Naropin

(Ropivacaine)

ApprovedSmall molecule

Ropivacaine is a local anesthetic used to numb specific areas of the body during surgery, dental procedures, or to relieve pain after certain medical procedures.[2] Naropin is currently approved and in use across 76 indications[4].[1]

Naropin is one of 1015 small molecule programs targeting Childhood Cancer. It is currently in Approved.

Indications

500

Total Trials

Active Trials

1,014

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Childhood CancerActive, not recruiting

ArthropathyApproved

Plantar FasciitisActive, not recruiting

Ventral HerniaActive, not recruiting

ArrhythmiaActive, not recruiting

Neuropathic PainActive, not recruiting

Rib FractureApproved

Cerebral PalsyActive, not recruiting

Hip FractureApproved

SinusitisApproved

Childhood CancerPreclinical

Active, not recruiting

ArthropathyApproved

Approved

Plantar FasciitisPhase 1

Active, not recruiting

Ventral HerniaPreclinical

Active, not recruiting

ArrhythmiaPreclinical

Active, not recruiting

Neuropathic PainPreclinical

Active, not recruiting

Rib FractureApproved

Approved

Cerebral PalsyApproved

Active, not recruiting

Hip FractureApproved

Approved

SinusitisApproved

Approved

Showing 10 of 69 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Naropin

FFresenius Kabi Oncology Ltd.

Approved

2 2

Avastin

BBio-Thera Solutions

Preclinical

153 3

Gemzar

GGynecologic Oncology Group

Preclinical

22 4

Cymbalta

Alnylam Pharmaceuticals

Preclinical

3 5

Lupron

EEastern Cooperative Oncology Group

Preclinical

5 6

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 7

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 8

Zinecard

CChildren's Oncology Group

Preclinical

2 9

Tricor

JJagotec

Preclinical

1 10

Cortef

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 2Recruiting

Surgical

NCT06574269

Q4 2026

N/ARecruiting

Cesarean Section

NCT03382938

N/ANot yet recruiting

Efficacy

NCT07087015

Q2 2027

Post-ApprovalRecruiting

Dexmedetomidine

NCT07316166

Q4 2027

Post-ApprovalActive, not recruiting

Nerve Block

NCT03632044

Post-ApprovalRecruiting

Cardiac Surgery

NCT07116343

Clinical

Trials by Indication[1]

Total Knee Arthroplasty13 trials

Effect of Adductor-Canal-Blockade on High Pain Responders After Total Knee Arthroplasty

Completed·UUniversity Hospital, Gentofte, Copenhagen·Phase 4·NCT01549704·50 enrolled

Pain Control After Total Knee Arthroplasty: Benefit In Adding Single Shot Adductor Canal Block to Existing Pain Regimen Protocol?

Completed·HHenry Ford Health System·Phase 1·NCT02740192·128 enrolled

Effectiveness of Analgesia in Total Knee Arthroplasty

Completed·JJose Antonio Bernia Gil·Phase 4·NCT01304212·137 enrolled

Show 10 more trials

Does Continuous Adductor Canal Nerve Block Improve the Quality of Recovery for Outpatient Total Knee Arthroplasty Patients?

Completed·OOttawa Hospital Research Institute·N/A·NCT03038425·81 enrolled

Exparel Use in Adductor Canal Block After Total Knee Arthroplasty

Completed·SSt. Luke's Hospital, Pennsylvania·Phase 3·NCT04910165·100 enrolled

Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia

Completed·HHeron Therapeutics·Phase 2·NCT03015532·285 enrolled

Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)

Completed·TTowson Orthopaedic Associates·N/A·NCT01042093·160 enrolled

Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty

Unknown status·GGuangzhou General Hospital of Guangzhou Military Command·Phase 4·NCT02094339·45 enrolled

Posterior Capsular Injection With Femoral Nerve Block for Total Knee Arthroplasty

Completed·TTrinity Health Of New England·N/A·NCT02701296·80 enrolled

Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty

Terminated·VVirginia Commonwealth University·Phase 4·NCT02570503·64 enrolled

Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty.

Completed·—·Phase 4·NCT03353233·50 enrolled

Comparing Exparel & Ropivacaine for Pain Relief in Total Knee Arthroplasty

Unknown status·—·N/A·NCT02607579·200 enrolled

Continuous Versus Intermittent Sciatic Block for Total Knee Arthroplasty

Completed·KKreiskrankenhaus Dormagen·Phase 4·NCT01843153·140 enrolled

Nerve Block8 trials

Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT02740127·52 enrolled

Popliteal Sciatic Nerve Block: Intraneural or Extraneural?

