Rifadin

(Rifampin)

ApprovedSmall molecule

Rifampin is an antibiotic used to treat bacterial infections, most commonly tuberculosis and leprosy. It works by killing bacteria that cause these serious infections.[2] Rifadin is currently approved and in use across 49 indications[4].[1]

Rifadin is one of 944 small molecule programs targeting Coronary Artery Disease. It is currently in Approved.

Indications

178

Total Trials

Active Trials

943

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Coronary Artery DiseaseApproved

Scrub TyphusActive, not recruiting

HIV InfectionApproved

RhinoscleromaActive, not recruiting

Essential HypertensionApproved

Erectile DysfunctionApproved

Thrombotic DiseaseApproved

Buruli Ulcer DiseaseApproved

OnchocerciasisApproved

LymphomaActive, not recruiting

Coronary Artery DiseaseApproved

Approved

Scrub TyphusPreclinical

Active, not recruiting

HIV InfectionApproved

Approved

RhinoscleromaPhase 1

Active, not recruiting

Essential HypertensionApproved

Approved

Erectile DysfunctionApproved

Approved

Thrombotic DiseaseApproved

Approved

Buruli Ulcer DiseaseApproved

Approved

OnchocerciasisApproved

Approved

LymphomaPhase 1

Active, not recruiting

Showing 10 of 47 indications

Competition

Competitive Landscape

1774 competitors in Lymphoma

#DrugCompanyPhaseTrials

Rifadin

Sanofi

Approved

1 2

Velban

EEastern Cooperative Oncology Group

Preclinical

15 3

Oncaspar

SServier

Preclinical

15 4

Wellcovorin

GGlaxo Dba Glaxosmithkline

Preclinical

4 5

Tafasitamab

Incyte

Preclinical

7 6

Nuvigil

NNuvo Research GmbH

Preclinical

1 7

Elitek

AAzienda U.S.L. 1 di Massa e Carrara

Systemic Therapy

1 9

Rhg-CSF

CCSPC Baike (Shandong) Biopharmaceutical Co., Ltd.

Preclinical

3 10

CAR-T

HHebei Senlang Biotechnology Inc., Ltd.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 3Active, not recruiting

Duchenne Muscular Dystrophy

NCT04768231

Q4 2026

Phase 1Recruiting

Interaction

NCT07357610

N/ARecruiting

Leprosy

NCT06222372

Q1 2027

Phase 2Active, not recruiting

Drug

NCT05556746

Phase 1Not yet recruiting

Human Immunodeficiency Virus (HIV)

NCT07600775

Q3 2027

Phase 3Recruiting

Children

NCT06253715

Clinical

Trials by Indication[1]

Interaction35 trials

Drug-Interaction Study to Evaluate the Effect of Rifampin, a Potent CYP3A4 Inducer, on the Systemic Exposure of Pacritinib in Healthy Subjects

Completed·CCTI BioPharma·Phase 1·NCT02807116·18 enrolled

A Study to Evaluate Drug-Drug Interaction of TAK-788 With Itraconazole and Rifampin in Healthy Adult Participants

Completed· Takeda logo

Takeda·Phase 1·NCT03928327·24 enrolled

PK Study to Assess Drug-drug Interaction Between Sitravatinib and a P-gp Inducer and an Inhibitor.

Completed·MMirati Therapeutics Inc.·Phase 1·NCT05255276·36 enrolled

Show 32 more trials

Drug-drug Interaction (DDI) With a P-gp Inhibitor, Organic Anion Transporting Polypeptide OATP-inhibitor, Food Effect

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT03116893·15 enrolled

Drug-Drug Interaction Study With Rifampin

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT01002079·20 enrolled

Study to Assess Pharmacokinetic Drug-Drug Interaction Between Avatrombopag When Co-Administered With Fluconazole, Itraconazole, or Rifampin in Healthy Subjects

Completed· Eisai logo

Eisai·Phase 1·NCT02809768·48 enrolled

An Open-Label Drug Interaction Clinical Study to Evaluate Itraconazole, Rifampin, Midazolam and SIM0270 in Chinese Healthy Adult Participants

Recruiting· Jiangsu Simcere Pharmaceutical Co., Ltd. logo

Jiangsu Simcere Pharmaceutical Co., Ltd.·Phase 1·NCT07357610·60 enrolled

A Study To Investigate The Drug-Drug Interaction Potential Of Rifampin OnThe Investigational Agent Palbociclib (PD-0332991)

Completed· Pfizer logo

Pfizer·Phase 1·NCT01953731·15 enrolled

A Study to Evaluate the Drug-drug Interaction Effect of Rifampin on the Pharmacokinetics of AMG 510 in Healthy Participants

Completed· Amgen logo

Amgen·Phase 1·NCT05577624·14 enrolled

Drug to Drug Interaction Study of KBP-5074 in Healthy Subjects

Completed·KKBP Biosciences·Phase 1·NCT04606537·24 enrolled

Annovera™ Drug-Drug Interaction Study

Completed·TTherapeuticsMD·Phase 1·NCT04290390·67 enrolled

Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation

Completed· GSK logo

GSK·Phase 1·NCT00964106·87 enrolled

A Study to Evaluate Drug-Drug Interaction of Larotinib With Itraconazole and Rifampin in Healthy Adult Participants

