ENBREL

ApprovedSmall molecule

Pfizer

ENBREL is one of 176 small molecule programs targeting Cachexia. It is currently in Approved.

Indications

Total Trials

Active Trials

175

Competitors

Pipeline

Status by Indication[3][1]

Indication

CachexiaActive, not recruiting

Pemphigus VulgarisActive, not recruiting

Primary Systemic AmyloidosisActive, not recruiting

Rheumatoid ArthritisActive, not recruiting

PsoriasisActive, not recruiting

Psoriatic ArthritisActive, not recruiting

Ankylosing SpondylitisActive, not recruiting

CachexiaPhase 2/Phase 3

Active, not recruiting

Pemphigus VulgarisPhase 2

Active, not recruiting

Primary Systemic AmyloidosisPhase 2

Active, not recruiting

Rheumatoid ArthritisPhase 3

Active, not recruiting

PsoriasisPreclinical

Active, not recruiting

Psoriatic ArthritisApproved

Active, not recruiting

Ankylosing SpondylitisApproved

Active, not recruiting

Competition

Competitive Landscape

791 competitors in Rheumatoid Arthritis

#DrugCompanyPhaseTrials

ENBREL

Pfizer

Approved

13 2

Actemra

Cimzia

30 4

Enbrel

IImmunex

Preclinical

64 5

Remicade

OOrganon and Co

Preclinical

43 6

Arcoxia

Novartis

Preclinical

4 7

Kevzara

AAzienda U.S.L. 1 di Massa e Carrara

Preclinical

14 8

Ilaris

Novartis

Preclinical

3 9

Actos

Takeda

Preclinical

2 10

Celexa

AbbVie

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Rheumatoid Arthritis13 trials

Rheumatoid Arthritis DMARD Intervention and UtilizationStudy

Completed· Amgen logo

Amgen··NCT00116727·5,103 enrolled

Study to Assess the Safety and Efficacy of Enbrel Administered by Sofusa DoseConnect for Rheumatoid Arthritis

Unknown status·SSorrento Therapeutics, Inc.·Phase 1·NCT04559412·11 enrolled

A Study of Rheumatoid Arthritis Treatment With Enbrel in Adult Patient in Outpatient Department

Terminated· Pfizer logo

Pfizer··NCT01411215·160 enrolled

Show 10 more trials

Study To Evaluate The Response To Enbrel And The Impact Of Rheumatoid Factor(RF) And Anti-Cyclic Citrullinated Peptide(Anti-CCP) In Rheumatoid Arthritis(RA) Patients

Completed· Pfizer logo

Pfizer··NCT04428424·1,493 enrolled

A Study Comparing LBEC0101 to Enbrel® in Subjects With Active Rheumatoid Arthritis Despite Methotrexate Therapy

Unknown status·LLG Life Sciences·Phase 3·NCT02357069·372 enrolled

TNRF:Fc to Treat Eye Inflammation in Juvenile Rheumatoid Arthritis

Completed·NNational Eye Institute (NEI)·Phase 2·NCT00001862·15 enrolled

Registry of Etanercept (Enbrel®) In Children With Juvenile Rheumatoid Arthritis

Completed· Amgen logo

Amgen··NCT00078793·600 enrolled

A Study to Compare Efficacy, Pharmacokinetics, Safety and Immunogenicity of MB04 [proposed Etanercept Biosimilar] to Enbrel® [EU-sourced] in Rheumatoid Arthritis

Recruiting·MmAbxience Research S.L.·Phase 3·NCT06596772·458 enrolled

Comparison of Two Etanercept Regimens (REUMATOCEPT® Versus ENBREL®) for Treatment of Rheumatoid Arthritis

Withdrawn·EEMS·Phase 3·NCT01394913

A Study Comparing SB4 to Enbrel® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate Therapy

Completed·SSamsung Bioepis Co., Ltd.·Phase 3·NCT01895309·596 enrolled

Study of Enbrel in Rheumatoid Arthritis (RA) Subjects With Comorbid Disorders

Completed· Amgen logo

Amgen·Phase 4·NCT00132418·564 enrolled

Tolerance, Pharmacokinetics and Preliminary Efficacy of T0001 in RA (Rheumatoid Arthritis)

Terminated·SShanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.·Phase 1·NCT02481180·36 enrolled

Study Evaluating Enbrel in Patients With Rheumatoid Arthritis

Completed· Pfizer logo

Pfizer··NCT00245934·1,500 enrolled

Ankylosing Spondylitis7 trials

Observational Non-Interventional Study With Enbrel (Etanercept) in Patients With Ankylosing Spondylitis

Completed· Pfizer logo

Pfizer··NCT01188655·89 enrolled

An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis

Completed· Pfizer logo

Pfizer·Phase 4·NCT00444340·70 enrolled

Study Evaluating Etanercept Treatment of Patients With Ankylosing Spondylitis

Completed· Pfizer logo

Pfizer·Phase 3·NCT00421915·84 enrolled

Show 4 more trials

Extension Study Evaluating Etanercept in Ankylosing Spondylitis

Completed· Pfizer logo

Pfizer·Phase 4·NCT00410046·84 enrolled

Study Evaluating Etanercept in the Treatment of Subjects With Ankylosing Spondylitis

Completed· Pfizer logo

Pfizer·Phase 3·NCT00434044·150 enrolled

Etanercept and Celecoxib Alone/Combined Treatment in Effectiveness and Safety of Active Ankylosing Spondylitis

Completed·SSun Yat-sen University·Phase 4·NCT01934933·150 enrolled

Work Productivity in Active Ankylosing Spondylitis (AS) Patients Treated With Enbrel.

