Vibramycin

(Doxycycline)

ApprovedSmall molecule

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Doxycycline is an antibiotic used to treat bacterial infections such as acne, urinary tract infections, respiratory infections, and certain sexually transmitted infections. It works by killing bacteria or stopping their growth.[2] Vibramycin is currently approved and in use across 123 indications[4].[1]

Vibramycin is one of 1665 small molecule programs targeting Scrub Typhus. It is currently in Approved.

123

Indications

214

Total Trials

Active Trials

1,664

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

Scrub TyphusActive, not recruiting

EmphysemaActive, not recruiting

Bacterial DiseaseActive, not recruiting

SyphilisApproved

Ischemic CardiomyopathyActive, not recruiting

AbscessActive, not recruiting

Lupus ErythematosusActive, not recruiting

OrnithosisActive, not recruiting

Sexually Transmitted DiseaseApproved

Pelvic Inflammatory DiseaseActive, not recruiting

Scrub TyphusPhase 3

Active, not recruiting

EmphysemaPhase 2

Active, not recruiting

Bacterial DiseaseApproved

Active, not recruiting

SyphilisApproved

Approved

Ischemic CardiomyopathyPhase 2

Active, not recruiting

AbscessPhase 2/Phase 3

Active, not recruiting

Lupus ErythematosusApproved

Active, not recruiting

OrnithosisApproved

Active, not recruiting

Sexually Transmitted DiseaseApproved

Approved

Pelvic Inflammatory DiseasePhase 2

Active, not recruiting

Showing 10 of 121 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Vibramycin

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

1 2

MS Contin

Merck & Co.

Preclinical

2 3

Lexiscan

Astellas

Preclinical

1 4

Adenocard

Astellas

Preclinical

1 5

Lupron

EEastern Cooperative Oncology Group

Preclinical

5 6

Effexor

WWyeth-Lederle Vaccines

Preclinical

2 7

Recentin

NNational Cancer Institute (NCI)

Preclinical

2 8

Sporanox

SSebela Pharmaceuticals Development LLC

Preclinical

1 9

Tricor

JJagotec

Preclinical

1 10

Acupan

YYonsei University

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 2Active, not recruiting

Kawasaki Disease

NCT01917721

Phase 2Not yet recruiting

Lymphatic Malformation

NCT07320001

Q4 2026

Phase 1Active, not recruiting

Intratumoral Injection

NCT03435952

Phase 1/2Active, not recruiting

Schwannoma

NCT05521048

Q1 2027

Phase 1/2Active, not recruiting

Acne

NCT02713607

Phase 2Active, not recruiting

Emphysema

NCT05382208

Clinical

Trials by Indication[1]

Rosacea9 trials

Lipidome and Microbiome Profile of the Eye in Rosacea

Completed·UUniversity of California, Davis·Phase 1·NCT03655197·30 enrolled

Analysis of the Microbiome in Rosacea

Active, not recruiting·JJohns Hopkins University·Phase 1·NCT04108897·150 enrolled

A Clinical Trial to Determine the Effects of 40 Mg Doxycycline Versus a Placebo Control for the Treatment of Rosacea

Completed·CCollaGenex Pharmaceuticals·Phase 3·NCT00126399·528 enrolled

Show 6 more trials

A Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea (MVOR-2)

Completed·UUnknown Sponsor·Phase 3·NCT05343455·330 enrolled

Safety and Efficacy Study to Compare Two Rosacea Treatment Regimens

Completed·CCollaGenex Pharmaceuticals·Phase 4·NCT00495313·91 enrolled

RosaC-RF : Bipolar Radiofrequency vs Doxycycline in Rosacea

Completed·—·N/A·NCT02204254·20 enrolled

Evaluation of Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea® vs Placebo

Completed·GGalderma R&D·Phase 4·NCT01308619·170 enrolled

A Randomized, Double-Blind Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea.

Completed·UUnknown Sponsor·Phase 3·NCT05296629·323 enrolled

Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline or Metronidazole Gel 1% Plus Anti-inflammatory Dose Doxycycline in Moderate Papulopustular Rosacea

Completed· LEO Pharma logo

LEO Pharma·Phase 4·NCT00855595·207 enrolled

Treatment8 trials

Comparative Efficacy of Single-dose Doxycycline Versus Standard 5- Day Amoxicillin Treatment

Completed·IInstitut de Recherche pour le Developpement·Phase 4·NCT03765931·274 enrolled

The Effect of Doxycycline 100mg and Doxycycline 20mg in Treatment of Mild and Moderate Acne

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 2/3·NCT00388778·100 enrolled

A Study of ALTY-0501 for the Treatment of Dry Eye Administered 4 Times a Day for a 56 Day Period