Completed· Sunshine Lake Pharma Co., Ltd. logo

Sunshine Lake Pharma Co., Ltd.·Phase 1·NCT05057949·32 enrolled

Drug-Drug Interaction of SHR1459 With a Strong CYP3A Index Inducer (Rifampicin)

Completed·JJiangsu HengRui Medicine Co., Ltd.·Phase 1·NCT04649723·20 enrolled

Drug-Drug Interaction and Food Effect of Sudapyridine(WX-081) With Itraconazole and Rifampin in Healthy Chinese Adults

Not yet recruiting·SShanghai Jiatan Pharmatech Co., Ltd·Phase 1·NCT06701136·16 enrolled

A 3-Part, Open-Label, Drug-Drug Interaction Study of Concomitant Administration of E2609 With Itraconazole, Rifampin, Digoxin, or Donepezil

Completed· Eisai logo

Eisai·Phase 1·NCT02055703·195 enrolled

Drug Interaction Study of ALXN2050 With Fluconazole and Rifampin in Healthy Adult Participants

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT04933682·16 enrolled

Drug-durg Interaction of Leritrelvir(RAY1216) With Midazolam, Omeprazole, Rosuvastatin, Verapamil, and Rifampin

Completed·GGuangdong Raynovent Biotech Co., Ltd·Phase 1·NCT06031454·56 enrolled

TMC435350-TiDP16-C105: Phase I, 3-way Crossover, Drug-drug Interaction Between TMC435350 and Rifampin After Multiple Dosing.

Completed· Tibotec Pharmaceuticals, Ireland logo

Tibotec Pharmaceuticals, Ireland·Phase 1·NCT00741169·21 enrolled

Drug-drug Interaction Study of Ozanimod With Inhibitor or Inducer of CYP2C8 and/or CYP3A

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03624959·100 enrolled

A Study to Evaluate the One-way Interaction of Calcium Carbonate, Omeprazole, or Rifampin on ACP-196

Completed·AAcerta Pharma BV·Phase 1·NCT04914936·72 enrolled

A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers

Completed· Roche logo

Roche·Phase 1·NCT01814709·32 enrolled

Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin

Completed·AAkebia Therapeutics·Phase 1·NCT03801746·40 enrolled

Drug-Drug Interaction Study Between EDP-938, Itraconazole, Rifampin, and Quinidine in Healthy Subjects

Completed·EEnanta Pharmaceuticals, Inc·Phase 1·NCT03755778·72 enrolled

Drug-drug Interaction Study of SPH3127

Completed·SShanghai Pharmaceuticals Holding Co., Ltd·Phase 1/2·NCT05359055·40 enrolled

A Drug Interaction Study in Healthy Participants to Assess the Effect of Rifampin on the Pharmacokinetics of JNJ-42847922

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02661893·14 enrolled

Drug-drug Interaction Study Between EDP-305, Intraconazole and Rifampin in Healthy Volunteers

Completed·EEnanta Pharmaceuticals, Inc·Phase 1·NCT03213145·48 enrolled

A Drug-Drug Interaction Study of CYP3A4 Inhibition and Pan-CYP Induction on APX001

Completed· Basilea Pharmaceutica logo

Basilea Pharmaceutica·Phase 1·NCT04166669·36 enrolled

Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects

Not yet recruiting·JJemincare·Phase 1·NCT06348290·72 enrolled

Drug-Drug Interaction Study in Healthy Adult Volunteers

Completed·KKowa Research Institute, Inc.·Phase 1·NCT02275962·20 enrolled

A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib

Completed· Pfizer logo

Pfizer·Phase 1·NCT03723395·116 enrolled

A Study to Evaluate Potential Cytochrome P450 and Transporter Protein Interactions With CC-99677

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT04268394·48 enrolled

Pharmacokinetic Interaction Study to Assess the Effect of Repeat Doses of Rifampin on Mirabegron (YM178) in Healthy Volunteers

Completed· Astellas logo

Astellas·Phase 1·NCT00776516·24 enrolled

HMPL-689 Drug Interaction Study With CYP3A Inhibitor/CYP2C9 Inhibitor/CYP3A Inducer/PPI

Completed·HHutchmed·Phase 1·NCT05602597·59 enrolled

A Drug-Drug Interaction Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Apremilast

Completed· Amgen logo

Amgen·Phase 1·NCT01561963·21 enrolled

Tics26 trials

A Study To Evaluate The Effect Of Rifampin On Pharmacokinetics Of PF-06463922 In Healthy Volunteers

Completed· Pfizer logo

Pfizer·Phase 1·NCT02804399·12 enrolled

Understanding The Effect Of A Strong CYP3A4 Inducer On Glasdegib Pharmacokinetics