Completed· Pfizer logo

Pfizer··NCT01421303·80 enrolled

Immunogenicity2 trials

Enbrel Liquid Immunogenicity Protocol

Completed· Amgen logo

Amgen·Phase 3·NCT00249041·447 enrolled

Comparative Efficacy, Safety and Immunogenicity Study of Etanercept and Enbrel

Unknown status·JJoint Stock Company "Farmak"·Phase 3·NCT04079374·160 enrolled

Psoriasis2 trials

Study To Evaluate The Impact Of Difficult To Treat Sites On Biological Response In Moderate-To-Severe Plaque Psoriasis(PsO).

Completed· Pfizer logo

Pfizer··NCT04428411·486 enrolled

Study to Evaluate the Efficacy of Enbrel as a Biological Treatment in Moderate to Severe Plaque Psoriasis Patients

Completed· Pfizer logo

Pfizer··NCT04398732·486 enrolled

Tics2 trials

Study to Compare the Safety and Pharmacokinetic Characteristics of LBEC0101 25 mg With Those of Enbrel®

Completed·LLG Life Sciences·Phase 1·NCT01145950·36 enrolled

Study to Compare the Safety and Pharmacokinetic Characteristics of LBEC0101 25mg With Those of Enbrel®

Completed·LLG Life Sciences·Phase 1·NCT01725620·48 enrolled

11 more indications

Psoriatic Arthritis2 trials

Enbrel® in Psoriatic Arthritis

Completed· Amgen logo

Amgen·Phase 4·NCT00111124

Study To Evaluate The Impact Of Anti-Cyclic Citrullinated Peptide(Anti-CCP) For Management With Enbrel In Patients With Psoriatic Arthritis(PsA)

Completed· Pfizer logo

Pfizer··NCT04428502·127 enrolled

Efficacy2 trials

Study Evaluating the Efficacy of Enbrel (Etanercept) in Subjects in Japan

Completed· Pfizer logo

Pfizer··NCT00503503

Study to Demonstrate Equivalent Efficacy and to Compare Safety of Biosimilar Etanercept (GP2015) and Enbrel

Completed· Novartis logo

Novartis·Phase 3·NCT01891864·531 enrolled

Primary Systemic Amyloidosis1 trial

Phase II Trial of Enbrel in Patients With Primary Systemic Amyloidosis

Completed·TThe Cleveland Clinic·Phase 2·NCT00224393·60 enrolled

GIST1 trial

REKinDLE: Registry With Enbrel® or Kineret® in a Database Using Longitudinal Evaluations

Completed· Amgen logo

Amgen··NCT00121056

Observational Study1 trial

Observational Study to Evaluate the Real-Life Effectiveness of Benepali Following Transition From Enbrel

Completed· Biogen logo

Biogen··NCT03100734·585 enrolled

Pemphigus Vulgaris1 trial

Study of Etanercept (Enbrel) in the Treatment of Pemphigus Vulgaris

Completed·MMassachusetts General Hospital·Phase 2·NCT00135720·12 enrolled

Safety and Efficacy1 trial

Study Evaluating the Safety and Efficacy of Enbrel (Etanercept) in Japan

Completed· Pfizer logo

Pfizer··NCT00503139·684 enrolled

Islet Transplantation1 trial

Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00789308·24 enrolled

Tolerance1 trial

Study Evaluating the Tolerance and Safety of Enbrel (Etanercept) in Adults and Children

Completed· Pfizer logo

Pfizer··NCT00484809·100 enrolled

Cachexia1 trial

Enbrel Versus Placebo With Radiation Therapy to Combat Fatigue and Cachexia

Terminated·TThe University of Texas Health Science Center at San Antonio·Phase 2/3·NCT00127387·54 enrolled

Unspecified1 trial

Study Evaluating Etanercept 25mg or 50mg Administered Subcutaneously to Healthy Chinese Male Subjects

Completed· Pfizer logo

Pfizer·Phase 1·NCT00502879

Sources

References

[1]
ClinicalTrials.gov — 39 trial records for ENBREL. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — ENBREL compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for ENBREL. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Pfizer

ENBREL

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Rheumatoid Arthritis13 trials

Ankylosing Spondylitis7 trials

Immunogenicity2 trials

Psoriasis2 trials

Tics2 trials

Psoriatic Arthritis2 trials

Efficacy2 trials

Primary Systemic Amyloidosis1 trial

GIST1 trial

Observational Study1 trial

Pemphigus Vulgaris1 trial

Safety and Efficacy1 trial

Islet Transplantation1 trial

Tolerance1 trial

Cachexia1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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