Medrol

(Methylprednisolone)

ApprovedSmall molecule

Methylprednisolone is a steroid that reduces inflammation and suppresses the immune system, used to treat conditions like allergies, arthritis, asthma, and autoimmune diseases.[2] Medrol is currently approved and in use across 156 indications[4].[1]

Medrol is one of 1647 small molecule programs targeting Sciatica. It is currently in Approved.

156

Indications

538

Total Trials

Active Trials

1,646

Competitors

105

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

SciaticaActive, not recruiting

Chronic RhinosinusitisActive, not recruiting

Systemic Lupus ErythematosusActive, not recruiting

HysterectomyActive, not recruiting

Lupus NephritisCompleted

LymphomaCompleted

PneumoniaCompleted

COVID-19Terminated

Stem Cell TransplantCompleted

MethylprednisoloneCompleted

SciaticaApproved

Active, not recruiting

Chronic RhinosinusitisApproved

Active, not recruiting

Systemic Lupus ErythematosusPhase 3

Active, not recruiting

HysterectomyApproved

Active, not recruiting

Lupus NephritisApproved

Completed

LymphomaPhase 3

Completed

PneumoniaApproved

Completed

COVID-19Approved

Terminated

Stem Cell TransplantPhase 2

Completed

MethylprednisoloneApproved

Completed

Showing 10 of 150 indications

Competition

Competitive Landscape

449 competitors in Non-Small Cell Lung Cancer

#DrugCompanyPhaseTrials

Medrol

Pfizer

Approved

538 2

Navelbine

PPierre Fabre Medicament

Phase 3

24 3

Pyrotinib

HHengrui Therapeutics, Inc.

Phase 3

3 4

JAB 21822

AAllist Pharmaceuticals, Inc.

Phase 3

1 5

Remeron

OOrganon and Co

Preclinical

1 6

Valemetostat Tosylate

Daiichi Sankyo

Preclinical

1 7

Aqupla

Jiangsu Simcere Pharmaceutical Co., Ltd.

Preclinical

—8

Ftorafur

TThe First Affiliated Hospital with Nanjing Medical University

Preclinical

—9

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Treatment

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalNot yet recruiting

Methylprednisolone

NCT06510114

Phase 2Recruiting

Methylprednisolone

NCT07208799

Phase 2Recruiting

Neuromyelitis Optica

NCT07184840

Phase 3Recruiting

Adhesive Capsulitis

NCT06848374

N/ARecruiting

Neuromyelitis Optica

NCT06763848

Q1 2027

Phase 2Not yet recruiting

Baricitinib

NCT06768294

Clinical

Trials by Indication[1]

Methylprednisolone12 trials

Pirfenidone Combined With Methylprednisolone Versus Methylprednisolone in the Treatment of CIP

Unknown status·ZZhou Chengzhi·Phase 1·NCT05280873·48 enrolled

Triamcinolone Versus Methylprednisolone in Transversus Abdominis Plane Block

Completed·Gghada fouad·Phase 2/3·NCT04480775·84 enrolled

PreOperative Methylprednisolone on Thoracic Endovascular Repair for Reducing Post-implantation Syndrome (POMTEVAR)

Unknown status·GGuangdong Provincial People's Hospital·N/A·NCT05349071·158 enrolled

Show 9 more trials

Effect of Methylprednisolone on Quadriceps Muscle Function in Patients Undergoing Total Knee-arthroplasty

Completed·RRigshospitalet, Denmark·Phase 3·NCT02319343·70 enrolled

Preoperative Methylprednisolone in Endovascular Aortic Repair

Completed·LLouise de la Motte·N/A·NCT00989729·150 enrolled

Coagulation After Intravenous Methylprednisolone Administration

Completed·PPiotr Miskiewicz··NCT03535090·26 enrolled

A Randomized Clinical Trial of Intravenous Methylprednisolone With 2 Protocols in Patients With Graves Orbitopathy

Not yet recruiting·TThird Affiliated Hospital, Sun Yat-Sen University·Phase 4·NCT06510114·150 enrolled

Treatment of Refractory Gout With ACTH or Methylprednisolone

Unknown status·SShanghai 10th People's Hospital·N/A·NCT04808856·60 enrolled

Heart Rhythm After Intravenous Methylprednisolone Administration

Completed·MMedical University of Warsaw··NCT04391439·40 enrolled

Comparison of Submucosal Dexamethasone and Methylprednisolone in Postoperative Sequelae of Parasymphsis Fractures

Recruiting·NNishtar Medical University·Phase 2·NCT07208799·72 enrolled

Comparison of Efficacy of Dexamethasone and Methylprednisolone in Moderate to Severe Covid 19 Disease

Completed·FFatima Memorial Hospital·Phase 3·NCT04603729·100 enrolled

Methylprednisolone During the Switch Between Natalizumab and Fingolimod

Unknown status·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT02769689·56 enrolled

Lymphoma7 trials

Combination Chemotherapy Followed by Rituximab and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed or Refractory AIDS-Related Non-Hodgkin's Lymphoma

Withdrawn·AAIDS Malignancy Consortium·Phase 2·NCT00310128

Fludeoxyglucose F 18 Positron Emission Tomography in Predicting Risk of Relapse in Patients With Non-Hodgkin's Lymphoma Who Are Undergoing Combination Chemotherapy With or Without Autologous Stem Cell or Bone Marrow Transplant

Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 2·NCT00238368·59 enrolled

S0350 Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Peripheral T-Cell Non-Hodgkin's Lymphoma

Completed·SSWOG Cancer Research Network·Phase 2·NCT00109928·34 enrolled

Show 4 more trials

Three Different Therapy Regimens in Treating Patients With Previously Untreated Hodgkin Lymphoma

Terminated·FFrench Innovative Leukemia Organisation·Phase 3·NCT00920153·442 enrolled

Combination Chemotherapy in Treating Patients With Intermediate-Grade or Immunoblastic Non-Hodgkin's Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT00002565·61 enrolled

Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00002524·46 enrolled

Polatuzumab Vedotin and Combination Chemotherapy for the Treatment of Previously Untreated Lymphoma

Active, not recruiting·BBarbara Ann Karmanos Cancer Institute·Phase 2·NCT04479267·8 enrolled

Pneumonia7 trials

The Role of Olive Oil in the Treatment of Covid-19 Pneumonia

Completed·GGiresun University··NCT06677658·130 enrolled

Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00000730·240 enrolled

The Efficacy of Different Hormone Doses in 2019-nCoV Severe Pneumonia

Unknown status·TTongji Hospital·Phase 4·NCT04263402·100 enrolled

Show 4 more trials

Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP)

Recruiting·CCopenhagen Respiratory Research·Phase 4·NCT06892197·1,600 enrolled

Steroids and Unfractionated Heparin in Critically Ill Patients With Pneumonia From COVID-19 Infection

Unknown status·MMassimo Girardis·Phase 3·NCT04528888·210 enrolled

The Safety and Effectiveness of Methylprednisolone in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Children With AIDS

Withdrawn·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00000741

Corticosteroid Therapy for Severe Community-Acquired Pneumonia

Unknown status·PPeking Union Medical College Hospital·Phase 4·NCT02552342·610 enrolled

Kidney Transplant5 trials

Veloxis de Novo Kidney Transplant ECSWD

Unknown status·SSimon Tremblay, PharmD, PhD·Phase 4·NCT03828682·60 enrolled

Effects of Inhibiting Early Inflammation in Kidney Transplant Patients

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT02495077·290 enrolled

OPERA Study: A Study of Two Dosing Regimens of CellCept (Mycophenolate Mofetil) in Kidney Transplant Patients.

Completed· Roche logo

Roche·Phase 3·NCT02005562·252 enrolled

Show 2 more trials

A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant

Completed· Amgen logo

Amgen·Phase 2·NCT04046549·25 enrolled

Belatacept to Prevent Organ Rejection in Kidney Transplant Patients

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00346151·5 enrolled

Treatment5 trials

Treatment of ITP With Rituximab and / or Accutane

Unknown status·PPeking University People's Hospital·Phase 2·NCT02757196·112 enrolled

The Research of Standard Diagnosis and Treatment for HSPN in Children

Unknown status·NNanjing Children's Hospital·Phase 2·NCT02532777·100 enrolled

Alternative Treatment Paradigm for Natalizumab Trial

Withdrawn·UUniversity of Texas Southwestern Medical Center·Phase 2·NCT01710228

Show 2 more trials

Corticosteroid Treatment in the Acute Phase of Caustic Ingestion Management

Unknown status·AAssistance Publique - Hôpitaux de Paris·Phase 2·NCT03760354·30 enrolled

L-DEP as an Initial Treatment for EBV-HLH

Unknown status·—·Phase 3·NCT02912702·120 enrolled

123 more indications

Multiple Sclerosis4 trials

A Pilot Study in Participants With Relapsing Remitting Multiple Sclerosis (RR-MS)

Terminated· Merck & Co. logo

Merck & Co.·Phase 2·NCT03387046·7 enrolled

Efficacy Study of Adrenocorticotropin Hormone to Treat Multiple Sclerosis (MS) Relapses After Sub-responding to an Initial 3 Day Course of Intravenous (IV) Methylprednisolone

Terminated·NNeurologique Foundation, Inc.·Phase 2/3·NCT00947895·30 enrolled

Phase I Study of High-Dose Cyclophosphamide and Total Body Irradiation With T Lymphocyte-Depleted Autologous Peripheral Blood Stem Cell or Bone Marrow Rescue in Patients With Multiple Sclerosis

Completed·—·Phase 1·NCT00017628·20 enrolled

Show 1 more trial

Oral Corticotherapy in Megadoses to Treat Multiple Sclerosis During Relapse

Completed·GGermans Trias i Pujol Hospital·Phase 4·NCT00753792·49 enrolled

Rheumatoid Arthritis4 trials

A Study to Evaluate Rituximab in Combination With Methotrexate in Methotrexate-Naive Patients With Active Rheumatoid Arthritis

Completed· Roche logo

Roche·Phase 3·NCT00299104·755 enrolled

Extension Study to Assess the Efficacy and Safety of Repeat Treatment With Rituximab (MabThera) in Participants With Active Rheumatoid Arthritis (RA)

Completed· Roche logo

Roche·Phase 2·NCT02093026·465 enrolled

A Study to Evaluate Ocrelizumab in Combination With Methotrexate Compared With Infliximab Plus Methotrexate in Patients With Active Rheumatoid Arthritis Currently Responding Inadequately to Etanercept or Adalimumab

Terminated· Roche logo

Roche·Phase 2·NCT00808210·28 enrolled

Show 1 more trial

A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate

Completed· Roche logo

Roche·Phase 4·NCT01000610·18 enrolled

Carpal Tunnel Syndrome4 trials

Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome

Completed·RRegion Skane·Phase 4·NCT02652390·111 enrolled

Steroid Injection Treatment of Carpal Tunnel Syndrome

Completed·RRegion Skane·Phase 2/3·NCT00806871·112 enrolled

A Comparison of Ultrasound-guided Steroid Injection With Wrist Splint in Carpal Tunnel Syndrome

Unknown status·MMercy Health Ohio·Phase 4·NCT04515966·70 enrolled

Show 1 more trial

Carpal Tunnel Syndrome - Randomized Clinical Trial Evaluating Effectiveness of Ultrasound in Corticosteroid Injection

Unknown status·UUniversité de Sherbrooke·N/A·NCT02036125·50 enrolled

Stem Cell Transplant3 trials

Lupus Immunosuppressive/Immunomodulatory Therapy or Stem Cell Transplant (LIST)

Withdrawn·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00230035

Laboratory-Treated Lymphocyte Infusion After Haploidentical Donor Stem Cell Transplant

Completed·—·Phase 1·NCT00376480·19 enrolled

Donor Stem Cell Transplant or Donor White Blood Cell Infusions in Treating Patients With Hematologic Cancer

