Gemcabene

Phase 2Small molecule

NNeuroBo Pharmaceuticals Inc.

Gemcabene is one of 86 small molecule programs targeting Hypercholesterolemia. It is currently in Phase 2.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

HypercholesterolemiaActive, not recruiting

HypertriglyceridemiaActive, not recruiting

Homozygous Familial HypercholesterolemiaActive, not recruiting

HypercholesterolemiaPhase 2

Active, not recruiting

HypertriglyceridemiaPhase 2

Active, not recruiting

Homozygous Familial HypercholesterolemiaPhase 2

Active, not recruiting

Competition

Competitive Landscape

130 competitors in Hypercholesterolemia

#DrugCompanyPhaseTrials

Avapro

Sanofi

Phase 3

1 2

Lescol

Novartis

Phase 3

1 3

Micardis

Boehringer Ingelheim

Phase 3

1 4

Comparator: Statins

Merck & Co.

Phase 3

3 5

Statin

Bristol-Myers Squibb

Phase 3

2 6

Kynamro

KKastle Therapeutics, LLC

Phase 3

1 7

Anacetrapib

Merck & Co.

Phase 3

1 8

Lapaquistat Acetate

Takeda

Phase 3

9 9

Bococizumab

Pfizer

Phase 3

1 10

Niacin/laropiprant

Merck & Co.

Phase 3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Efficacy and Safety3 trials

Efficacy and Safety of Gemcabene in Patients With Low HDL-C and Either Normal or Elevated Triglycerides

Completed·NNeuroBo Pharmaceuticals Inc.·Phase 2·NCT02585869·161 enrolled

Efficacy and Safety of Gemcabene in Hypercholesterolemic Patients on Stable Statin Therapy

Completed·NNeuroBo Pharmaceuticals Inc.·Phase 2·NCT02571257·66 enrolled

Efficacy and Safety of Gemcabene in Hypercholesterolemic Patients as Monotherapy or in Combination With Atorvastatin

Completed·NNeuroBo Pharmaceuticals Inc.·Phase 2·NCT02591836·277 enrolled

Pediatric NAFLD1 trial

Gemcabene for the Treatment of Pediatric NAFLD

Terminated·EEmory University·Phase 2·NCT03436420·6 enrolled

Adult1 trial

Study of Gemcabene in Adults With FPLD

Completed·EElif Oral·Phase 1/2·NCT03508687·5 enrolled

Tics1 trial

Pharmacokinetics and Pharmacodynamics Study of Gemcabene in Healthy Volunteers

Completed·NNeuroBo Pharmaceuticals Inc.·Phase 1·NCT02587364·50 enrolled

Insulin Sensitivity1 trial

The Effect of Gemcabene on Insulin Sensitivity in Nondiabetic Subjects

Completed·NNeuroBo Pharmaceuticals Inc.·Phase 2·NCT02586168·53 enrolled

5 more indications

Atorvastatin1 trial

Effect of Gemcabene on the Pharmacokinetics of Atorvastatin in Healthy Volunteers

Completed·NNeuroBo Pharmaceuticals Inc.·Phase 1·NCT02587416·20 enrolled

Statin1 trial

Effect of Gemcabene on the Pharmacokinetics of Simvastatin in Healthy Volunteers

Completed·NNeuroBo Pharmaceuticals Inc.·Phase 1·NCT02587390·20 enrolled

Hypercholesterolemia1 trial

A 12-Week, Phase 2 Study of Gemcabene in Hypercholesterolemia Patients on Stable Moderate and High-Intensity Statins

Completed·NNeuroBo Pharmaceuticals Inc.·Phase 2·NCT02634151·105 enrolled

Hypertriglyceridemia1 trial

A 12-Week Study to Assess the Efficacy Safety and Tolerability of Gemcabene in Subjects With Severe Hypertriglyceridemia

Completed·NNeuroBo Pharmaceuticals Inc.·Phase 2·NCT02944383·91 enrolled

Homozygous Familial Hypercholesterolemia1 trial

Efficacy and Safety of Gemcabene in Patients With Homozygous Familial Hypercholesterolemia on Stable, Lipid-Lowering Therapy (COBALT-1)

Completed·NNeuroBo Pharmaceuticals Inc.·Phase 2·NCT02722408·8 enrolled

Sources

References

[1]
ClinicalTrials.gov — 12 trial records for Gemcabene. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Gemcabene compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Gemcabene. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — NeuroBo Pharmaceuticals Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 2[1]
Company: NNeuroBo Pharmaceuticals Inc.

Gemcabene

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Efficacy and Safety3 trials

Pediatric NAFLD1 trial

Adult1 trial

Tics1 trial

Insulin Sensitivity1 trial

Atorvastatin1 trial

Statin1 trial

Hypercholesterolemia1 trial

Hypertriglyceridemia1 trial

Homozygous Familial Hypercholesterolemia1 trial

References

Drug Info

Quick Facts

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