Medrol

(Methylprednisolone)

ApprovedSmall molecule

Methylprednisolone is a steroid that reduces inflammation and suppresses the immune system, used to treat conditions like allergies, arthritis, asthma, and autoimmune diseases.[2] Medrol is currently approved and in use across 150 indications[4].[1]

Medrol is one of 1584 small molecule programs targeting Sciatica. It is currently in Approved.

150

Indications

540

Total Trials

Active Trials

1,583

Competitors

105

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

SciaticaActive, not recruiting

Chronic RhinosinusitisActive, not recruiting

Systemic Lupus ErythematosusTerminated

HysterectomyActive, not recruiting

Lupus NephritisCompleted

PneumoniaUnknown status

COVID-19Unknown status

MethylprednisoloneCompleted

Mycoplasma Pneumoniae PneumoniaApproved

Stage 5 Chronic Kidney DiseaseApproved

SciaticaApproved

Active, not recruiting

Chronic RhinosinusitisApproved

Active, not recruiting

Systemic Lupus ErythematosusPhase 3

Terminated

HysterectomyApproved

Active, not recruiting

Lupus NephritisApproved

Completed

PneumoniaApproved

Unknown status

COVID-19Approved

Unknown status

MethylprednisoloneApproved

Completed

Mycoplasma Pneumoniae PneumoniaApproved

Approved

Stage 5 Chronic Kidney DiseaseApproved

Approved

Showing 10 of 144 indications

Competition

Competitive Landscape

414 competitors in Non-Small Cell Lung Cancer

#DrugCompanyPhaseTrials

Medrol

Oleclumab

7 3

AK104

AAkeso

Phase 3

6 4

Pyrotinib

HHengrui Therapeutics, Inc.

Phase 3

4 5

Remeron

OOrganon and Co

Preclinical

1 6

Aqupla

Jiangsu Simcere Pharmaceutical Co., Ltd.

Preclinical

—7

Ftorafur

TThe First Affiliated Hospital with Nanjing Medical University

Preclinical

—8

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Treatment

1 10

PD-1 Inhibitors

BBioNTech US Inc.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2027

Phase 1Recruiting

Multiple Myeloma

NCT03110822

Q2 2027

Phase 1Recruiting

Methylprednisolone

NCT06225310

Post-ApprovalRecruiting

Steroid

NCT06268704

Q3 2027

N/ARecruiting

Hyperbilirubinemia

NCT06922669

Q4 2027

Post-ApprovalNot yet recruiting

Chronic Planter Fascitis

NCT07394894

Clinical

Trials by Indication[1]

Methylprednisolone16 trials

Pirfenidone Combined With Methylprednisolone Versus Methylprednisolone in the Treatment of CIP

Unknown status·ZZhou Chengzhi·Phase 1·NCT05280873·48 enrolled

Evaluation of Tolerability and Efficacy of Erythropoietin (EPO) Treatment in Spinal Shock: Comparative Study Versus Methylprednisolone (MP)

Terminated·NNiguarda Hospital·Phase 3·NCT00561067·10 enrolled

Impact of Intravenous Methylprednisolone Treatment on Blood Pressure

Completed·MMedical University of Warsaw··NCT03590080·32 enrolled

Show 13 more trials

Effect of Methylprednisolone on Immune Signaling in Hip-arthroplasty Patients

Completed·RRigshospitalet, Denmark·Phase 2/3·NCT02542592·64 enrolled

A Trial of Selinexor, Ruxolitinib and Methylprednisolone

Recruiting·OOncotherapeutics·Phase 1·NCT06225310·30 enrolled

A Study Comparing Drug Availability Of Methylprednisolone In Liquid Form Versus Methylprednisolone In Tablet Form

Completed· Pfizer logo

Pfizer·Phase 1·NCT01267201·24 enrolled

Effect of Methylprednisolone on Complement Activation in Patients Undergoing Total Knee-arthroplasty

Completed·RRigshospitalet, Denmark·Phase 3·NCT02332616·70 enrolled

Administration of Methylprednisolone for Prevention of Ovarian Hyper Stimulation Syndrome

Completed·RRoyan Institute·Phase 1/2·NCT01014104·218 enrolled

The Effect of Methylprednisolone on the Reversal Time of Rocuronium by Sugammadex in the Pediatric Patient Group

Completed·KKonya City Hospital·Phase 4·NCT06623370·80 enrolled

Triamcinolone Versus Methylprednisolone in Transversus Abdominis Plane Block

Completed·Gghada fouad·Phase 2/3·NCT04480775·84 enrolled

PreOperative Methylprednisolone on Thoracic Endovascular Repair for Reducing Post-implantation Syndrome (POMTEVAR)

Unknown status·GGuangdong Provincial People's Hospital·N/A·NCT05349071·158 enrolled

Rapamycin Plus Methylprednisolone Versus Methylprednisolone Alone in Active, Moderate-to-severe Graves' Orbitopathy.

Unknown status·FFirst Affiliated Hospital Xi'an Jiaotong University·Phase 1·NCT05532072·140 enrolled

Campath-1H + FK506 and Methylprednisolone for GVHD

Completed·—·Phase 2·NCT00109993·34 enrolled

Methylprednisolone N Acetylcysteine in Hepatic Resections

Terminated·IIstituto Clinico Humanitas·Phase 2·NCT01726465·50 enrolled

Effect of Methylprednisolone on Glucose Homeostasis in Patients Undergoing Total Hip- and Knee-arthroplasty

Completed·RRigshospitalet, Denmark·Phase 3·NCT02332603·134 enrolled

A Bioequivalence Study Comparing Methylprednisolone Suspension to Methylprednisolone Tablets Under Fed Conditions

Withdrawn· Pfizer logo

Pfizer·Phase 1·NCT01405170

Bone Marrow Transplantation9 trials

Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma

Completed·VVirginia Commonwealth University·Phase 2/3·NCT00003187·19 enrolled

Bone Marrow Transplantation in Treating Patients With Acute Leukemia in First or Second Remission