Terminated·OOHSU Knight Cancer Institute·Phase 2·NCT00281879·200 enrolled

Myocarditis3 trials

MYTHS - MYocarditis THerapy With Steroids

Recruiting·NNiguarda Hospital·Phase 3·NCT05150704·288 enrolled

MYTHS-MR Trial (MYocarditis THerapy With Steroids in Patients With Mildly Reduced Ejection Fraction)

Recruiting·UUniversity Hospital, Antwerp·Phase 3·NCT05974462·174 enrolled

Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis

Completed·MMayo Clinic·Phase 2·NCT00004482·40 enrolled

Lupus Nephritis3 trials

Comparison of Low Dose Versus High Dose Cyclophosphamide as Induction Therapy in the Treatment of Lupus Nephritis

Completed·JJawaharlal Institute of Postgraduate Medical Education & Research·Phase 4·NCT02645565·75 enrolled

Trial of Belimumab Combined With Multi-target Induction Therapy in Lupus Nephritis

Unknown status·NNanjing University School of Medicine·Phase 3·NCT05863936·15 enrolled

A Study to Evaluate the Efficacy and Safety of Rituximab in Subjects With International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 Class III or IV Lupus Nephritis

Completed· Roche logo

Roche·Phase 3·NCT00282347·144 enrolled

Acute Graft Versus Host Disease3 trials

Safety and Efficacy Study of Adult Human Mesenchymal Stem Cells to Treat Acute Graft Versus Host Disease (GVHD)

Completed·MMesoblast, Ltd.·Phase 2·NCT00136903·32 enrolled

Methylprednisolone With or Without Daclizumab in Treating Patients With Acute Graft-Versus-Host Disease

Completed·—·Phase 3·NCT00053976·105 enrolled

Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00410657·53 enrolled

Acute Lymphoblastic Leukemia3 trials

Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·Phase 2/3·NCT00720109·63 enrolled

Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 2·NCT00002785

Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00557193·218 enrolled

IgA Nephropathy3 trials

Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study)

Completed·TThe George Institute·N/A·NCT01560052·503 enrolled

A Controlled Study of Steroids Therapy for Patients of IgA Nephropathy With Active Pathological Changes.

Unknown status·SSun Yat-sen University·Phase 2·NCT02160132·180 enrolled

Steroids Therapy in IgA Nephropathy With Crescents

Unknown status·SSixth Affiliated Hospital, Sun Yat-sen University·Phase 3·NCT04833374·200 enrolled

COVID-193 trials

Dexamethasone Vs Methylprednisolone for the Treatment of Patients With ARDS Caused by COVID-19

Unknown status·—·Phase 3·NCT04499313·60 enrolled

High-Dose Corticosteroid or Tocilizumab for Clinical Worsening of COVID-19

Withdrawn·MMarmara University·Phase 4·NCT05133635

Methylprednisolone in COVID-19 Patients (Methyl19LGH)

Unknown status·LLahore General Hospital·N/A·NCT04559113·200 enrolled

Spinal Cord Injury2 trials

Umbilical Cord Blood Mononuclear Cell Transplant to Treat Chronic Spinal Cord Injury

Completed·CChina Spinal Cord Injury Network·Phase 1/2·NCT01354483·20 enrolled

TNFα Monoclonal Antibody for Acute Spinal Cord Injury

Unknown status·SShanghai Changzheng Hospital·Phase 1/2·NCT04988425·90 enrolled

Myocardial Infarction2 trials

Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction

Unknown status·TThomas Engstrom·Phase 2·NCT05462730·530 enrolled

Prehospital Pulse-dose Glucocorticoid in Patients With ST-segment Elevation Myocardial Infarction 2 - The PULSE-MI 2 Trial

Not yet recruiting·TThomas Engstrom·Phase 3·NCT07478003·5,204 enrolled

Bone Marrow Transplantation2 trials

Bone Marrow Transplantation in Treating Patients With Severe Aplastic Anemia or Rejection of Previous Bone Marrow Transplant

Terminated·HH. Lee Moffitt Cancer Center and Research Institute·Phase 2·NCT00005852

Bone Marrow Transplantation in Treating Patients With Leukemia

Withdrawn·MMasonic Cancer Center, University of Minnesota·Phase 3·NCT00006451

Hepatitis2 trials

Steroids in Fulminant Hepatitis A in the Pediatric Age Group

Completed·NNational Liver Institute, Egypt·Phase 4·NCT02375867·33 enrolled

Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis

Completed·MMack Mitchell·Phase 2/3·NCT01809132·104 enrolled

Leukemia2 trials

Peripheral Stem Cell Transplant in Treating Patients With High-Risk Leukemia

Terminated·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT00066417·51 enrolled

Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma

Completed·CChildren's Oncology Group·Phase 2·NCT00057811·97 enrolled

Glucocorticoid2 trials

The Prospective Evaluation of Peri-Operative Glucocorticoid Use in the Management of Cervicofacial Infections of Odontogenic Origin

Completed·UUniversity of Manitoba·Phase 2/3·NCT05951504·29 enrolled

Glucocorticoid Inflammation Paradox in Human Skeletal Muscle

Withdrawn·TTexas A&M University·Phase 3·NCT03529929

Total Knee Arthroplasty2 trials

Oral Steroid Taper After Total Knee Arthroplasty

Recruiting·—·Phase 1·NCT07070882·130 enrolled

Large Doses of Methylprednisolone Combined With Gabapentin in Total Knee Arthroplasty

Completed·JJagiellonian University·Phase 4·NCT04653415·160 enrolled

Asthma2 trials

A Study To Assess The Safety And Effectiveness Of Medrol® In Acute Asthma In Indian Patients

Withdrawn· Pfizer logo

Pfizer··NCT00971893

Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma

Unknown status·UUniversity of Karachi··NCT06171932·60 enrolled

Neuromyelitis Optica2 trials

Eculizumab For the Acute Attack of Neuromyelitis Optica Spectrum Disorder

Recruiting·TTianjin Medical University General Hospital·Phase 2·NCT07184840·110 enrolled

Protein A immuNoaDsorption for the Treatment of Acute Episodes of Neuromyelitis Optica Spectrum Disorder

Recruiting·TThird Affiliated Hospital, Sun Yat-Sen University·N/A·NCT06763848·144 enrolled

Osteoarthritis2 trials

Comparison of Efficacy of Intra-articular Morphine vs Methylprednisolone in Patients With Knee Osteoarthritis.

