Saphnelo
(Anifrolumab)ApprovedMonoclonal antibody
AstraZenecaAnifrolumab is used to treat systemic lupus erythematosus (SLE), an autoimmune disease where the body's immune system attacks its own tissues, causing inflammation and damage to joints, skin, kidneys, and other organs.[2] Saphnelo is currently approved and in use across 11 indications[4].[1]
Saphnelo is one of 287 monoclonal antibody programs targeting Systemic Lupus Erythematosus. It is currently in Approved.
11
Indications
31
Total Trials
15
Active Trials
286
Competitors
2
FDA Applications
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Competition
Competitive Landscape
836 competitors in Ovarian Cancer
#DrugCompanyPhaseTrials
1Saphnelo
AstraZenecaApproved
Avastin
BBio-Thera Solutions
Phase 3
Trodelvy
GileadPhase 3
Nolvadex
AstraZenecaPhase 3
Neupogen
EEastern Cooperative Oncology Group
Phase 3
H2 Receptor Antagonist
Merck & Co.Phase 3
SHR-A1811
Suzhou Suncadia Biopharmaceuticals Co., Ltd.Phase 3
Karenitecin
BBioNumerik Pharmaceuticals, Inc.
Phase 3
Batiraxcept
AAravive, Inc.
Phase 3
TLK286
TTelik
Phase 3
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Systemic Lupus Erythematosus15 trials
Show 12 more trials
ESS2 trials
Lupus Nephritis2 trials
Single Dose1 trial
10 more indications
Fatigue1 trial
Primary Sjögren's Syndrome1 trial
Intravenous1 trial
Vitiligo1 trial
Lupus1 trial
Regulatory
FDA Approval Timeline[5]
Jul 30, 2021
SAPHNELO
BLA BLA761123
Apr 24, 2026
SAPHNELO
BLA BLA761451
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Saphnelo drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Anifrolumab. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]
- [7]
Details
Drug Info
Quick Facts
- Mechanism of Action
- Type I IFN Receptor Inhibitor[3]
- Modality
- Monoclonal antibody[3]
- Highest Phase
- Approved[1]
- Company