Completed·AAlacrity Biosciences, Inc.·Phase 2·NCT00439400·160 enrolled

Show 5 more trials

Low Glycemic Index and Load Diet for the Treatment of Acne

Completed·CCentro Dermatológico Dr. Ladislao de la Pascua·N/A·NCT03585140·52 enrolled

Doxycycline for the Treatment of Nodding Syndrome

Unknown status·MMakerere University·Phase 2·NCT02850913·230 enrolled

Low Dose Doxycycline in the Treatment of Corneal Burn

Unknown status·SSun Yat-sen University·Phase 2/3·NCT01886560·40 enrolled

Erlotinib Pharmacokinetics During Doxycycline Treatment for Erlotinib-induced Rash

Withdrawn·NNorthwestern University·N/A·NCT00803842

Efficacy & Safety Comparison of Epiduo With Doxycycline Versus Vehicle With Isotretinoin in the Treatment of Severe Acne

Completed·GGalderma R&D·Phase 3·NCT01474590·266 enrolled

Erythema7 trials

Doxycycline in Therapy of Erythema Migrans

Completed·UUniversity Medical Centre Ljubljana··NCT01475708·400 enrolled

Antibiotic Treatment of Multiple Erythema Migrans

Unknown status·UUniversity Medical Centre Ljubljana·N/A·NCT01163994·500 enrolled

Duration of Antibiotic Treatment of Erythema Migrans

Completed·UUniversity Medical Centre Ljubljana·N/A·NCT00910715·306 enrolled

Show 4 more trials

The Efficacy and Safety of Anti-inflammation Treatment (Hirudoid Introduction Followed by Yellow Light Therapy) Combined With Tofacitinib and Doxycycline in Chinese Adult Patients With Mild to Moderate Erythematous Telangiectatic Rosacea

Recruiting·TThe Fourth Affiliated Hospital of Zhejiang University School of Medicine·N/A·NCT07343635·186 enrolled

Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice

Completed·MMorten Lindbaek·Phase 4·NCT01368341·225 enrolled

Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome

Completed·UUniversity Medical Centre Ljubljana·Phase 4·NCT01518192·544 enrolled

Comparison of Doxycycline and Cefuroxime Axetil in Erythema Migrans

Completed·UUniversity Medical Centre Ljubljana·N/A·NCT03584919·509 enrolled

Syphilis6 trials

Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex with Men (DaDHS)

Completed·BBritish Columbia Centre for Disease Control·Phase 4·NCT02864550·52 enrolled

Impact of the Daily Doxycycline Pre-exposure Prophylaxis (PrEP) on the Incidence of Syphilis, Gonorrhoea and Chlamydia

Unknown status·KKirby Institute··NCT03709459·100 enrolled

Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline

Terminated·NNational Taiwan University Hospital·Phase 4·NCT05980871·109 enrolled

Show 3 more trials

Clinical Trial of Doxycycline VS BPG for Early Syphilis (SY-DOXY)

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT04838717·200 enrolled

Azithromycin/Bicillin Syphilis

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00031499·593 enrolled

Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline

Recruiting·NNational Taiwan University Hospital·N/A·NCT06069141·688 enrolled

COVID-195 trials

Hydroxychloroquine and Zinc With Either Azithromycin or Doxycycline for Treatment of COVID-19 in Outpatient Setting

Completed·SSt. Francis Hospital, New York·Phase 4·NCT04370782·18 enrolled

DYNAMIC Study (DoxycYcliNe AMbulatoIre COVID-19)

Withdrawn·NNantes University Hospital·Phase 3·NCT04371952

RepurpoSing Old Drugs TO SuppRess a Modern Threat: COVID-19 STORM

Withdrawn·TTemple University·Phase 2·NCT04433078

Show 2 more trials

An Outpatient Clinical Trial Using Ivermectin and Doxycycline in COVID-19 Positive Patients at High Risk to Prevent COVID-19 Related Hospitalization

Unknown status·UUnknown Sponsor·Phase 4·NCT04729140·150 enrolled

Safety and Efficacy of Doxycycline and Rivaroxaban in COVID-19

Unknown status·YYaounde Central Hospital·Phase 4·NCT04715295·200 enrolled

120 more indications

Chronic Obstructive Pulmonary Disease4 trials

Placebo Versus Antibiotics in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)

Completed·MMedical Center Alkmaar·Phase 4·NCT00170222·258 enrolled

Development of an Optimal Antibiotic Regime for Long-term Therapy in Stable Chronic Obstructive Pulmonary Disease (COPD)

Unknown status·UUniversity College, London·Phase 3·NCT01398072·200 enrolled

Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)

Unknown status·MMedical Center Alkmaar·Phase 4·NCT00857038·30 enrolled

Show 1 more trial

Antibiotics in Chronic Obstructive Pulmonary Disease (COPD)