Completed·AASST Gaetano Pini-CTO·Phase 4·NCT01987128·88 enrolled

Abdominal Wall Nerve Blockade: A Comparison With Local Port Site Injection as Well as Between the Use of Ultrasound and Laparoscopy to Guide Placement

Withdrawn·MMarcus Malek·N/A·NCT02945696

Show 5 more trials

The Use of Bupivacaine and Ropivacaine for Sciatic Nerve Block

Completed·NNorthwestern University·Phase 4·NCT01272921·142 enrolled

Ultrasound-Guided Obturator Nerve Block for Ambulatory Hip Arthroscopy

Unknown status·—·N/A·NCT02346357·70 enrolled

Evaluation of Trigeminal Nerve Blockade

Active, not recruiting·UUniversity of Florida·Phase 4·NCT03632044·40 enrolled

Application of Combined Lumbar Plexus and Sciatic Nerve Block

Completed·GGuangzhou General Hospital of Guangzhou Military Command·Phase 4·NCT02084368·34 enrolled

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Orchiopexy Repair

Completed·—·N/A·NCT03041935·90 enrolled

Dexmedetomidine7 trials

Addition of Dexmedetomidine to Ropivacaine-induced Supraclavicular Block (ADRIB Trial)

Completed·GGuangzhou First People's Hospital·Phase 4·NCT02630290·60 enrolled

Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine

Recruiting·RRhode Island Hospital·Phase 4·NCT07316166·120 enrolled

Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve (PECS) Block

Recruiting·FFayoum University·Phase 4·NCT06636578·90 enrolled

Show 4 more trials

The Effect of Dexmedetomidine as an Adjuvant for Lower Limb Nerve Blocks

Unknown status·XXiaofeng Bai·Phase 4·NCT03118076·40 enrolled

Effects of Dexmedetomidine as Adjunct to Pudendal Block for Pediatric Penile Surgery

Completed·YYonsei University·Phase 4·NCT02848157·40 enrolled

The Effect of Dexmedetomidine on Brachial Plexus Block for Shoulder Surgery

Completed·WWomen's College Hospital·Phase 2·NCT02225054·99 enrolled

Remifentanil-dexmedetomidine Anesthesia With a Caudal for Elective Surgery. (Remi-dex)

Withdrawn·MMofya Diallo·Phase 4·NCT02799589

Local Anesthetic6 trials

Effects of Epidural Local Anesthetics on Propofol Induction

Completed·FFirst Hospital of China Medical University·Phase 4·NCT02000973·80 enrolled

Sole Local Anesthetic Versus Opioid Plus Local Anesthesia in Epidural Labor Analgesia

Completed·NNanjing Medical University·Phase 4·NCT02036242·500 enrolled

Initial Local Anesthetic Dose With Continuous Interscalene Analgesia

Completed·CCorewell Health East·N/A·NCT00672100·36 enrolled

Show 3 more trials

Diffusion Length of Local Anesthetics in the Subparaneural Space and Duration of Analgesia

Unknown status·GGeneral Hospital of Ningxia Medical University·N/A·NCT05437835·90 enrolled

Duration of Leg Nerve Blocks With Dexamethasone Added to Local Anesthetic

Withdrawn·UUniversity of New Mexico·Phase 4·NCT01511211

Local Anesthetic Concentration and Nerve Block Duration

Completed·NNordsjaellands Hospital·Phase 4·NCT03326609·60 enrolled

Hip Fracture5 trials

EXPAREL Facia Iliaca Compartment Block for Intertrochanteric Hip Fracture

Withdrawn· Pacira Pharmaceuticals, Inc logo

Pacira Pharmaceuticals, Inc·Phase 4·NCT03955458

Continuous Fascia Iliaca Block for Acute Hip Fractures

Completed·UUniversity of Saskatchewan·Phase 4·NCT03588689·30 enrolled

Postoperative Analgesia With Local Infiltration After Hip Fracture Of Intertrochanteric Type

Completed·OOdense University Hospital·Phase 4·NCT01119209·74 enrolled

Show 2 more trials

Analgesia for Positioning Hip Fracture Patients for Spinal Anesthesia

Completed·—·N/A·NCT02037633·41 enrolled

Blind Fascia Iliaca Compartment Block Compared to Ultrasound-guided Femoral Nerve Block in Patients With Hip Fractures

Unknown status·UUniversity Hospital, Linkoeping··NCT05365555·100 enrolled

100 more indications

Cesarean Section5 trials

Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section

Unknown status·—·Phase 4·NCT02279628·150 enrolled

The Effect of the Transversus Abdominis Plane Block to Postoperative Analgesia for Cesarean Section

Completed·GGia Dinh People Hospital·N/A·NCT03634111·60 enrolled

Comparison of Different Methods of Pain Control After Cesarean Section for Patients on Buprenorphine or Methadone

Withdrawn·—·N/A·NCT02091297

Show 2 more trials

Dexmedetomidine Wound Infiltration in Cesarean Section

Recruiting·—·N/A·NCT03382938·100 enrolled

Comparison of TAP, Anterior QL, or ESP Block for Elective Cesarean Section

Terminated·—·Phase 4·NCT03695172·12 enrolled

Bupivacaine4 trials

Comparing Ropivacaine and Bupivacaine in DTFNB Anesthesia in Patients Undergoing Phacoemulsification

Completed·GGovernment Medical College, Haldwani·N/A·NCT02925832·100 enrolled

Spinal Anaesthesia With Levobupivacaine 0.5% and Ropivacaine 0.75% for Lower Limb Orthopaedic Surgery

Completed·—·Phase 4·NCT02201784·60 enrolled

Bupivacaine Versus Ropivacaine on Diaphragmatic Motility and Ventilatory Function

