Neupogen

(filgrastim)

ApprovedProtein / enzyme

Filgrastim is used to help the body produce more white blood cells, which fight infections. It's commonly given to cancer patients undergoing chemotherapy whose immune systems are weakened.[2] Neupogen is currently approved and in use across 156 indications[4].[1]

Neupogen is one of 2420 biologic programs targeting Glioma. It is currently in Approved.

156

Indications

819

Total Trials

Active Trials

2,419

Competitors

Pipeline

Status by Indication[4][1]

Indication

GliomaActive, not recruiting

Coronary Artery DiseaseActive, not recruiting

EpendymomaActive, not recruiting

FibrosarcomaActive, not recruiting

HIV InfectionUnknown

Systemic Lupus ErythematosusActive, not recruiting

Hepatic FailureActive, not recruiting

Cirrhosis of LiverActive, not recruiting

Non-Hodgkins LymphomaActive, not recruiting

Uterine LeiomyosarcomaActive, not recruiting

GliomaPhase 1/Phase 2

Active, not recruiting

Coronary Artery DiseasePhase 1

Active, not recruiting

EpendymomaPhase 3

Active, not recruiting

FibrosarcomaPhase 2

Active, not recruiting

HIV InfectionPreclinical

Unknown

Systemic Lupus ErythematosusPhase 1

Active, not recruiting

Hepatic FailurePhase 3

Active, not recruiting

Cirrhosis of LiverPhase 3

Active, not recruiting

Non-Hodgkins LymphomaPhase 3

Active, not recruiting

Uterine LeiomyosarcomaPhase 3

Active, not recruiting

Showing 10 of 155 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Neupogen

EEastern Cooperative Oncology Group

Approved

71 2

Tykerb

GSK

Preclinical

80 3

Avastin

BBio-Thera Solutions

Preclinical

153 4

Nolvadex

SSan Diego Pacific Oncology & Hematology Associates

Preclinical

78 5

Prolia

Amgen

Preclinical

14 6

Blenoxane

Bristol-Myers Squibb

Preclinical

1 7

Lexiscan

Astellas

Preclinical

1 8

Adenocard

Astellas

Preclinical

1 9

Voltaren

Novartis

Preclinical

1 10

Lupron

EEastern Cooperative Oncology Group

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1Active, not recruiting

Lymphoma

NCT02337985

Q3 2027

Phase 2Not yet recruiting

Neutropenia

NCT06926751

Phase 3Active, not recruiting

Acute Lymphoblastic Leukemia

NCT03007147

Q4 2027

Phase 2Active, not recruiting

Sickle Cell Disease

NCT02105766

Q2 2028

Phase 2Active, not recruiting

Lymphoma

NCT01920932

Phase 1/2Recruiting

Peripheral Blood Stem Cell Transplantation

NCT05436418

Clinical

Trials by Indication[1]

Lymphoma23 trials

Yttrium Y 90 Ibritumomab Tiuxetan, Etoposide, Cyclophosphamide, and an AHSCT in Non-Hodgkin's Lymphoma Patients

Completed·—·Phase 1/2·NCT00562978·54 enrolled

Combination Chemotherapy Plus Rituximab in Treating Patients With Intermediate-Grade or High-Grade Non-Hodgkin's Lymphoma

Unknown status· Amgen logo

Amgen·Phase 2·NCT00005959

S0816 Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy With or Without Additional Chemotherapy and G-CSF in Treating Patients With Stage III or Stage IV Hodgkin Lymphoma

Completed·SSWOG Cancer Research Network·Phase 2·NCT00822120·371 enrolled

Show 20 more trials

Combination Chemotherapy Plus Filgrastim With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma

Unknown status·CCommissie Voor Klinisch Toegepast Onderzoek·Phase 3·NCT00028717·400 enrolled