Completed·MMemorial Sloan Kettering Cancer Center·Phase 3·NCT00002534

Treatment of Bone Marrow to Prevent Graft-Versus-Host Disease in Patients With Acute or Chronic Leukemia Undergoing Bone Marrow Transplantation

Completed·UUnknown Sponsor·Phase 2/3·NCT00004255

Show 6 more trials

Phase II Study of Bone Marrow Transplantation Using Related Donors in Patients With Aplastic Anemia

Completed·NNational Center for Research Resources (NCRR)·Phase 2·NCT00004323·10 enrolled

Bone Marrow Transplantation With Specially Treated Bone Marrow in Treating Patients With Hematologic Cancer That Have Not Responded to Previous Therapy

Completed·—·Phase 1·NCT00005988·5 enrolled

Removal of T Cells to Prevent Graft-Versus-Host Disease in Patients Undergoing Bone Marrow Transplantation

Terminated·HH. Lee Moffitt Cancer Center and Research Institute·Phase 2·NCT00005641

Bone Marrow Transplantation in Treating Patients With Severe Aplastic Anemia or Rejection of Previous Bone Marrow Transplant

Terminated·HH. Lee Moffitt Cancer Center and Research Institute·Phase 2·NCT00005852

Donor Bone Marrow Transplantation in Treating Patients With Hematologic Cancer

Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT00003960·36 enrolled

Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies

Terminated·—·N/A·NCT00006054

Pneumonia8 trials

The Role of Olive Oil in the Treatment of Covid-19 Pneumonia

Completed·GGiresun University··NCT06677658·130 enrolled

Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00000730·240 enrolled

Extended Steroid in Use in Community Acquired Pneumonia (CAP)(e)

Completed·VVA Office of Research and Development·Phase 3·NCT01283009·584 enrolled

Show 5 more trials

Trial of an Alternate Mode of Providing Artificial Breaths to Children With Very Severe Pneumonia

Terminated·PPost Graduate Institute of Medical Education and Research, Chandigarh·N/A·NCT02167698·52 enrolled

Corticosteroid Therapy for Severe Community-Acquired Pneumonia

Unknown status·PPeking Union Medical College Hospital·Phase 4·NCT02552342·610 enrolled

Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell Transplant

Completed·CChildren's Oncology Group·Phase 2·NCT00309907·39 enrolled

Low Versus High Corticosteroid Use in Ventilator Associated Pneumonia

Completed·KKing Abdul Aziz Specialist Hospital·Phase 2·NCT04467892·240 enrolled

Efficacy Assessment of Methylprednisolone and Heparin in Patients With COVID-19 Pneumonia

Withdrawn·DD'Or Institute for Research and Education·Phase 3·NCT04485429

Lymphoma6 trials

Combination Chemotherapy in Treating Patients With Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma

Unknown status·TTheradex·Phase 1·NCT00053105

Combination Chemotherapy Followed by Rituximab and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed or Refractory AIDS-Related Non-Hodgkin's Lymphoma

Withdrawn·AAIDS Malignancy Consortium·Phase 2·NCT00310128

Pixantrone, Cytarabine, Methylprednisolone, and Cisplatin in Treating Patients With Aggressive Non-Hodgkin's Lymphoma in First Relapse

Unknown status·TTheradex·Phase 2·NCT00069966

Show 3 more trials

Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma

Completed·UUNICANCER·Phase 3·NCT00003650·179 enrolled

Rituximab, Temozolomide, and Methylprednisolone in Treating Patients With Recurrent Primary CNS Non-Hodgkin's Lymphoma

Terminated·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT00248534·16 enrolled

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Aggressive Non-Hodgkin's Lymphoma

Completed·SSwiss Cancer Institute·Phase 3·NCT00003215·400 enrolled

Multiple Sclerosis5 trials

A Pilot Study in Participants With Relapsing Remitting Multiple Sclerosis (RR-MS)

Terminated· Merck & Co. logo

Merck & Co.·Phase 2·NCT03387046·7 enrolled

Imatinib for Multiple Sclerosis (MS) Relapses

Unknown status·TTomas Olsson·Phase 2·NCT03674099·200 enrolled

A Study to Characterize Subcutaneous or Intravenous Alemtuzumab in Patients With Progressive Multiple Sclerosis

Completed· Sanofi logo

Sanofi·Phase 1·NCT02583594·24 enrolled

Show 2 more trials

Chronotherapy in Acute Multiple Sclerosis (MS) Attack

Terminated·SSykehuset Innlandet HF·N/A·NCT00764413·57 enrolled

Maximizing Outcome of Multiple Sclerosis Transplantation

Terminated·NNorthwestern University·Phase 3·NCT03342638·66 enrolled

115 more indications

Rheumatoid Arthritis5 trials

Study Evaluating 2 Dosing Regimens Of TRU-015 In Rheumatoid Arthritis

Terminated· Pfizer logo

Pfizer·Phase 2·NCT00634933·222 enrolled

A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis

Completed· Roche logo

Roche·Phase 4·NCT01382940·351 enrolled

A Study of MabThera/Rituxan (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis and Inadequate Response to DMARD Therapy

Completed· Roche logo

Roche·Phase 3·NCT02006706·15 enrolled

Show 2 more trials

A Study of the Safety and Efficacy of Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis Receiving Methotrexate

Completed· Roche logo

Roche·Phase 2·NCT00243412·42 enrolled

Infliximab as Induction Therapy in Early Rheumatoid Arthritis (IDEA)

Completed·UUniversity of Leeds·Phase 4·NCT01308255·112 enrolled

Treatment4 trials

Treatment of ITP With Rituximab and / or Accutane

Unknown status·PPeking University People's Hospital·Phase 2·NCT02757196·112 enrolled

Treatment Interruption of Natalizumab

Completed· Biogen logo

Biogen·Phase 2·NCT01071083·175 enrolled

The Research of Standard Diagnosis and Treatment for HSPN in Children

Unknown status·NNanjing Children's Hospital·Phase 2·NCT02532777·100 enrolled

Show 1 more trial

Is IFN-beta Treatment in MS Useful After a Washout Period in Patients With Neutralizing Antibodies to Interferon Beta