Completed· Pfizer logo

Pfizer·Phase 1·NCT02430545·12 enrolled

Effects of Rifampin on the Pharmacokinetics of Ataluren

Completed·PPTC Therapeutics·Phase 1·NCT02409004·15 enrolled

Show 23 more trials

A Study to Evaluate the Relative Bioavailability of STI-1558 and the Effect of Itraconazole and Rifampin on the Pharmacokinetics of STI-1558

Completed·ZZhejiang ACEA Pharmaceutical Co. Ltd.·Phase 1·NCT05685719·37 enrolled

A Study to Assess the Effect of Rifampin on the Pharmacokinetics of PCI-32765 in Healthy Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT01763021·18 enrolled

A Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Divarasib in Healthy Participants

Completed· Roche logo

Roche·Phase 1·NCT06835465·18 enrolled

A Study to Evaluate the Effect of 2 Drugs on the Pharmacokinetics of BMS-986205 in Healthy Subjects

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03346837·53 enrolled

A Study to Evaluate the Effects of Rifampin on Single-Dose Pharmacokinetics of Canagliflozin in Healthy Volunteers

Completed· Johnson & Johnson Pharmaceutical Research & Development, L.L.C. logo

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.·Phase 1·NCT01395927·14 enrolled

Evaluation of the Effect of Rifampin and Rabeprazole on the Pharmacokinetics of Camlipixant

Completed·—·Phase 1·NCT05899829·42 enrolled

A Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SY-5007 in Healthy Subjects

Not yet recruiting·SShouyao Holdings (Beijing) Co. LTD·Phase 1·NCT06332053·28 enrolled

Study Evaluating the Effects of Food, Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of CC-122

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03340662·81 enrolled

A Study to Evaluate the Effect of Rifampin on the Single-dose Pharmacokinetics of BMS-986177 in Healthy Subjects

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02959060·16 enrolled

Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibition and Induction on the Pharmacokinetics of CC-220 in Healthy Subjects

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02820935·36 enrolled

Study to Determine the Impact of Multiple Doses of Rifampin on Single-dose Pharmacokinetics of HCV-796

Completed· Pfizer logo

Pfizer·Phase 1·NCT00384280·24 enrolled

Study to Evaluate the Effect of Repeat-Dose Rifampin on the Pharmacokinetics (PK) of PF-06651600

Completed· Pfizer logo

Pfizer·Phase 1·NCT04266509·12 enrolled

Effect Of Rifampin On Pharmacokinetics Of Sitaxsentan

Withdrawn· Pfizer logo

Pfizer·Phase 1·NCT01251835

Pharmacokinetics of Tasimelteon Alone and in Combination With a CYP3A4 Inhibitor, Ketoconazole, or a CYP3A4 Inducer, Rifampin.

Completed·VVanda Pharmaceuticals·Phase 1·NCT01637636·48 enrolled

Evaluation of the Effects of Omeprazole and Rifampin on the Pharmacokinetics of VX-548 in Healthy Participants

Completed· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 1·NCT05635110·31 enrolled

A Pharmacokinetics (PK) Study to Investigate the Effect of Rifampin on PK of Vemurafenib (Zelboraf)

Completed· Roche logo

Roche·Phase 1·NCT01765543·27 enrolled

A Study to Investigate the Effect of Itraconazole and Rifampin on Pharmacokinetics (PK) of Vemurafenib at Steady State

Completed· Roche logo

Roche·Phase 1·NCT02608034·32 enrolled

Estimation Of Effect Of Rifampin On Pharmacokinetics Of Crizotinib In Healthy Volunteers

Completed· Pfizer logo

Pfizer·Phase 1·NCT01147055·15 enrolled

A Study to Assess Pharmacokinetics (PK) of Brensocatib Alone and With Multiple Doses of Rifampin or Esomeprozole in Healthy Participants

Completed·IInsmed Incorporated·Phase 1·NCT05826574·32 enrolled

Pharmacokinetics, Safety and Tolerability of Escalating Rifapentine Doses in Healthy Volunteers

Completed·JJohns Hopkins University·Phase 1·NCT01162486·37 enrolled

Study in Healthy Volunteers to Investigate the Effects of Rifampin on the Pharmacokinetics of NKTR-118

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT01533870·22 enrolled

A Study to Evaluate the Effect of Rifampin on the Single-dose Pharmacokinetics (PK) of BMS-986141 in Healthy Subjects

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02957448·16 enrolled

Evaluation of Effect of Rifampin on the Pharmacokinetics of Vonoprazan in Healthy Participants

Withdrawn·PPhathom Pharmaceuticals, Inc.·Phase 1·NCT04558216

Tuberculosis16 trials

Short-Course Anti-tuberculosis Regimens for Mild Spinal Tuberculosis

Not yet recruiting·SShandong University·Phase 2·NCT06917495·300 enrolled

The Treatment of Tuberculosis in HIV-Infected Patients

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00001033·650 enrolled

Rifampin Versus Isoniazid for the Treatment of Latent Tuberculosis Infection in Children (P4v9)

