BMS-986278

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Idiopathic Pulmonary FibrosisPulmonary Fibrosis

46 competitors in Idiopathic Pulmonary Fibrosis

#DrugCompanyPhaseTrials

1

Esbriet

LLegacy Health System

Approved

202

Medrol

Pfizer

Approved

13

Viagra

VViatris Specialty LLC

Approved

64

Remodulin

United Therapeutics

Approved

—5

Rapamune

PPrism Pharmaceuticals

Approved

16

Rayos

RRoxane Laboratories

Approved

—7

Proair HFA

GGlaxo Dba Glaxosmithkline

Approved

—8

Qvar

SSchering-Plough

Approved

—9

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

—10

Acetadote

AArbor Pharmaceuticals, Inc.

Approved

—Show 30 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

ART3 trials

A Study to Assess the Levels in Blood Plasma of BMS-986278 in Healthy Participants Following Administration of Tablets, With or Without Food, and in the Presence of an Antacid (Esomeprazole)

Completed·Bristol-Myers Squibb·Phase 1·NCT04468815·24 enrolled

Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986278 in Healthy Male Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT04567667·9 enrolled

A Study to Evaluate Comparative Bioavailability of BMS-986278 in Healthy Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT06715683·48 enrolled

Experimental2 trials

An Investigational Study of Experimental Medication BMS-986278 Given With the Antibiotic Rifampin in Healthy Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT03712540·39 enrolled

A Study of Experimental Medication BMS-986278 Given to Healthy Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT03429933·112 enrolled

Interaction2 trials

A Study to Assess the Extent of Drug Interaction Between BMS-986278 and Nintedanib, the Relative Bioavailability of BMS-986278 in Tablet and the Effect That Food Has on BMS-986278 in Tablet Formulations in Healthy Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT06568458·71 enrolled

A Study of the Pharmacokinetic Interaction Between Pirfenidone and BMS-986278 in Healthy Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT03981094·22 enrolled

Pulmonary Fibrosis2 trials

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis

Active, not recruiting·Bristol-Myers Squibb·Phase 3·NCT06025578·1,057 enrolled

An Open-label, Multi-center, Long-term Extension Study to Evaluate the Long-term Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis

Not yet recruiting·Bristol-Myers Squibb·Phase 3·NCT07441408·2,380 enrolled

CAR1 trial

A Study to Assess the Effect of Multiple Doses of Itraconazole, Gemfibrozil, or Carbamazepine on BMS-986278 in Healthy Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT05932303·47 enrolled

9 more indications

Female1 trial

A Study to Investigate the Effects of BMS-986278 on Drospirenone and Ethinyl Estradiol Drug Levels in Healthy Female Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT05985590·37 enrolled

Adult1 trial

A Study Investigating the Safety, Tolerability, Drug Levels and Drug Effect of BMS-986278 in Healthy Adult Participants (Part 1) and Japanese Participants (Part 2)

Completed·Bristol-Myers Squibb·Phase 1·NCT05684289·61 enrolled

Idiopathic Pulmonary Fibrosis1 trial

A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis

Active, not recruiting·Bristol-Myers Squibb·Phase 3·NCT06003426·1,255 enrolled

Drug1 trial

A Study to Evaluate the Drug Levels, Safety, and Tolerability of BMS-986278 in Healthy Chinese Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT05805904·24 enrolled

Hepatic Impairment1 trial

Study to Assess Drug Levels and Safety of BMS-986278 in Healthy Participants and Participants With Different Degrees of Hepatic Impairment

Completed·Bristol-Myers Squibb·Phase 1·NCT06425198·37 enrolled

Cardiac Repolarization1 trial

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of BMS-986278 and the Effects of BMS-986278 on Cardiac Repolarization in Healthy Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT06746402·42 enrolled

Fibrosis1 trial

A Study Measuring the Effectiveness, Safety, and Tolerability of BMS-986278 in Participants With Lung Fibrosis

Completed·Bristol-Myers Squibb·Phase 2·NCT04308681·403 enrolled

End-Stage Renal Disease1 trial

A Study to Evaluate BMS-986278 in Participants With Normal Renal Function, Severe Renal Impairment, or End-Stage Renal Disease on Intermittent Hemodialysis

Completed·Bristol-Myers Squibb·Phase 1·NCT06723535·27 enrolled

Unspecified1 trial

A Phase 1, Randomized, Double-blind, Positive-controlled, Placebo-controlled, 4-Period Crossover, Thorough QT/QTc Study to Evaluate the Effect of Multiple Doses of BMS-986278 on Cardiac Repolarization in Healthy Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT07422298·32 enrolled

Details

Drug Info

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