Withdrawn·OOdense University Hospital·Phase 4·NCT00952861·140 enrolled

Lyme Neuroborreliosis4 trials

Study of Lyme Neuroborreliosis

Completed·TTurku University Hospital·Phase 4·NCT01635530·210 enrolled

Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis

Unknown status·UUniversity Medical Centre Ljubljana·N/A·NCT00942006·200 enrolled

Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis

Completed·SSorlandet Hospital HF·Phase 3·NCT00138801·120 enrolled

Show 1 more trial

Six Versus Two Weeks Treatment With Doxycycline in Lyme Neuroborreliosis

Completed·SSorlandet Hospital HF·Phase 3·NCT02553473·121 enrolled

Pleural effusion3 trials

Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population

Unknown status·OOttawa Hospital Research Institute·Phase 2·NCT01411202·40 enrolled

Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions

Recruiting·MM.D. Anderson Cancer Center··NCT03465774·208 enrolled

Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions

Completed·EEastern Cooperative Oncology Group·Phase 3·NCT00002872·480 enrolled

Antibiotics3 trials

Antibiotics and Hydroxychloroquine in Crohn's

Completed·RRoyal Liverpool University Hospital·Phase 2·NCT01783106·59 enrolled

Effect of Prophylactic Antibiotics for Hysterosalpingography on Post Procedure Morbidity

Unknown status·—·N/A·NCT04234945·78 enrolled

Velocity 2: An Anthrax Vaccine and Antibiotics Clinical Study

Completed· Emergent BioSolutions logo

Emergent BioSolutions·Phase 2·NCT04067011·210 enrolled

Amyloidosis3 trials

BCD With or Without Doxycycline in Mayo Stage II-III Light Chain Amyloidosis Patients

Completed·JJian Li·N/A·NCT03401372·140 enrolled

Doxycycline to Upgrade Organ Response in Light Chain (AL) Amyloidosis Trial

Completed·MMedical College of Wisconsin·Phase 2·NCT02207556·32 enrolled

Safety and Efficacy Study of Doxycycline/UrsoDeoxyCholicAcid on Disease Progression in ATTR Amyloidosis

Completed·UUmeå University·Phase 2·NCT02016365·55 enrolled

Cystic Fibrosis3 trials

Trial of Doxycycline to Reduce Sputum MMP-9 Activity in Adult Cystic Fibrosis (CF) Patients

Completed·UUniversity of Alabama at Birmingham·N/A·NCT01112059·40 enrolled

Doxycycline Effects on Inflammation in Cystic Fibrosis

Completed·UUniversity of Southern California·Phase 4·NCT01323101·21 enrolled

Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial

Not yet recruiting·TThe University of Queensland·Phase 2·NCT07485010·300 enrolled

Acne Vulgaris3 trials

the Comparison Efficacy of Azithromycin With Doxycycline in the Treatment of Acne Vulgaris

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 2·NCT00419848·100 enrolled

A Novel Combination Oral Agent to Treat Acne Vulgaris

Unknown status·NNexgen Dermatologics, Inc.·Phase 1/2·NCT01301586·60 enrolled

Comedone Extraction and Oral Doxycycline In The First Line Treatment of Moderate Acne Vulgaris

Completed·IIndonesia University·Phase 1·NCT04206631·140 enrolled

Azithromycin3 trials

Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection

Unknown status·UUniversity Hospital, Bordeaux·Phase 4·NCT03532464·460 enrolled

NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole)

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00322465·305 enrolled

Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT03608774·177 enrolled

Lymphedema3 trials

A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali

Completed·TThe Task Force for Global Health·Phase 3·NCT02927496·220 enrolled

A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka

Completed·TThe Task Force for Global Health·Phase 3·NCT02929134·219 enrolled

A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India

Completed·TThe Task Force for Global Health·Phase 3·NCT02929121·235 enrolled

Prophylaxis3 trials

Doxy-Post-exposure Prophylaxis

Completed·EEmory University·Phase 4·NCT05853120·45 enrolled

Combo-PEP: Multipurpose Prevention of Post-Exposure Prophylaxis Regimens

Completed·EEmory University·Phase 4·NCT04860505·20 enrolled

The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.

Recruiting·BBangrak STIs Center·Phase 4·NCT07397403·400 enrolled

Efficacy and Safety2 trials

Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo

Completed·GGalderma R&D·Phase 4·NCT01426269·235 enrolled

Placebo Controlled Efficacy and Safety Study of CD2475/101 40 mg Tablets vs. Placebo and Doxycycline 100 mg Capsules Once Daily in the Treatment of Inflammatory Lesions of Acne Vulgaris

Completed·GGalderma R&D·Phase 2·NCT01320033·662 enrolled

Colorectal Cancer2 trials

Pre-emptive Cycline Treatment on Cetuximab Induced Skin Toxicity in Colorectal Cancer

