Glutathione

Phase 3Small molecule

UUniversity of Chicago

Glutathione is one of 167 small molecule programs targeting Hyperbilirubinemia. It is currently in Phase 3.

Indications

Total Trials

Active Trials

166

Competitors

Pipeline

Status by Indication[3][1]

Indication

HyperbilirubinemiaActive, not recruiting

Oxidative StressActive, not recruiting

AutismActive, not recruiting

AlcoholCompleted

Advanced NSCLCRecruiting

Autism Spectrum DisorderTerminated

HyperbilirubinemiaPreclinical

Active, not recruiting

Oxidative StressPreclinical

Active, not recruiting

AutismPreclinical

Active, not recruiting

AlcoholPreclinical

Completed

Advanced NSCLCPhase 1

Recruiting

Autism Spectrum DisorderPhase 3

Terminated

Competition

Competitive Landscape

60 competitors in Advanced NSCLC

#DrugCompanyPhaseTrials

Beyfortus

BeiGene

Approved

3 2

Tagrisso

AstraZeneca

Phase 3

4 3

Taxotere

AAvyxa

Phase 3

12 4

Alimta

SShawn Eagle

Phase 3

8 5

Paraplatin

AAvyxa

Phase 3

8 6

Tarceva

OOSI Pharmaceuticals

Phase 3

7 7

Keytruda

Merck & Co.

Phase 2

7 8

Opdivo

Bristol-Myers Squibb

Phase 2

6 9

Taxol

Teva

Phase 2

6 10

Avastin

Roche

Phase 2

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

N/ARecruiting

Hyperbilirubinemia

NCT06922669

Q4 2027

Phase 1Recruiting

Advanced NSCLC

NCT06896422

Q2 2028

PreclinicalRecruiting

Autism Spectrum Disorder

NCT07304440

Clinical

Trials by Indication[1]

Whitening2 trials

Oral Glutathione As A Skin Whitening Agent

Completed·DDr Irma Bernadette S Sitohang·Phase 1·NCT04105504·90 enrolled

Role of Oral Glutathione in Skin Whitening

Completed·—·Phase 1·NCT01016080·60 enrolled

Autism Spectrum Disorder2 trials

A Study of Glutathione in Children With Autism Spectrum Disorder

Terminated·UUniversity of Chicago·Phase 4·NCT05954052·6 enrolled

Adia MED of Winter Park LLC Autism Spectrum Disorder Research Study

Recruiting·AAdia Med of Winter Park LLC·Preclinical·NCT07304440·100 enrolled

Autism1 trial

Study of Glutathione, Vitamin C and Cysteine in Children With Autism and Severe Behavior Problems

Completed·UUniversity of Louisville·N/A·NCT00889538·24 enrolled

Oxidative Stress1 trial

Polymorphism of Oxidative Stress Genes in the Pathogenesis and Antioxidant Prevention of Contrast Induced Nephropathy

Completed·HHuashan Hospital·N/A·NCT01142024·1,000 enrolled

Ischemia1 trial

Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 2·NCT02251041·143 enrolled

9 more indications

Parkinson's Disease1 trial

Glutathione (GSH) In The Treatment of Parkinson's Disease

Completed·UUniversity of South Florida·Phase 2·NCT01177319·20 enrolled

Hyperbilirubinemia1 trial

Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia

Recruiting·GGeneral Hospital of Shenyang Military Region·N/A·NCT06922669·232 enrolled

Unknown status·SSeattle Cancer Treatment and Wellness Center·Phase 2·NCT00323583·80 enrolled

Fallopian Tube Cancer1 trial

Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carboplatin in Patients With Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT02311907·195 enrolled

Alcohol1 trial

Effect of Glutathione on Blood Alcohol and Hangover Symptoms

Completed·—·N/A·NCT00127309·100 enrolled

Complication1 trial

Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation

Completed·—·Phase 3·NCT02584283·157 enrolled

Cystic Fibrosis1 trial

The Role of Oral Glutathione on Growth Parameters in Children With Cystic Fibrosis

Completed·UUniversity of Minnesota·Phase 2·NCT03020719·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 16 trial records for Glutathione. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Glutathione compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Glutathione. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — University of Chicago company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: UUniversity of Chicago

Glutathione

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2027

Q4 2027

Q2 2028

Trials by Indication[1]

Whitening2 trials

Autism Spectrum Disorder2 trials

Autism1 trial

Oxidative Stress1 trial

Ischemia1 trial

Parkinson's Disease1 trial

Hyperbilirubinemia1 trial

Clinical Trial1 trial

Advanced NSCLC1 trial

Pancreatic Cancer1 trial

Fallopian Tube Cancer1 trial

Alcohol1 trial

Complication1 trial

Cystic Fibrosis1 trial

References

Drug Info

Quick Facts

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