Comparator: statins

ApprovedSmall molecule

Merck & Co.

Comparator: statins is one of 419 small molecule programs targeting Metabolic Syndrome. It is currently in Approved.

Indications

Total Trials

Active Trials

418

Competitors

Pipeline

Status by Indication[3][1]

Indication

Metabolic SyndromeActive, not recruiting

Low Back PainActive, not recruiting

Essential HypertensionActive, not recruiting

HyperlipidemiaActive, not recruiting

DysmenorrheaActive, not recruiting

Chronic AsthmaActive, not recruiting

AtherosclerosisActive, not recruiting

Allergic RhinitisActive, not recruiting

HypertensionActive, not recruiting

Rheumatoid ArthritisActive, not recruiting

Metabolic SyndromePhase 3

Active, not recruiting

Low Back PainApproved

Active, not recruiting

Essential HypertensionPhase 3

Active, not recruiting

HyperlipidemiaPhase 3

Active, not recruiting

DysmenorrheaPhase 3

Active, not recruiting

Chronic AsthmaPhase 2

Active, not recruiting

AtherosclerosisApproved

Active, not recruiting

Allergic RhinitisPhase 3

Active, not recruiting

HypertensionPhase 3

Active, not recruiting

Rheumatoid ArthritisPhase 3

Active, not recruiting

Showing 10 of 17 indications

Competition

Competitive Landscape

1050 competitors in Asthma

#DrugCompanyPhaseTrials

Comparator: statins

Merck & Co.

Approved

3 2

Xolair

Roche

Preclinical

25 3

Cinqair

Teva

Preclinical

13 4

Dupixent

AAzienda U.S.L. 1 di Massa e Carrara

Preclinical

30 5

Asmanex

Novartis

Preclinical

5 6

Arcoxia

Novartis

Preclinical

—7

Blood Withdrawn

Emergent BioSolutions

Preclinical

1 8

Paracetamol

GSK

Preclinical

1 9

Blood Collection

AAssistance Publique - Hôpitaux de Paris

Preclinical

1 10

Allergen Immunotherapy Extract

JJohns Hopkins University

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Seasonal Allergic Rhinitis5 trials

A Study Investigating the Effect of Montelukast in Patients With Seasonal Allergic Rhinitis (MK-0476-192)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00960141·829 enrolled

Montelukast in Patients With Seasonal Allergic Rhinitis - Spring 2000 Study (MK-0476A-162)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00979901·1,577 enrolled

Montelukast in Seasonal Allergic Rhinitis - Fall 1999 Study (0476A-117)

Completed·OOrganon and Co·Phase 3·NCT00963599·907 enrolled

Show 2 more trials

Montelukast in Seasonal Allergic Rhinitis - Spring 2001 Study (0476-235)

Completed·OOrganon and Co·Phase 3·NCT00972738·1,214 enrolled

Montelukast in Seasonal Allergic Rhinitis: Fall 2001 Study (0476-240)

Completed·OOrganon and Co·Phase 3·NCT00963469·1,079 enrolled

Montelukast4 trials

Montelukast in Exercise-Induced Bronchospasm - 2004 (0476-275)

Completed·OOrganon and Co·Phase 3·NCT00090142·62 enrolled

Montelukast Post-Marketing Comparative Study With Ketotifen (0476-379)

Completed·OOrganon and Co·Phase 4·NCT00446056·188 enrolled

Montelukast Compared With Placebo and Salmeterol in Exercise-Induced Bronchoconstriction (0476-316)

Completed·OOrganon and Co·Phase 3·NCT00245570·47 enrolled

Show 1 more trial

Montelukast in Exercise-Induced Bronchospasm - 2003 (0476-270)

Completed·OOrganon and Co·Phase 3·NCT00092131·51 enrolled

Cholesterol3 trials

A Study to Determine the Number of Patients Who Reach Optimal Cholesterol Levels on Each of Three Different Treatments (0653A-121)

Completed·OOrganon and Co·Phase 3·NCT00462748·786 enrolled

Comparing an Investigational Medication Versus an Approved Medication in Reducing Cholesterol Levels (0653-025)