Withdrawn·HHenry Ford Health System·Phase 2·NCT06163755

A Study Comparing Viscosupplementation and Corticosteroid Injections for Knee Osteoarthritis

Unknown status·LLifeMark Health·N/A·NCT01132677·78 enrolled

Interstitial Lung Disease2 trials

Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease

Completed·TTurkish Thoracic Society·Phase 4·NCT04988282·262 enrolled

Effects of Telitacicept vs Cyclophosphamide on Lupus Related Interstitial Lung Disease

Recruiting·TTongji Hospital·Phase 4·NCT07077486·100 enrolled

Aneurysm2 trials

Efficacy and Safety of Methylprednisolone After Flow-Diverter Stent Implantation in Unruptured Intracranial Aneurysms

Not yet recruiting·DDuan Chuanzhi·Phase 4·NCT07353749·864 enrolled

Methylprednisolone Pulse Therapy for Coronary Artery Dilatation or Aneurysm Formation in Kawasaki Disease

Unknown status·—·Phase 1·NCT04509219·10 enrolled

Steroid Injection2 trials

Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections

Unknown status·UUniversity of Manitoba·Phase 4·NCT06000709·40 enrolled

Prospective Clinical Analysis of Ultrasound-guided Biceps Corticosteroid Injections

Terminated·RRush University Medical Center·N/A·NCT02591953·22 enrolled

Glucocorticoids2 trials

Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT02798523·33 enrolled

Glucocorticoids and Bone in Graves' Ophthalmopathy

Completed·TTorben Harsløf··NCT03122847·39 enrolled

Chronic Obstructive Pulmonary Disease2 trials

Evaluation Of The Efficacy Of Corticosteroids In Patients With An Acute Exacerbation Of Chronic Obstructive Pulmonary Disease Receiving Ventilator Support

Terminated·HHospital Universitario Getafe·Phase 4·NCT01281748·83 enrolled

Comparing Hydrocortisone and Prednisolone for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

Recruiting·CCopenhagen Respiratory Research·Phase 4·NCT06892210·2,000 enrolled

Adhesive Capsulitis2 trials

Dose Efficacy in Adhesive Capsulitis

Recruiting·UUniversity Health Network, Toronto·Phase 3·NCT06848374·40 enrolled

Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis

Completed·VVanderbilt University Medical Center·Phase 4·NCT03479502·1 enrolled

Multiple Myeloma2 trials

Selinexor Treatment for Multiple Myeloma Patients Who Are Refractory to Lenalidomide-containing Therapy.

Unknown status·OOncotherapeutics·Phase 1·NCT04519476·22 enrolled

An Efficacy and Safety Study of Daratumumab in Patients With Multiple Myeloma Who Have Received at Least 3 Prior Lines of Therapy (Including a Proteasome Inhibitor [PI] and Immunomodulatory Drug [IMiD]) or Are Double Refractory to a PI and an IMiD

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 2·NCT01985126·124 enrolled

Orthognathic Surgery1 trial

Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery

Completed·JJean Charles Doucet·Phase 4·NCT03190642·180 enrolled

Lung Cancer1 trial

Methylprednisolone Before Fludeoxyglucose-Labeled Positron Emission Tomography in Patients With Lung Cancer

Withdrawn·OOhio State University Comprehensive Cancer Center·N/A·NCT01789892

Renal Transplant1 trial

Effect of Everolimus on the Pharmacokinetics of Tacrolimus in Renal Transplant Patients

Completed·NNational Taiwan University Hospital·Phase 4·NCT02077556·14 enrolled

Vestibular Dysfunction1 trial

Vestibular Prognosis Assessment of ISSNHL With Vestibular Dysfunction Treated With Oral or Intratympanic Glucocorticoids

Unknown status·EEye & ENT Hospital of Fudan University·N/A·NCT03974867·72 enrolled

First Line Therapy1 trial

Trimethoprim/Sulfamethoxazole Combined With Caspofungin as First-line Therapy in PCP

Unknown status·BBin Du·Phase 4·NCT03978559·122 enrolled

Facial palsy1 trial

Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT00438087·313 enrolled

Intraoperative1 trial

Use of Local Intraoperative Steroid in MIS TLIF

Completed·RRush University Medical Center·Phase 3·NCT03308084·105 enrolled

Hyperbilirubinemia1 trial

Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia

Recruiting·GGeneral Hospital of Shenyang Military Region·N/A·NCT06922669·232 enrolled

Fanconi Anemia1 trial

Hematopoietic Stem Cell Transplantation in High Risk Patients With Fanconi Anemia

Completed·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00258427·14 enrolled

Lymphoproliferative Disease1 trial

Cyclophosphamide, Rituximab, and Either Prednisone or Methylprednisolone in Treating Patients With Lymphoproliferative Disease After Solid Organ Transplantation

Completed·CChildren's Oncology Group·Phase 2·NCT00066469·55 enrolled

Rejection1 trial

The Effect of Steroid Pulse Therapy for the Reduction of Acute Rejection Episode in Subclinical Borderline Changes

Unknown status·SSamsung Medical Center·N/A·NCT02664493·154 enrolled

Sinusitis1 trial

Evaluation of Inhaled Treatment in Sinusitis

Completed·CCliniques universitaires Saint-Luc- Université Catholique de Louvain·Phase 2/3·NCT01907204·50 enrolled

