Medrol
(Methylprednisolone)ApprovedSmall molecule
PfizerMethylprednisolone is a steroid that reduces inflammation and suppresses the immune system, used to treat conditions like allergies, arthritis, asthma, and autoimmune diseases.[2] Medrol is currently approved and in use across 220 indications[4].[1]
Medrol is one of 2648 small molecule programs targeting Plantar Fasciitis. It is currently in Approved.
220
Indications
535
Total Trials
24
Active Trials
2,647
Competitors
5
FDA Applications
NDA/BLA/ANDA regulatory filings
Pipeline
Status by Indication[4][1]
Indication
Showing 10 of 214 indications
Competition
Competitive Landscape
2828 competitors in Breast Cancer
#DrugCompanyPhaseTrials
1Medrol
PfizerApproved
Adriamycin
GGynecologic Oncology Group
Preclinical
Gemzar
GGynecologic Oncology Group
Preclinical
Methylthioninium Chloride
PProvepharm SAS
Preclinical
MS Contin
HHikma Pharmaceuticals LLC
Preclinical
Zinecard
CChildren's Oncology Group
Preclinical
Systemic Therapy
Bristol-Myers SquibbPreclinical
Aquasol E
NNational Eye Institute (NEI)
Preclinical
Neoadjuvant Therapy
SSun Yat-sen University
Preclinical
QS21
MMemorial Sloan Kettering Cancer Center
Preclinical
Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.
Timeline
Expected Milestones
Clinical
Trials by Indication[1]
Acute Lymphoblastic Leukemia11 trials
Show 8 more trials
05-001: Treatment of Acute Lymphoblastic Leukemia in Children
Completed·—·Phase 3·NCT00400946·800 enrolled
Pneumonia7 trials
Show 4 more trials
Methylprednisolone7 trials
Show 4 more trials
COVID-197 trials
Glucocorticoid Therapy in Coronavirus Disease COVID-19 Patients
Terminated·FFundación Instituto de Estudios de Ciencias de la Salud de Castilla y León·Phase 4·NCT04780581·128 enrolled
Methylprednisolone in Patients with Cognitive Deficits in Post-COVID-19 Syndrome (PCS)
Unknown status·—·Phase 2·NCT05986422·418 enrolled
Show 4 more trials
Efficacy and Safety of Corticosteroids in COVID-19
Completed·—·N/A·NCT04273321·86 enrolled
Rheumatoid Arthritis6 trials
118 more indications
Acute Graft Versus Host Disease6 trials
Show 3 more trials
Methylprednisolone With or Without Daclizumab in Treating Patients With Acute Graft-Versus-Host Disease
Completed·—·Phase 3·NCT00053976·105 enrolled
Multiple Sclerosis6 trials
Lymphoma5 trials
Show 2 more trials
Fludeoxyglucose F 18 Positron Emission Tomography in Predicting Risk of Relapse in Patients With Non-Hodgkin's Lymphoma Who Are Undergoing Combination Chemotherapy With or Without Autologous Stem Cell or Bone Marrow Transplant
Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT00238368·59 enrolled
Bone Marrow Transplantation5 trials
Kidney Transplant4 trials
Optimization of NULOJIX® Usage Towards Minimizing CNI Exposure in Simultaneous Pancreas and Kidney Transplantation
Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT01790594·46 enrolled
Show 1 more trial
Effects of Inhibiting Early Inflammation in Kidney Transplant Patients
Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT02495077·290 enrolled
Lupus Nephritis4 trials
Rituximab and Belimumab for Lupus Nephritis
Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT02260934·43 enrolled
Show 1 more trial
Multiple Myeloma3 trials
Stem Cell Transplantation3 trials
Hematologic Cancer3 trials
Umbilical Cord Blood Transplantation in Treating Patients With High-Risk Hematologic Cancer
Completed·—·Phase 2·NCT00003335·44 enrolled
Treatment3 trials
L-DEP as an Initial Treatment for EBV-HLH
Unknown status·—·Phase 3·NCT02912702·120 enrolled
Asthma2 trials
Thrombocytopenia2 trials
Cardiac Arrest2 trials
Colitis2 trials
Systemic Lupus Erythematosus2 trials
Mycoplasma pneumoniae pneumonia2 trials
Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia (MCMP)
Completed·—·N/A·NCT02303587·424 enrolled
Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children
Terminated·—·N/A·NCT01217099·47 enrolled
Cardiac Surgery2 trials
Neuroma2 trials
Morton's Neuroma: Manipulation Versus Steroid Injection
Unknown status·—·N/A·NCT02304094·64 enrolled
Neuromyelitis Optica2 trials
Steroid2 trials
Steroids in Patients With Early ARDS
Unknown status·—·Phase 2/3·NCT00562835·400 enrolled
Ultrasound1 trial
Antibody-mediated Rejection1 trial
Ankylosing Spondylitis1 trial
Efficacy and Safety of MEthylprednisolone Administered Intravenously for the Treatment of Patients With Active AnkyLosing spondyLitis (METALL)
Unknown status·—·Phase 2·NCT01790022·20 enrolled
Juvenile Dermatomyositis1 trial
Pathophysiology1 trial
TReatment for ImmUne Mediated PathopHysiology
Recruiting·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT04862221·163 enrolled