Completed·OOrganon and Co·Phase 3·NCT00092716·655 enrolled

Study of an Approved Drug With a Statin (a Medication That Lowers Cholesterol Levels) as Compared to Statin Therapy Alone in Patients With High Cholesterol (0653-040)

Completed·OOrganon and Co·Phase 3·NCT00092586·2,904 enrolled

Rheumatoid Arthritis3 trials

A Study to Evaluate the Safety of an Investigational Drug (Etoricoxib) in Patients With Osteoarthritis (OA) or Rheumatoid Arthritis (RA)(0663-066)

Completed·OOrganon and Co·Phase 3·NCT00250445·23,498 enrolled

Investigational Drug Versus an Approved Drug in Patients With Rheumatoid Arthritis (0663-072)

Completed·OOrganon and Co·Phase 3·NCT00092742·4,086 enrolled

Rheumatoid Arthritis Dose Ranging Study (0663-086)(COMPLETED)

Completed·OOrganon and Co·Phase 2·NCT00264147·761 enrolled

Migraine3 trials

Study to Test Rizatriptan in the Early Treatment of Acute Migraine (0462-081)

Completed·OOrganon and Co·Phase 3·NCT00516737·207 enrolled

Study to Test a Marketed Product in the Treatment of Migraine-associated Nausea

Completed·OOrganon and Co·Phase 3·NCT00250458·346 enrolled

A Study to Evaluate the Efficacy and Tolerability of Rizatriptan for Treatment of Acute Migraine (0462-087)

Completed·OOrganon and Co·Phase 3·NCT00894556·109 enrolled

31 more indications

Osteoarthritis3 trials

A Study of MK0663 and an Approved Drug in the Treatment of Osteoarthritis (0663-076)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00092768·500 enrolled

A Study of MK0663 and an Approved Drug in the Treatment of Osteoarthritis (0663-077)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00092781·500 enrolled

Investigational Drug Versus an Approved Drug in Patients With Osteoarthritis (0663-061)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00092703·6,000 enrolled

Hypercholesterolemia3 trials

A Study of Ezetimibe Added On to Rosuvastatin Versus Up Titration of Rosuvastatin in Patients With Hypercholesterolemia (MK0653-139)

Completed·OOrganon and Co·Phase 3·NCT00783263·440 enrolled

Investigational Drug in Patients With Hypercholesterolemia or in Patients With Sitosterolemia (0653-026)(COMPLETED)

Terminated·OOrganon and Co·Phase 3·NCT00092833·49 enrolled

A Study to Evaluate Ezetimibe in Korean Patients With Primary Hypercholesterolemia (0653-042)

Completed·OOrganon and Co·Phase 3·NCT00157911·136 enrolled

Asthma3 trials

A Study to Compare Effectiveness of Montelukast Sodium With Comparator in Mild to Moderate Persistent Asthmatics (0476-329)

Completed·OOrganon and Co·Phase 4·NCT00157937·31 enrolled

Montelukast Asthmatic Smoker Study (0476-332)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00284856·1,640 enrolled

Early Airway Response to Allergen in Asthmatics (MK-0000-176)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT01061333·16 enrolled

Hyperlipidemia3 trials

Two Investigational Drugs in Patients With Mixed Hyperlipidemia (0653-036)

Completed·OOrganon and Co·Phase 3·NCT00092560·587 enrolled

Study of Ezetimibe and Fenofibrate in Patients With Mixed Hyperlipidemia (0653-036)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00092573·576 enrolled

To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With Type IIa or Type IIb Hyperlipidemia (0653A-091)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00271817·1,220 enrolled

Vitamin D2 trials

A Study of the Bioequivalence of 70-mg Alendronate and 70-mg Alendronate in Combination With 5600 IU Vitamin D (MK0217A-253)

Completed·OOrganon and Co·Phase 1·NCT00803790·318 enrolled

A Study of the Bioequivalence of 70 mg Alendronate and 70 mg Alendronate in Combination With 2800 IU Vitamin D