Completed· Biogen logo

Biogen·Phase 4·NCT00493116·20 enrolled

COVID-194 trials

Methylprednisolone in Patients with Cognitive Deficits in Post-COVID-19 Syndrome (PCS)

Unknown status·—·Phase 2·NCT05986422·418 enrolled

Clinical Trial to Evaluate Methylprednisolone Pulses and Tacrolimus in Patients With COVID-19 Lung Injury

Unknown status·HHospital Universitari de Bellvitge·Phase 3·NCT04341038·84 enrolled

Early Short Course Corticosteroids in COVID-19

Completed·HHenry Ford Health System··NCT04374071·250 enrolled

Show 1 more trial

Study to Evaluate the Efficacy and Safety of Tocilizumab Versus Corticosteroids in Hospitalised COVID-19 Patients With High Risk of Progression

Unknown status·UUniversity of Malaya·Phase 3·NCT04345445·310 enrolled

Acute Lymphoblastic Leukemia4 trials

Combination Chemotherapy in Treating Young Adult Patients With Acute Lymphoblastic Leukemia

Completed·GGruppo Italiano Malattie EMatologiche dell'Adulto·N/A·NCT01156883·76 enrolled

Chemotherapy With or Without Imatinib and/or Peripheral Stem Cell Transplant in Acute Lymphoblastic Leukemia

Completed·GGruppo Italiano Malattie EMatologiche dell'Adulto·Phase 2·NCT00458848·470 enrolled

Combination Chemotherapy in Treating Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Unknown status·OOhio State University Comprehensive Cancer Center·Phase 2·NCT01005758·180 enrolled

Show 1 more trial

Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma

Unknown status·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00003728·1,500 enrolled

Stem Cell Transplant3 trials

Lupus Immunosuppressive/Immunomodulatory Therapy or Stem Cell Transplant (LIST)

Withdrawn·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00230035

Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Patients With Hematologic Disorders

Completed·UUniversity of California, San Francisco·Phase 2·NCT00301834·35 enrolled

CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant

Active, not recruiting·DDiane George·Phase 1/2·NCT02061800·14 enrolled

Kidney Transplant3 trials

Veloxis de Novo Kidney Transplant ECSWD

Unknown status·SSimon Tremblay, PharmD, PhD·Phase 4·NCT03828682·60 enrolled

OPERA Study: A Study of Two Dosing Regimens of CellCept (Mycophenolate Mofetil) in Kidney Transplant Patients.

Completed· Roche logo

Roche·Phase 3·NCT02005562·252 enrolled

A Study to Compare the Efficacy and Safety of FK506MR vs Prograf® in Patients Undergoing Kidney Transplantation

Completed· Astellas logo

Astellas·Phase 3·NCT00481819·240 enrolled

Multiple Myeloma3 trials

An Efficacy and Safety Study of Daratumumab in Patients With Multiple Myeloma Who Have Received at Least 3 Prior Lines of Therapy (Including a Proteasome Inhibitor [PI] and Immunomodulatory Drug [IMiD]) or Are Double Refractory to a PI and an IMiD

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 2·NCT01985126·124 enrolled

A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients

Recruiting·OOncotherapeutics·Phase 1·NCT03110822·134 enrolled

Pilot Study Using Changes in Serum BCMA to Determine Disease Progression in Multiple Myeloma

Recruiting·OOncotherapeutics·Phase 1·NCT06209606·30 enrolled

Stem Cell Transplantation3 trials

Combination Chemotherapy and Interferon Alfa With or Without Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Myeloma

Unknown status·MMedical Research Council·Phase 3·NCT00002599·750 enrolled

Stem Cell Transplantation in Treating Patients With Hematologic Cancer

Completed·NNorthwestern University·Phase 1·NCT00004904

Bone Marrow and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer

Completed·NNorthwestern University·Phase 1·NCT00004232

Acute Graft Versus Host Disease3 trials

Low-Dose Prednisone or Methylprednisolone in Treating Patients With Newly Diagnosed Acute Graft-versus-Host Disease

Completed·FFred Hutchinson Cancer Center·Phase 3·NCT00929695·164 enrolled

A Study of IBI377 in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease

Terminated· Innovent Biologics (Suzhou) Co. Ltd. logo

Innovent Biologics (Suzhou) Co. Ltd.·Phase 1/2·NCT04220632·1 enrolled

Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00357084·53 enrolled

Steroid3 trials

Steroids in Patients With Early ARDS

Unknown status·—·Phase 2/3·NCT00562835·400 enrolled

Distal Radius Steroid

Terminated·IIndiana Hand to Shoulder Center·Phase 1·NCT05655130·30 enrolled

Particulate vs. Non-Particulate Steroid for Sacroiliac Joint Injection

Recruiting·UUniversity of New Mexico·Phase 4·NCT06268704·230 enrolled

Acute Respiratory Distress Syndrome2 trials

Procollagen-3 Driven Corticosteroids for Persistent Acute Respiratory Distress Syndrome

Terminated·AAssistance Publique Hopitaux De Marseille·Phase 3·NCT03371498·21 enrolled

Acute Respiratory Distress Syndrome Clinical Network (ARDSNet)

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 3·NCT00000579

Spinal Cord Injury2 trials

Umbilical Cord Blood Mononuclear Cell Transplant to Treat Chronic Spinal Cord Injury

Completed·CChina Spinal Cord Injury Network·Phase 1/2·NCT01354483·20 enrolled

Methylprednisolone Given by 24-Hour or 48-Hour Infusion Versus Tirilazad for Acute Spinal Cord Injury

Completed·NNational Institute of Neurological Disorders and Stroke (NINDS)·Phase 3·NCT00004759·497 enrolled

Membranous Nephropathy2 trials

Sequential Therapy With Tacrolimus and Rituximab in Primary Membranous Nephropathy

Completed·HHospital Universitario 12 de Octubre·Phase 3·NCT01955187·86 enrolled

Rituximab Versus Steroids and Cyclophosphamide in the Treatment of Idiopathic Membranous Nephropathy

Unknown status·AAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia·Phase 3·NCT03018535·76 enrolled