Gene Therapy and Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma

Active, not recruiting·—·Phase 1·NCT02337985·10 enrolled

Combination Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Lymphoma

Completed·CChildren's Oncology Group·Phase 3·NCT00302003·287 enrolled

DX-8951f in Treating Children With Advanced Solid Tumors or Lymphomas

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 1·NCT00004212

Adcetris (Brentuximab Vedotin), Combination Chemotherapy, and Radiation Therapy in Treating Younger Patients With Stage IIB, IIIB and IV Hodgkin Lymphoma

Active, not recruiting·SSt. Jude Children's Research Hospital·Phase 2·NCT01920932·77 enrolled

Rituximab and Cyclophosphamide Followed by Vaccine Therapy in Treating Patients With Relapsed Hodgkin Lymphoma

Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 1/2·NCT00134082·31 enrolled

Methotrexate, Cyclophosphamide, and Etoposide Phosphate Given With Osmotic Blood-Brain Barrier Disruption Plus Dexamethasone and Cytarabine in Treating Patients With Primary CNS Lymphoma

Completed·OOHSU Knight Cancer Institute·Phase 2·NCT00074178·22 enrolled

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Older Patients With Refractory or Relapsed Intermediate-Grade Non-Hodgkin's Lymphoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00002982

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Aggressive Non-Hodgkin's Lymphoma

Completed·SSwiss Cancer Institute·Phase 3·NCT00003215·400 enrolled

Filgrastim and Chemotherapy Followed by Peripheral Stem Cell Transplant in Treating Patients With Hodgkin's Lymphoma or Non-Hodgkin's Lymphoma

Completed·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00005985·213 enrolled

Plerixafor Plus Granulocyte Colony-Stimulating Factor For Mobilization And Collection Of Peripheral Hematopoietic Stem Cells In Japanese Participants With Non-Hodgkin Lymphoma

Completed· Sanofi logo

Sanofi·Phase 2·NCT02221492·32 enrolled

Combination Chemotherapy in Treating Pediatric Patients With Advanced-Stage Large Cell Lymphoma

Completed·CChildren's Oncology Group·Phase 3·NCT00002618·242 enrolled

Bortezomib, Ifosfamide, and Vinorelbine Tartrate in Treating Young Patients With Hodgkin's Lymphoma That is Recurrent or Did Not Respond to Previous Therapy

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00381940·26 enrolled

Rituximab and Combination Chemotherapy Combined With Yttrium Y 90 Ibritumomab Tiuxetan in Treating Older Patients With Previously Untreated B-Cell Lymphoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00058422·65 enrolled

Chemotherapy Plus Interferon Alfa Alone or With Radiation Therapy and Peripheral Stem Cell Transplantation in Treating Patients With Stage III or Stage IV Follicular Non-Hodgkin's Lymphoma

Terminated·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00003152·469 enrolled

Etoposide, Filgrastim, and Plerixafor in Improving Stem Cell Mobilization in Treating Patients With Non-Hodgkin Lymphoma

Terminated·—·N/A·NCT01408043·25 enrolled

Interleukin-12 Following Chemotherapy in Treating Patients With Refractory HIV-Associated Non-Hodgkin's Lymphoma

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00003575·40 enrolled

Rituximab and Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With B-Cell Non-Hodgkin's Lymphoma

Completed·UUnknown Sponsor·Phase 3·NCT00278408·700 enrolled

Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00002524·46 enrolled

Treatment for Subjects With Non-Hodgkin's Lymphoma

Completed· Amgen logo

Amgen·Phase 2·NCT00117897

Breast Cancer19 trials

Biological Therapies Following Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Advanced Breast Cancer

Terminated·MMasonic Cancer Center, University of Minnesota·Phase 1·NCT00005993

High-Dose Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT00002837·21 enrolled

A Non-inferiority Study Comparing Two Filgrastim Preparations in Breast Cancer

Completed·EEurofarma Laboratorios S.A.·Phase 3·NCT01079676·220 enrolled

Show 16 more trials

Chemotherapy Followed by Surgery in Treating Women With Stage II or Stage III Breast Cancer

Completed·—·Phase 2·NCT00003953·39 enrolled

Oblimersen Plus Doxorubicin and Docetaxel in Treating Patients With Metastatic or Locally Advanced Breast Cancer

