

Caudal Anesthesia1 trial

Low Dose IV Dexamethasone in Prolonging Caudal Anesthesia in Children Undergoing Genitourinary Surgery

Terminated·IIndiana University·Phase 4·NCT02436265·8 enrolled

Pain1 trial

Achilles Pain Block

Completed·RRuth Chimenti·Phase 2/3·NCT03316378·46 enrolled

Gastrostomy1 trial

Trial Evaluating the Efficacy of the Combination of ROpivacaine With Reference XYlocaine in the Evaluation of Pain During the Installation of Percutaneous Radiological GASTrostomy

Terminated·—·Phase 2·NCT04250805·17 enrolled

Thoracoscopic Surgery1 trial

Comparative Study of Nonintubated Uniport Thoracoscopic Surgery Using Thoracic Paravertebral Nerve Block Versus Intercostal Nerve Block for Peripheral Solitary Pulmonary Nodule Patients

Completed·SShenzhen Third People's Hospital·N/A·NCT03086213·48 enrolled

Laparoscopic Appendectomy1 trial

Nebulized Analgesia for Laparoscopic Appendectomy Trial

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 1/2·NCT02624089·200 enrolled

Thyroid1 trial

Bilateral Superficial Cervical Block for Thyroidectomy

Unknown status·—·Phase 4·NCT01171885·120 enrolled

Umbilical hernia1 trial

Percutaneous Rectus Sheath Block Versus Intra-operative Rectus Sheath Block for Pediatric Umbilical Hernia Repair

Completed·JJohns Hopkins All Children's Hospital·N/A·NCT02341144·61 enrolled

Hip Replacement Surgery1 trial

Effect of a Lateral Nerve of the Thigh Block on Postoperative Pain After Total Hip Replacement Surgery

Completed·DDaniel Hägi-Pedersen·Phase 4·NCT02289937·100 enrolled

Treatment1 trial

Pain Treatment After TKA With LIA and Intra-articular Continuous Infusion Pump

Completed·RRegion Skane·Phase 4·NCT01726686·200 enrolled

Plantar Fasciitis1 trial

Therapeutic Effect of Botulinum Toxin A for the Treatment of Plantar Fasciitis.

Completed·UUniversidad Autonoma de Nuevo Leon·Phase 1·NCT03054610·60 enrolled

Sinus Surgery1 trial

Ropivacaine and Bupivacaine in Sphenopalatine Ganglion Block in Sinus Surgery

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT03013361·60 enrolled

Shoulder Arthroplasty1 trial

Multimodal Analgesia in Shoulder Arthroplasty

Withdrawn·RRush University Medical Center·Phase 3·NCT03586934

ACL Reconstruction1 trial

USG Nerve Blocks for ACL Reconstruction

Completed·JJens Borglum Neimann·N/A·NCT01840800·82 enrolled

Inguinal hernia1 trial

PRO-RSTAP: Effect of TAP and RS Blocks on Recovery After Inguinal Hernia Surgery (PRO-RSTAP)

Recruiting·TTampere University Hospital·N/A·NCT07423910·200 enrolled

Chronic pain1 trial

Pectoral Nerves Blocks for Chronic Pain

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·Phase 1·NCT02719795·140 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Adductor Canal Block Versus Femoral Nerve Block for Analgesia After Anterior Cruciate Ligament Reconstruction Arthroscopically

Unknown status·SShanghai Jiao Tong University Affiliated Sixth People's Hospital·Phase 4·NCT02355093·40 enrolled

Hip Arthroplasty1 trial

Blood Levels of Local Anaesthetic in Hip Arthroplasty

Completed·GGolden Jubilee National Hospital··NCT01869946·20 enrolled

Spine Fusion1 trial

Efficacy of Ropivacaine Continuous Wound Instillation Versus Single Shot After Spine Fusion Surgery

Terminated·—·Phase 4·NCT00823576·60 enrolled

Catheter1 trial

Optimal Volume, Rate, and Interval of Bolus Nerve Catheters for Shoulder Surgery

Withdrawn·—·Phase 4·NCT02946268

Pancreaticoduodenectomy1 trial

Paravertebral Block vs no Block in Open Pancreaticoduodenectomy

Terminated·MMayo Clinic·Phase 4·NCT05820997·2 enrolled

Hemodynamic Changes1 trial

The Study of Regional Hemodynamic Changes After Specific Brachial Plexus Block by Ultrasound Guidance