Glucocorticoids2 trials

Glucocorticoids and Bone in Graves' Ophthalmopathy

Completed·TTorben Harsløf··NCT03122847·39 enrolled

Intracoronary Administration of Glucocorticoids as a Treatment Method for No-Glucocorticoid Treatment for No-Reflow in STEMI

Completed·AAmosov National Institute of Cardiovascular Surgery·Phase 2·NCT06552442·10 enrolled

Myocarditis2 trials

Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis

Completed·MMayo Clinic·Phase 2·NCT00004482·40 enrolled

MYTHS - MYocarditis THerapy With Steroids

Recruiting·NNiguarda Hospital·Phase 3·NCT05150704·288 enrolled

Neuroma2 trials

Morton's Neuroma: Manipulation Versus Steroid Injection

Completed·DDundee Podiatry Clinic·N/A·NCT05707572·62 enrolled

Morton's Neuroma: Manipulation Versus Steroid Injection

Unknown status·—·N/A·NCT02304094·64 enrolled

Thyroid Eye Disease2 trials

A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease

Terminated· GSK logo

GSK·Phase 2·NCT01114503·2 enrolled

Sirolimus vs Corticosteroids in Treatment of Thyroid Eye Disease

Recruiting·HHaukeland University Hospital·Phase 2·NCT04936854·60 enrolled

Inflammatory Response2 trials

A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG

Not yet recruiting·—·Phase 1/2·NCT07101367·60 enrolled

Effect of Methylprednisolone on Systemic Inflammatory Response During Pediatric Congenital Open-Heart Surgery

Recruiting·—·Phase 4·NCT05927233·60 enrolled

Leukemia2 trials

Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00002471

Donor Umbilical Cord Blood Transplantation in Treating Patients With Leukemia, Lymphoma, or Nonmalignant Hematologic Disorders

Completed·RRoswell Park Cancer Institute·Phase 2·NCT00055653

Renal Transplant Recipients2 trials

Steroid Withdrawal in Pediatric Renal Transplant Recipients Under Cyclosporine (CyA) and Mycophenolate Mofetil (MMF)

Completed·KKlinik für Kinder- und Jugendmedizin·Phase 3·NCT00309218·42 enrolled

Selective CD28 Blockade in Renal Transplant Recipients

Withdrawn·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT04903054

Optic Neuritis2 trials

Longitudinal Optic Neuritis Study (LONS)

Unknown status·NNational Eye Institute (NEI)·N/A·NCT00000147

Optic Neuritis Treatment Trial (ONTT)

Unknown status·NNational Eye Institute (NEI)·Phase 3·NCT00000146

Lupus Nephritis2 trials

A Study to Evaluate the Safety and Efficacy of Obinutuzumab Compared With Placebo in Participants With Lupus Nephritis (LN)

Completed· Roche logo

Roche·Phase 2·NCT02550652·126 enrolled

Comparison of Low Dose Versus High Dose Cyclophosphamide as Induction Therapy in the Treatment of Lupus Nephritis

Completed·JJawaharlal Institute of Postgraduate Medical Education & Research·Phase 4·NCT02645565·75 enrolled

Hematologic Cancer2 trials

Umbilical Cord Blood Transplantation in Treating Patients With High-Risk Hematologic Cancer

Completed·—·Phase 2·NCT00003335·44 enrolled

Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

Completed·RRoswell Park Cancer Institute·Phase 2·NCT00003661·3 enrolled

Arthritis2 trials

Psoriatic Oligoarthritis Intervention With Symptomatic thErapy

Completed·UUniversity of Oxford·Phase 4·NCT03797872·1 enrolled

Seronegative Oligoarthritis of the Knee Study (SOKS)

Terminated·UUniversity of Leeds·Phase 2·NCT01216631·1 enrolled

Hyperbilirubinemia1 trial

Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia

Recruiting·GGeneral Hospital of Shenyang Military Region·N/A·NCT06922669·232 enrolled

Intraoperative1 trial

Use of Local Intraoperative Steroid in MIS TLIF

Completed·RRush University Medical Center·Phase 3·NCT03308084·105 enrolled

Myocardial Infarction1 trial

Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction

Unknown status·TThomas Engstrom·Phase 2·NCT05462730·530 enrolled

Renal Transplant1 trial

Effect of Everolimus on the Pharmacokinetics of Tacrolimus in Renal Transplant Patients

Completed·NNational Taiwan University Hospital·Phase 4·NCT02077556·14 enrolled

Lung Cancer1 trial

Methylprednisolone Before Fludeoxyglucose-Labeled Positron Emission Tomography in Patients With Lung Cancer

Withdrawn·OOhio State University Comprehensive Cancer Center·N/A·NCT01789892

Natural Killer Cell1 trial

Donor Umbilical Cord Blood Natural Killer Cells, Aldesleukin and Umbilical Cord Blood Transplant in Patients With Refractory Hematologic Cancers.

Terminated·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00354172·16 enrolled

Asthma1 trial

Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma

Unknown status·UUniversity of Karachi··NCT06171932·60 enrolled

Facial palsy1 trial

Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT00438087·313 enrolled

Total Hip Arthroplasty1 trial

Effects of Methylprednisolone After Total Hip Arthroplasty

Completed·HHvidovre University Hospital·Phase 4·NCT00968903·48 enrolled

Myelodysplastic Syndrome1 trial

Thymoglobulin and Cyclosporine in Patients With Aplastic Anemia or Myelodysplastic Syndrome

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00806598·53 enrolled

First Line Therapy1 trial

Trimethoprim/Sulfamethoxazole Combined With Caspofungin as First-line Therapy in PCP

Unknown status·BBin Du·Phase 4·NCT03978559·122 enrolled

Mortality1 trial

Investigation of Hospitalisation Times and Mortality According to Drug Dose in Patients Given Systemic Methylprednisolone With a Pre-diagnosis of Covid-19 Pneumonia; Retrospective Study