Completed·AAnesthesiology WSU/DMC-NorthStar·N/A·NCT02059070·39 enrolled

Show 1 more trial

Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia

Completed·CCentro Cardiologico Monzino·Phase 4·NCT00552864·61 enrolled

Post Operative Pain4 trials

Infiltration in the Region of the Palatine Ganglion Spheno by Ropivacaine on Postoperative Pain

Completed·UUniversity Hospital, Lille·Phase 3·NCT02821169·184 enrolled

Effect of Local Infiltration Anesthesia With Ropivacaine on Postoperative Pain After Hip Hemiarthroplasty

Completed·SSt. Olavs Hospital·N/A·NCT02585011·123 enrolled

Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery

Completed·—·Phase 4·NCT02829944·84 enrolled

Show 1 more trial

Is PECS Block Equivalent to Paravertebral Block in Preventing Postoperative Pain After Breast Surgery?

Completed·OOspedale Regionale Bellinzona e Valli·Phase 4·NCT02645474·23 enrolled

Total Hip Arthroplasty4 trials

Effect of Nervus Cutaneous Femoris Lateralis-Blockade on Moderate Pain Responders After Total Hip Arthroplasty

Completed·DDaniel Hägi-Pedersen·Phase 4·NCT02344264·60 enrolled

Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty

Completed·CCorewell Health East·Phase 4·NCT02658149·100 enrolled

Total Hip Arthroplasty: Multiple Blocks by UltraSound

Unknown status·—·N/A·NCT01276925·81 enrolled

Show 1 more trial

Dexamethasone With Ropivacaine for PENG Block in Total Hip Arthroplasty

Completed·PPoznan University of Medical Sciences·Phase 4·NCT06470334·60 enrolled

Epidural Block3 trials

Incidence of Urethrocutaneous Fistula With and Without Caudal Epidural Block

Completed·SSir Ganga Ram Hospital·N/A·NCT03812731·30 enrolled

Horner's SD After Thoracic Epidural Block

Completed·SSoonchunhyang University Hospital··NCT02130739·450 enrolled

The Effect of Epidural Steroid Use in Patients With Continous Epidural Block in PHN Patients.

Unknown status·KKorea University Guro Hospital·Phase 4·NCT03995563·40 enrolled

Analgesic Efficacy3 trials

Analgesic Efficacy of Inter Pleural Ropivacaine Road in Post Thoracotomy Pain for Oncologic Surgery

Completed·IInstitut Bergonié·Phase 2·NCT00210132·90 enrolled

Analgesic Efficacy of Perineural Dexamethasone During Supraclavicular Block for Hand Surgery

Terminated·—·Phase 2·NCT02154048·5 enrolled

The Analgesic Efficacy of Pericapsular Nerve Group (PENG) Block in Patients Undergoing Primary Total Hip Arthoplasty:

Recruiting·DDiakonie-Klinikum Stuttgart·N/A·NCT06557044·110 enrolled

Postoperative Pain Control3 trials

Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement

Withdrawn·RRush University Medical Center·Phase 4·NCT03119038

Ultrasound-guided Selective Supraclavicular Nerve Block for Postoperative Pain Control in Pediatric Patients.

Completed·SSeoul National University Hospital·N/A·NCT05015907·50 enrolled

Local Infiltration With Ropivacaine Improves Postoperative Pain Control in Patients

Completed·—·N/A·NCT02649179·140 enrolled

Inguinal hernia3 trials

The Addition of Hydromorphone to Local Anesthetics for the Repair of Inguinal Hernias in Elderly Patients

Completed·SSecond Hospital of Jilin University·N/A·NCT06218160·63 enrolled

Efficacy of an Anterior Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair

Completed·OOstfold Hospital Trust·N/A·NCT03023462·60 enrolled

PRO-RSTAP: Effect of TAP and RS Blocks on Recovery After Inguinal Hernia Surgery (PRO-RSTAP)

Recruiting·TTampere University Hospital·N/A·NCT07423910·200 enrolled

Knee Arthroplasty3 trials

Blood Levels of Local Anaesthetic in Knee Arthroplasty

Completed·GGolden Jubilee National Hospital··NCT01873313·20 enrolled

Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty

Unknown status·LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·Phase 3·NCT02540070·135 enrolled

A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty

Completed·KKootenai Health·Phase 4·NCT02543801·239 enrolled

Epidural Analgesia3 trials

Comparison of Programmed Intermittent Epidural Bolus With Continuous Epidural Infusion for Labor Epidural Analgesia

Unknown status·NNanjing Maternity and Child Health Care Hospital·N/A·NCT02873091·186 enrolled

Effect of Epidural Analgesia on the Length of Labor and Delivery and Fetal Outcomes

Unknown status·UUniversity of Cagliari··NCT02396563·100 enrolled

Spinal Versus Epidural Analgesia in Laparotomic Liver Surgery

Unknown status·OOspedale San Raffaele·N/A·NCT02647047·40 enrolled

Interscalene Block3 trials

the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block

Completed·MMontefiore Medical Center·Phase 4·NCT02653144·105 enrolled

Efficacy of Continuous Infusion Ropivacaine Interscalene Blocks

Completed·OOrlando Health, Inc.·Phase 4·NCT02462382·51 enrolled

Ropivacaine Use in Interscalene Block; What is the Minimal Effective Analgesic Concentration (MEAC 90)