Terminated·IInstitut Cancerologie de l'Ouest·N/A·NCT01317433·25 enrolled

Comparison of Two Preemptive Treatment Strategies of Panitumumab Mediated Skin Toxicity and Assessment of QoL in Patient With Ras-wt Colorectal Cancer

Completed·AAIO-Studien-gGmbH·Phase 2·NCT01668498·88 enrolled

Alzheimer's Disease2 trials

A Pilot Study of Inflammatory Markers in Alzheimer's Disease

Unknown status·MMcMaster University·Phase 3·NCT00715858·21 enrolled

Effects of Doxycycline and Rifampicin on Biomarkers of Alzheimer's Disease in the Cerebrospinal Fluid

Completed·HHamilton Health Sciences Corporation·Phase 3·NCT00439166·100 enrolled

Abortion2 trials

A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions

Completed·MMedstar Health Research Institute·N/A·NCT02756403·181 enrolled

Serum Levels of Doxycycline at the Time of Abortion With Two Dosing Regimens

Completed·UUniversity of Pittsburgh·Phase 4·NCT00177333·40 enrolled

Lymphoma2 trials

Phase II Trial of First-line Doxycycline for Ocular Adnexal Marginal Zone Lymphoma Treatment

Active, not recruiting·IInternational Extranodal Lymphoma Study Group (IELSG)·Phase 2·NCT01820910·34 enrolled

A Clinico-Pathological Study to Investigate the Possible Infective Causes of Non-Hodgkin Lymphoma of the Ocular Adnexae

Completed·IInternational Extranodal Lymphoma Study Group (IELSG)·Phase 2·NCT01010295·54 enrolled

Pneumonia2 trials

Treatment of Macrolide-resistant Mycoplasma Pneumoniae

Unknown status·NNational Taiwan University Hospital·N/A·NCT03530319·100 enrolled

Treatment and Vaccine Development of Mycoplasma Pneumoniae

Unknown status·NNational Taiwan University Hospital·N/A·NCT03911440·100 enrolled

Chlamydial Infection2 trials

Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00980148·567 enrolled

A Study of Doxycycline to Treat Chlamydial Infection

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT05840159·526 enrolled

Pulmonary Tuberculosis2 trials

Doxycycline Host-directed Therapy to Improve Lung Function and Decrease Tissue Destruction in Pulmonary Tuberculosis

Recruiting·NNational University Hospital, Singapore·Phase 3·NCT05473520·150 enrolled

Doxycycline in Human Pulmonary Tuberculosis

Completed·NNational University Hospital, Singapore·Phase 2·NCT02774993·40 enrolled

Rheumatoid Arthritis2 trials

Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)

Completed·NNYU Langone Health·N/A·NCT01198509·178 enrolled

Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial

Completed·—·N/A·NCT03194204·160 enrolled

Helicobacter Pylori2 trials

Doxycycline for Helicobacter Pylori Rescue Treatment

Recruiting·SShanghai Jiao Tong University School of Medicine·Phase 4·NCT05874570·368 enrolled

Comparing Efficacy of 14-day Therapy Doxycycline With Bismuth Subsalicylate Versus Levofloxacin With Tinadizole on Treatment Helicobacter Pylori

Completed·—·Phase 4·NCT04348786·78 enrolled

Helicobacter Pylori Eradication2 trials

Helicobacter Pylori Eradication and Follow-up

Recruiting·SShanghai Zhongshan Hospital·Phase 4·NCT05061732·4,447 enrolled

Levofloxacin-Doxycycline for Helicobacter Pylori Eradication in Saudi Arabia

Completed·KKing Faisal Specialist Hospital & Research Center·N/A·NCT02884713·55 enrolled

Mycoplasma Genitalium2 trials

Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced

Unknown status·OOstergotland County Council, Sweden·Phase 4·NCT01661985·160 enrolled

Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA)

Completed·UUniversity of Washington·Phase 3·NCT00358462·606 enrolled

Scrub Typhus2 trials

Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus

Completed·DDong-Min Kim·Phase 3·NCT00351182·92 enrolled

Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus

Completed·DDong-Min Kim·N/A·NCT00568711·476 enrolled

Chronic Periodontitis2 trials

Effect of Probiotic Inersan and Doxycycline in Chronic Periodontitis

Completed·CCD Pharma India Pvt. Ltd.·Phase 3·NCT02174757·30 enrolled

Evaluation of Local Doxycycline in Smokers With Chronic Periodontitis

Completed·UUniversity of Campinas, Brazil·Phase 2·NCT02726646·40 enrolled

Lyme disease2 trials

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seropositive Chronic Lyme Disease

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00001101·194 enrolled

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seronegative Chronic Lyme Disease