Completed·—··NCT04847687·300 enrolled

Vasculitis1 trial

Anti-Cytokine Therapy for Vasculitis

Completed·UUniversity Hospital Birmingham NHS Foundation Trust·Phase 2·NCT00753103·37 enrolled

aGVHD1 trial

Safety and Clinical Activity of Itolizumab in aGVHD

Unknown status·BBiotech Pharmaceutical Co., Ltd.·Phase 1·NCT05823675·44 enrolled

Vestibular Dysfunction1 trial

Vestibular Prognosis Assessment of ISSNHL With Vestibular Dysfunction Treated With Oral or Intratympanic Glucocorticoids

Unknown status·EEye & ENT Hospital of Fudan University·N/A·NCT03974867·72 enrolled

Third Molar1 trial

Assessment of the Operative Course in Connection With Removal of Lower Third Molars

Completed·UUniversity of Aarhus·N/A·NCT00805298·154 enrolled

Autoimmune Disease1 trial

Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases

Unknown status·—·N/A·NCT00006055·10 enrolled

Total Knee Arthroplasty1 trial

Effects of Methylprednisolone After Total Knee Arthroplasty

Completed·HHvidovre University Hospital·Phase 4·NCT00968578·48 enrolled

Elderly Patients1 trial

CORTERAS STUDY: The Effect of Corticosteroids on Early Recovery After Major Surgery in Elderly Patients

Completed·ZZiekenhuis Oost-Limburg·Phase 4·NCT05220319·751 enrolled

Effectiveness1 trial

MIS-C Comparative Effectiveness Study

Completed·UUniversity of California, San Diego·Phase 2/3·NCT04898231·73 enrolled

Cardiac Surgery1 trial

Extracorporeal Cytokine Adsorption in Cardiac Surgery

Completed·UUniversity Medical Centre Ljubljana·Phase 3·NCT02666703·60 enrolled

Cardiac Arrest1 trial

Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest

Completed·CChristian Hassager·Phase 2·NCT04624776·158 enrolled

Metabolic Disease1 trial

Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Other Hematologic or Metabolic Diseases

Completed·RRoswell Park Cancer Institute·Phase 2·NCT00003662·90 enrolled

Ulcerative Colitis1 trial

Endovenous Corticosteroid Pulses in Moderate Ulcerative Colitis

Terminated·GGrupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa·Phase 4·NCT02921555·75 enrolled

Hematoma1 trial

Treatment of Chronic Subdural Hematoma by Corticosteroids

Completed·RRennes University Hospital·Phase 3·NCT02650609·202 enrolled

Genetic Disorder1 trial

Combination Chemotherapy Followed by Donor Bone Marrow Transplant or Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer or Genetic Disorders

Unknown status·HHerbert Irving Comprehensive Cancer Center·Phase 2·NCT00008307·52 enrolled

Mycoplasma pneumoniae pneumonia1 trial

Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children

Terminated·—·N/A·NCT01217099·47 enrolled

Relapsing-Remitting Multiple Sclerosis1 trial

Nanocort in Acute Exacerbation of Relapsing-Remitting Multiple Sclerosis (MS)

Terminated·GGalapagos NV·Phase 2·NCT01039103·15 enrolled

Acute Lung Injury1 trial

Trial of Steroids in Pediatric Acute Lung Injury/ARDS

Unknown status·UUniversity of Tennessee·Phase 2·NCT01274260·100 enrolled

Inflammatory Bowel Disease1 trial

Dexamethasone Versus Methylprednisolone for the Treatment of Active Inflammatory Bowel Disease

Terminated·UUniversity of Chicago·N/A·NCT00152620·40 enrolled

Bronchopulmonary Dysplasia1 trial

Phase III Randomized, Double-Blind Study of Dexamethasone Vs Dexamethasone/Methylprednisolone Vs Placebo for Bronchopulmonary Dysplasia

Completed·NNational Center for Research Resources (NCRR)·Phase 3·NCT00004785·54 enrolled

Graft Versus Host Disease1 trial

Beclomethasone Plus Prednisone in Treating Patients With Graft-Versus-Host Disease

Completed·MMemorial Sloan Kettering Cancer Center·Phase 3·NCT00043147

Juvenile Dermatomyositis1 trial

Absorption of Corticosteroids in Children With Juvenile Dermatomyositis

Completed·NNorthwestern University·Phase 2·NCT00004357·6 enrolled

Anemia1 trial

Phase I/II Study of Total Body Irradiation, Cyclophosphamide, and Fludarabine Followed by Alternate Donor Hematopoietic Cell Transplantation in Patients With Fanconi's Anemia

Completed·UUniversity of Minnesota·Phase 1/2·NCT00005898·30 enrolled

Advanced1 trial

Steroids and Azathioprine in Advanced IgAN

Completed·—·Phase 3·NCT01392833·46 enrolled

Neuropathy1 trial

Surgery for Traumatic Optic Neuropathy

Unknown status·SShanghai Changzheng Hospital·N/A·NCT02711982·2 enrolled

Primary Gonarthrosis1 trial

The Effect of Different Intra-articular Injections Primary Gonarthrosis

Completed·NNevsehir Haci Bektas Veli University·N/A·NCT05291793·80 enrolled

Post-Extubation Laryngeal Edema1 trial

Prevention of Post-Extubation Laryngeal Edema With Intravenous Corticosteroids

Completed·UUniversity Hospital, Limoges·Phase 3·NCT00199576·670 enrolled

Aplastic Anemia1 trial

Study of Allogeneic Bone Marrow and T-Cell Depleted, CD34+ Peripheral Blood Stem Cell Transplantation in Patients With Aplastic Anemia

Unknown status·—·N/A·NCT00017654·3 enrolled

Chronic Planter Fascitis1 trial

Local Percutaneous Pulsed Radiofrequency Ablation Versus Ultrasound Guided Steroids Injection in Management of Pain in Cases of Chronic Planter Fascitis, Randomised Double Blinded Study

Not yet recruiting·—·Phase 4·NCT07394894·122 enrolled

Severe Acute Respiratory Syndrome1 trial

Methylprednisolone for Patients With COVID-19 Severe Acute Respiratory Syndrome

Completed·UUniversity of Trieste··NCT04323592·173 enrolled

Thrombocytopenia1 trial

Cyclophosphamide and Hydroxychloroquine for Thrombocytopenia in SLE

Terminated·CChinese SLE Treatment And Research Group·Phase 3·NCT02444728·50 enrolled