Pilot Study1 trial

Pilot Study Of Unrelated UCB Transplant for Non-Malignant Hematologic Conditions

Completed·—·Phase 2·NCT00003336·6 enrolled

Epidural1 trial

Maternal Epidural Steroids and Hyperthemia

Terminated·MMedical University of South Carolina·Phase 1·NCT02212210·135 enrolled

Recurrent or Metastatic1 trial

Donor Stem Cell Transplant After Conditioning Therapy in Treating Patients With Hematologic Cancer, Recurrent or Metastatic Solid Tumor, or Other Disease

Completed·—·N/A·NCT00521430·30 enrolled

Acute Respiratory Failure1 trial

Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia

Not yet recruiting·QQingyuan Zhan·Phase 1/2·NCT07357935·500 enrolled

Hernia1 trial

Epidural Steroid Following Discectomy for Herniated Disc Reduces Morbidity

Completed·NNorthern Orthopaedic Division, Denmark·N/A·NCT01499641·200 enrolled

Peritoneal Carcinomatosis1 trial

Octreotide Compared to Placebo in Patients With Inoperable Bowel Obstruction Due to Peritoneal Carcinomatosis

Completed· Novartis logo

Novartis·Phase 2·NCT00332696·64 enrolled

Corticosteroids1 trial

Comparison of Corticosteroids vs Placebo on Duration of Ventilatory Support During Severe Acute Exacerbations of COPD Patients in the ICU

Unknown status·VVersailles Hospital·Phase 3·NCT04163536·440 enrolled

Optic Neuritis1 trial

Optic Neuritis Treatment Trial (ONTT)

Unknown status·NNational Eye Institute (NEI)·Phase 3·NCT00000146

Cluster headache1 trial

GON-injection for a Sooner and Better Treatment of Cluster Headache

Completed·LLeiden University Medical Center·Phase 4·NCT04014634·70 enrolled

Acute Leukemia1 trial

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous or Acute Leukemia

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT00002831·24 enrolled

Natural Killer Cell1 trial

Donor Umbilical Cord Blood Natural Killer Cells, Aldesleukin and Umbilical Cord Blood Transplant in Patients With Refractory Hematologic Cancers.

Terminated·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00354172·16 enrolled

Phase 21 trial

Phase 2 Poor Risk DLBCL of TLI and ATG Followed by Matched Allogeneic HT as Consolidation to Autologous HCT

Terminated·SStanford University·Phase 2·NCT00482053·3 enrolled

Arthralgia1 trial

Arthralgia of the Temporomandibular Joint. Pain Relief Following One Intra-articular Injection of Methylprednisolone

Completed·UUppsala University·Phase 4·NCT01995019·56 enrolled

Hematologic Cancer1 trial

Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

Completed·RRoswell Park Cancer Institute·Phase 2·NCT00003270·20 enrolled

Status Asthmaticus1 trial

Steroid Metabolism in Obese and Non-Obese Pediatric Patients Hospitalized for Status Asthmaticus

Completed·—··NCT04874610·15 enrolled

Cardiac Surgery1 trial

Steroids In caRdiac Surgery Trial (SIRS Trial)

Unknown status·PPopulation Health Research Institute·Phase 4·NCT00427388·7,507 enrolled

Synovitis1 trial

MRI Evaluation Assessing Synovitis to Address the Unmet Need for Reliable Endpoints in SLE

Terminated·OOklahoma Medical Research Foundation·Phase 2·NCT03355482·9 enrolled

Chronic Graft Versus Host Disease1 trial

GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

Terminated· Incyte logo

Incyte·Phase 2/3·NCT03584516·155 enrolled

Encephalitis1 trial

Steroids in Treatment of Viral Encephalitis

Unknown status·—·Phase 4·NCT04103684·100 enrolled

Systemic Inflammation1 trial

STeroids to REduce Systemic Inflammation After Infant Heart Surgery

Completed·KKevin Hill·Phase 3·NCT03229538·1,263 enrolled

Aortic Valve Replacement1 trial

Effect of Steroids on Cerebral Inflammation and Neuronal Damage After Surgical Aortic Valve Replacement

Completed·SSahlgrenska University Hospital·N/A·NCT01755338·30 enrolled

Age1 trial

Effect of Anti-Inflammatory Agents on Biological Responses to Endotoxin Inhalation in Healthy Subjects

Completed·—·Phase 1·NCT02252809·51 enrolled

Hematopoietic Stem Cell Transplant1 trial

Hematopoietic Stem Cell Transplant in Devic's Disease

Completed·NNorthwestern University·Phase 1/2·NCT00787722·13 enrolled

Vasculitis1 trial

Exploring Durable Remission With Rituximab in Antineutrophil Cytoplasmic Antibody(ANCA)-Associated Vasculitis

Unknown status·LLeiden University Medical Center·Phase 3·NCT03942887·100 enrolled

Orthostatic Intolerance1 trial

Effect of Methylprednisolone on Orthostatic Intolerance and Heart Rate Variability in Hip-arthroplasty Patients

Completed·RRigshospitalet, Denmark·Phase 2/3·NCT02445898·64 enrolled

Central Nervous System Lymphoma1 trial

a Phase II Study in Primary Central Nervous System Lymphoma

Unknown status·NNational Health Research Institutes, Taiwan·Phase 2·NCT00455286·25 enrolled

Macrophage Activation Syndrome1 trial

Ruxolitinib and Methylprednisolone as a First-line Treatment for Macrophage Activation Syndrome

Unknown status·—·Phase 3·NCT05137496·40 enrolled

Dysphagia1 trial

Corticosteroids for Post-Extubation Dysphagia

Recruiting·UUniversity of Colorado, Denver·Phase 2·NCT06670521·80 enrolled

Radiculopathy1 trial

A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy

Completed·JJohns Hopkins University·Phase 2/3·NCT00733096·84 enrolled

Trial1 trial

Trial of Rituximab for Graves' Ophthalmopathy

Completed·RRebecca Bahn·Phase 2/3·NCT00595335·25 enrolled

Single Dose1 trial

Single Dose of Etomidate and Adrenal Cortex

Completed·IIstanbul University·Phase 4·NCT01792037·90 enrolled

Systemic Lupus Erythematosus1 trial

A Study to Evaluate Two Doses of Ocrelizumab in Patients With Active Systemic Lupus Erythematosus (BEGIN)

