Corifollitropin alfa

Phase 3Biologic

Corifollitropin alfa is a biologic that works as a Follicle Stimulating Hormone Receptor Agonist.[2] It is being investigated across 4 indications, with its most advanced program in Phase 3.[1]

Corifollitropin alfa is one of 106 biologic programs targeting Female Infertility. It is currently in Phase 3.

Indications

Total Trials

Active Trials

105

Competitors

Pipeline

Status by Indication[3][1]

Indication

Female InfertilityActive, not recruiting

Hypogonadotropic HypogonadismActive, not recruiting

InfertilityUnknown

GrowthActive, not recruiting

Female InfertilityPreclinical

Active, not recruiting

Hypogonadotropic HypogonadismPhase 3

Active, not recruiting

InfertilityPreclinical

Unknown

GrowthPhase 2

Active, not recruiting

Competition

Competitive Landscape

364 competitors in Growth

#DrugCompanyPhaseTrials

Corifollitropin alfa

OOrganon and Co

Phase 3

1 2

Genotropin

EMD Serono

Preclinical

35 3

Lovenox

Sanofi

Preclinical

2 4

Zolymbus

AbbVie

Preclinical

1 5

Aricept

Eisai

Preclinical

1 6

Lenvima

Eisai

Preclinical

1 7

Somavaratan

Herceptin

4 9

EGRIFTA WR

TTheratechnologies

Preclinical

2 10

Glucophage

EMD Serono

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Pregnancy5 trials

Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial 38833 (P05783)

Completed·OOrganon and Co··NCT00702520·15 enrolled

Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05787 (P05712)

Completed·OOrganon and Co··NCT00703014·541 enrolled

Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05693 (P05713)

Completed·OOrganon and Co··NCT00702338·1 enrolled

Show 2 more trials

Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05690 (Care Program) (P05710)

Completed·OOrganon and Co··NCT00702624·113 enrolled

Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05714 (Care Program)(P05715)

Completed·OOrganon and Co··NCT00702234·268 enrolled

Ovarian Stimulation4 trials

Continuous Double Ovarian Stimulation.

Completed·IInstituto Bernabeu·Phase 4·NCT05815719·30 enrolled

To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001)

Completed·OOrganon and Co·Phase 3·NCT00702845·397 enrolled

Corifollitropin Alfa Versus Recombinant Follicle Stimulating Hormone (FSH) in Ovarian Stimulation of Women Undergoing in Vitro Fertilisation

Completed·NNational and Kapodistrian University of Athens·Phase 1/2·NCT01319695·140 enrolled

Show 1 more trial

A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787)

Completed·OOrganon and Co·Phase 3·NCT00696800·1,509 enrolled

Embryo Transfer3 trials

Frozen-thawed Embryo Transfer (FTET) Cycle Follow-up Protocol (P06031)

Completed·OOrganon and Co·Phase 3·NCT01146418·307 enrolled

Follow-up Protocol on the Outcome of Frozen-thawed Embryo Transfer Cycles From Clinical Trial P05690 (P05711)

Completed·OOrganon and Co··NCT00702546·102 enrolled

Follow-up Study of Frozen-thawed Embryo Transfer (FTET) Cycles After Cryopreservation of Embryos in Clinical Trial P05787 (P05716)

Completed·OOrganon and Co··NCT00702273·344 enrolled

Ovarian3 trials

Corifollitropin Alpha and Ovarian Response

Completed·HHospital de Clinicas de Porto Alegre·N/A·NCT04416607·300 enrolled

Corifollitropin Alfa Followed by Menotropin for Poor Ovarian Responders Trial

Completed·UUniversitair Ziekenhuis Brussel·Phase 3·NCT01816321·150 enrolled

The Relationship Between Serum AMH Dynamics and Early or Normal Ovarian Response to Corifollitropin Alfa

Unknown status·AAzienda Ospedaliero-Universitaria di Modena··NCT04482751·80 enrolled

Controlled Ovarian Stimulation2 trials

Corifollitropin Alfa in Participants Undergoing Repeated Controlled Ovarian Stimulation (COS) Cycles Using a Multiple Dose Gonadatropin Releasing Hormone (GnRH) Antagonist Protocol (Study 38825)(P05714)

Completed·OOrganon and Co·Phase 3·NCT00696878·682 enrolled

Corifollitropin Alfa Versus Daily rFSH in the Controlled Ovarian Stimulation of Poor Responders

Terminated·VVida Recoletas Sevilla·Phase 4·NCT02254928·26 enrolled

15 more indications

Treatment2 trials

Treatment of Poor Ovarian Responders With Corifollitropin Alfa Followed by hpHMG in a Short GnRH Agonist Protocol

