Ezetimibe/simvastatin

ApprovedSmall molecule

Ezetimibe/simvastatin is one of 106 small molecule programs targeting Acute Coronary Syndrome. It is currently in Approved.

Indications

Total Trials

Active Trials

105

Competitors

Pipeline

Status by Indication[3][1]

Indication

Acute Coronary SyndromeActive, not recruiting

Diabetic PolyneuropathyActive, not recruiting

Type 1 DiabetesActive, not recruiting

Heart DiseaseActive, not recruiting

Acute Coronary SyndromePhase 3

Active, not recruiting

Diabetic PolyneuropathyPhase 2

Active, not recruiting

Type 1 DiabetesPhase 2

Active, not recruiting

Heart DiseaseApproved

Active, not recruiting

Competition

Competitive Landscape

384 competitors in Type 1 Diabetes

#DrugCompanyPhaseTrials

Ezetimibe/simvastatin

Pfizer

Approved

1 2

Symlin

AstraZeneca

Preclinical

4 3

Symlin

AstraZeneca

Preclinical

3 4

Aldomet

Neurocrine Biosciences

Preclinical

2 5

Pitocin

RRetrophin

Preclinical

1 6

Glargine

Eli Lilly

Preclinical

4 7

Cytoxan

BBaxter Healthcare Corporation

Preclinical

1 8

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 9

Foradil

Viatris

Preclinical

1 10

SGLT2 Inhibitor

Eli Lilly

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Efficacy and Safety1 trial

A Study to Evaluate the Efficacy and Safety of Vytorin Versus Standard Treatment of Other Statins in Moderate, Moderately High and High Risk Participants (MK-0653A-406)

Withdrawn·OOrganon and Co·Phase 4·NCT01587235

Atorvastatin1 trial

Ezetimibe/Simvastatin (10 mg/40 mg) vs. the Doubling of Atorvastatin in High Risk Participants (MK-0653A-134 AM1)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00782184·250 enrolled

Heart Disease1 trial

The Effects of Ezetimibe/Simvastatin 10/20 mg Versus Simvastatin 40 mg in High Cholesterol and Coronary Heart Disease Study (P04039AM2)(COMPLETED)

Completed·OOrganon and Co·Phase 4·NCT00423579·120 enrolled

Treatment1 trial

Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE

Completed·UUniversity of Oxford·Phase 3·NCT00461630·25,673 enrolled

Clinical Trial1 trial

A Clinical Trial Comparing Torcetrapib/Atorvastatin to Ezetimibe/Simvastatin In Subjects With A Cholesterol Disorder.

Terminated· Pfizer logo

Pfizer·Phase 3·NCT00267267·1,784 enrolled

4 more indications

Diabetic Polyneuropathy1 trial

Statins for Oxidative Stress and Mitochondrial Function in Diabetic Polyneuropathy

Completed·UUniversity of Guadalajara·Phase 2·NCT02129231·74 enrolled

Type 1 Diabetes1 trial

Clinical Trial of Zocor (Simvastatin) and Vytorin (Ezetimibe/Simvastatin) in Adolescents With Type 1 Diabetes

Completed·UUniversity of Colorado, Denver·Phase 2·NCT00477204·9 enrolled

Acute Coronary Syndrome1 trial

IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103)

Completed·OOrganon and Co·Phase 3·NCT00202878·18,144 enrolled

Biomarker1 trial

Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment

Completed·UUniversity of Maryland, Baltimore·Phase 4·NCT00819403·15 enrolled

Sources

References

[1]
ClinicalTrials.gov — 9 trial records for Ezetimibe/simvastatin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Ezetimibe/simvastatin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Ezetimibe/simvastatin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Pfizer company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Pfizer

Ezetimibe/simvastatin

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Efficacy and Safety1 trial

Atorvastatin1 trial

Heart Disease1 trial

Treatment1 trial

Clinical Trial1 trial

Diabetic Polyneuropathy1 trial

Type 1 Diabetes1 trial

Acute Coronary Syndrome1 trial

Biomarker1 trial

References

Drug Info

Quick Facts

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