Terminated· Roche logo

Roche·Phase 3·NCT00539838·33 enrolled

Steroid1 trial

Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion

Withdrawn·RRush University Medical Center·Phase 3·NCT03327272

Pulmonary Arterial Hypertension1 trial

Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT01086540·57 enrolled

Children1 trial

Clofarabine or High-Dose Cytarabine and Pegaspargase in Children with ALL

Completed·UUniversitätsklinikum Hamburg-Eppendorf·Phase 2/3·NCT01228331·745 enrolled

Efficacy1 trial

A Proof of Concept Study to Determine the Local Delivery and Efficacy of Nanocort

Unknown status·—·Phase 1/2·NCT01647685·21 enrolled

Cardiac Transplant1 trial

A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation

Completed· Roche logo

Roche·Phase 4·NCT00048165·434 enrolled

Contact Dermatitis1 trial

A Study To Assess Safety And Effectiveness Of Medrol In Contact Dermatitis In Indian Patients

Completed· Pfizer logo

Pfizer··NCT00929981·80 enrolled

Ulcerative Colitis1 trial

Upadacitinib Combined With Corticosteroids vs Corticosteroid Monotherapy Induction for Inpatients and Outpatients With Acute Severe Ulcerative Colitis

Recruiting·BBerinstein, Jeffrey·Phase 4·NCT07258771·110 enrolled

Tocilizumab1 trial

Tocilizumab in Active Moderate-severe Graves' Orbitopathy

Unknown status·FFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico·Phase 2·NCT04876534·64 enrolled

Infantile Spasms1 trial

Intravenous Methylprednisolone Versus Oral Prednisolone for Infantile Spasms

Unknown status·SSuvasini Sharma·Phase 2/3·NCT03876444·128 enrolled

Chronic Knee Pain1 trial

Phenol Neurolysis of Genicular Nerves for Chronic Knee Pain

Withdrawn·NNorthwestern University·Phase 4·NCT03973177

Erythema Multiforme1 trial

Severe Erythema Multiforme - CORTICO

Not yet recruiting·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT06266221·96 enrolled

Heart Failure1 trial

Comparative Effects of Methylprednisolone and Prednisolone on the Risk of Acute Decompensated Heart Failure - An Emulated Target Trial

Completed·—··NCT06468007·12,000 enrolled

TED1 trial

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

Recruiting·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT03579875·48 enrolled

Migraine1 trial

Efficacy of Nerve Blocks for Episodic Migraine

Recruiting·MMayo Clinic·Phase 2·NCT05734625·60 enrolled

Guillain-Barre syndrome1 trial

Early and Late Prognosis in Patients With Guillain-Barre Syndrome

Unknown status·FFirst Affiliated Hospital of Wenzhou Medical University·Phase 4·NCT06041451·450 enrolled

Randomised Controlled Trial1 trial

A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin Versus Standard Therapy for Transverse Myelitis

Terminated·GGuy's and St Thomas' NHS Foundation Trust·Phase 3·NCT02398994·2 enrolled

Genicular Nerve Block1 trial

Depomedrol for Genicular Nerve Block.

Completed·MMenoufia University·N/A·NCT05893771·48 enrolled

Nephropathy1 trial

Avacopan in Crescentic Immunoglobulin A Nephropathy (IgAN)

Recruiting·MMayo Clinic·Phase 2·NCT06676579·16 enrolled

Nausea1 trial

Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults

Not yet recruiting·KKonya City Hospital·N/A·NCT07187037·130 enrolled

Hysterectomy1 trial

The Effect of a Preoperative Single-dose Methylprednisolone on the Postoperative Rehabilitation After Abdominal Hysterectomy

Completed·HHolbaek Sygehus·Phase 4·NCT01106547·55 enrolled

Baricitinib1 trial

Baricitinib in CPPD - the BAPTIST Study

Not yet recruiting·II.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio·Phase 2·NCT06768294·32 enrolled

Microscopic Polyangiitis1 trial

Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2/3·NCT00104299·197 enrolled

Postimplantation Syndrome1 trial

Steroid Treatment to Prevent Thoracic Endovascular Aortic Repair Postimplantation Syndrome

Not yet recruiting·UUniversity of Belgrade·N/A·NCT07328906·174 enrolled

Anterior Ischemic Optic Neuropathy1 trial

Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 3·NCT02439866·90 enrolled

Left Bundle-Branch Block1 trial

EArly Effect of Glucocorticoid on Incidence of Persistent Left BundlE Branch Block (LBBB) Post-TAVR (EAGLE-TAVR Trial)

Not yet recruiting·XXiao-dong Zhuang·Phase 4·NCT06762145·200 enrolled

Necrosis1 trial

Monosialoganglioside Ganglioside in Cerebral Radiation Necrosis

Unknown status·ZZhejiang Cancer Hospital·Phase 2·NCT03067753·28 enrolled

Pain1 trial

Pain Increases After Shoulder Injection

Completed·CCampbell Clinic·Phase 4·NCT05438277·421 enrolled

Arthroscopic Shoulder Surgery1 trial

Intra-Operative Corticosteroid Injection During Arthroscopic Shoulder Surgery

Terminated·PPeter Chang·Phase 4·NCT02867904·12 enrolled

Neurodevelopment1 trial

Gene Replacement Therapy for Treatment of Paediatric Patients With CTNNB1 Neurodevelopmental Syndrome

Recruiting·CCTNNB1 Foundation·Phase 1/2·NCT07270549·12 enrolled

Graft Versus Host Disease1 trial

Intra Arterial (IA) Steroids Infusion for Hepatic Acute Hepatic Graft Versus Host Disease (aGVHD)

