Ethambutol hydrochloride

Phase 3Small molecule

Ethambutol hydrochloride is one of 61 small molecule programs targeting Mycobacterium avium complex disease. It is currently in Phase 3.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Mycobacterium Avium Complex DiseaseActive, not recruiting

Pulmonary TuberculosisActive, not recruiting

TuberculosisActive, not recruiting

Mycobacterium Avium Complex DiseasePhase 3

Active, not recruiting

Pulmonary TuberculosisPreclinical

Active, not recruiting

TuberculosisPhase 3

Active, not recruiting

Competition

Competitive Landscape

297 competitors in Tuberculosis

#DrugCompanyPhaseTrials

Rifadin

Sanofi

Phase 3

16 2

Sirturo

WWim Janssens

Phase 3

10 3

Cycloserine

UUniversity of Calgary

Phase 3

1 4

Ethambutol hydrochloride

Pfizer

Phase 3

3 5

RHB-104

RRedHill Biopharma Limited

Phase 3

1 6

Tebrazid

AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Preclinical

22 7

Rifapentine and Moxifloxacin

CCenters for Disease Control and Prevention

Phase 3

3 8

Gamtbvac

GGamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation

Phase 3

2 9

Tivicay

GSK

Preclinical

4 10

Cabenuva

GSK

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Mycobacterium Avium Complex5 trials

A Study of Rifabutin, Used Alone or With Ethambutol in the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia in Patients With AIDS

Completed·PPharmacia·Phase 4·NCT00002343·200 enrolled

A Comparison of Three Drug Combinations Containing Clarithromycin in the Treatment of Mycobacterium Avium Complex (MAC) Disease in Patients With AIDS

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00001058·246 enrolled

Tolerance, Safety, and Activity of Rifapentine Alone and in Combination Therapy in AIDS Patients With Mycobacterium Avium Complex Bacteremia.

Completed·AAnderson Clinical Research·Phase 2·NCT00002192

Show 2 more trials

Evaluation of Treatment for Mycobacterium Avium Complex (MAC) Infection in HIV-Infected Patients

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00001039·24 enrolled

A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination With Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients

Completed· Pfizer logo

Pfizer·Phase 3·NCT00002140

Completed·AAbbott·N/A·NCT00002331

Bacteremia1 trial

A Three-Arm Comparative Trial for the Treatment of MAC Bacteremia in AIDS: A Clarithromycin/Ethambutol Regimen Containing Rifabutin (450 Mg) or Rifabutin (300 Mg) or Placebo

Completed·PPharmacia·Phase 3·NCT00002101·450 enrolled

2 more indications

Pulmonary Tuberculosis1 trial

A Prospective Study of Multidrug Resistance and a Pilot Study of the Safety of and Clinical and Microbiologic Response to Levofloxacin in Combination With Other Antimycobacterial Drugs for Treatment of Multidrug-Resistant Pulmonary Tuberculosis (MDRTB) in HIV-Infected Patients.

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000796·525 enrolled

HIV-Infected Individuals1 trial

A Phase II/III Trial of Rifampin, Ciprofloxacin, Clofazimine, Ethambutol, and Amikacin in the Treatment of Disseminated Mycobacterium Avium Infection in HIV-Infected Individuals.

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00000641·90 enrolled

Sources

References

[1]
ClinicalTrials.gov — 13 trial records for Ethambutol hydrochloride. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Ethambutol hydrochloride compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Ethambutol hydrochloride. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Pfizer

Ethambutol hydrochloride

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Mycobacterium Avium Complex5 trials

Tuberculosis3 trials

Mycobacterium avium complex disease1 trial

Effectiveness1 trial

Bacteremia1 trial

Pulmonary Tuberculosis1 trial

HIV-Infected Individuals1 trial

References

Drug Info

Quick Facts

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