Completed·MMcGill University·Phase 3·NCT00170209·844 enrolled

Show 13 more trials

Tuberculosis Treatment Shortening Trial

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00130247·394 enrolled

Interaction of Buprenorphine With HIV Medications and Tuberculosis Medications

Completed·UUniversity of California, San Francisco·Phase 1·NCT00877591·63 enrolled

Assessing PA-824 for Tuberculosis (the APT Trial)

Completed·JJohns Hopkins University·Phase 2·NCT02256696·157 enrolled

Pharmacokinetic and Pharmacodynamic Study of High-Dose Rifapentine and Moxifloxacin for Treatment of Tuberculosis

Completed·CCenters for Disease Control and Prevention·Phase 3·NCT02563327·53 enrolled

Sitafloxacin-containing Regimens for Shortening Tuberculosis Treatment

Not yet recruiting·FFirst Affiliated Hospital of Zhejiang University·Phase 3·NCT05454345·620 enrolled

Rifampin-Based Tuberculosis Treatment Versus Rifabutin-Based Tuberculosis Treatment in Persons With HIV

Terminated·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·Phase 2·NCT01601626·71 enrolled

A Randomized Trial of DOTS Versus Enhanced DOTS for Community Control of Tuberculosis

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00317330·6,400 enrolled

Tuberculosis Prevention for HIV Infected Adults

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00057122·1,148 enrolled

Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis

Active, not recruiting·UUniversity of Cape Town·Phase 3·NCT04951986·732 enrolled

TBTC Study 29: Rifapentine During Intensive Phase Tuberculosis (TB) Treatment

Completed·CCenters for Disease Control and Prevention·Phase 2·NCT00694629·865 enrolled

Metabolism of Antituberculosis Drugs in HIV-Infected Persons With Tuberculosis

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000950·50 enrolled

Safety and Efficacy of High Dose Rifampicin in Tuberculosis (TB)-HIV Co-infected Patients on Efavirenz- or Dolutegravir-based Antiretroviral Therapy

Completed·MMakerere University·Phase 2·NCT03982277·130 enrolled

Evaluating the Safety and Drug Interaction of PA-824, an Investigational Tuberculosis Medication, Together With Efavirenz, Ritonavir-Boosted Lopinavir, or Rifampin

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT01571414·52 enrolled

Drug Interactions5 trials

Phenotypic Drug Probes as Predictors of Drug-drug Interactions With Tacrolimus

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 4·NCT02576366·24 enrolled

A Study to Assess CYP3A4 Modulator, Oral Contraceptive, and pH Modifier Drug Interactions for ABI-H2158 in Healthy Adults

Completed·AAssembly Biosciences·Phase 1·NCT04142762·80 enrolled

Pharmacokinetics Study to Evaluate Drug-Drug Interactions and Safety of Elpida® in Co-Administration With Other Drugs

Completed·VViriom·Phase 1·NCT03709355·56 enrolled

Show 2 more trials

A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion

Completed· Eisai logo

Eisai·Phase 1·NCT02085967·106 enrolled

A Study to Assess the Effect of Food Intake and Drug-drug Interactions of E7090 When Co-administered With Rabeprazole or Rifampin in Healthy Participants

Completed· Eisai logo

Eisai·Phase 1·NCT04565574·42 enrolled

Adult5 trials

Study to Evaluate the Effect of Multiple Doses of Itraconazole and Rifampin on the Single-Dose Pharmacokinetics of Mitapivat Sulfate (AG-348) in Healthy Adult Participants

Completed·AAgios Pharmaceuticals, Inc.·Phase 1·NCT03991312·28 enrolled

A Study of Soticlestat and Rifampin in Healthy Adults

Completed· Takeda logo

Takeda·Phase 1·NCT05098041·15 enrolled

A Study to Evaluate the Effect of Itraconazole and Rifampin on the Drug Levels of AR-LDD (BMS-986365) in Healthy Adult Male Participants

Recruiting· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT07242781·42 enrolled

Show 2 more trials

Safety, Tolerability, and Blood Levels of Ritonavir-Boosted Atazanavir and Rifampin When Taken Together in HIV Uninfected Adults

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00096850·18 enrolled

A Study to Assess the Effects of Itraconazole and Rifampin on Lazertinib in Healthy Adult Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT04410094·32 enrolled

59 more indications

ART4 trials

A Study of Effects of Itraconazole and Rifampin on Selpercatinib (LY3527723) in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT05338489·24 enrolled

A Study of LY2835219 in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT02256267·24 enrolled

A Study of Evacetrapib and Rifampin in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT01908582·26 enrolled

Show 1 more trial

Study of the Effects of Itraconazole and Rifampin on LOXO-305 in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT05134337·27 enrolled

Pulmonary Tuberculosis3 trials

Short-course Regimens for the Treatment of Pulmonary Tuberculosis

Active, not recruiting·CCenters for Disease Control and Prevention·Phase 2/3·NCT05766267·288 enrolled

Study of Daily Rifapentine for Pulmonary Tuberculosis

Completed·JJohns Hopkins University·Phase 2·NCT00814671·153 enrolled

A Prospective Study of Multidrug Resistance and a Pilot Study of the Safety of and Clinical and Microbiologic Response to Levofloxacin in Combination With Other Antimycobacterial Drugs for Treatment of Multidrug-Resistant Pulmonary Tuberculosis (MDRTB) in HIV-Infected Patients.