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00000938·66 enrolled

Encephalitis2 trials

Tick-borne Encephalitis and Borrelial Antibodies in Serum

Recruiting·UUniversity Medical Centre Ljubljana·N/A·NCT03956446·80 enrolled

Tick-borne Encephalitis and Positive Borrelial Antibodies

Unknown status·UUniversity Medical Centre Ljubljana·N/A·NCT02463942·100 enrolled

Bleeding2 trials

Management of Etonogestrel Subdermal Implant-related Bleeding

Completed·—·Phase 3·NCT01658995·82 enrolled

Norplant and Irregular Bleeding/Spotting

Unknown status·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 4·NCT00064766·50 enrolled

Ulcerative Colitis2 trials

Trial of Antimicrobials Versus Placebo in Addition to Fecal Transplant Therapy in Ulcerative Colitis

Completed·HHamilton Health Sciences Corporation·Phase 2·NCT02606032·75 enrolled

Antibiotics for the Treatment of Ulcerative Colitis

Completed·UUniversity of Dundee·N/A·NCT00355602·40 enrolled

Tuberculosis2 trials

Adjunctive Doxycycline for Central Nervous System Tuberculosis

Recruiting·NNational University Hospital, Singapore·Phase 2·NCT06446245·200 enrolled

Characterization of Tuberculosis Associated Lung Fibrosis and Respiratory Impairment, and Prevention Using Doxycycline

Recruiting·MMakerere University·Phase 2·NCT06477185·200 enrolled

Chronic Rhinosinusitis2 trials

Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial

Completed·UUniversity Hospital, Ghent·Phase 2·NCT01198912·33 enrolled

Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis

Completed·UUniversity of North Carolina, Chapel Hill·Phase 4·NCT01825408·40 enrolled

Polycystic Ovarian Syndrome1 trial

Effect of a Commonly Used Antibiotic, Doxycycline, in Women With Polycystic Ovarian Syndrome

Completed·UUniversity of Rochester·Phase 3·NCT01788215·10 enrolled

Humans1 trial

Examination of the Anti-inflammatory and Insulin Sensitizing Properties of Doxycycline in Humans

Completed·UUniversity of California, San Diego·Phase 4·NCT01375491·39 enrolled

AIN1 trial

Doxycycline- and Furazolidone-containing Quadruple Regimen is Superior of Tailored Therapy

Unknown status·SSir Run Run Shaw Hospital·Phase 4·NCT02894268·300 enrolled

Parkinson's Disease1 trial

Effect of Doxycycline in Levodopa Treated Parkinson's Disease Patients

Unknown status·—·Phase 2·NCT05492019·60 enrolled

Advanced Cancer1 trial

Spironolactone in Preventing Rash in Patients With Advanced Cancer Receiving Panitumumab and Cetuximab

Completed·—·Phase 2·NCT01867294·19 enrolled

Lupus Erythematosus1 trial

Doxycycline Outcomes in Lupus Erythematosus

Withdrawn·JJohns Hopkins University·Phase 4·NCT01014260

Abdominal Aortic Aneurysm1 trial

Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial

Completed·UUniversity of Maryland, Baltimore·Phase 2·NCT01756833·261 enrolled

Spironolactone1 trial

Randomized Double-blind Study on the Benefit of Spironolactone for Treating Acne of Adult Woman.

Completed·NNantes University Hospital·Phase 3·NCT03334682·158 enrolled

Bladder Pain Syndrome1 trial

Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study

Terminated·IInsel Gruppe AG, University Hospital Bern·Phase 4·NCT01879930·5 enrolled

Oral1 trial

A Study of Continuous Oral Contraceptives and Doxycycline

Completed·OOregon Health and Science University·N/A·NCT00480532·131 enrolled

Acute Respiratory Failure1 trial

Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia

Withdrawn·—·Phase 3·NCT04528927

AL amyloidosis1 trial

A Trial of Doxycycline vs. Standard Supportive Therapy in Newly-diagnosed Cardiac AL Amyloidosis Patients Undergoing Bortezomib-based Therapy

Terminated·FFondazione IRCCS Policlinico San Matteo di Pavia·Phase 2/3·NCT03474458·19 enrolled

Current Smoker1 trial

Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers

Completed·TThe Forsyth Institute·Phase 2·NCT00066066·146 enrolled

Sexually Transmitted Infection1 trial

Daily Doxycycline to Inform Sexually Transmitted Infection Prophylaxis Regimens

Completed·EEmory University·Phase 4·NCT06545656·23 enrolled

Skin rash1 trial

Skin Rash Study Before Chemotherapy in Colorectal & Head and Neck Cancer Patients