Unknown status·—·Phase 4·NCT04833296·45 enrolled

Interscalene Brachial Plexus Block3 trials

Ultrasound Guidance for Interscalene Brachial Plexus Block

Completed·UUniversity of Parma·Phase 4·NCT00702416·50 enrolled

The Effect of Dexamedetomidine for Interscalene Brachial Plexus Block on Plasma Biomarkers After Rotator Cuff Repair

Completed·—·N/A·NCT02766556·50 enrolled

Effectiveness of Interscalene Brachial Plexus Block and Intra-articular Injection of Ropivacaine for Post-operative Analgesia in Arthroscopic Shoulder Stabilization Surgery

Unknown status·NNHS Grampian·N/A·NCT01589354·60 enrolled

Erector Spinae Plane Block3 trials

Erector Spinae Plane Block and Pain Management in Cardiac Surgery

Completed·VVinmec Healthcare System·N/A·NCT03541837·40 enrolled

Ultrasound-guided Erector Spinae Plane Blocks

Completed·MMayo Clinic·Phase 1·NCT04916691·40 enrolled

Ropivacaine Plasma Concentrations and Pharmacokinetics Following Erector Spinae Plane Block in the Pediatric Population

Completed·—·Phase 4·NCT04298099·4 enrolled

Dexamethasone3 trials

Ropivacaine Block Alone or With Perineural or Systemic Dexamethasone for Pain in Shoulder Surgery

Completed·MMayo Clinic·Phase 4·NCT01450007·130 enrolled

The Effects of Dexamethasone on the Duration of Sciatic Nerve Blocks

Terminated·LLoma Linda University·N/A·NCT00616603·43 enrolled

Perineural Low-dose Dexamethasone Added to Infraclavicular Block Anesthesia

Completed·FFoisor Orthopedics Clinical Hospital·Phase 3·NCT02698995·180 enrolled

Labor Analgesia3 trials

Epidural Dexamethasone for Labor Analgesia: the Effects on Ropivacaine Consumption and Labour Outcome

Withdrawn·—·Phase 3·NCT02857465

Effect of Epidural Hydromorphone Combined With Ropivacaine in Labor Analgesia

Completed·MMaternal and Child Health Hospital of Hubei Province·Phase 2·NCT05901441·240 enrolled

Comparison of PIEB vs CEI for Labor Analgesia

Completed·—·Phase 4·NCT02949271·179 enrolled

Regional Anesthesia3 trials

Use of Regional Anesthesia in Hip Arthroscopy

Unknown status·GGeorgetown University·Phase 4·NCT02851888·70 enrolled

Regional Anesthesia in Total Hip and Knee Arthroplasty

Unknown status·OOttawa Hospital Research Institute·Phase 4·NCT04257682·135 enrolled

Is Regional Anesthesia of the Hip Preferable Over Traditional Analgesia in the Acute Stage of the Management of Patients With a Fracture of the Hip

Terminated·LLandstinget i Värmland·Phase 4·NCT01593319·37 enrolled

Analgesia2 trials

Local Analgesia to Prevent Pain in Patient Undergoing Removal of the Uterus Through Vaginal Route

Completed·—·Phase 4·NCT03099720·48 enrolled

Effect of Mode of Femoral Nerve Analgesia on Quadriceps Muscle Strength

Unknown status·SSeoul National University Hospital·N/A·NCT02007850·36 enrolled

Infiltration2 trials

Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular Infiltration

Completed·UUniversity of Texas Southwestern Medical Center·N/A·NCT02658240·60 enrolled

Evaluation of the Value of Perianal Infiltration During Thermodestruction of Haemorrhoidal Disease by Radiofrequency

Completed·—·Phase 4·NCT05519189·134 enrolled

Clinical Trial2 trials

Ischemic Pain Control With Analgesic Methods Clinical Trial

Unknown status·UUniversity of Sao Paulo General Hospital·Phase 3·NCT02841488·56 enrolled

Prospective Clinical Trial Comparing Infraclavicular Versus Axillary Approach to Brachial Plexus Block

Unknown status·FFederal University of São Paulo·N/A·NCT02208245·46 enrolled

Erector Spinae Block2 trials

Ropivacaine Pharmacokinetics After Erector Spinae Block

Unknown status·MMcGill University Health Centre/Research Institute of the McGill University Health Centre·Phase 4·NCT05755334·46 enrolled

Continuous Erector Spinae Block Versus Continuous Paravertebral Block

Terminated·—·Phase 3·NCT03768440·100 enrolled

Chronic pain2 trials

Fascia Iliaca Compartment Block in Acute and Chronic Pain Management in Hip Fracture Patients

Completed·—·N/A·NCT02479828·198 enrolled

Pectoral Nerves Blocks for Chronic Pain

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·Phase 1·NCT02719795·140 enrolled

Quadratus Lumborum Block2 trials

Ropivacaine Plasma Concentration With or Without Epinephrine for Posterior Quadratus Lumborum Block

