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Intron A

(interferon)

Phase 3Small molecule

Interferon is used to treat certain viral infections like hepatitis C and some cancers by helping the immune system fight disease. It can also be used for multiple sclerosis to reduce the frequency of relapses.[1] Intron A is currently being investigated across 9 indications[3], with its most advanced program in Phase 3.[1]

Intron A is one of 180 small molecule programs targeting Chronic Hepatitis B Virus Infection. It is currently in Phase 3.

9

Indications

25

Total Trials

4

Active Trials

179

Competitors

Pipeline

Status by Indication[3][1]

Indication

Chronic Hepatitis B Virus InfectionActive, not recruiting

Hepatitis B Virus InfectionActive, not recruiting

Human Papilloma Virus InfectionActive, not recruiting

Eye InfectionUnknown

Chronic HepatitisActive, not recruiting

Locally Advanced Esophageal Squamous Cell CarcinomaRecruiting

ImmunotherapyNot yet recruiting

Acute Myeloid LeukemiaRecruiting

HBV InfectionNot yet recruiting

Chronic Hepatitis B Virus InfectionPreclinical

Active, not recruiting

Hepatitis B Virus InfectionPreclinical

Active, not recruiting

Human Papilloma Virus InfectionPreclinical

Active, not recruiting

Eye InfectionPreclinical

Unknown

Chronic HepatitisPreclinical

Active, not recruiting

Locally Advanced Esophageal Squamous Cell CarcinomaPhase 2

Recruiting

ImmunotherapyPhase 1

Not yet recruiting

Acute Myeloid LeukemiaPhase 3

Recruiting

HBV InfectionPhase 3

Not yet recruiting

Competition

Competitive Landscape

255 competitors in Acute Myeloid Leukemia

#DrugCompanyPhaseTrials

Idamycin

Novantrone

Xospata

Cerubidine

EEastern Cooperative Oncology Group

Mylotarg

WWyeth-Lederle Vaccines

Neupogen

EEastern Cooperative Oncology Group

Cerubidine

HHikma Pharmaceuticals LLC

Cellcept

Busulfex

Akero Therapeutics

Trexall

Jazz Pharmaceuticals

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Post-ApprovalNot yet recruiting

HBV Infection

NCT06503796

Phase 3Recruiting

Acute Myeloid Leukemia

NCT06802718

Q4 2028

Phase 2Recruiting

Locally Advanced Esophageal Squamous Cell Carcinoma

NCT07787273

Q2 2029

Phase 1Not yet recruiting

Immunotherapy

NCT07199413

Clinical

Trials by Indication[1]

Chronic Hepatitis7 trials

The Curative Effect and Security of Interferon Combined Resveratrol on HBeAg Positive Chronic Hepatitis B Patients

Completed·TThe First Hospital of Jilin University·N/A·NCT03546530·228 enrolled

An Observational Cohort Study of Clinical Outcomes After Antiviral Treatment of Chronic Hepatitis C

Unknown status·—··NCT04301882·1,000 enrolled

Observational Cohort Study of Clinical Outcomes After Antiviral Therapy for Chronic Hepatitis C

Unknown status·—··NCT04071353·1,000 enrolled

Show 4 more trials

Study of COVID-19 Infection and Its Clinical Prognosis in Chronic Hepatitis B Patients With Antiviral Therapy

Unknown status·—··NCT05792878·600 enrolled

A Cohort Study on Long-term Clinical Outcomes of Antiviral Therapy in Patients With Chronic Hepatitis B and Cirrhosis

Unknown status·—··NCT04301908·10,000 enrolled

Cohort Study of Efficacy and Safety of Interferon Intermittent Treatment of Chronic Hepatitis B

Completed·—··NCT04028856·400 enrolled

Early Response to Interferon Combined Short-Term Nucleoside Analogue Therapy in HBeAg(+) Chronic Hepatitis B

Unknown status·SSun Yat-sen University·N/A·NCT00860626·50 enrolled

Multiple Sclerosis2 trials

Characteristic Study on Chinese Patients With Multiple Sclerosis

Unknown status·SSun Yat-sen University·N/A·NCT00818103·600 enrolled

Phase II Study of Teriflunomide as Adjunctive Therapy to Interferon-beta in Subjects With Multiple Sclerosis