Terminated·HHadassah Medical Organization·N/A·NCT01140984·2 enrolled

Cardiopulmonary Bypass1 trial

Preoperative Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass

Completed·MMedical University of South Carolina·N/A·NCT00934843·77 enrolled

Aortic dissection1 trial

Glucocorticoids for Post-operative Patients With Acute Type A Aortic Dissection (The GLAD Trial)

Completed·SShanghai Zhongshan Hospital·Phase 4·NCT05329740·212 enrolled

Plantar Fasciitis1 trial

Platelet Rich Plasma in Plantar Fasciitis

Completed·MMinia University·N/A·NCT05339542·98 enrolled

Sacro Iliac Joint Pain1 trial

Ketorolac Versus Corticosteroid Injections for Sacroiliac Joint Pain

Not yet recruiting·MMcMaster University·Phase 1·NCT06081101·20 enrolled

Tolerance1 trial

BMT and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT02029638·4 enrolled

Tacrolimus1 trial

Canadian Cardiology de Novo Study: A Comparison Between Tacrolimus- and Cyclosporine- Based Immunoprophylactic Regimens

Completed· Astellas logo

Astellas·Phase 3·NCT00157014·111 enrolled

Tics1 trial

A Study of the Pharmacokinetics and Safety of MK-8808 (MK-8808-002)

Terminated· Merck & Co. logo

Merck & Co.·Phase 1·NCT01390441·100 enrolled

Renal Transplantation1 trial

Optimization of NULOJIX® Usage As A Means of Avoiding CNI and Steroids in Renal Transplantation

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT01436305·19 enrolled

NMO Spectrum Disorder1 trial

Autologous Transplant To End NMO Spectrum Disorder

Withdrawn·NNorthwestern University·Phase 2/3·NCT03829566

Immunoglobulin G4-related Disease1 trial

Elotuzumab in Immunoglobulin G4-Related Disease (IgG4-RD)

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT04918147·8 enrolled

Inflammatory Response1 trial

Impact of Steroids on Inflammatory Response in Covid-19

Completed·—·Phase 3·NCT04909918·60 enrolled

Childhood Acute Lymphoblastic Leukemia1 trial

Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015)

Unknown status·FFederal Research Institute of Pediatric Hematology, Oncology and Immunology·N/A·NCT03390387·4,000 enrolled

Randomized1 trial

Randomized Trial for Mixed Acute Rejection

Completed·UUniversity of Cincinnati·Phase 2·NCT00771875·30 enrolled

Secondary Progressive Multiple Sclerosis1 trial

Efficacy of Cyclophosphamide Versus Methylprednisolone in Patients With Secondary Progressive Multiple Sclerosis

Completed·UUniversity Hospital, Bordeaux·Phase 3·NCT00241254·138 enrolled

Bursitis1 trial

Relationship to Dose of Triamcinolone Acetonide and Methylyprednisolone to Improvement in Subacromial Bursitis

Completed·KKeesler Air Force Base Medical Center·N/A·NCT02242630·61 enrolled

Thyroid Eye Disease1 trial

A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease

Terminated· GSK logo

GSK·Phase 2·NCT01114503·2 enrolled

Total Hip Arthroplasty1 trial

Effects of Methylprednisolone After Total Hip Arthroplasty

Completed·HHvidovre University Hospital·Phase 4·NCT00968903·48 enrolled

Cardiac Arrest1 trial

Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest

Completed·CChristian Hassager·Phase 2·NCT04624776·158 enrolled

Sts1 trial

Treg Modulation With CD28 and IL-6 Receptor Antagonists

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1/2·NCT04066114·24 enrolled

Myelodysplastic Syndrome1 trial

Thymoglobulin and Cyclosporine in Patients With Aplastic Anemia or Myelodysplastic Syndrome

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00806598·53 enrolled

Acute Respiratory Distress Syndrome1 trial

Procollagen-3 Driven Corticosteroids for Persistent Acute Respiratory Distress Syndrome

Terminated·AAssistance Publique Hopitaux De Marseille·Phase 3·NCT03371498·21 enrolled

Unspecified2 trials

Pulse ACTH vs. MP for MS

Completed·UUniversity of Southern California·Phase 1·NCT01049451·23 enrolled

Sirolimus in Graves' Orbitopathy

Completed·UUniversity of Pisa··NCT05345119·30 enrolled

Regulatory

FDA Approval Timeline[5]