Completed·FFondazione Policlinico Universitario Agostino Gemelli IRCCS·N/A·NCT04562103·52 enrolled

The Difference Between the Extrafascial Injection and the Subfascial Injection of Quadratus Lumborum Block

Completed·TThird Military Medical University·N/A·NCT03421821·80 enrolled

Total Shoulder Arthroplasty2 trials

Pain Management After Total Shoulder Arthroplasty

Terminated·TThe Christ Hospital·Phase 4·NCT03219983·22 enrolled

The Impact of a Preoperative Nerve Block on the Consumption of Sevoflurane in Total Shoulder Arthroplasty

Terminated·UUniversity of Alberta·Phase 2/3·NCT04020601·17 enrolled

Preoperative2 trials

The Impact of a Preoperative Nerve Block on the Consumption of Sevoflurane

Completed·UUniversity of Alberta·Phase 2/3·NCT03533452·27 enrolled

The Effect of Preoperative SGB on POAF After VATS

Unknown status·PPeking University People's Hospital·N/A·NCT05753644·480 enrolled

Agitation2 trials

Influence of 0.75% Ropivacaine Topicalization on Emergence Agitation in Children

Unknown status·—·N/A·NCT02848287·84 enrolled

Effect of Infraorbital and Infratrochlear Nerve Block on Emergence Agitation in Patients Undergoing Septorhinoplasty

Unknown status·—·Phase 4·NCT02751268·66 enrolled

Hemodynamic Changes2 trials

The MEC90 of Epidural Ropivacaine Blunting Hemodynamic Changes to Pneumoperitoneum

Unknown status·KKeimyung University Dongsan Medical Center·N/A·NCT04247373·50 enrolled

The Study of Regional Hemodynamic Changes After Specific Brachial Plexus Block by Ultrasound Guidance

Completed·WWenzhou Medical University·Phase 1·NCT02139982·110 enrolled

Hemodynamic2 trials

The Hemodynamic Effect Between Two Types of Anesthesia in Esophageal Surgery

Completed·UUniversity Hospital, Lille·N/A·NCT03185403·54 enrolled

Evaluate Efficacy Levobupivacaine 0.125% Versuss Ropivacaine 0.2% in Hemodynamic Alterations in Labor and Fetal Repercussions

Unknown status·—·Phase 4·NCT05877131·40 enrolled

Anterior Cruciate Ligament Reconstruction2 trials

Exparel Infiltration in Anterior Cruciate Ligament Reconstruction

Completed·HHenry Ford Health System·Phase 4·NCT02606448·84 enrolled

Adductor Canal Block Versus Femoral Nerve Block for Analgesia After Anterior Cruciate Ligament Reconstruction Arthroscopically

Unknown status·SShanghai Jiao Tong University Affiliated Sixth People's Hospital·Phase 4·NCT02355093·40 enrolled

Video-Assisted Thoracoscopic Surgery2 trials

The Effects of Serratus Anterior Plane Block on Postoperative Quality of Recovery and Analgesia After Video-assisted Thoracoscopic Surgery

Completed·YYonsei University·N/A·NCT02311517·90 enrolled

Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery.

Completed·—·Phase 4·NCT03809442·116 enrolled

Femoral Nerve Block2 trials

Clonidine in Femoral Nerve Block Surgery in Children

Withdrawn·NNationwide Children's Hospital·Phase 2·NCT01293149

Ropivacaine Use in Femoral Nerve Block; What is the Minimal Effective Analgesic Concentration (MEAC 90)

Unknown status·—·Phase 4·NCT04834440·45 enrolled

Laparoscopic Cholecystectomy2 trials

Transmuscular Quadratus Lumborum Block for Laparoscopic Cholecystectomy

Withdrawn·JJens Borglum Neimann·N/A·NCT02225418

Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy

Completed·JJohns Hopkins All Children's Hospital·N/A·NCT02494336·48 enrolled

Efficacy2 trials

Efficacy of Cervical Sympathetic Blocks for PTSD

Not yet recruiting·SStanford University·N/A·NCT07087015·20 enrolled

Evaluation of Efficacy of Lumbar Plexus Bloc After Hip Surgery

Completed·UUniversity Hospital, Angers·N/A·NCT00150865·60 enrolled

Catheter2 trials

Optimal Volume, Rate, and Interval of Bolus Nerve Catheters for Shoulder Surgery

Withdrawn·—·Phase 4·NCT02946268

Paravertebral Catheters for VATS Procedures

Completed·UUniversity of Minnesota·Phase 1·NCT02361775·50 enrolled

Cesarean Delivery2 trials

TAP vs QLB in Patients After Cesarean Delivery

Completed·MMedical University of Lublin·Phase 4·NCT03404908·105 enrolled

Efficacy of the Transversus Abdominus Plane (TAP) Block for Post-Cesarean Delivery Analgesia

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT00573963·100 enrolled

Local Infiltration2 trials

Local Infiltration Analgesia With Ropivacaine Versus Placebo in Caesarean Section

Completed·HHvidovre University Hospital·Phase 4·NCT00891540·90 enrolled

Local Infiltration Analgesia With Ropivacaine in Posterior Vaginal Wall Prolapse:a Randomized, Double-Blind Study