Completed·WWenzhou Medical University·Phase 1·NCT02139982·110 enrolled

Amputation1 trial

Comparison of Two Kinds of Postoperative Analgesia After Amputation

Unknown status·GGuangzhou General Hospital of Guangzhou Military Command·Phase 4·NCT02114463·36 enrolled

Cardiac Surgery1 trial

Intrapleural Ropivacaine Infusion in Cardiac Surgery

Recruiting·SSaint Petersburg State University, Russia·Phase 4·NCT07116343·116 enrolled

GAN1 trial

Sphenopalatine Ganglion Blocks RCT

Completed·UUniversity of California, San Francisco·Phase 4·NCT03666663·10 enrolled

Breast Cancer1 trial

MIRs 04 : Interpectoral Nerve Block With Ropivacaine Versus Placebo Before Breast Cancer Surgery

Completed·IInstitut Curie·Phase 3·NCT04327063·182 enrolled

Interscalene Brachial Plexus Block1 trial

Interscalene Brachial Plexus Block Combined With Suprascapular Nerve Block

Completed·—·N/A·NCT02424630·52 enrolled

Injury1 trial

Prevention of Myocardial Dysfunction and Injury Resulting From Salter Innominate Osteotomy by Caudal Block

Unknown status·SSi-Qin Chen·Phase 4·NCT02144766·40 enrolled

Pilot Study1 trial

The T REX Pilot Study: a Study to Investigate the Use of an Alternative Anaesthetic in Infants.

Completed·MMurdoch Childrens Research Institute·Phase 4·NCT02353182·60 enrolled

Arteriovenous Fistula1 trial

Anesthetic Effect of Ropivacaine on Local Infiltration Anesthesia in Arteriovenous Fistula Surgery

Active, not recruiting·TThe First People's Hospital of Lianyungang·Phase 4·NCT07259772·40 enrolled

Shoulder pain1 trial

Exparel for Total Shoulder Pain

Not yet recruiting·UUniversity of South Florida·Phase 2/3·NCT03739021·60 enrolled

Rib Fracture1 trial

The Erector Spinae Plane Block and Its Effect on Respiratory Status and Pain Management in Rib Fracture Patients

Terminated·VVirginia Commonwealth University·Phase 1·NCT03805360·4 enrolled

Ovarian Cancer1 trial

The IPLA-OVCA Trial, Intra-Peritoneal Local Anaesthetics in Ovarian Cancer

Active, not recruiting·KKarolinska Institutet·Phase 3·NCT04065009·220 enrolled

Anesthesia1 trial

Cutaneous Anesthesia of the Lateral Femoral Cutaneous Nerve

Completed·ZZealand University Hospital·Phase 2·NCT03138668·20 enrolled

Knee Surgery1 trial

The Optimal Dosage of Ropivacaine for Arthroscopic Knee Surgery

Completed·YYanchao Yang·Phase 1·NCT04759742·115 enrolled

Neuroblastoma1 trial

Local Injection of Pain Medication to Reduce Pain After Bone Marrow Procedures in Pediatric Neuroblastoma Patients

Completed·MMemorial Sloan Kettering Cancer Center·N/A·NCT02924324·56 enrolled

Ambulatory Surgery1 trial

Does the Use of Ropivacaine Facilitates Cholecystectomy by Laparoscopy in Ambulatory Surgery?