Oct 24, 1957

MEDROL

NDA NDA011153

May 18, 1959

SOLU-MEDROL

NDA NDA011856

May 27, 1959

DEPO-MEDROL

NDA NDA011757

Sep 10, 1976

MEDROL

NDA NDA011153

Apr 11, 1978

MEDROL

NDA NDA011153

Jul 12, 1978

DEPO-MEDROL

NDA NDA011757

Apr 5, 1979

MEDROL

NDA NDA011153

Apr 5, 1979

MEDROL

NDA NDA011153

May 30, 1979

MEDROL

NDA NDA011153

Nov 13, 1979

SOLU-MEDROL

NDA NDA011856

Apr 14, 1980

MEDROL

NDA NDA011153

Apr 28, 1980

SOLU-MEDROL

NDA NDA011856

Jul 29, 1980

DEPO-MEDROL

NDA NDA011757

Sep 30, 1980

SOLU-MEDROL

NDA NDA011856

Oct 8, 1980

MEDROL

NDA NDA011153

Feb 17, 1981

DEPO-MEDROL

NDA NDA011757

Feb 20, 1981

SOLU-MEDROL

NDA NDA011856

Aug 11, 1981

SOLU-MEDROL

NDA NDA011856

Oct 16, 1981

SOLU-MEDROL

NDA NDA011856

Jan 1, 1982

MEDROL ACETATE

NDA NDA012421

Jan 1, 1982

SOLU-MEDROL

NDA NDA011856

Jan 1, 1982

DEPO-MEDROL

NDA NDA011757

Jan 1, 1982

MEDROL

NDA NDA011153

Jan 1, 1982

MEDROL

NDA NDA018102

Mar 9, 1983

DEPO-MEDROL

NDA NDA011757

Mar 9, 1983

MEDROL

NDA NDA011153

Mar 9, 1983

DEPO-MEDROL

NDA NDA011757

May 3, 1983

SOLU-MEDROL

NDA NDA011856

Feb 27, 1985

SOLU-MEDROL

NDA NDA011856

Mar 28, 1985

SOLU-MEDROL

NDA NDA011856

Jan 23, 1986

SOLU-MEDROL

NDA NDA011856

Jan 31, 1986

SOLU-MEDROL

NDA NDA011856

Feb 14, 1986

SOLU-MEDROL

NDA NDA011856

May 12, 1986

DEPO-MEDROL

NDA NDA011757

May 12, 1986

DEPO-MEDROL

NDA NDA011757

May 12, 1986

DEPO-MEDROL

NDA NDA011757

Dec 8, 1986

SOLU-MEDROL

NDA NDA011856

Dec 8, 1986

SOLU-MEDROL

NDA NDA011856

Feb 24, 1987

MEDROL

NDA NDA011153

Jan 5, 1989

DEPO-MEDROL

NDA NDA011757

Jan 5, 1989

MEDROL

NDA NDA011153

Mar 22, 1989

SOLU-MEDROL

NDA NDA011856

Jul 11, 1989

SOLU-MEDROL

NDA NDA011856

Oct 2, 1989

SOLU-MEDROL

NDA NDA011856

Dec 14, 1989

DEPO-MEDROL

NDA NDA011757

Apr 24, 1990

SOLU-MEDROL

NDA NDA011856

Nov 15, 1990

DEPO-MEDROL

NDA NDA011757

Dec 7, 1990

SOLU-MEDROL

NDA NDA011856

Sep 4, 1991

SOLU-MEDROL

NDA NDA011856

Jan 28, 1993

MEDROL

NDA NDA011153

Nov 5, 1993

SOLU-MEDROL

NDA NDA011856

Dec 28, 1993

MEDROL

NDA NDA011153

Dec 28, 1993

DEPO-MEDROL

NDA NDA011757

Jan 7, 1994

DEPO-MEDROL

NDA NDA011757

Mar 25, 1994

SOLU-MEDROL

NDA NDA011856

Apr 6, 1994

SOLU-MEDROL

NDA NDA011856

Apr 22, 1994

SOLU-MEDROL

NDA NDA011856

Sep 15, 1994

SOLU-MEDROL

NDA NDA011856

Jan 24, 1995

DEPO-MEDROL

NDA NDA011757

Feb 26, 1998

SOLU-MEDROL

NDA NDA011856

Mar 16, 1999

SOLU-MEDROL

NDA NDA011856

Dec 1, 1999

MEDROL

NDA NDA011153

Apr 3, 2000

SOLU-MEDROL

NDA NDA011856

Apr 4, 2000

DEPO-MEDROL

NDA NDA011757

May 22, 2002

DEPO-MEDROL

NDA NDA011757

Oct 21, 2002

SOLU-MEDROL

NDA NDA011856

Oct 25, 2002

MEDROL

NDA NDA011153

Apr 7, 2009

DEPO-MEDROL

NDA NDA011757

Apr 7, 2009

DEPO-MEDROL

NDA NDA011757

Jun 24, 2010

SOLU-MEDROL

NDA NDA011856

Oct 20, 2011

SOLU-MEDROL

NDA NDA011856

Oct 20, 2011

SOLU-MEDROL

NDA NDA011856

Jul 18, 2013

MEDROL

NDA NDA011153

Oct 7, 2013

DEPO-MEDROL

NDA NDA011757

Oct 11, 2013

DEPO-MEDROL

NDA NDA011757

Mar 28, 2014

SOLU-MEDROL

NDA NDA011856

Apr 4, 2014

SOLU-MEDROL

NDA NDA011856

Jun 9, 2014

DEPO-MEDROL

NDA NDA011757

Jun 9, 2014

SOLU-MEDROL

NDA NDA011856

Jul 3, 2014

SOLU-MEDROL

NDA NDA011856

Jul 3, 2014

DEPO-MEDROL

NDA NDA011757

Jul 22, 2014

SOLU-MEDROL

NDA NDA011856

Aug 6, 2015

SOLU-MEDROL

NDA NDA011856

Sep 8, 2016

DEPO-MEDROL

NDA NDA011757

Sep 8, 2016

SOLU-MEDROL

NDA NDA011856

Sep 8, 2016

SOLU-MEDROL

NDA NDA011856

Mar 15, 2017

DEPO-MEDROL

NDA NDA011757

Mar 28, 2018

SOLU-MEDROL

NDA NDA011856

Jul 24, 2018

MEDROL

NDA NDA011153

Jul 24, 2018

DEPO-MEDROL

NDA NDA011757

Jul 24, 2018

SOLU-MEDROL

NDA NDA011856

Aug 26, 2019

MEDROL

NDA NDA011153

Feb 11, 2021

DEPO-MEDROL

NDA NDA011757

May 27, 2021

DEPO-MEDROL

NDA NDA011757

May 27, 2021

SOLU-MEDROL

NDA NDA011856

Oct 27, 2021

SOLU-MEDROL

NDA NDA011856

Dec 19, 2023

MEDROL

NDA NDA011153

Dec 20, 2023

DEPO-MEDROL

NDA NDA011757

Dec 20, 2023

SOLU-MEDROL

NDA NDA011856

Jun 5, 2024

DEPO-MEDROL

NDA NDA011757

Jun 5, 2024

MEDROL

NDA NDA011153

Jun 5, 2024

SOLU-MEDROL

NDA NDA011856

Nov 4, 2025

SOLU-MEDROL

NDA NDA011856

Nov 4, 2025

DEPO-MEDROL

NDA NDA011757

Nov 4, 2025

MEDROL

NDA NDA011153

Sources

References

[1]
ClinicalTrials.gov — 538 trial records for Methylprednisolone. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Medrol drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Methylprednisolone compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Methylprednisolone. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA011856). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Glucocorticoid Receptor Agonist[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Pfizer