Completed·HHvidovre University Hospital·Phase 4·NCT00769054·48 enrolled

Postoperative Analgesia2 trials

QLESP Block Versus Periarticular Infiltration for Postoperative Analgesia in Hip Surgery

Completed·HHuazhong University of Science and Technology·N/A·NCT06688136·68 enrolled

Postoperative Analgesia With Local Infiltration After Periacetabular Osteotomy

Completed·OOdense University Hospital·Phase 4·NCT00815503·70 enrolled

Thoracic Paravertebral Block2 trials

Effects of Dexmedetomidine Used in Continuous Thoracic Paravertebral Blocks

Completed·WWeifeng Tu·Phase 4·NCT02619513·60 enrolled

Thoracic Paravertebral Block for Postoperative Analgesia After Video-assisted Thoracic Surgery.

Completed·HHospices Civils de Lyon·Phase 3·NCT01082744·90 enrolled

Muscle weakness1 trial

Transmucular Quadratus Lumborum Block: Potential Quadriceps Muscle Weakness

Completed·ZZealand University Hospital·Phase 4·NCT05023343·20 enrolled

Breast Surgery1 trial

Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT00542542·89 enrolled

Lumbar Erector Spinae Plane Block1 trial

The Use of Lumbar Erector Spinae Plane Block for Hip Arthroplasty at the L4 Interspace

Terminated·MMontefiore Medical Center··NCT03801863·65 enrolled

Inflammatory Bowel Disease1 trial

Efficacy of Erector Spinae Plane (ESP) Block in Patients With Inflammatory Bowel Disease (IBD)

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT06230003·67 enrolled

Intravenous Lidocaine1 trial

Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery

Not yet recruiting·—·Phase 3·NCT07414706·182 enrolled

Intraperitoneal1 trial

Intraperitoneal Local Anaesthetic in Colonic Surgery

Completed·UUniversity of Auckland, New Zealand·Phase 1·NCT00722709·60 enrolled

Adductor Canal Block1 trial

Comparing Ropivacaine Adductor Canal Blockade by Surgeon Versus Anesthesiologist

Unknown status·RRothman Institute Orthopaedics·Phase 4·NCT03864588·164 enrolled

Rectus Sheath Block1 trial

Ropivacaine With Clonidine For Pediatric Rectus Sheath Blocks- The Magic Combination

Terminated·MMihaela Visoiu·N/A·NCT02439281·50 enrolled

Cerebral Palsy1 trial

Postoperative Pain in Children With Cerebral Palsy After Pelvic and Femoral Osteotomies

Completed·UUniversity of Aarhus·Phase 4·NCT00964639·12 enrolled

Amputation1 trial

Comparison of Two Kinds of Postoperative Analgesia After Amputation

Unknown status·GGuangzhou General Hospital of Guangzhou Military Command·Phase 4·NCT02114463·36 enrolled

Popliteal Nerve Block1 trial

Effectiveness of Perineural Clonidine as an Adjuvant With Ropivacaine for Popliteal Nerve Block in Patients Undergoing Foot and Ankle Surgery

Terminated·UUniversity of Alabama at Birmingham·Phase 1/2·NCT01986751·14 enrolled

Gynecologic Surgery1 trial

Postoperative Narcotic Use After Laparoscopic Gynecologic Surgery

Withdrawn·—·N/A·NCT04118777

Bowel Surgery1 trial

A Pain Study Comparing Two Commonly Used Medications to Treat Pain After Bowel Surgery

Completed·—·N/A·NCT02849678·68 enrolled

Cardiac Surgery1 trial

Intrapleural Ropivacaine Infusion in Cardiac Surgery

Recruiting·SSaint Petersburg State University, Russia·Phase 4·NCT07116343·116 enrolled

GAN1 trial

Sphenopalatine Ganglion Blocks RCT

Completed·UUniversity of California, San Francisco·Phase 4·NCT03666663·10 enrolled

Natural Killer Cell1 trial

Influence of Epidural Analgesia on Natural Killer Cell (NK) Activity After Colonic Cancer Surgery

Unknown status·HHillel Yaffe Medical Center·N/A·NCT02326727·30 enrolled

Femoral Neck Fracture1 trial

Perioperative Analgesia by Femoral Perineural Catheter for Femoral Neck Fracture - Study KTcol

Completed·UUniversity Hospital, Angers·Phase 4·NCT01052974·60 enrolled

Ultrasound1 trial

Ultrasound Guided Psoas Compartment Block vs Suprainguinal Fascia Iliaca Compartment Block

Unknown status·TTanta University·N/A·NCT05543109·85 enrolled

Ankle Fracture1 trial

Anesthesia for Pain After Ankle Fracture Surgery

Completed·UUniversity of Cincinnati·Phase 4·NCT02950558·14 enrolled

Aneurysm1 trial

Application of Brachial Plexus Block in Patients Undergoing Cerebral Aneurysm Embolization Via Transradial Approach

Unknown status·TThe First Affiliated Hospital with Nanjing Medical University·N/A·NCT06035692·176 enrolled

Gynecologic Laparoscopic Surgery1 trial

Intraperitoneal Atomization of Ropivacaine During Gynecologic Laparoscopic Surgery