Completed·UUniversity of Louisville·Phase 2·NCT01874860·24 enrolled

Antibiotic Therapy1 trial

Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients

Completed·IImperial College London·Phase 3·NCT02305940·222 enrolled

Rhinoscleroma1 trial

Efficacy Of Doxycycline & Versus Rifampin In Treatment Of Rhinoscleroma

Unknown status·—·Phase 1·NCT05431673·45 enrolled

Melanoma1 trial

Doxycycline, Temozolomide and Ipilimumab in Melanoma

Terminated·MM.D. Anderson Cancer Center·Phase 1/2·NCT01590082·12 enrolled

Chemotherapy1 trial

Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection

Completed·IIndian Council of Medical Research·Phase 4·NCT02005653·146 enrolled

Intratumoral Injection1 trial

Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT

Active, not recruiting·MM.D. Anderson Cancer Center·Phase 1·NCT03435952·18 enrolled

Colonization1 trial

S. Aureus Decolonization in HPN Patients.

Terminated·RRadboud University Medical Center·N/A·NCT03173053·63 enrolled

Abscess1 trial

Finding the Optimal Regimen for Mycobacterium Abscessus Treatment

Recruiting·TThe University of Queensland·Phase 2/3·NCT04310930·300 enrolled

Peritonitis1 trial

Doxycycline for the Prevention of Spontaneous Bacterial Peritonitis

Completed·MMethodist Health System··NCT04153604·841 enrolled

Meibomian Gland Dysfunction1 trial

Effect of Topical Azithromycin on Tear Film Thickness in Patients With Meibomian Gland Dysfunction

Completed·MMedical University of Vienna·Phase 4·NCT03162497·23 enrolled

Infants1 trial

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Recruiting·—··NCT03511118·1,600 enrolled

Aggressive Periodontitis1 trial

Doxycycline in the Treatment of Aggressive Periodontitis

Completed·MMohammed V Souissi University·Phase 1/2·NCT03727620·24 enrolled

Ischemic Cardiomyopathy1 trial

Safety and Efficacy of Doxycycline in Patients With Non-Ischemic Cardiomyopathy

Terminated·VVirginia Commonwealth University·Phase 2·NCT01935622·10 enrolled

Myocardial Infarction1 trial

Tetracycline (Doxycycline) and Post Myocardial Infarction Remodeling

Completed·—·Phase 2·NCT00469261·110 enrolled

Kawasaki Disease1 trial

Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease

Active, not recruiting·HHawaii Pacific Health·Phase 2·NCT01917721·50 enrolled

Type 2 Diabetes Mellitus1 trial

Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population

Completed·MMedical University of South Carolina·Phase 4·NCT01798225·113 enrolled

Hailey-Hailey disease1 trial

Skin Microbiome Profile in Hailey-Hailey Disease

Completed·GGangnam Severance Hospital··NCT05007223·18 enrolled

Bacteremia1 trial

An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures

Not yet recruiting·UUniversity of Santiago de Compostela·Phase 4·NCT06422221·150 enrolled

Seroma1 trial

Doxycycline Versus Standard Care to Prevent Seroma Formation

Withdrawn·NNorthwell Health·N/A·NCT01188954

Tics1 trial

Pharmacokinetics of Doxycycline in Skin of Healthy Volunteers

Completed·MMedical University of Vienna·Phase 1·NCT03478436·6 enrolled

Progesterone1 trial

Doxycycline in Treatment of Bleeding With Depot Medroxyprogesterone Acetate (DMPA)

Completed·OOmar Mamdouh Shaaban·Phase 3·NCT01254799·68 enrolled

Breast Cancer1 trial

Combining Doxycycline With Bone-Targeted Therapy in Patients With Metastatic Breast Cancer

Completed·OOttawa Hospital Research Institute·Phase 2·NCT01847976·73 enrolled

Lip1 trial

Lipids of the Human Tear Film and Their Effect on Tear Stability

Completed·UUniversity of Louisville·Phase 4·NCT00803452·31 enrolled

Buruli ulcer disease1 trial

Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana

Completed·KKwame Nkrumah University of Science and Technology·Phase 2·NCT02281643·200 enrolled

Endometrial1 trial

Oral Contraceptives and Subantimicrobial Doxycycline: Effect on Endometrial Matrix Metalloproteinases

Completed·UUniversity of Hawaii·N/A·NCT01469585·20 enrolled

Epistaxis1 trial

NOrth American Study for the Treatment of Recurrent epIstaxis With DoxycycLine: The NOSTRIL Trial

Completed·UUniversity of California, Los Angeles·Phase 4·NCT04167085·26 enrolled

COPD Exacerbation1 trial

A Study Comparing Doxycycline and Levofloxacin for Treating COPD Exacerbations

Not yet recruiting·AAmina Aslam·N/A·NCT06915688·188 enrolled

Cerebral arteriovenous malformation1 trial

Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms

Completed·UUniversity of California, San Francisco·Phase 1·NCT00243893·26 enrolled

Acne1 trial

Lipidome and Microbiome Profile of Acne

Active, not recruiting·UUniversity of California, Davis·Phase 1/2·NCT02713607·30 enrolled