Completed·—·Phase 4·NCT02085902·120 enrolled

Thoracic Surgery1 trial

Continuous Wound Infusion in Lumbar or Thoracic Surgery

Completed·UUniversity Hospital, Grenoble·Phase 2/3·NCT01743794·60 enrolled

General Anesthesia1 trial

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

Completed·—·N/A·NCT05279898·70 enrolled

Erector Spinae Block1 trial

Continuous Erector Spinae Block Versus Continuous Paravertebral Block

Terminated·—·Phase 3·NCT03768440·100 enrolled

Bowel Surgery1 trial

A Pain Study Comparing Two Commonly Used Medications to Treat Pain After Bowel Surgery

Completed·—·N/A·NCT02849678·68 enrolled

Natural Killer Cell1 trial

Influence of Epidural Analgesia on Natural Killer Cell (NK) Activity After Colonic Cancer Surgery

Unknown status·HHillel Yaffe Medical Center·N/A·NCT02326727·30 enrolled

Femoral Neck Fracture1 trial

Perioperative Analgesia by Femoral Perineural Catheter for Femoral Neck Fracture - Study KTcol

Completed·UUniversity Hospital, Angers·Phase 4·NCT01052974·60 enrolled

Kidney Transplant1 trial

Transversus Abdominis Plane Catheter Following Kidney Transplantation

Unknown status·WWestern University, Canada·Phase 3·NCT04786470·120 enrolled

Pulmonary Function1 trial

Pulmonary Function and Interscalene Block

Completed·UUniversity of Pennsylvania·N/A·NCT02181296·50 enrolled

Surgery1 trial

TAP-Block in Abdominal Aortic Surgery

Completed·—·Phase 4·NCT03657979·50 enrolled

Cardiovascular1 trial

Cardiovascular Safety Research: Bupivacaine With Vasoconstrictor Versus Ropivacaine in Brachial Plexus Block

Unknown status·UUniversity of Sao Paulo·Phase 4·NCT00523289·48 enrolled

Postoperative Pain Management1 trial

Selective Block of the Axillary Nerve in Postoperative Pain Management

Completed·HHillerod Hospital, Denmark·N/A·NCT01463865·60 enrolled

Pain Control1 trial

Ropivacaine For Post-POEM Pain Control

Completed·LLawrence Charles Hookey·N/A·NCT03702647·20 enrolled

Unspecified3 trials

Bilateral Transversus Abdominis Plane Block With or Without Magnesium

Terminated·—·Phase 4·NCT02680626·86 enrolled

Exparel vs Exparel Plus ACB in TKAs

Withdrawn·TThe Hawkins Foundation·Phase 4·NCT02365727

Quadratus Lumborum vs Erector Spinae Supplementary Blocks With Lumbar Plexus Blocks for Hip PAO

Withdrawn·—·Phase 4·NCT04481451

Regulatory

FDA Approval Timeline[5]

May 1, 1998

NAROPIN

NDA NDA020533

Feb 9, 2000

NAROPIN

NDA NDA020533

Jun 22, 2000

NAROPIN

NDA NDA020533

Nov 2, 2000

NAROPIN

NDA NDA020533

Nov 14, 2000

NAROPIN

NDA NDA020533

Jul 17, 2002

NAROPIN

NDA NDA020533

Aug 11, 2004

NAROPIN

NDA NDA020533

Aug 8, 2006

NAROPIN

NDA NDA020533

Feb 19, 2010

NAROPIN

NDA NDA020533

Feb 19, 2010

NAROPIN

NDA NDA020533

Jan 4, 2011

NAROPIN

NDA NDA020533

Nov 9, 2012

NAROPIN

NDA NDA020533

Nov 15, 2012

NAROPIN

NDA NDA020533

Dec 26, 2012

NAROPIN

NDA NDA020533

Feb 16, 2013

NAROPIN

NDA NDA020533

Apr 21, 2013

NAROPIN

NDA NDA020533

Oct 29, 2014

NAROPIN

NDA NDA020533

Jun 6, 2016

NAROPIN

NDA NDA020533

Feb 15, 2018

NAROPIN

NDA NDA020533

Nov 2, 2018

NAROPIN

NDA NDA020533

Jun 15, 2022

NAROPIN

NDA NDA020533

Jun 28, 2022

NAROPIN

NDA NDA020533

Sources

References

[1]
ClinicalTrials.gov — 507 trial records for Ropivacaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Naropin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Ropivacaine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Ropivacaine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA020533). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Naropin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Fresenius Kabi USA, LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Sodium Channel Alpha Subunit Blocker[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: FFresenius Kabi USA, LLC

Patent Landscape[6]

Patent Cliff

Nov 28, 2026

Earliest patent expiration — generic entry possible after this date

Patent #Expires

7857802Nov 28, 2026