Completed·OOrganon and Co·Phase 1·NCT00806416·244 enrolled

Osteoporosis2 trials

A Study and 12 Month Extension to Evaluate Two Investigational Drugs in Postmenopausal Women With Osteoporosis (MK-0217-907)

Completed·OOrganon and Co·Phase 3·NCT00092040·936 enrolled

Efficacy and Safety Study of Fosamax Plus D in Postmenopausal Women With Osteoporosis (0217A-263)

Completed·OOrganon and Co·Phase 4·NCT00729651·343 enrolled

Chronic Asthma2 trials

The Safety and Effectiveness of MK0476 (Montelukast) in Patients With Chronic Asthma (0476-388)

Completed·OOrganon and Co·Phase 1·NCT00739297·68 enrolled

Study of Inhaled Corticosteroid Plus Montelukast Compared With Inhaled Corticosteroid Therapy Alone in Patients With Chronic Asthma (0476-386)

Completed·OOrganon and Co·Phase 2·NCT00666679·134 enrolled

Lip2 trials

Vytorin Treating Uncontrolled Lipids (VyTUL) Study (0653A-122)

Terminated·OOrganon and Co·Phase 3·NCT00395603·550 enrolled

Study of Extended Release Niacin/Laropiprant on Lipids (0524A-067)

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT00479388·1,216 enrolled

MPA2 trials

MK0462 5 mg, Sumatriptan 50 mg, and Placebo Comparison Study (0462-029)

Completed·OOrganon and Co·Phase 3·NCT00897104·933 enrolled

Rizatriptan 5 mg and 10 mg, Sumatriptan 100 mg, and Placebo Comparison Study (0462-030)

Completed·OOrganon and Co·Phase 3·NCT00898677·1,268 enrolled

Allergic Rhinitis2 trials

An Approved Drug to Study a New Indication for Allergic Rhinitis (0476-327)

Completed·OOrganon and Co·Phase 3·NCT00127647·1,375 enrolled

Montelukast in Perennial Allergic Rhinitis - 2001-2002 Study (0476-246)

Completed·OOrganon and Co·Phase 3·NCT00974571·1,365 enrolled

LAI1 trial

First Step With Singulair® Therapy (0476-323)

Completed·OOrganon and Co·Phase 4·NCT00545324·399 enrolled

Dental Pain1 trial

A Study to Asses the Effect of MK0663 in the Treatment of Patients With Postoperative Dental Pain (0663-092)

Completed·OOrganon and Co·Phase 3·NCT00694369·588 enrolled

Proteinuric Renal Disease1 trial

Antiproteinuric Efficacy of Losartan Potassium in Patients With Non-Diabetic Proteinuric Renal Diseases (0954-213)

Completed·OOrganon and Co·Phase 4·NCT00140985·97 enrolled

Atherosclerosis1 trial

LAAS (Losartan Anti-Atherosclerosis Study)(0954-330)(COMPLETED)

Completed·OOrganon and Co·Phase 4·NCT00496834·201 enrolled

Elevated Cholesterol1 trial

Study to Evaluate the Cholesterol Lowering Effects of Two Marketed Drugs in Patients With Elevated Cholesterol Levels (0653A-058)

Completed·OOrganon and Co·Phase 3·NCT00090298·2,815 enrolled

Dysmenorrhea1 trial

An Investigational Drug Study in the Treatment of Primary Dysmenorrhea (0663-064)

Completed·OOrganon and Co·Phase 3·NCT00092729·129 enrolled

Treatment1 trial

INdians Followed for INtensive Lipid Lowering Treatment and Its safetY

Terminated·SSunnybrook Health Sciences Centre·Phase 3·NCT00664469·64 enrolled

Low back pain1 trial

Study of MK0663 in Patients With Chronic Low Back Pain (0663-806)(COMPLETED)

Completed·OOrganon and Co·Phase 4·NCT00090181·401 enrolled

Essential Hypertension1 trial

BP-EASE -Effectiveness of Losartan 50 mg/Hydrochlorothiazide (HCTZ) 12.5 mg Versus Valsartan 80 mg/HCTZ 12.5 mg Titrated as Needed in Patients With Essential Hypertension Not Controlled on Monotherapy (0954A-333)

