Ceftolozane/tazobactam

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

2 competitors in Bacteremia

#DrugCompanyPhaseTrials

1

Pradaxa

Boehringer Ingelheim

Approved

12

Beta-Lactam

Roche

Phase 3

13

Ceftolozane/tazobactam

Merck & Co.

Preclinical

1

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Pneumonia3 trials

Safety and Efficacy Study of Ceftolozane/Tazobactam to Treat Ventilated Nosocomial Pneumonia (MK-7625A-008)

Completed·Merck & Co.·Phase 3·NCT02070757·726 enrolled

Plasma Pharmacokinetics (PK) & Lung Penetration of Ceftolozane/Tazobactam in Participants With Pneumonia (MK-7625A-007)

Completed·Merck & Co.·Phase 1·NCT02387372·37 enrolled

Safety and Pharmacokinetics of Ceftolozane/Tazobactam in Pediatric Participants With Nosocomial Pneumonia (MK-7625A-036)

Completed·Merck & Co.·Phase 1·NCT04223752·41 enrolled

Intra-abdominal Infection2 trials

MK-7625A Plus Metronidazole Versus Meropenem in Pediatric Participants With Complicated Intra-Abdominal Infection (cIAI) (MK-7625A-035)

Completed·Merck & Co.·Phase 2·NCT03217136·94 enrolled

Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem for Participants With Complicated Intra-abdominal Infection (MK-7625A-015)

Completed·Merck & Co.·Phase 3·NCT03830333·268 enrolled

Cystic Fibrosis2 trials

Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients

Completed·JJoseph L. Kuti, PharmD·Phase 4·NCT02421120·21 enrolled

Ceftolozane/Tazobactam Continuous Infusion for Infective Exacerbations of Cystic Fibrosis and Bronchiectasis

Unknown status·—·Phase 4·NCT06035055·30 enrolled

Urinary Tract Infection1 trial

MK-7625A Versus Meropenem in Pediatric Participants With Complicated Urinary Tract Infection (cUTI) (MK-7625A-034)

Completed·Merck & Co.·Phase 2·NCT03230838·134 enrolled

Pseudomonas Aeruginosa1 trial

In Vitro Activity of Ceftolozane/Tazobactam and Imipenem/Relebactam in Clinical Isolates of Pseudomonas Aeruginosa and Enterobacterales Collected From Hematology and Oncology Patients

Unknown status·EEmilio Bouza··NCT04196608·1,005 enrolled

8 more indications

Critically Ill Patients1 trial

Ceftolozane-tazobactam for the Treatment of Respiratory Infections Due to Extensively Drug-resistant Pseudomonas Aeruginosa Among Critically Ill Patients: a Retrospective Study.

Unknown status·SSemmelweis University··NCT04352855·55 enrolled

Infections1 trial

Tissue Penetration of Ceftolozane/Tazobactam in Diabetic Patients With Lower Limb Infections

Completed·HHartford Hospital·Phase 1·NCT02620774·16 enrolled

Burns1 trial

Pharmacokinetics of Ceftolozane/Tazobactam in Patients With Burns

Terminated·TTexas Tech University Health Sciences Center·Phase 4·NCT03002506·6 enrolled

Antibiotic Therapy1 trial

Pharmacokinetic and Safety Study of Ceftolozane/Tazobactam in Pediatric Participants Receiving Antibiotic Therapy for Proven or Suspected Gram-negative Infection or for Peri-operative Prophylaxis (MK-7625A-010)

Completed·Merck & Co.·Phase 1·NCT02266706·43 enrolled

Bacteremia1 trial

Ceftolozane/Tazobactam vs. Piperacillin/Tazobactam for the Treatment of Bacteremia in Hemato-oncological Patients

Recruiting·IInstituto Nacional de Cancerologia de Mexico·N/A·NCT06422533·226 enrolled

SMA1 trial

Monitoring of Ceftolozane-Tazobactam Plasmatic Levels in Critical Patients

Unknown status·FFundación Pública Andaluza para la gestión de la Investigación en Sevilla··NCT04257812·20 enrolled

Ventilator-Associated Pneumonia1 trial

Study of Intravenous Ceftolozane/Tazobactam Compared to Piperacillin/Tazobactam in Ventilator-Associated Pneumonia

Terminated·Merck & Co.·Phase 3·NCT01853982·4 enrolled

Tics1 trial

Pharmacokinetics of Ceftolozane/Tazobactam in Plasma and Cerebrospinal Fluid

Completed·—·Phase 1/2·NCT03309657·10 enrolled

Details

Drug Info

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