Liver Transplant1 trial

Cyclosporine A C-2h Monitoring Versus Tacrolimus C-0h Monitoring in de Novo Liver Transplant Recipients

Completed· Novartis logo

Novartis·Phase 4·NCT00149994·171 enrolled

Neuromyelitis Optica1 trial

Association Between the Effect of Glucocorticoid Pulse Therapy on Neuromyelitis Optica (NMO) and Gene Polymorphism

Unknown status·—··NCT04601142·350 enrolled

Prostate Cancer1 trial

Study of Relugolix in Men With Metastatic Castration-Sensitive Prostate Cancer or Non-Metastatic or Metastatic Castration-Resistant Prostate Cancer

Completed· Sumitomo Pharma America, Inc. logo

Sumitomo Pharma America, Inc.·Phase 1·NCT04666129·48 enrolled

Stroke1 trial

High Dose Steroids in Children With Stroke

Recruiting·IInsel Gruppe AG, University Hospital Bern·Phase 3·NCT04873583·70 enrolled

Malignant Solid Tumors1 trial

Busulfan, Melphalan, and Antithymocyte Globulin Followed By Umbilical Cord Blood Transplant in Treating Young Patients With Refractory or Relapsed Malignant Solid Tumors

Unknown status·MMilton S. Hershey Medical Center·Phase 1·NCT00436761·20 enrolled

Atorvastatin1 trial

Effects of Atorvastatin in Graves' Orbitopathy (GO)

Completed·UUniversity of Pisa·Phase 2·NCT03110848·88 enrolled

Thyroid Associated Ophthalmopathy1 trial

99Tc-MDP for Thyroid-Associated Ophthalmopathy

Completed·—·Phase 4·NCT03948191·50 enrolled

Diabetes Mellitus1 trial

Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus

Completed·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 2/3·NCT03289338·36 enrolled

Chronic Rhinosinusitis1 trial

Systemic Methylprednisolone in Chronic Rhinosinusitis

Completed·OOndokuz Mayıs University·Phase 4·NCT01205984·48 enrolled

Hematologic Malignancies1 trial

Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Completed·—·Phase 2·NCT01093586·14 enrolled

Fasting Conditions1 trial

A Bioequivalence Study Comparing Methylprednisolone Suspension To Methylprednisolone Tablets Under Fasting Conditions

Withdrawn· Pfizer logo

Pfizer·Phase 1·NCT01405157

Lymphoproliferative Disease1 trial

Cyclophosphamide, Rituximab, and Either Prednisone or Methylprednisolone in Treating Patients With Lymphoproliferative Disease After Solid Organ Transplantation

Completed·CChildren's Oncology Group·Phase 2·NCT00066469·55 enrolled

Rejection1 trial

The Effect of Steroid Pulse Therapy for the Reduction of Acute Rejection Episode in Subclinical Borderline Changes

Unknown status·SSamsung Medical Center·N/A·NCT02664493·154 enrolled

Sinusitis1 trial

Evaluation of Inhaled Treatment in Sinusitis

Completed·CCliniques universitaires Saint-Luc- Université Catholique de Louvain·Phase 2/3·NCT01907204·50 enrolled

Pilot Study1 trial

Pilot Study Of Unrelated UCB Transplant for Non-Malignant Hematologic Conditions

Completed·—·Phase 2·NCT00003336·6 enrolled

Dysphagia1 trial

Effect of Local Intraoperative Steroid on Dysphagia After ACDF

Completed·RRush University Medical Center·Phase 3·NCT03311425·140 enrolled

Epidural1 trial

Maternal Epidural Steroids and Hyperthemia

Terminated·MMedical University of South Carolina·Phase 1·NCT02212210·135 enrolled

Recurrent or Metastatic1 trial

Donor Stem Cell Transplant After Conditioning Therapy in Treating Patients With Hematologic Cancer, Recurrent or Metastatic Solid Tumor, or Other Disease

Completed·—·N/A·NCT00521430·30 enrolled

Acute Respiratory Failure1 trial

Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia

Not yet recruiting·QQingyuan Zhan·Phase 1/2·NCT07357935·500 enrolled

Hernia1 trial

Epidural Steroid Following Discectomy for Herniated Disc Reduces Morbidity

Completed·NNorthern Orthopaedic Division, Denmark·N/A·NCT01499641·200 enrolled

Peritoneal Carcinomatosis1 trial

Octreotide Compared to Placebo in Patients With Inoperable Bowel Obstruction Due to Peritoneal Carcinomatosis

Completed· Novartis logo

Novartis·Phase 2·NCT00332696·64 enrolled

Cluster headache1 trial

GON-injection for a Sooner and Better Treatment of Cluster Headache

Completed·LLeiden University Medical Center·Phase 4·NCT04014634·70 enrolled

Acute Leukemia1 trial

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous or Acute Leukemia

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT00002831·24 enrolled

Refractory Solid Tumors1 trial

Donor Stem Cell Transplant in Treating Young Patients With Relapsed or Refractory Solid Tumors

Completed·MMilton S. Hershey Medical Center·Phase 1·NCT00112645·10 enrolled

Orthognathic Surgery1 trial

Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery

Completed·JJean Charles Doucet·Phase 4·NCT03190642·180 enrolled

Aortic Valve Replacement1 trial

Glucocorticoid Treatment in Transaortic Valve Replacement to Reduce the Incidence of Conduction Disturbances (GLUCO-TAVR).

Unknown status·—·Phase 4·NCT06076824·100 enrolled

Endothelial Function1 trial

Effect of Methylprednisolone on Endothelial Function in Patients Undergoing Total Knee-arthroplasty

Completed·RRigshospitalet, Denmark·Phase 3·NCT02332629·70 enrolled

Stage II1 trial

Rituximab, Yttrium Y 90 Ibritumomab Tiuxetan in Patients W/Relapsed Stage II, III, or IV Follicular NHL

Completed·UUniversity of Arizona·Phase 2·NCT00732498·28 enrolled

Idiopathic Pulmonary Fibrosis1 trial

Azithromycin in the Management of Patients With Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Recruiting·—·N/A·NCT05842681·30 enrolled

Osteoarthritis1 trial

Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis

Completed·MMayo Clinic·Phase 4·NCT02576249·29 enrolled

Induction Therapy1 trial

Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.

