Glutathione

Phase 3Small molecule

UUniversity of Chicago

Glutathione is one of 261 small molecule programs targeting Ischemia. It is currently in Phase 3.

Indications

Total Trials

Active Trials

260

Competitors

Pipeline

Status by Indication[3][1]

Indication

IschemiaActive, not recruiting

HyperbilirubinemiaActive, not recruiting

Oxidative StressActive, not recruiting

Fallopian Tube CancerActive, not recruiting

Autism Spectrum DisorderActive, not recruiting

Pancreatic CancerActive, not recruiting

Cystic FibrosisActive, not recruiting

AutismActive, not recruiting

IschemiaPhase 2

Active, not recruiting

HyperbilirubinemiaPreclinical

Active, not recruiting

Oxidative StressPreclinical

Active, not recruiting

Fallopian Tube CancerPhase 3

Active, not recruiting

Autism Spectrum DisorderPhase 1/Phase 2

Active, not recruiting

Pancreatic CancerPhase 2

Active, not recruiting

Cystic FibrosisPhase 2

Active, not recruiting

AutismPreclinical

Active, not recruiting

Competition

Competitive Landscape

1063 competitors in Pancreatic Cancer

#DrugCompanyPhaseTrials

Glutathione

UUniversity of Chicago

Phase 3

1 2

Gemzar

GGynecologic Oncology Group

MS Contin

1 4

Medrol

Pfizer

Preclinical

1 5

Byetta

AstraZeneca

Preclinical

1 6

Sulfonylureas

Eli Lilly

Preclinical

1 7

Thiazolidinediones

Sanofi

Preclinical

1 8

Alpha-Glucosidase Inhibitors

Sanofi

Preclinical

1 9

Meglitinides

Sanofi

Preclinical

1 10

Chemotherapy Agents

Takeda

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2027

N/ARecruiting

Hyperbilirubinemia

NCT06922669

Q4 2027

Phase 1Recruiting

Advanced NSCLC

NCT06896422

Q2 2028

Phase 1/2Recruiting

Autism Spectrum Disorder

NCT07304440

Clinical

Trials by Indication[1]

Autism Spectrum Disorder2 trials

Adia MED of Winter Park LLC Autism Spectrum Disorder Research Study

Recruiting·AAdia Med of Winter Park LLC·Phase 1/2·NCT07304440·100 enrolled

A Study of Glutathione in Children With Autism Spectrum Disorder

Terminated·UUniversity of Chicago·Phase 4·NCT05954052·6 enrolled

Whitening2 trials

Oral Glutathione As A Skin Whitening Agent

Completed·DDr Irma Bernadette S Sitohang·Phase 1·NCT04105504·90 enrolled

Role of Oral Glutathione in Skin Whitening

Completed·—·Phase 1·NCT01016080·60 enrolled

Autism1 trial

Study of Glutathione, Vitamin C and Cysteine in Children With Autism and Severe Behavior Problems

Completed·UUniversity of Louisville·N/A·NCT00889538·24 enrolled

Fallopian Tube Cancer1 trial

Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carboplatin in Patients With Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT02311907·195 enrolled

Alcohol1 trial

Effect of Glutathione on Blood Alcohol and Hangover Symptoms

Completed·—·N/A·NCT00127309·100 enrolled

9 more indications

Pancreatic Cancer1 trial

Weekly Dosing of an Integrative Chemotherapy Combination to Treat Advanced Pancreatic Cancer

Unknown status·SSeattle Cancer Treatment and Wellness Center·Phase 2·NCT00323583·80 enrolled

Oxidative Stress1 trial

Polymorphism of Oxidative Stress Genes in the Pathogenesis and Antioxidant Prevention of Contrast Induced Nephropathy

Completed·HHuashan Hospital·N/A·NCT01142024·1,000 enrolled

Cystic Fibrosis1 trial

The Role of Oral Glutathione on Growth Parameters in Children With Cystic Fibrosis

Completed·UUniversity of Minnesota·Phase 2·NCT03020719·60 enrolled

Ischemia1 trial

Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)

Completed·UUniversitaire Ziekenhuizen KU Leuven·Phase 2·NCT02251041·143 enrolled

Parkinson's Disease1 trial

Glutathione (GSH) In The Treatment of Parkinson's Disease

Completed·UUniversity of South Florida·Phase 2·NCT01177319·20 enrolled

Hyperbilirubinemia1 trial

Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia

Recruiting·GGeneral Hospital of Shenyang Military Region·N/A·NCT06922669·232 enrolled

Advanced NSCLC1 trial

Randomized Trial of Glutathione With Anti-PD-1 and Chemotherapy in Advanced NSCLC

Recruiting·TThe First Affiliated Hospital of Zhengzhou University·Phase 1·NCT06896422·80 enrolled

Complication1 trial

Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation

Completed·—·Phase 3·NCT02584283·157 enrolled

Clinical Trial1 trial

Glutathione vs. Curcumin Clinical Trial

Unknown status·SSouth Florida Veterans Affairs Foundation for Research and Education·Phase 1/2·NCT02848417·75 enrolled

Sources

References

[1]
ClinicalTrials.gov — 16 trial records for Glutathione. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Glutathione compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Glutathione. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — University of Chicago company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: UUniversity of Chicago

Glutathione

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2027

Q4 2027

Q2 2028

Trials by Indication[1]

Autism Spectrum Disorder2 trials

Whitening2 trials

Autism1 trial

Fallopian Tube Cancer1 trial

Alcohol1 trial

Pancreatic Cancer1 trial

Oxidative Stress1 trial

Cystic Fibrosis1 trial

Ischemia1 trial

Parkinson's Disease1 trial

Hyperbilirubinemia1 trial

Advanced NSCLC1 trial

Complication1 trial

Clinical Trial1 trial

References

Drug Info

Quick Facts

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