VivoSeq
Psychiatry

Autism

89

Pipeline Programs↗

30

Active Trials↗

46

Companies Involved↗

Autism is a moderately active landscape with 89 programs across 46 companies. The most active players are Bristol-Myers Squibb, COMPASS Pathways, Eastern Cooperative Oncology Group. 18 therapies are approved with 15 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

70/100

Pipeline Velocity

30/100

Mech. Concentration

7/100

Completion Rate

89/100

Attrition Rate

7/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Bristol-Myers Squibb logo

Bristol-Myers Squibb

1 program

Phase 1COMPASS Pathways logo

COMPASS Pathways

1 program

Phase 1E

Eastern Cooperative Oncology Group

2 programs

Phase 2Y

Yamo Pharmaceuticals LLC

1 program

Phase 2P

PediaMed Pharmaceuticals

1 program

Phase 2T

Translational Biosciences

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical11

Lidocaine Hydrochloride

Citius Pharmaceuticals, Inc.

Oxcarbazepine

Novartis

Melatonin

Neurim Pharmaceuticals Ltd.

Metformin

EMD Serono

Propranolol

Wyeth-Lederle Vaccines

Phase 18

Buspirone

Bristol-Myers Squibb

Acamprosate

Forest Laboratories

Psilocybin

COMPASS Pathways

Allorx

The Foundation for Orthopaedics and Regenerative Medicine

Nicotine

Pfizer

Phase 237

Memantine

AbbVie

Dextromethorphan

Pfizer

Divalproex Sodium

Teva

Donepezil Hydrochloride

Eisai

Sulforaphane

Eastern Cooperative Oncology Group

Phase 315

Galantamine

Wim Janssens

Fluvoxamine

Solvay Pharmaceuticals

Oxytocin

Retrophin

Fluoxetine

Vitae Pharmaceuticals Inc., an Allergan affiliate

Lurasidone

Sunovion Respiratory Development Inc.

Approved18

Risperidone

Wim Janssens

Baclofen

Novartis

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Aripiprazole

Otsuka

Acetylcysteine

Arbor Pharmaceuticals, Inc.

Analysis

Modality Breakdown

94%

Small molecule

99 of 105 classified programs — the dominant modality here.

6%ALL OTHERSCell therapy66%

Small molecule leads; the ring shows all 105 classified programs, each share of the total. Modality classified for 100% of 110 pipeline programs.

Analysis

Trial Status

136

clinical trials

Completed90 · 66%
Recruiting18 · 13%
Active, not recruiting7 · 5%
Unknown status5 · 4%
Withdrawn5 · 4%
Terminated5 · 4%
Other6 · 4%

Clinical Trials

Trial Activity

136 trials

The TEAM Study - Treatment Efficacy for Autism/Attention Using Mixed Amphetamine
Recruiting·—·Phase 4·NCT06853665·196 enrolled
Trial of Zolpidem for Sleep in Children With Autism
Recruiting·SStanford University·Phase 2·NCT05540574·26 enrolled
Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Single-dose
Recruiting·SStanford University·Phase 2·NCT04278898·24 enrolled
Allogeneic Wharton Jelly Mesenchymal Stromal Cell (WJMSC) for Treatment of Autism
Recruiting·UUniversity of Jordan·Phase 1·NCT06293950·14 enrolled
Psilocybin for Treatment-Resistant Depression in Autism
Recruiting·CCentre for Addiction and Mental Health·Phase 1·NCT06731621·20 enrolled
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intravenous Infusion for Autism
Recruiting·TThe Foundation for Orthopaedics and Regenerative Medicine·Phase 1·NCT05003960·15 enrolled
Treatment of Social and Language Deficits With Leucovorin for Young Children With Autism
Recruiting·SSouthwest Autism Research & Resource Center·Phase 2·NCT04060030·80 enrolled
Role of Bumetanide in Treatment of Autism
Recruiting·—·Phase 3·NCT04766177·80 enrolled
Placebo-Controlled Study of Terpenes-Enriched Cannabis Oil T1/C28 for Children With Autism
Recruiting·BBazelet Nehushtan LtD.·Phase 2·NCT07199218·78 enrolled
Trial of Suvorexant for Sleep in Children With Autism
Recruiting·SStanford University·Phase 2·NCT05546554·26 enrolled
Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Trial
Recruiting·SStanford University·Phase 2/3·NCT05664789·144 enrolled
Trial of Diphenhydramine for Sleep in Children With Autism
Recruiting·SStanford University·Phase 2·NCT05501678·26 enrolled
Prospective Clinical Study on Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Childhood Autism
Recruiting·—·Phase 1/2·NCT07243561·40 enrolled
Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism
Recruiting·—·Phase 2·NCT07091279·60 enrolled
A Transdiagnostic Toolkit to Improve Mental Health Treatment for Autistic Individuals
Recruiting·FFlorida International University·Preclinical·NCT07539519·18 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)