Completed· Sanofi logo

Sanofi·Phase 2·NCT00489489·118 enrolled

Chronic Lymphocytic Leukemia1 trial

Reactogenicity, Immunogenicity of Trivalent Influenza Vaccine With Recombinant Interferon Alpha Among Chronic Lymphocytic Leukemia

Withdrawn·MM.D. Anderson Cancer Center·Phase 1/2·NCT00962715

Metastatic Melanoma1 trial

IPI-Biotherapy for Patients Previously Treated With Cytotoxic Drugs With Metastatic Melanoma

Withdrawn·MM.D. Anderson Cancer Center·Phase 1/2·NCT01409187

Acute Lymphoblastic Leukemia1 trial

Imatinib Mesylate With Vincristine and Dexamethasone in Acute Lymphoblastic Leukemias With BCR-ABL Positive

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 2·NCT00763763·55 enrolled

13 more indications

Melanoma1 trial

A Phase II Study of Imatinib Versus Interferon as Adjuvant Therapy in KIT-mutated Melanoma

Unknown status·PPeking University Cancer Hospital & Institute·Phase 2·NCT01782508·40 enrolled

Renal Cell Carcinoma1 trial

BAY43-9006 (Sorafenib) Versus Interferon Alpha-2a in Patients With Unresectable and/or Metastatic Renal Cell Carcinoma

Completed· Bayer logo

Bayer·Phase 2·NCT00117637·189 enrolled

Acute Myeloid Leukemia1 trial

Interferon-alpha As Maintenance Therapy for Favorable-risk Acute Myeloid Leukemia

Recruiting·PPeking University People's Hospital·Phase 3·NCT06802718·96 enrolled

HBV Infection1 trial

Antiviral Therapy in Infants With HBV Infection

Not yet recruiting·—·Phase 4·NCT06503796·60 enrolled

Immunotherapy1 trial

Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and Immunotherapy: A Phase I Pilot Safety and Feasibility Study for Solid Tumor Patients With CNS Metastases

Not yet recruiting·MMedical College of Wisconsin·Phase 1·NCT07199413·20 enrolled

Granuloma1 trial

Treatment and Natural History Study of Lymphomatoid Granulomatosis

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00001379·94 enrolled

Monotherapy1 trial

Glivec® (Imatinib Mesylate, STI571) in Monotherapy Versus Glivec®-Interferon Alpha in the Treatment of Chronic-Phase Chronic Myeloid Leukaemia

Completed·PPETHEMA Foundation·Phase 4·NCT00390897·360 enrolled

Chronic HBV Infection1 trial

Cohort Study of Clinical Outcomes in Chronic HBV Infection Patients With Low HBsAg Under Unplanned Intervention

Unknown status·—··NCT04030039·420 enrolled

Zollinger-Ellison Syndrome1 trial

Interferon and Octreotide to Treat Zollinger-Ellison Syndrome and Advanced Non-B Islet Cell Cancer

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT00001228·50 enrolled

HCV1 trial

Safety Study of Recombinant Interferon Variant(PEG-IFN-SA) to Treat HCV Disease

Completed·TThe First Hospital of Jilin University·Phase 1/2·NCT01605513·80 enrolled

Interstitial Cystitis1 trial

Assessing the Effectiveness and Safety of Interferon Bladder Infusion for the Treatment of Interstitial Cystitis

Unknown status·WWest China Hospital·Phase 2/3·NCT05912946·129 enrolled

Lymphoma1 trial

Fludarabine, Mitoxantrone, and Dexamethasone (FND) Plus Rituximab for Lymphoma Patients

Completed·MM.D. Anderson Cancer Center·Phase 3·NCT00577993·210 enrolled

Locally Advanced Esophageal Squamous Cell Carcinoma1 trial

Study of Efficacy and Safety of Interferon Gamma Combined With Camrelizumab for Neoadjuvant Therapy in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma

Recruiting·HHefei Cancer Hospital of the Chinese Academy of Sciences·Phase 2·NCT07787273·84 enrolled

Sources

References

[1]
ClinicalTrials.gov — 25 trial records for interferon. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — interferon compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for interferon. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Sanofi company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: Sanofi

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