Elderly Patients1 trial
Metabolic Disease1 trial
Diabetes Mellitus1 trial
Olfactory Dysfunction1 trial
Factors Influencing the Prognosis of Olfactory Dysfunction After Upper Sensation
Not yet recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 2·NCT04918953·90 enrolled
Idiopathic Nephrotic Syndrome1 trial
Relapsing-Remitting Multiple Sclerosis1 trial
Bronchopulmonary Dysplasia1 trial
Acute Myeloid Leukemia1 trial
First Line Therapy1 trial
Infusion1 trial
Parkinson's Disease1 trial
Ulcerative Colitis1 trial
Endovenous Corticosteroid Pulses in Moderate Ulcerative Colitis
Terminated·GGrupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa·Phase 4·NCT02921555·75 enrolled
Friedreich ataxia1 trial
Methylprednisolone Treatment of Friedreich Ataxia
Completed·—·Phase 1·NCT02424435·11 enrolled
Third Molar Surgery1 trial
Small Cell Lung Cancer1 trial
Genetic Disorder1 trial
Neutropenia1 trial
Renal Transplant Recipients1 trial
Post-Extubation Laryngeal Edema1 trial
Tolerance1 trial
BMT and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance
Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT02029638·4 enrolled
Aplastic Anemia1 trial
Study of Allogeneic Bone Marrow and T-Cell Depleted, CD34+ Peripheral Blood Stem Cell Transplantation in Patients With Aplastic Anemia
Unknown status·—·N/A·NCT00017654·3 enrolled
Chronic Planter Fascitis1 trial
Local Percutaneous Pulsed Radiofrequency Ablation Versus Ultrasound Guided Steroids Injection in Management of Pain in Cases of Chronic Planter Fascitis, Randomised Double Blinded Study
Not yet recruiting·—·Phase 4·NCT07394894·122 enrolled
Lymphoblastic Lymphoma1 trial
Myelodysplastic Syndrome1 trial
Idiopathic Inflammatory Myopathy1 trial
Severe Acute Respiratory Syndrome1 trial
Tacrolimus1 trial
Blastic Plasmacytoid Dendritic Cell Neoplasm1 trial
Renal Transplantation1 trial
Optimization of NULOJIX® Usage As A Means of Avoiding CNI and Steroids in Renal Transplantation
Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT01436305·19 enrolled
Malignant Solid Tumors1 trial
Stem Cell Transplant1 trial
Thyroid Associated Ophthalmopathy1 trial
99Tc-MDP for Thyroid-Associated Ophthalmopathy
Completed·—·Phase 4·NCT03948191·50 enrolled
Acute Respiratory Distress Syndrome1 trial
Juvenile Myelomonocytic Leukemia1 trial
Hematologic Malignancies1 trial
Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies
Completed·—·Phase 2·NCT01093586·14 enrolled
Fasting Conditions1 trial
Lymphoproliferative Disease1 trial
Immunoglobulin G4-related Disease1 trial
Elotuzumab in Immunoglobulin G4-Related Disease (IgG4-RD)
Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT04918147·8 enrolled
Rejection1 trial
Sinusitis1 trial
Evaluation of Inhaled Treatment in Sinusitis
Completed·CCliniques universitaires Saint-Luc- Université Catholique de Louvain·Phase 2/3·NCT01907204·50 enrolled
Pilot Study1 trial
Pilot Study Of Unrelated UCB Transplant for Non-Malignant Hematologic Conditions
Completed·—·Phase 2·NCT00003336·6 enrolled
Carpal Tunnel Syndrome1 trial
Respiratory Failure1 trial
Graft Versus Host Disease1 trial
Recurrent or Metastatic1 trial
Donor Stem Cell Transplant After Conditioning Therapy in Treating Patients With Hematologic Cancer, Recurrent or Metastatic Solid Tumor, or Other Disease
Completed·—·N/A·NCT00521430·30 enrolled
Acute Respiratory Failure1 trial
Efficacy and Safety1 trial
Efficacy and Safety of Glucocorticosteroid Treatment in the Patients With Chronic Recurrent DILI
Completed·—·Phase 1/2·NCT02651350·80 enrolled
Inflammatory Response1 trial
Impact of Steroids on Inflammatory Response in Covid-19
Completed·—·Phase 3·NCT04909918·60 enrolled
Primary Progressive Multiple Sclerosis1 trial
Sciatica1 trial
Hepatitis1 trial
Chronic Hepatitis1 trial
Myasthenia Gravis1 trial
Granuloma1 trial
Status Asthmaticus1 trial
Steroid Metabolism in Obese and Non-Obese Pediatric Patients Hospitalized for Status Asthmaticus
Completed·—··NCT04874610·15 enrolled
Inflammatory Bowel Disease1 trial
Lung Transplantation1 trial
Adductor Canal Block1 trial
Regulatory
FDA Approval Timeline[5]
Jan 1, 1982
MEDROL
NDA NDA018102
Jan 1, 1982
DEPO-MEDROL
NDA NDA011757
Jan 1, 1982
SOLU-MEDROL
NDA NDA011856
Jan 1, 1982
MEDROL ACETATE
NDA NDA012421
Jan 1, 1982
MEDROL
NDA NDA011153
Sources
References
- [1]
- [2]MedlinePlus Drug Information — Medrol drug information. U.S. National Library of Medicine, National Institutes of Health.
- [3]
- [4]Open Targets Platform — Drug–disease associations for Methylprednisolone. EMBL-EBI & Wellcome Sanger Institute.
- [5]
- [6]