Completed·OOrganon and Co·Phase 3·NCT00546754·808 enrolled

Interaction1 trial

MD Ezetimibe Cyclosporine Interaction (0653-057)

Completed·OOrganon and Co·Phase 1·NCT00653276·13 enrolled

High Cardiovascular Risk1 trial

MK0653C in High Cardiovascular Risk Patients With High Cholesterol (Switch Study)(MK-0653C-162)

Completed·OOrganon and Co·Phase 3·NCT01154036·1,547 enrolled

Pediatric Patients1 trial

The Effect of Montelukast on Difficulty in Breathing After Exercise in Pediatric Patients (MK0476-377)(COMPLETED)

Completed·OOrganon and Co·Phase 4·NCT00534976·364 enrolled

Heart Disease1 trial

A Study Comparing Ezetimibe Plus Simvastatin Versus Simvastatin Alone in Patients at Risk for Heart Disease (0653-023)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00551447·616 enrolled

Indomethacin1 trial

A Study Evaluating the Effect of Etoricoxib and Indomethacin in the Treatment of Acute Gout (0663-081)(COMPLETED)

Completed·OOrganon and Co·Phase 4·NCT00142558·180 enrolled

Metabolic Syndrome1 trial

Ezetimibe/Simvastatin in Patients With Metabolic Syndrome (0653A-107)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00409773·1,143 enrolled

Atorvastatin1 trial

To Evaluate Ezetimibe Plus Atorvastatin Versus Atorvastatin in Patients With High Cholesterol Not Controlled on Atorvastatin 20 mg (0653-079)(COMPLETED)

Completed·OOrganon and Co·Phase 3·NCT00276458·196 enrolled

Hypertension1 trial

Obese Hypertension Study (0954-315)

Completed·OOrganon and Co·Phase 3·NCT00289887·261 enrolled

Tics1 trial

Eze/Simva Switch Study in Diabetics (0653A-807)

Completed·OOrganon and Co·Phase 3·NCT00541697·648 enrolled

Heart1 trial

A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808)

Completed·OOrganon and Co·Phase 3·NCT00132717·450 enrolled

Blood Pressure1 trial

The Effect of Losartan and Losartan Plus Isosorbide Mononitrate on Central Blood Pressure Measurements (0954-317)

Completed·OOrganon and Co·Phase 1·NCT00943852·13 enrolled

Unspecified2 trials

Study of the Bioequivalence of the 20% and 30% Etoricoxib Tablet Formulations (0663-070)

Completed·OOrganon and Co·Phase 1·NCT00945035·36 enrolled

Induced Sputum Study (0000-065)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT00623714·13 enrolled

Sources

References

[1]
ClinicalTrials.gov — 64 trial records for Comparator: statins. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Comparator: statins compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Comparator: statins. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Merck & Co. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Approved[1]
Company: Merck & Co.

Comparator: statins

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Seasonal Allergic Rhinitis5 trials

Montelukast4 trials

Cholesterol3 trials

Rheumatoid Arthritis3 trials

Migraine3 trials

Osteoarthritis3 trials

Hypercholesterolemia3 trials

Asthma3 trials

Hyperlipidemia3 trials

Vitamin D2 trials

Osteoporosis2 trials

Chronic Asthma2 trials

Lip2 trials

MPA2 trials

Allergic Rhinitis2 trials

LAI1 trial

Dental Pain1 trial

Proteinuric Renal Disease1 trial

Atherosclerosis1 trial

Elevated Cholesterol1 trial

Dysmenorrhea1 trial

Treatment1 trial

Low back pain1 trial

Essential Hypertension1 trial

Interaction1 trial

High Cardiovascular Risk1 trial

Pediatric Patients1 trial

Heart Disease1 trial

Indomethacin1 trial

Metabolic Syndrome1 trial

Atorvastatin1 trial

Hypertension1 trial

Tics1 trial

Heart1 trial

Blood Pressure1 trial

Unspecified2 trials

References

Drug Info

Quick Facts

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