Emphysema1 trial

Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)

Active, not recruiting·WWeill Medical College of Cornell University·Phase 2·NCT05382208·133 enrolled

Uterine Cancer1 trial

Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer

Unknown status·SSidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University·Phase 2·NCT02874430·27 enrolled

Sexually Transmitted Infections1 trial

Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP

Completed·UUniversity of Washington·Phase 4·NCT04050540·449 enrolled

Efficacy1 trial

Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy

Completed·SSun Yat-sen University·Phase 1/2·NCT01727973·14 enrolled

Surgical1 trial

Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal Therapy

Terminated·PPeter Eickholz·Phase 4·NCT01030666·61 enrolled

Catheter1 trial

Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis

Terminated·MM.D. Anderson Cancer Center·Phase 4·NCT02623959·3 enrolled

Advanced NSCLC1 trial

Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO

Completed· Pfizer logo

Pfizer·Phase 2·NCT01465802·236 enrolled

Migraine1 trial

The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute Migraine

Withdrawn·TThe Cleveland Clinic·N/A·NCT01653522

Preoperative1 trial

Does Preoperative Administration of Oral Doxycycline Decrease the Colonization Rate of Propionibacterium Acnes in the Dermis of the Shoulder?

Unknown status·RRothman Institute Orthopaedics·N/A·NCT02688738

Completed·HHorizon Health Network·N/A·NCT01438515·100 enrolled

Pelvic Inflammatory Disease1 trial

The Importance of Anti-anaerobic Therapy for Acute Pelvic Inflammatory Disease (PID)

Completed·HHarold Wiesenfeld·Phase 2·NCT01160640·233 enrolled

Aneurysm1 trial

The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm

Completed·LLeiden University Medical Center·Phase 2·NCT00538967·60 enrolled

Renal Disease1 trial

A Trial of Doxycycline in Renal Disease

Completed·UUniversity of California, San Francisco·Phase 1·NCT02753426·11 enrolled

Head and Neck Squamous Cell Carcinoma1 trial

Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma

Terminated·SSidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University·Phase 2·NCT03076281·7 enrolled

Shoulder Arthroplasty1 trial

Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?

Completed·RRush University Medical Center·N/A·NCT03115177·56 enrolled

Fatigue1 trial

The Qure Study: Q-fever Fatigue Syndrome - Response to Treatment

Completed·RRadboud University Medical Center·Phase 4·NCT01318356·156 enrolled

Blepharitis1 trial

Oral Azithromycin Versus Doxycycline in Posterior Blepharitis

Completed·TTehran University of Medical Sciences·Phase 2·NCT01783860·100 enrolled

Labor1 trial

Collaborative Urological Prosthetics Investigation Directive Research Group

Active, not recruiting·UUniversity of Chicago·Phase 1·NCT05100654·800 enrolled

STEMI1 trial

Changes in Myocardial Biomechanics and Early Short-term Doxycycline Therapy in Patients With Primary Anterior STEMI

Unknown status·RRussian Academy of Medical Sciences·Phase 2/3·NCT02562651·45 enrolled

Treatment Failure1 trial

Lefamulin for M. Genitalium Treatment Failures

Terminated·UUniversity of Washington·Phase 1/2·NCT05111002·12 enrolled

Lymphangioleiomyomatosis1 trial

Doxycycline In Lymphangioleiomyomatosis (LAM)

Completed·UUniversity of Nottingham·Phase 4·NCT00989742·24 enrolled

ESS1 trial

Doxycycline and OA Progression

Completed·IIndiana University·Phase 3·NCT00000403·432 enrolled

Pancreatic Cancer1 trial

Efficacy of Doxycycline on Metakaryote Cell Death in Patients With Resectable Pancreatic Cancer

Completed·MMedical College of Wisconsin·Phase 2·NCT02775695·12 enrolled

Chronic Rhinosinusitis With Nasal Polyps1 trial

Doxycycline in Treating Patients With Chronic Rhinosinusitis With Nasal Polyps

Terminated·IIcahn School of Medicine at Mount Sinai·Phase 2·NCT02569437·49 enrolled

Malaria1 trial

Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis.

Completed·SState University of New York - Upstate Medical University·Phase 4·NCT02564471·103 enrolled

CTCL1 trial

CTCL Directed Therapy

Unknown status·JJames J. Peters Veterans Affairs Medical Center·Phase 1·NCT03116659·8 enrolled

RCT1 trial

Doxycycline for Lateral Epicondylalgia - RCT

Unknown status·UUnknown Sponsor·N/A·NCT00631501·34 enrolled

Aortic Aneurysm1 trial

Adjunctive Treatment With Doxycycline to Enhance the Durability of Endovascular Aortic Aneurysm Repair

Completed·—·N/A·NCT00126204·75 enrolled

Diabetic Foot1 trial

Safety and Efficacy of Gentamicin Topical Gel (AppliGel-G) for Treatment of Mild to Moderately Infected Diabetic Foot Ulcers

Terminated·RRoyer Biomedical, Inc.·Phase 1/2·NCT02036528·9 enrolled

Antibiotic1 trial

Persistent Lyme Empiric Antibiotic Study Europe

Completed·RRadboud University Medical Center·Phase 4·NCT01207739·280 enrolled

COPD1 trial

Doxycycline for COPD in HIV-Infected Patients

Completed·WWeill Medical College of Cornell University·N/A·NCT01744093·61 enrolled

TED1 trial

Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.