Withdrawn·MMidAmerica Neuroscience Research Foundation at Rowe Neurology Institute·Phase 4·NCT00037115

Hematologic Disease1 trial

Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Nonmalignant Hematologic Disease

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00003913·390 enrolled

Glucocorticoid1 trial

Comparison of the Effectiveness of Two Glucocorticoid Regimens for Treatment of Graves' Orbitopathy

Completed·MMedical University of Sofia··NCT05793359·62 enrolled

Renal Allograft Recipients1 trial

Study Comparing Two Immunosuppressive Regimens in De Novo Renal Allograft Recipients

Completed· Pfizer logo

Pfizer·Phase 4·NCT00261820·160 enrolled

Hemangioma1 trial

Pulse Steroids Versus Oral Steroids in Problematic Hemangiomas of Infancy

Completed·TThe Hospital for Sick Children·Phase 3·NCT00312520·20 enrolled

Total Knee Replacement1 trial

Methylprednisolone Taper After Total Knee Replacement

Completed·EEmory University·Phase 4·NCT05859269·101 enrolled

Efficacy and Safety1 trial

Efficacy and Safety of Human Lipoprotein Lipase (LPL)[S447X] Expressed by an Adeno-Associated Viral Vector in LPL-deficient Subjects

Completed·AAmsterdam Molecular Therapeutics·Phase 2/3·NCT00891306·5 enrolled

Suicide1 trial

Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Gene

Terminated·MM.D. Anderson Cancer Center·Phase 1/2·NCT01875237·3 enrolled

Allogeneic Stem Cell Transplantation1 trial

Ultraviolet-B Light Therapy and Allogeneic Stem Cell Transplantation in Treating Patients With Hematologic Malignancies

Completed·—·N/A·NCT00068523·10 enrolled

Abiraterone Acetate1 trial

Extension of SoluMatrix TM Abiraterone Acetate in Patients Who Completed Study Number CHL-AA-201

Completed·GGU Research Network, LLC·Phase 3·NCT02887976·2 enrolled

Systemic Sclerosis1 trial

The Effect of High Dose Methylprednisolone on Nailfold in Early Systemic Sclerosis ( SSc )

Unknown status·RRadboud University Medical Center·Phase 1·NCT03059979·30 enrolled

Local Anesthetic1 trial

Efficacy Of Magnesium In Radicular Pain When Added To Local Anesthetics And Steroids In Transforaminal Epidural Injection

Unknown status·FFayoum University·Phase 1·NCT04532775·100 enrolled

Intussusception1 trial

Follow-up and Steroid Treatment Results in Intussusception

Completed·—·Phase 1/2·NCT05640375·92 enrolled

Venous thrombosis1 trial

Steroid for Treatment of Acute/Subacute Severe Cerebral Venous Thrombosis.

Completed·XXuanwu Hospital, Beijing··NCT05990894·170 enrolled

Appendicitis1 trial

Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy

Completed·JJakob Kleif·Phase 2·NCT02711449·78 enrolled

Lymphoid Malignancies1 trial

Penostatin, Rituximab and Ontak and Allogeneic Natural Killer (NK) Cells for Refractory Lymphoid Malignancies

Completed·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT01181258·16 enrolled

Henoch-Schönlein Purpura1 trial

Clinical Study on Strategy for Refractory Henoch-Schönlein Purpura

Recruiting·—·N/A·NCT03647852·150 enrolled

Fanconi Anemia1 trial

Hematopoietic Stem Cell Transplantation in High Risk Patients With Fanconi Anemia

Completed·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00258427·14 enrolled

Unspecified3 trials

Differences in Flare Reaction Incidence and Intensity Following Trigger Finger Injections

Completed·WWest Virginia University·Phase 4·NCT04900220·66 enrolled

Pulse ACTH vs. MP for MS

Completed·UUniversity of Southern California·Phase 1·NCT01049451·23 enrolled

Safety and Feasibility of Umbilical Cord Blood Cell Transplant Into Injured Spinal Cord

Completed·CChina Spinal Cord Injury Network·Phase 1/2·NCT01046786·8 enrolled

Regulatory

FDA Approval Timeline[5]