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000796·525 enrolled

Patients With Advanced Solid Tumors3 trials

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced Solid Tumors

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT01218620·17 enrolled

The Effect of Tesetaxel on the QTc Interval and the Effect of Food, Itraconazole, and Rifampin on Tesetaxel Pharmacokinetics in Patients With Advanced Solid Tumors

Terminated·OOdonate Therapeutics, Inc.·Phase 1·NCT04312282·93 enrolled

A Study to Evaluate the Effect of Itraconazole and Rifampin on the Pharmacokinetics of Talazoparib in Patients With Advanced Solid Tumors

Completed· Pfizer logo

Pfizer·Phase 1·NCT03077607·36 enrolled

Drug3 trials

Ultra-Short Course Bedaquiline, Clofazimine, Pyrazinamide and Delamanid Versus Standard Therapy for Drug-Susceptible TB

Active, not recruiting·—·Phase 2·NCT05556746·94 enrolled

A Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibitor (Itraconazole) and Inducer (Rifampin) on the Drug Levels of Golcadomide (BMS-986369) in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT06363630·35 enrolled

Study to Evaluate the Effect of Rifampin on the Drug Levels in Blood and Safety of BMS-986235 in Healthy Participants

Withdrawn· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT04301310

Cystic Fibrosis3 trials

Improving Treatment of Nontuberculous Mycobacterial Infection in Cystic Fibrosis

Completed·UUniversity of Colorado, Denver·N/A·NCT02372383·31 enrolled

Epidemiology and Treatment of Small-colony Variant Staphylococcus Aureus in Cystic Fibrosis

Withdrawn·JJohns Hopkins University·Phase 4·NCT02547116

Early Methicillin-resistant Staphylococcus Aureus (MRSA) Therapy in Cystic Fibrosis (CF)

Terminated·UUniversity of North Carolina, Chapel Hill·Phase 2·NCT01349192·47 enrolled

Adult Subject3 trials

A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects

Completed· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 1·NCT01768663·80 enrolled

A Drug-Drug Interaction Study of N91115 +/- Rifampin in Healthy Adult Subjects

Completed·NNivalis Therapeutics, Inc.·Phase 1·NCT02500667·15 enrolled

Effect of Rifampin and Efavirenz on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03983239·32 enrolled

Phase 13 trials

Phase 1, Open Label, Two Arm, Fixed Sequence Study to Evaluate the Effect of Rifampin and Rifabutin on GSK1349572 Pharmacokinetics in Healthy Male and Female Volunteers

Completed· GSK logo

GSK·Phase 1·NCT01231542·27 enrolled

Phase 1 Study to Investigate Effect of Rifampin and Itraconazole on the Pharmacokinetics of BGB-3111 in Healthy Subjects

Completed· BeiGene logo

BeiGene·Phase 1·NCT03301181·40 enrolled

Phase 1 Study in Healthy Subjects to Evaluate the Effect of Rifampin on the Pharmacokinetics of IPI-145

Completed·SSecuraBio·Phase 1·NCT01947777·14 enrolled

Metabolism3 trials

A Study to Evaluate How a Drug That Alters Liver Enzymes (Rifampin) Affects the Metabolism of Enzalutamide in Men

Completed· Astellas logo

Astellas·Phase 1·NCT02138799·28 enrolled

A Study to Assess the Effect of Rifampin on the Metabolism of ABT-199

Withdrawn· AbbVie logo

AbbVie·Phase 1·NCT01969682

A Study to Assess the Effect of Rifampin on the Metabolism of Navitoclax

Completed· AbbVie logo

AbbVie·Phase 1·NCT01121133·12 enrolled

Advanced Cancer3 trials

Influence of Rifampin on the Pharmacokinetics of Romidepsin in Patients With Advanced Cancer

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT01324323·14 enrolled

Effect of Rifampin on the Pharmacokinetics of Ixabepilone in Patients With Advanced Cancer

Completed·RR-Pharm·Phase 1·NCT00207090·19 enrolled

A Study of the Interaction of Rifampin and Vinflunine in Subjects With Advanced Cancer

Withdrawn· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT00534807

Pulmonary TB2 trials

Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB

Completed·JJohns Hopkins University·Phase 2·NCT03174184·112 enrolled

A Multicenter, Phase 2b/c, Open-label, Randomized, Dose-finding Trial to Evaluate the Safety and Efficacy of a 4 Month Regimen of OPC-167832 in Combination With Delamanid and Bedaquiline in Subjects With Drug-susceptible Pulmonary Tuberculosis in Comparison With Standard Treatment

Completed· Otsuka logo

Otsuka·Phase 2·NCT05221502·122 enrolled

Experimental2 trials

An Investigational Study of Experimental Medication BMS-986278 Given With the Antibiotic Rifampin in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03712540·39 enrolled