Not yet recruiting·RRadboud University Medical Center·Phase 4·NCT07230028·50 enrolled

Phase II1 trial

A Phase II Study of Doxycycline in Relapsed NHL

Terminated·UUniversity of Rochester·Phase 2·NCT02086591·7 enrolled

Staphylococcus Aureus1 trial

Persistent Methicillin Resistant Staphylococcus Aureus Eradication Protocol (PMEP)

Completed·JJohns Hopkins University·Phase 2·NCT01594827·29 enrolled

Extremity1 trial

Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers

Completed·NNanoSHIFT LLC·Phase 2·NCT00764361·15 enrolled

Schwannoma1 trial

Doxycycline in Cutaneous Schwannoma (NF2)

Active, not recruiting·MMassachusetts Eye and Ear Infirmary·Phase 1/2·NCT05521048·19 enrolled

Brain Injury1 trial

Doxycycline in Acute Traumatic Brain Injury

Completed·—·Phase 4·NCT04239755·50 enrolled

Cardiac1 trial

Effect of Doxycycline on Cardiac Remodelling in STEMI Patients

Unknown status·FFelix Chikita Fredy, MD·Phase 3·NCT03960411·80 enrolled

Heart Disease1 trial

Anti-chlamydophila Antibiotic Combination Therapy in the Treatment of Patients With Coronary Heart Disease

Terminated·CCadrock Pty. Ltd.·Phase 2·NCT03618108·20 enrolled

Metastatic Colorectal Cancer1 trial

Skin Toxicity in Patients With Metastatic Colorectal Cancer Treated With Anti-EGFR and Chemotherapy (DERMIA)

Completed·FFundacion CRIS de Investigación para Vencer el Cáncer·Phase 2·NCT03448731·34 enrolled

Lymphatic Malformation1 trial

Injection Sclerotherapy With Bleomycin VS Doxycycline in Patients With Lymphatic Malformations

Not yet recruiting·BBasharat Hussain·Phase 2·NCT07320001·92 enrolled

Helicobacter Pylori Infection1 trial

High Dose Dual Therapy (HDDT) for Eradication of Helicobacter Pylori Infection

Unknown status·RRabin Medical Center·Phase 4·NCT02553083·300 enrolled

Prospective1 trial

Prospective Evaluation of Oral Antibiotics for Treatment of Shoulder PJI

Unknown status·RRothman Institute Orthopaedics·Phase 3·NCT04636125·100 enrolled

Adhesive Capsulitis1 trial

Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis

Completed·VVanderbilt University Medical Center·Phase 4·NCT03479502·1 enrolled

Unspecified4 trials

LOAD VS Levofloxacine Concomitant

Unknown status·—·Phase 4·NCT04626193·80 enrolled

Tetracycline Versus Doxycycline for HP Rescue Therapy

Unknown status·SShanghai Zhongshan Hospital·Phase 4·NCT05018923·242 enrolled

Doxycycline vs. Macrolide for MRMP (DOMINO)

Not yet recruiting·YYoung June Choe·Phase 4·NCT07306234·208 enrolled

Show 1 more trial

Effects of Doxycycline on Persistent Symptoms Post-neuroborreliosis

Completed·LLinkoeping University·N/A·NCT01205464·15 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

VIBRAMYCIN

NDA NDA050006

Jan 1, 1982

VIBRAMYCIN

NDA NDA050480

Feb 10, 1992

MONODOX

NDA NDA050641

May 26, 2006

ORACEA

NDA NDA050805

Sources

References

[1]
ClinicalTrials.gov — 214 trial records for Doxycycline. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Vibramycin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Doxycycline compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Doxycycline. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA050805). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Vibramycin. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Pfizer's Upjohn has merged with Mylan to form Viatris Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Matrix Metalloproteinase 8 Inhibitor; Matrix Metalloproteinase-1 Inhibitor; Bacterial 70s Ribosome Inhibitor; Matrix Metalloproteinase 13 Inhibitor; Matrix Metalloproteinase 7 Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Patent Landscape[6]

Patent Cliff

Dec 19, 2027

Earliest patent expiration — generic entry possible after this date

Patent #Expires

7749532Dec 19, 2027