Unknown status·UUniversity of Padova·Phase 3·NCT01623635·200 enrolled

Surgical1 trial

A Study on TLC590 for Managing Postsurgical Pain

Recruiting·TTLC Biopharmaceuticals, Inc.·Phase 2·NCT06574269·120 enrolled

POI1 trial

The Effect and Safety of the Four Points Transversus Abdominis Plane Block

Completed·GGia Dinh People Hospital·N/A·NCT03598192·30 enrolled

Lidocaine1 trial

Effect of Transversus Abdominis Plane Block With Compound Lidocaine on Pain After Gynecological Surgery

Completed·TTianjin Medical University General Hospital·N/A·NCT04938882·164 enrolled

Elective1 trial

Effects of Intra-Operative Ropivaciane Epidural Injection on Post-Operative Outcomes Following Elective Lumbar Fusion

Unknown status·HHorizon Health Network·Phase 4·NCT03035656·228 enrolled

Trial1 trial

The PATHFINDER Study: A Feasibility Trial

Completed·—·Phase 1·NCT04016740·22 enrolled

Blood Pressure1 trial

Decision Support for Intraoperative Low Blood Pressure

Completed·VVanderbilt University Medical Center·N/A·NCT02726620·22,435 enrolled

Epidermolysis Bullosa1 trial

Evaluation of the Efficacy of ROPIVACAINE in Children and Young Adults With Hereditary Epidermolysis Bullosa

Completed·AAssistance Publique - Hôpitaux de Paris·N/A·NCT03730584·10 enrolled

Ropivacaine1 trial

Ropivacaine Versus Ropivacaine Plus Mepivacaine for Sciatic Block

Completed·—·Phase 4·NCT00567450·30 enrolled

Extremity1 trial

USG Brachial Plexus Block for Upper Extremity Surgery

Completed·JJens Borglum Neimann·N/A·NCT01993290·120 enrolled

Coronary Artery Bypass1 trial

Analgesia in Minimally Invasive Direct Coronary Artery Bypass Grafting: Programmed Intermittent Bolus Infusions of Erector Spinae Plane Block Versus Paravertebral Block

Completed·PPeking University Third Hospital·N/A·NCT05320718·140 enrolled

Liposomal Bupivacaine1 trial

Liposomal Bupivacaine in Rotator Cuff Repair

Completed·UUniversity of Alabama at Birmingham·Phase 4·NCT03738696·64 enrolled

Delirium1 trial

Delirium in Elderly Patients With Trauma of the Hip

Terminated·—·Phase 4·NCT02689024·239 enrolled

Ventral Hernia1 trial

Improving Pain Relief Following Laparoscopic Ventral Hernia Repair

Withdrawn·UUniversity of Auckland, New Zealand·N/A·NCT02785276

Efficacy and Safety1 trial

A Study to Evaluate Analgesic Efficacy and Safety of PRF-110 for Post-surgical Pain

Completed·PPainReform LTD·Phase 3·NCT05773846·428 enrolled

Surgery1 trial

Erector Spine Block for Back Surgery

Completed·UUniversity Hospital, Antwerp·N/A·NCT03214536·15 enrolled

Breast Cancer1 trial

MIRs03: Paravertebral Block With Ropivacaine Before Breast Cancer Surgery

Completed·IInstitut Curie·Phase 3·NCT02408393·380 enrolled

Local Anesthesia1 trial

The Benefit of Local Anesthesia at the Sternum in Patients With Coronary Surgery

Completed·CCMC Ambroise Paré·Phase 4·NCT03734159·35 enrolled

Postoperative Pain Management1 trial

Analgesic Efficacy of an Opioid-free Postoperative Pain Management Strategy Versus a Conventional Opioid-based Strategy Following Video-assisted Thoracoscopic Lobectomy

Not yet recruiting·—·Phase 1·NCT06570538·140 enrolled

Gastrectomy1 trial

Comparison of the Analgesic Effect Between Intrathecal Morphine and IV-fentanyl Patient Controlled Analgesia (ITM-IVPCA) and Epidural PCA (PCEA) in Patients Undergoing Gastrectomy -Randomized Allocation Study-

Completed·YYonsei University·Phase 4·NCT01234272·59 enrolled

Mastectomy1 trial

Continues Cicatricial Perfusion of Ropivacaine Versus Placebo After Mastectomy : Rehabilitation After Treatment

Terminated·IInstitut Paoli-Calmettes·Phase 3·NCT02525211·59 enrolled

Total Knee Replacement1 trial

Femoral Block With or Without Ropivacaine for Analgesia After Total Knee Replacement (TKR)

Completed·HHopital de l'Enfant-Jesus·Phase 1/2·NCT00910013·80 enrolled

Pain After Surgery1 trial

Effect of Transversus Abdominis Plane Block With Compound Lidocaine and Esketamine on Pain After Surgery

Unknown status·TTianjin Medical University General Hospital·N/A·NCT05122338·160 enrolled

Neurotoxicity1 trial

Neurotoxicity of Spinal Anesthesia With Ropivacaine and Bupivacaine

Unknown status·—·Phase 4·NCT03293472·60 enrolled

Effectiveness1 trial

A Safety and Effectiveness Pilot Study of PRF-108 and PRF-110 in Healthy Volunteers