Oct 24, 1957

MEDROL

NDA NDA011153

May 18, 1959

SOLU-MEDROL

NDA NDA011856

May 27, 1959

DEPO-MEDROL

NDA NDA011757

Sep 10, 1976

MEDROL

NDA NDA011153

Apr 11, 1978

MEDROL

NDA NDA011153

Jul 12, 1978

DEPO-MEDROL

NDA NDA011757

Apr 5, 1979

MEDROL

NDA NDA011153

Apr 5, 1979

MEDROL

NDA NDA011153

May 30, 1979

MEDROL

NDA NDA011153

Nov 13, 1979

SOLU-MEDROL

NDA NDA011856

Apr 14, 1980

MEDROL

NDA NDA011153

Apr 28, 1980

SOLU-MEDROL

NDA NDA011856

Jul 29, 1980

DEPO-MEDROL

NDA NDA011757

Sep 30, 1980

SOLU-MEDROL

NDA NDA011856

Oct 8, 1980

MEDROL

NDA NDA011153

Feb 17, 1981

DEPO-MEDROL

NDA NDA011757

Feb 20, 1981

SOLU-MEDROL

NDA NDA011856

Aug 11, 1981

SOLU-MEDROL

NDA NDA011856

Oct 16, 1981

SOLU-MEDROL

NDA NDA011856

Jan 1, 1982

MEDROL ACETATE

NDA NDA012421

Jan 1, 1982

SOLU-MEDROL

NDA NDA011856

Jan 1, 1982

DEPO-MEDROL

NDA NDA011757

Jan 1, 1982

MEDROL

NDA NDA011153

Jan 1, 1982

MEDROL

NDA NDA018102

Mar 9, 1983

DEPO-MEDROL

NDA NDA011757

Mar 9, 1983

MEDROL

NDA NDA011153

Mar 9, 1983

DEPO-MEDROL

NDA NDA011757

May 3, 1983

SOLU-MEDROL

NDA NDA011856

Feb 27, 1985

SOLU-MEDROL

NDA NDA011856

Mar 28, 1985

SOLU-MEDROL

NDA NDA011856

Jan 23, 1986

SOLU-MEDROL

NDA NDA011856

Jan 31, 1986

SOLU-MEDROL

NDA NDA011856

Feb 14, 1986

SOLU-MEDROL

NDA NDA011856

May 12, 1986

DEPO-MEDROL

NDA NDA011757

May 12, 1986

DEPO-MEDROL

NDA NDA011757

May 12, 1986

DEPO-MEDROL

NDA NDA011757

Dec 8, 1986

SOLU-MEDROL

NDA NDA011856

Dec 8, 1986

SOLU-MEDROL

NDA NDA011856

Feb 24, 1987

MEDROL

NDA NDA011153

Jan 5, 1989

DEPO-MEDROL

NDA NDA011757

Jan 5, 1989

MEDROL

NDA NDA011153

Mar 22, 1989

SOLU-MEDROL

NDA NDA011856

Jul 11, 1989

SOLU-MEDROL

NDA NDA011856

Oct 2, 1989

SOLU-MEDROL

NDA NDA011856

Dec 14, 1989

DEPO-MEDROL

NDA NDA011757

Apr 24, 1990

SOLU-MEDROL

NDA NDA011856

Nov 15, 1990

DEPO-MEDROL

NDA NDA011757

Dec 7, 1990

SOLU-MEDROL

NDA NDA011856

Sep 4, 1991

SOLU-MEDROL

NDA NDA011856

Jan 28, 1993

MEDROL

NDA NDA011153

Nov 5, 1993

SOLU-MEDROL

NDA NDA011856

Dec 28, 1993

MEDROL

NDA NDA011153

Dec 28, 1993

DEPO-MEDROL

NDA NDA011757

Jan 7, 1994

DEPO-MEDROL

NDA NDA011757

Mar 25, 1994

SOLU-MEDROL

NDA NDA011856

Apr 6, 1994

SOLU-MEDROL

NDA NDA011856

Apr 22, 1994

SOLU-MEDROL

NDA NDA011856

Sep 15, 1994

SOLU-MEDROL

NDA NDA011856

Jan 24, 1995

DEPO-MEDROL

NDA NDA011757

Feb 26, 1998

SOLU-MEDROL

NDA NDA011856

Mar 16, 1999

SOLU-MEDROL

NDA NDA011856

Dec 1, 1999

MEDROL

NDA NDA011153

Apr 3, 2000

SOLU-MEDROL

NDA NDA011856

Apr 4, 2000

DEPO-MEDROL

NDA NDA011757

May 22, 2002

DEPO-MEDROL

NDA NDA011757

Oct 21, 2002

SOLU-MEDROL

NDA NDA011856

Oct 25, 2002

MEDROL

NDA NDA011153

Apr 7, 2009

DEPO-MEDROL

NDA NDA011757

Apr 7, 2009

DEPO-MEDROL

NDA NDA011757

Jun 24, 2010

SOLU-MEDROL

NDA NDA011856

Oct 20, 2011

SOLU-MEDROL

NDA NDA011856

Oct 20, 2011

SOLU-MEDROL

NDA NDA011856

Jul 18, 2013

MEDROL

NDA NDA011153

Oct 7, 2013

DEPO-MEDROL

NDA NDA011757

Oct 11, 2013

DEPO-MEDROL

NDA NDA011757

Mar 28, 2014

SOLU-MEDROL

NDA NDA011856

Apr 4, 2014

SOLU-MEDROL

NDA NDA011856

Jun 9, 2014

DEPO-MEDROL

NDA NDA011757

Jun 9, 2014

SOLU-MEDROL

NDA NDA011856

Jul 3, 2014

SOLU-MEDROL

NDA NDA011856

Jul 3, 2014

DEPO-MEDROL

NDA NDA011757

Jul 22, 2014

SOLU-MEDROL

NDA NDA011856

Aug 6, 2015

SOLU-MEDROL

NDA NDA011856

Sep 8, 2016

DEPO-MEDROL

NDA NDA011757

Sep 8, 2016

SOLU-MEDROL

NDA NDA011856

Sep 8, 2016

SOLU-MEDROL

NDA NDA011856

Mar 15, 2017

DEPO-MEDROL

NDA NDA011757

Mar 28, 2018

SOLU-MEDROL

NDA NDA011856

Jul 24, 2018

MEDROL

NDA NDA011153

Jul 24, 2018

DEPO-MEDROL

NDA NDA011757

Jul 24, 2018

SOLU-MEDROL

NDA NDA011856

Aug 26, 2019

MEDROL

NDA NDA011153

Feb 11, 2021

DEPO-MEDROL

NDA NDA011757

May 27, 2021

DEPO-MEDROL

NDA NDA011757

May 27, 2021

SOLU-MEDROL

NDA NDA011856

Oct 27, 2021

SOLU-MEDROL

NDA NDA011856

Dec 19, 2023

MEDROL

NDA NDA011153

Dec 20, 2023

DEPO-MEDROL

NDA NDA011757

Dec 20, 2023

SOLU-MEDROL

NDA NDA011856

Jun 5, 2024

DEPO-MEDROL

NDA NDA011757

Jun 5, 2024

MEDROL

NDA NDA011153

Jun 5, 2024

SOLU-MEDROL

NDA NDA011856

Nov 4, 2025

SOLU-MEDROL

NDA NDA011856

Nov 4, 2025

DEPO-MEDROL

NDA NDA011757

Nov 4, 2025

MEDROL

NDA NDA011153

Sources

References

[1]
ClinicalTrials.gov — 540 trial records for Methylprednisolone. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Medrol drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Methylprednisolone compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Methylprednisolone. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA011856). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Glucocorticoid Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Pfizer