Terminated·NNational Cancer Institute (NCI)·Phase 1/2·NCT00063934·31 enrolled

Study of the Efficacy and Safety of Empegfilgrastim for Neutropenia Prophylaxis in Breast Cancer Patients

Completed·BBiocad·Phase 3·NCT02104830·135 enrolled

Biomarker (p53 Gene) Analysis and Combination Chemotherapy Followed by Radiation Therapy and Surgery in Treating Women With Large Operable or Locally Advanced or Inflammatory Breast Cancer

Completed·EEuropean Organisation for Research and Treatment of Cancer - EORTC·Phase 3·NCT00017095·1,856 enrolled

Chemotherapy and Stem Cell Transplantation in Treating Patients With Stage IIIB Breast Cancer

Completed·—·Phase 2·NCT00003042·41 enrolled

Radioimmunotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Stage IV Breast Cancer

Completed·—·Phase 1/2·NCT00004085·15 enrolled

A Study to Investigate Atezolizumab and Chemotherapy Compared With Placebo and Chemotherapy in the Neoadjuvant Setting in Participants With Early Stage Triple Negative Breast Cancer

Completed· Roche logo

Roche·Phase 3·NCT03197935·333 enrolled

Vaccine and Chemotherapy for Previously Untreated Metastatic Breast Cancer

Terminated·NNational Cancer Institute (NCI)·Phase 1/2·NCT00048893·37 enrolled

Doxorubicin and Paclitaxel in Treating Women With Locally Advanced Breast Cancer

Completed·GGeorgetown University·Phase 2·NCT00003035·40 enrolled

Chemotherapy, Filgrastim, and Stem Cell Transplantation With Radiation Therapy in Treating Patients With Stage III or Stage IV Breast Cancer

Completed·NNorthwestern University·Phase 2·NCT00004172

Tipifarnib, Doxorubicin, and Cyclophosphamide in Treating Women With Locally Advanced Breast Cancer

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00049114·62 enrolled

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Women With Metastatic Breast Cancer

Completed·HHackensack Meridian Health·Phase 2·NCT00004900

Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer

Unknown status·AAnglo Celtic Cooperative Oncology Group·Phase 4·NCT00030758·816 enrolled

Taxotere Plus Weekly Navelbine and G-CSF: A Study in Stage IV Breast Cancer

Completed·UUniversity of Washington·Phase 2·NCT00194740·48 enrolled

AZD2171 and Combination Chemotherapy in Treating Women With Locally Advanced Breast Cancer

Completed·NNational Cancer Institute (NCI)·N/A·NCT00310089·33 enrolled

High Dose Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Standard Therapy in Treating Women With Locally Recurrent or Metastatic Breast Cancer

Completed·UUNICANCER·Phase 3·NCT00002870·180 enrolled

Multiple Myeloma10 trials

Bendamustine Hydrochloride, Etoposide, Dexamethasone, and Filgrastim For Peripheral Blood Stem Cell Mobilization in Treating Patients With Refractory or Recurrent Lymphoma or Multiple Myeloma

Completed·UUniversity of Washington·Phase 2·NCT01110135·43 enrolled

S0204 Thalidomide, Chemotherapy, and Peripheral Stem Cell Transplant in Treating Patients With Multiple Myeloma

Completed·SSWOG Cancer Research Network·Phase 2·NCT00040937·147 enrolled

TMI With HD Mel in ASCT for R/R Multiple Myeloma (BMT-03)

Completed·UUniversity of Illinois at Chicago·Phase 1·NCT02043847·12 enrolled

Show 7 more trials

Filgrastim With or Without Plerixafor in Treating Patients With Multiple Myeloma Previously Treated With Lenalidomide

Terminated·—·Phase 3·NCT01301963·9 enrolled

High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Newly Diagnosed Stage I, Stage II, or Stage III Multiple Myeloma

Unknown status·EErasme University Hospital·Phase 2·NCT00526734·100 enrolled

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma

Unknown status·—·Phase 2·NCT00004903

High-Dose Melphalan, Total-Body Irradiation, and Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma in First Relapse