Completed·PPainReform LTD·Phase 1/2·NCT00883194·15 enrolled

Hypotension1 trial

The Prevention of Hypotension After Epidural Analgesia After Major Surgery

Completed·UUniversity of Florida·Phase 1/2·NCT02722746·66 enrolled

Laparoscopic Surgery1 trial

Bilateral Dual Transversus Abdominis Plane Block for Robotic Assisted Laparoscopic Surgery

Terminated·—·N/A·NCT01760161·80 enrolled

Supraclavicular Brachial Plexus Block1 trial

The Study of Ropivacaine Median Effective Concentration in Ultrasound-guided Supraclavicular Brachial Plexus Block

Unknown status·YYu Shan·Phase 4·NCT02323282·60 enrolled

Femur Fracture1 trial

Analgesia For Positioning Patient With Femur Fracture For Spinal Anaesthesia

Completed·—·N/A·NCT02983344·24 enrolled

Median Sternotomy1 trial

A Phase II/III Study of Continuous Local Anesthetic Infusion in Median Sternotomy Following Cardiac Surgery

Terminated·MMayo Clinic·Phase 2/3·NCT00586976·125 enrolled

Tics1 trial

Distribution, Pharmacokinetics and Extent of Sensory Blockade in ESP Blocks

Completed·MMilton S. Hershey Medical Center·Phase 4·NCT03476642·12 enrolled

Thoracoscopic Surgery1 trial

New Truncal Nerve Blocks for Thoracoscopic Surgery and Open Heart Surgery.

Unknown status·TTampere University Hospital·Phase 4·NCT03704753·200 enrolled

Preperitoneal Infiltration1 trial

Liposomal Bupivacaine Versus Ropivacaine for Preperitoneal Infiltration Analgesia in Upper Abdominal Laparotomy

Recruiting·QQilu Hospital of Shandong University·N/A·NCT07271979·146 enrolled

Postoperative Pain Relief1 trial

Postoperative Pain Relief With Transversus Thoracis Muscle Plane Block After Cardiac Surgery

Completed·TTurku University Hospital·Phase 4·NCT04916418·120 enrolled

Gastrostomy1 trial

Trial Evaluating the Efficacy of the Combination of ROpivacaine With Reference XYlocaine in the Evaluation of Pain During the Installation of Percutaneous Radiological GASTrostomy

Terminated·—·Phase 2·NCT04250805·17 enrolled

Lateral Femoral Cutaneous Nerve Block1 trial

Preemptive Femoral & Lateral Femoral Cutaneous Nerve Blocks for THA Acute Pain

Terminated·RRush University Medical Center·N/A·NCT01997567·3 enrolled

Hysterectomy1 trial

Analgesic Efficacy of Transmuscular Quadratus Lumborum in Patients Undergoing Total Abdominal Hysterectomy

Completed·—·N/A·NCT02586454·64 enrolled

Bariatric Surgery1 trial

Effect of Ultrasound-guided Transversus Abdominis Plane Block After Laparoscopic Bariatric Surgery

Unknown status·TTianjin Medical University General Hospital·Phase 2·NCT05016180·120 enrolled

Post-craniotomy1 trial

Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Post-craniotomy Pain

Unknown status·—·Phase 4·NCT04141319·100 enrolled

Gastric Bypass Surgery1 trial

The Use of Laparoscopic Transversus Abdominis Plane Block in Gastric Bypass Surgery (LapTAP)

Unknown status·OOttawa Hospital Research Institute·Phase 4·NCT03367728·150 enrolled

Kidney Transplant1 trial

Transversus Abdominis Plane Catheter Following Kidney Transplantation

Unknown status·WWestern University, Canada·Phase 3·NCT04786470·120 enrolled

Pulmonary Function1 trial

Pulmonary Function and Interscalene Block

Completed·UUniversity of Pennsylvania·N/A·NCT02181296·50 enrolled

Unspecified4 trials

Quadratus Lumborum vs Erector Spinae Supplementary Blocks With Lumbar Plexus Blocks for Hip PAO

Withdrawn·—·Phase 4·NCT04481451

The Significance of Peripheral Input

Unknown status·—·N/A·NCT04764045·12 enrolled

Adductor Canal Mid-thigh and Adductor Canal Distal Thigh: Is Cutaneous Sensory Blockade Similar Among Block Techniques?

Terminated·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT02788019·52 enrolled

Show 1 more trial

A Study Investigating Properties of the Transversus Abdominis Plane Block

Completed·HHillerod Hospital, Denmark·N/A·NCT01679392·16 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 4, 2011

NAROPIN

NDA NDA020533

Sources

References

[1]
ClinicalTrials.gov — 500 trial records for Ropivacaine. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Naropin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Ropivacaine compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Ropivacaine. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA020533). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Naropin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Fresenius Kabi Oncology Ltd. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Sodium Channel Alpha Subunit Blocker[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: FFresenius Kabi Oncology Ltd.

Patent Landscape[6]

Patent Cliff

Nov 28, 2026

Earliest patent expiration — generic entry possible after this date

Patent #Expires

7857802Nov 28, 2026