An Investigational Study to Evaluate the Effect of Rifampin on the Singe Dose of Experimental Medication BMS-986224 in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03563950·42 enrolled

Prosthetic-joint Infection2 trials

Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection

Terminated·AArrevus Inc.·Phase 2·NCT01756924·14 enrolled

Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection

Unknown status·UUniversity Hospital, Tours·Phase 2·NCT01757236·100 enrolled

Clinical Trial2 trials

Phase I Open Label BCG Clinical Trial Assessing TB Drugs and Vaccines

Completed·FFred Hutchinson Cancer Center·Phase 1·NCT05592223·20 enrolled

Randomized Clinical Trial Comparing 4RIF vs. 9INH for LTBI Treatment-effectiveness

Completed·MMcGill University·Phase 3·NCT00931736·6,031 enrolled

NEC2 trials

Study to Evaluate Effects of Probenecid, Rifampin and Verapamil on Bexagliflozin in Healthy Subjects

Completed· Theracos logo

Theracos·Phase 1·NCT03296800·48 enrolled

Effects of Rifampicin and Probenecid On The Pharmacokinetic Profile Of Rongliflozin In Healthy Subjects

Completed· Sunshine Lake Pharma Co., Ltd. logo

Sunshine Lake Pharma Co., Ltd.·Phase 1·NCT05497674·28 enrolled

Immunodeficiency2 trials

Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000638·2,000 enrolled

Prophylaxis Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00000636·2,000 enrolled

Advanced or Metastatic Solid Tumors1 trial

Effect of Rifampin on the Pharmacokinetics of Linifanib in Subjects With Advanced or Metastatic Solid Tumors

Completed·AAbbott·Phase 1·NCT01401933·14 enrolled

Endocarditis1 trial

Adjunctive Rifampin for the Treatment of Prosthetic Valve Endocarditis Due to S. Aureus

Recruiting·—·Phase 3·NCT07253688·330 enrolled

Growth1 trial

A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer

Completed· Pfizer logo

Pfizer·Phase 1·NCT00585195·596 enrolled

Methicillin-resistant Staphylococcus Aureus1 trial

Randomized Controlled Trial of Standard Versus Systemic Decolonization Therapy for the Eradication of Methicillin-resistant Staphylococcus Aureus (MRSA) Colonization

Completed·HHorizon Health Network·N/A·NCT01438515·100 enrolled

Clinical Pharmacology1 trial

Clinical Pharmacology Study of Brentuximab Vedotin (SGN-35)

Completed· Pfizer logo

Pfizer·Phase 1·NCT01026415·73 enrolled

Homeostasis1 trial

CYP3A4 Activity and Mineral Homeostasis

Completed·UUniversity of Washington·Phase 1·NCT02019875·92 enrolled

Treatment1 trial

Treatment of Latent TB Infection for Jailed Persons

Completed·UUniversity of California, San Francisco·Phase 3·NCT00128206·364 enrolled

Cancer1 trial

Study to Investigate the Effect of Rifampin and Itraconazole on the Action of Pamiparib in Participants With Cancer

Completed· BeiGene logo

BeiGene·Phase 1·NCT03994211·25 enrolled

Children1 trial

Shortened Regimen for Drug-susceptible TB in Children

Recruiting·JJohns Hopkins University·Phase 3·NCT06253715·860 enrolled

Rhinoscleroma1 trial

Efficacy Of Doxycycline & Versus Rifampin In Treatment Of Rhinoscleroma

Unknown status·—·Phase 1·NCT05431673·45 enrolled

Colonization1 trial

S. Aureus Decolonization in HPN Patients.

Terminated·RRadboud University Medical Center·N/A·NCT03173053·63 enrolled

Dapagliflozin1 trial

Effect of Rifampin on the Pharmacokinetics of Dapagliflozin in Healthy Subjects

Terminated· AstraZeneca logo

AstraZeneca·Phase 1·NCT01068756·14 enrolled

HIV-Infected Individuals1 trial

A Phase II/III Trial of Rifampin, Ciprofloxacin, Clofazimine, Ethambutol, and Amikacin in the Treatment of Disseminated Mycobacterium Avium Infection in HIV-Infected Individuals.

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00000641·90 enrolled

Non-Hodgkins Lymphoma1 trial

COPANLISIB (BAY80-6946) Drug-drug Interaction and Cardiovascular Safety Study in Advanced Solid Tumor and Non-Hodgkin's Lymphoma Patients

Completed· Bayer logo

Bayer·Phase 1·NCT02253420·51 enrolled

Single Dose1 trial

A Study of the Effect of Multiple Doses of Rifampin on the Single Dose Pharmacokinetics of RO5424802

Completed· Roche logo

Roche·Phase 1·NCT01940510·24 enrolled

Fruquintinib1 trial

Fruquintinib CYP3A Inhibitor and Inducer Study

Completed·HHutchison Medipharma Limited·Phase 1·NCT04557397·28 enrolled

Lymphoma1 trial

Pharmacokinetics Study of Oral IXAZOMIB in Participants With Advanced Nonhematologic Malignancies or Lymphoma