Completed·UUniversitair Ziekenhuis Brussel·Phase 2·NCT01732068·51 enrolled

Corifollitropin Alfa Followed by hpHMG in a Long GnRH Agonist Protocol for the Treatment of Poor Ovarian Responders

Completed·UUniversitair Ziekenhuis Brussel·Phase 2·NCT01732094·57 enrolled

Hypogonadotropic Hypogonadism2 trials

A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adult Men With Hypogonadotropic Hypogonadism (HH) (P07937)

Completed·OOrganon and Co·Phase 3·NCT01709331·18 enrolled

Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adolescent Males With Hypogonadotropic Hypogonadism (HH) (MK-8962-043)

Completed·OOrganon and Co·Phase 3·NCT03019575·17 enrolled

Infertility1 trial

A Phase 2 Trial to Evaluate if Corifollitropin Alfa (Org 36286), Followed by a Low Daily Dose of hCG or Recombinant FSH Can Induce Monofollicular Growth in Women With WHO Group II Anovulatory Infertility (P05693)

Terminated·OOrganon and Co·Phase 2·NCT00697255·8 enrolled

Observational Study1 trial

A Post Marketing Observational Study of the Safety and Efficacy of Elonva (Corifollitropin Alfa) in General Practice (P08165)

Completed·OOrganon and Co··NCT01408615·472 enrolled

Efficacy1 trial

Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients

Completed·VVietnam National University·Phase 4·NCT02466204·400 enrolled

PCOS1 trial

Corifollitropin Alfa Application in PCOS Patients

Unknown status·SShin Kong Wu Ho-Su Memorial Hospital·Phase 4·NCT02215135·30 enrolled

GnRH Antagonist1 trial

D2 Versus D4 Corifollitropin Alfa in GnRH Antagonists

Completed·UUniversitair Ziekenhuis Brussel·Phase 4·NCT01633580·67 enrolled

Oocyte1 trial

Use of Corifolitropin Alfa in Oocyte Donors

Unknown status·IIVI Madrid·Phase 4·NCT02213627·300 enrolled

RFS1 trial

Corifollitropin Alfa Compared to Daily rFSH in Poor Responders Undergoing ICSI

Completed·—·Phase 4·NCT02046655·80 enrolled

CLE1 trial

Optimisation of Follicular Recruitment in IVM Cycles

Completed·UUniversitair Ziekenhuis Brussel·Phase 3·NCT03197077·145 enrolled

Progesterone1 trial

Reduction of Progesterone Elevation at Trigger in POR After Long Acting COS Compared With Daily COS: a Prospective Randomized Trial

Completed·IIRCCS San Raffaele·Phase 4·NCT04695483·110 enrolled

Growth1 trial

A Phase 2, Trial to Investigate the Dose-Response Relationship of a Single Injection of Org 36286 (Corifollitropin Alfa) to Initiate Multiple Follicular Growth in a Controlled Ovarian (Study 38826)(P06055)(COMPLETED)

Completed·OOrganon and Co·Phase 2·NCT00598208·325 enrolled

Prospective1 trial

Prospective Randomized Trial Comparing Corifollitropin-alfa Late Start vs. Corifollitropin-alfa Standard Start in Expected Poor, Normal and High-responders Undergoing IVF

Completed·UUniversity of Turin, Italy·N/A·NCT03816670·113 enrolled

Embryo1 trial

Type of Gonadotropin and Embryo Kinetics of Development

Terminated·IIVI Madrid·Phase 4·NCT02402192·201 enrolled

Unspecified2 trials

Corifollitropin Alfa on D5 Versus D7 After Contraceptive Pill

Completed·FFundacion Dexeus·Phase 4·NCT02490150·70 enrolled

Elonva in Combination With Hp-FSH Versus Elonva With Low Dose hCG

Completed·AAZ Jan Palfijn Gent·Phase 4·NCT03208972·107 enrolled

Sources

References

[1]
ClinicalTrials.gov — 35 trial records for Corifollitropin alfa. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Corifollitropin alfa compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Corifollitropin alfa. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Organon and Co company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Follicle Stimulating Hormone Receptor Agonist[2]
Modality: Biologic[2]
Highest Phase: Phase 3[1]
Company: OOrganon and Co

Corifollitropin alfa

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Pregnancy5 trials

Ovarian Stimulation4 trials

Embryo Transfer3 trials

Ovarian3 trials

Controlled Ovarian Stimulation2 trials

Treatment2 trials

Hypogonadotropic Hypogonadism2 trials

Infertility1 trial

Observational Study1 trial

Efficacy1 trial

PCOS1 trial

GnRH Antagonist1 trial

Oocyte1 trial

RFS1 trial

CLE1 trial

Progesterone1 trial

Growth1 trial

Prospective1 trial

Embryo1 trial

Unspecified2 trials

References

Drug Info

Quick Facts

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