VivoSeq
Other

Oxidative Stress

116

Pipeline Programs↗

11

Active Trials↗

39

Companies Involved↗

Oxidative Stress is a highly competitive landscape with 116 programs across 39 companies. The most active players are Tonghua Anrate Biopharmaceutical Co., Ltd., Applied Therapeutics, Inc., AbbVie. 35 therapies are approved with 16 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

72/100

Pipeline Velocity

27/100

Mech. Concentration

7/100

Completion Rate

90/100

Attrition Rate

6/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

T

Tonghua Anrate Biopharmaceutical Co., Ltd.

1 program

Phase 1A

Applied Therapeutics, Inc.

1 program

Phase 1AbbVie logo

AbbVie

2 programs

Phase 1Novartis logo

Novartis

2 programs

Phase 2R

Retrophin

1 program

Phase 2Boehringer Ingelheim logo

Boehringer Ingelheim

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical36

Deferiprone

Chiesi Farmaceutici S.p.A.

Propofol

Fresenius Kabi Oncology Ltd.

Metformin

EMD Serono

Sevoflurane

AbbVie

Aspirin

Bayer

Phase 15

Clarithromycin

AbbVie

Trimethoprim

Conrado Roberto Hoffmann Filho

Human Albumin

Tonghua Anrate Biopharmaceutical Co., Ltd.

AT-001

Applied Therapeutics, Inc.

Penicillin V

Corewell Health East

Phase 224

Cisplatin

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Oxytocin

Retrophin

Losartan

Organon and Co

Valsartan

Novartis

Atorvastatin

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Phase 316

Finerenone

Bayer

Desflurane

Baxter Healthcare Corporation

Penthotal

Rennes University Hospital

Cholecalciferol

Hyundai Pharmaceutical Co., LTD.

Hydroxyurea

Theravia

Approved35

Pioglitazone

Takeda

Fentanyl

Cephalon

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Midazolam

Conrado Roberto Hoffmann Filho

Efavirenz

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Analysis

Modality Breakdown

97%

Small molecule

125 of 129 classified programs — the dominant modality here.

3%ALL OTHERSProtein / enzyme22%Vaccine22%

Small molecule leads; the ring shows all 129 classified programs, each share of the total. Modality classified for 100% of 139 pipeline programs.

Analysis

Trial Status

114

clinical trials

Completed66 · 58%
Unknown status30 · 26%
Recruiting7 · 6%
Terminated6 · 5%
Enrolling by invitation2 · 2%
Active, not recruiting2 · 2%
Other1 · 1%

Clinical Trials

Trial Activity

114 trials

Pesticides and Infertility: Oxidative Stress Via Circulating Cell-free DNA and Gut/Genital Microbiome Signatures in Women With Endometriosis
Recruiting·—·N/A·NCT07471373·160 enrolled
Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy
Recruiting·—·N/A·NCT07152912·80 enrolled
Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.
Recruiting·IInstituto Mexicano del Seguro Social·Phase 4·NCT07073846·104 enrolled
Oxidative Stress Effects of TIVA, CIVA, and Balanced Anesthesia in VATS
Recruiting·—·N/A·NCT07271472·60 enrolled
Effect of Sodium Glucose Co-tansporter 2 Inhibitors (SGLT2I) on Inflammatory and Oxidative Stress Markers Level in Heart Failure Patients
Recruiting·KKafrelsheikh University·N/A·NCT06585761·60 enrolled
Finerenone and Renal Oxidative Stress
Recruiting·UUniversity of Erlangen-Nürnberg Medical School·Phase 3·NCT06244758·75 enrolled
Transfusion-Related Changes in Oxidative Stress Biomarkers in Neonates - a Three-Part Prospective Observational Pilot Study
Recruiting·MMedical University of Graz·N/A·NCT07672275·170 enrolled
Cisplatin + Radiation in SCCHN and Correlation With Oxidative Stress Markers
Active, not recruiting·—·Phase 2·NCT02994069·80 enrolled
Effects of Fish Oil and Red Wine on Oxidative Stress Biomarkers
Active, not recruiting·—·N/A·NCT00682318·40 enrolled
Effect of Melatonin on Oxidative Stress Parameters in Levodopa-Treated Parkinson's Disease Patients
Enrolling by invitation·—·Phase 2·NCT07375693·70 enrolled
Effects of Magnesium Supplementation and Spinning Training on Cardiac Function, Oxidative Stress, Inflammation, and Aerobic Capacity
Enrolling by invitation·KKaramanoğlu Mehmetbey University·Preclinical·NCT07662954·48 enrolled
Effect of Replacement Volume of Haemodiafiltration and AST-120 on Toxins, Oxidative Stress and MicroInflammation
Completed·TTungs' Taichung Metroharbour Hospital·Phase 4·NCT01458652·30 enrolled
Exposure of Salvaged Blood to Inflammation and Oxidative Stress: the Effect of Different Anticoagulant Regimes (HECICS)
Completed·—·N/A·NCT02674906·75 enrolled
Oxidative Stress and Hemodialysis Access Failure
Completed·National Institute of Environmental Health Sciences (NIEHS)·N/A·NCT00410449·35 enrolled
The Effect of Januvia (Sitagliptin) on Oxidative Stress in Obese Type 2 Diabetic Subjects
Completed·UUniversity at Buffalo·N/A·NCT00659711·22 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)