Completed· Takeda logo

Takeda·Phase 1·NCT01454076·112 enrolled

Oral1 trial

A Study to Assess the Effect of Itraconazole, Rifampin, and Acid-Reducing Agents on INCB161734 Pharmacokinetics When Administered Orally in Healthy Participants

Completed· Incyte logo

Incyte·Phase 1·NCT07018635·63 enrolled

Multiple Sclerosis1 trial

Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis

Completed·NNational Center for Research Resources (NCRR)·Phase 2·NCT00043264·40 enrolled

Advanced Solid Tumors1 trial

A Study to Evaluate the Effects of Rifampin on Pharmacokinetics (PK) of Pevonedistat in Participants With Advanced Solid Tumors

Completed· Takeda logo

Takeda·Phase 1·NCT03486314·20 enrolled

AIN1 trial

This Study Tests the Effect of Certain Medicines on the Transport of Other Medicines in the Body of Healthy Men

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT03307252·45 enrolled

Pulmonary Sarcoidosis1 trial

Phase II Investigation of Antimycobacterial Therapy on Progressive, Pulmonary Sarcoidosis

Completed·VVanderbilt University·Phase 2·NCT02024555·97 enrolled

Statin1 trial

A Study to Assess the Drug Levels of CC-92480 After Coadministration With Rifampin and Itraconazole, and the Drug Levels of Digoxin and Rosuvastatin After Coadministration With CC-92480 in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT05389722·24 enrolled

Scrub Typhus1 trial

Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus

Completed·DDong-Min Kim·N/A·NCT00568711·476 enrolled

Resistance1 trial

TBTC Study 24: Intermittent Treatment of TB With Isoniazid Resistance or Intolerance

Completed·CCenters for Disease Control and Prevention·N/A·NCT00023374·98 enrolled

Intravenous1 trial

A Study to Evaluate the Effect of Single-Dose Intravenous Rifampin as a Prototypic Inhibitor of Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 on the Single-Dose Pharmacokinetics (PK) of Oral TAK-906 in Healthy Adult Participants

Completed· Takeda logo

Takeda·Phase 1·NCT04121078·12 enrolled

Efficacy1 trial

Impact of Two Genetic Variants of OATP1B3 or MRP2 or Rifampin on Systemic Disposition and Biological Efficacy of CCK-8

Completed·UUniversity Medicine Greifswald·Phase 1·NCT02507167·19 enrolled

Leprosy1 trial

Novel Interventions and Diagnostic Tests for Leprosy

Recruiting·AAnnemieke Geluk·N/A·NCT06222372·1,100 enrolled

Osteomyelitis1 trial

Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics

Completed·VVA Office of Research and Development·Phase 4·NCT03012529·843 enrolled

Mycobacterium avium complex disease1 trial

Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease

Completed·KKevin Winthrop·Phase 2/3·NCT03672630·474 enrolled

Effectiveness1 trial

Efficacy, Security, Adherence, Tolerability and Cost Effectiveness of Latent TB Treatment in Patients With TB/DM2 (TBL)

Completed·IInstituto Nacional de Salud Publica, Mexico·Phase 4·NCT03278483·396 enrolled

Esketamine1 trial

Pharmacokinetic, Safety, and Tolerability Study of Intranasally Administered Esketamine in Healthy Han Chinese, Korean, Japanese, and Caucasian Participants and the Effects of Rifampin on the Pharmacokinetics of Intranasally Administered Esketamine

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02846519·66 enrolled

Mycobacterium Avium Complex Pulmonary Disease1 trial

Phase II Study of Amithiozone (Thiacetazone) for Patients With Mycobacterium Avium Complex Pulmonary Disease

Completed·NNational Jewish Health·Phase 2·NCT00004689·50 enrolled

Staphylococcus Aureus1 trial

Persistent Methicillin Resistant Staphylococcus Aureus Eradication Protocol (PMEP)

Completed·JJohns Hopkins University·Phase 2·NCT01594827·29 enrolled

Blindness1 trial

Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness

Completed·CCenters for Disease Control and Prevention·Phase 2·NCT00127504·80 enrolled

Renal insufficiency1 trial

Pharmacokinetics of Midazolam, Dabigatran, Pitavastatin, Atorvastatin, and Rosuvastatin in Participants With Renal Insufficiency in the Presence and Absence of Rifampin (MK-0000-386)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT03311841·32 enrolled

Infants1 trial

Safety and Pharmacokinetics of Single and Multiple Dose Rifampin in Infants

Terminated·UUniversity of North Carolina, Chapel Hill·Phase 1·NCT01441206·2 enrolled

Irrigation1 trial

Irrisept vs Traditional Antibiotic Irrigation for Virgin Penile Prosthesis Placement

Active, not recruiting·RRush University Medical Center·Phase 3·NCT06489431·200 enrolled

Alzheimer's Disease1 trial

A Pilot Study of Inflammatory Markers in Alzheimer's Disease

Unknown status·MMcMaster University·Phase 3·NCT00715858·21 enrolled

ESS1 trial

A Study in Healthy Subjects to Assess How Dosing of Rifampin Affects What the Body Does to a Dose of GW679769 (Casopitant).

Completed· GSK logo

GSK·Phase 1·NCT00405080·12 enrolled

Human Immunodeficiency Virus (HIV)1 trial

An Open-label, Phase 1 Study to Characterize the Effects of Rifampin on the Pharmacokinetics of MK-8527 in Adult Participants With Latent Tuberculosis Infection

Not yet recruiting· Merck & Co. logo

Merck & Co.·Phase 1·NCT07600775·14 enrolled

Idiopathic Infantile Hypercalcaemia - Severe Form1 trial

Rifampin to Reduce Elevated Levels of Blood and Urine Calcium in Patients With Inactivating Mutations in the CYP24A1 Gene

Recruiting·CChildren's Hospital of Philadelphia·Phase 2·NCT03301038·60 enrolled

Duchenne Muscular Dystrophy1 trial

ESSENCE-53: Golodirsen in DMD Exon 53

Active, not recruiting· Sarepta Therapeutics logo

Sarepta Therapeutics·Phase 3·NCT04768231·95 enrolled

Unspecified8 trials

HMPL-523 CYP3A/P-gp Inhibitor and CYP Inducer Study

Completed·HHutchmed·Phase 1·NCT05720767·28 enrolled

Safety, Tolerability and Pharmacokinetic (PK) of Concomitant Esomeprazole and Rifampin, and QT Study on Single and Multiple-doses of Alisertib

Completed· Takeda logo

Takeda·Phase 1·NCT01844583·55 enrolled

Hypertonic Saline for MAC

Recruiting·OOregon Health and Science University·Phase 4·NCT04921943·50 enrolled

Show 5 more trials

Study of VX-770 and Rifampin in Healthy Male Subjects

Completed· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 1·NCT01018368·24 enrolled

Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin

Completed·UUniversity of Utah·Phase 1·NCT02097953·12 enrolled

TMC207 +/- Rifabutin/Rifampin

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT01341184·33 enrolled

Effects of Itraconazole and Rifampin on the Blood Tazemetostat Levels

Completed·EEpizyme, Inc.·Phase 1·NCT04537715·42 enrolled

Rifampin and the Contraceptive Implant

Completed·UUniversity of Colorado, Denver·Phase 4·NCT04463680·24 enrolled

Regulatory

FDA Approval Timeline[5]

Jan 1, 1982

RIFADIN

NDA NDA050420

Jan 1, 1982

RIMACTANE

NDA NDA050429

May 25, 1989

RIFADIN

NDA NDA050627

Sources

References

[1]
ClinicalTrials.gov — 178 trial records for Rifampin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Rifadin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Rifampin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Rifampin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA050627). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Sanofi company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Bacterial DNA-Directed RNA Polymerase Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: Sanofi

Rifadin

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q1 2027

Q3 2027

Trials by Indication[1]

Interaction35 trials

Tics26 trials

Tuberculosis16 trials

Drug Interactions5 trials

Adult5 trials

ART4 trials

Pulmonary Tuberculosis3 trials

Patients With Advanced Solid Tumors3 trials

Drug3 trials

Cystic Fibrosis3 trials

Adult Subject3 trials

Phase 13 trials

Metabolism3 trials

Advanced Cancer3 trials

Pulmonary TB2 trials

Experimental2 trials

Prosthetic-joint Infection2 trials

Clinical Trial2 trials

NEC2 trials

Immunodeficiency2 trials

Advanced or Metastatic Solid Tumors1 trial

Endocarditis1 trial

Growth1 trial

Methicillin-resistant Staphylococcus Aureus1 trial

Clinical Pharmacology1 trial

Homeostasis1 trial

Treatment1 trial

Cancer1 trial

Children1 trial

Rhinoscleroma1 trial

Colonization1 trial

Dapagliflozin1 trial

HIV-Infected Individuals1 trial

Non-Hodgkins Lymphoma1 trial

Single Dose1 trial

Fruquintinib1 trial

Lymphoma1 trial

Oral1 trial

Multiple Sclerosis1 trial

Advanced Solid Tumors1 trial

AIN1 trial

Pulmonary Sarcoidosis1 trial

Statin1 trial

Scrub Typhus1 trial

Resistance1 trial

Intravenous1 trial

Efficacy1 trial

Leprosy1 trial

Osteomyelitis1 trial

Mycobacterium avium complex disease1 trial

Effectiveness1 trial

Esketamine1 trial

Mycobacterium Avium Complex Pulmonary Disease1 trial

Staphylococcus Aureus1 trial

Blindness1 trial

Renal insufficiency1 trial

Infants1 trial

Irrigation1 trial

Alzheimer's Disease1 trial

ESS1 trial

Human Immunodeficiency Virus (HIV)1 trial

Idiopathic Infantile Hypercalcaemia - Severe Form1 trial

Duchenne Muscular Dystrophy1 trial

Unspecified8 trials

FDA Approval Timeline[5]

References

Drug Info

Quick Facts

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