Completed·MMayo Clinic·Phase 2·NCT00002630·50 enrolled

Desipramine Hydrochloride and Filgrastim For Stem Cell Mobilization in Patients With Multiple Myeloma Undergoing Stem Cell Transplant

Terminated·—·N/A·NCT01899326·10 enrolled

Non-inferiority Study of XM02 Filgrastim (Granix) and Filgrastim (Neupogen) in Combination With Plerixafor for Autologous Stem Cell Mobilization in Patients With Multiple Myeloma or Non-Hodgkin Lymphoma

Completed·WWashington University School of Medicine·Phase 2·NCT02098109·100 enrolled

First Line Treatment Trial in Multiple Myeloma, Finnish Myeloma Group- Multiple Myeloma 02

Completed·KKuopio University Hospital·Phase 2·NCT01790737·80 enrolled

Stem Cell Transplantation9 trials

Allogeneic Blood Stem Cell Transplantation and Adoptive Immunotherapy for Hodgkin's Disease

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00385788·52 enrolled

High-Dose Topotecan and Peripheral Stem Cell Transplantation in Treating Patients With Refractory Cancer

Terminated·YYale University·Phase 1·NCT00002948

Stem Cell Transplantation in Treating Patients With Hematologic Cancer

Completed·NNorthwestern University·Phase 1·NCT00004904

Show 6 more trials

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Hematologic Cancer

Withdrawn·JJonsson Comprehensive Cancer Center·Phase 1·NCT00004114

Radiolabeled Monoclonal Antibody, Combination Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory B-Cell Cancer

Unknown status·—·Phase 1·NCT00004086

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Sarcoma

Completed·—·Phase 2·NCT00002601·13 enrolled

Chemotherapy Plus Donor White Blood Cell Infusion in Treating Patients With Relapsed Hematologic Cancer Following Donor Peripheral Stem Cell Transplantation

Completed·UUniversity of Maryland, Baltimore·Phase 1·NCT00005946

Lymphocyte Reconstitution After Administration of Pegfilgrastim Versus Filgrastim After Peripheral Stem Cell Transplantation

Terminated·CCentre Leon Berard·N/A·NCT01541072·34 enrolled

Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Withdrawn·NNYU Langone Health·Phase 2·NCT00003273

Bone Marrow Transplantation7 trials

Trial of Filgrastim Versus Placebo Following Allogeneic Bone Marrow Transplantation

Unknown status·CCentre National de Greffe de Moelle Osseuse·Phase 3·NCT00207792·160 enrolled

Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy

Terminated·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00303719·342 enrolled

Bone Marrow Transplantation in Treating Patients With Hematologic Cancer

Completed·UUniversity of Maryland, Baltimore·Phase 4·NCT00003398·45 enrolled

Show 4 more trials

Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer

Completed·NNYU Langone Health·Phase 1·NCT00025558

Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Refractory Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Multiple Myeloma

Completed·BBarbara Ann Karmanos Cancer Institute·Phase 2·NCT00002552·40 enrolled

Chemotherapy Plus Bone Marrow Transplantation and Filgrastim in Treating Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

Completed·NNorthwestern University·Phase 2·NCT00004899

Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia

Unknown status·MMedical Research Council·Phase 3·NCT00002658·2,000 enrolled

85 more indications

Acute Myeloid Leukemia6 trials

Wee1 Kinase Inhibitor AZD1775 and Combination Chemotherapy in Treating Children, Adolescents and Young Adults With Relapsed or Refractory Acute Myeloid Leukemia

Withdrawn·NNational Cancer Institute (NCI)·Phase 1·NCT02791919

Clofarabine, Cytarabine, and G-CSF in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Completed·UUniversity of Washington·Phase 1/2·NCT00602225·50 enrolled

Daunorubicin & Cytarabine +/- Zosuquidar inTreating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or Refractory Anemia

Completed·EEastern Cooperative Oncology Group·Phase 3·NCT00046930·449 enrolled

Show 3 more trials

Busulfan, Fludarabine, Clofarabine With Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT00469014·72 enrolled

Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

Completed·TThe Cleveland Clinic·Phase 2·NCT00274807·40 enrolled

High Dose Chemotherapy, Peripheral Stem Cell Transplantation, and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia

Completed·RRoswell Park Cancer Institute·Phase 3·NCT00002945·61 enrolled

Neuroblastoma5 trials

Combination Chemotherapy in Treating Children With Neuroblastoma

Completed·CChildren's Oncology Group·Phase 3·NCT00003093·573 enrolled

Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

Completed·CChildren's Oncology Group·Phase 1·NCT01798004·150 enrolled

Multiple Therapies in Treating Patients With Advanced Neuroblastoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00040872

Show 2 more trials

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Neuroblastoma

Completed·CChildren's Oncology Group·Phase 2·NCT00017368·42 enrolled

Chemotherapy and Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma

Completed·GGerman Society for Pediatric Oncology and Hematology GPOH gGmbH·Phase 2·NCT00017225

Acute Lymphoblastic Leukemia5 trials

Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 2·NCT00002756·221 enrolled

Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Active, not recruiting·CChildren's Oncology Group·Phase 3·NCT03007147·475 enrolled

Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·N/A·NCT00049569·126 enrolled

Show 2 more trials

Combination Chemotherapy in Treating Children With Stage III or Stage IV Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 1·NCT00003217·20 enrolled

Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia

Completed·NNational Cancer Institute (NCI)·Phase 1/2·NCT00061945·302 enrolled

Primary Systemic Amyloidosis4 trials

S0115, High-Dose Melphalan and Autologous Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma or Primary Systemic Amyloidosis

Completed·SSWOG Cancer Research Network·Phase 2·NCT00064337·104 enrolled

Low-Dose Melphalan and Dexamethasone Compared With High-Dose Melphalan Followed By Autologous Stem Cell Transplant in Treating Patients With Primary Systemic Amyloidosis

Completed·MMayo Clinic·Phase 3·NCT00477971·89 enrolled

Melphalan, Thalidomide, and Dexamethasone in Treating Patients With Newly Diagnosed, Previously Untreated Primary Systemic Amyloidosis

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00089167

Show 1 more trial

Melphalan, Bortezomib, and Stem Cell Transplant in Treating Patients With Primary Systemic Amyloidosis

Completed·—·Phase 2·NCT00790647·10 enrolled

Chronic Lymphocytic Leukemia4 trials

Alemtuzumab Plus Peripheral Stem Cell Transplantation in Treating Patients With Chronic Lymphocytic Leukemia

Completed·EEastern Cooperative Oncology Group·Phase 2·NCT00006390

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Chronic Lymphocytic Leukemia

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT00002838·13 enrolled

Pentostatin, Cyclophosphamide, Rituximab, and Mitoxantrone in Treating Patients With Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Cancer

Completed·MMemorial Sloan Kettering Cancer Center·Phase 1/2·NCT00546377·50 enrolled

Show 1 more trial

Fludarabine and Cyclophosphamide With or Without Oblimersen in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia

Completed·GGenta Incorporated·Phase 3·NCT00024440

Chronic Myelogenous Leukemia4 trials

Chemotherapy in Treating Patients With Newly Diagnosed Acute or Chronic Myelogenous Leukemia or Myelodysplastic Syndrome

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00002800·60 enrolled

Chemotherapy and Bone Marrow Transplantation in Treating Patients With Chronic Myelogenous Leukemia

Completed·—·Phase 2·NCT00002592·40 enrolled

Chemotherapy and Peripheral Stem Cell Transplantation Followed by Immunotherapy in Treating Patients With Chronic Myelogenous Leukemia

Completed·UUniversity of Maryland, Baltimore·Phase 2·NCT00003727·22 enrolled

Show 1 more trial

Combination Chemotherapy in Treating Patients With Chronic Myelogenous Leukemia or Recurrent Acute Leukemia

Completed·MMayo Clinic·Phase 1·NCT00002693

Metastatic Melanoma3 trials

Vaccine Therapy in Treating Patients With Metastatic Melanoma

Completed·BBaylor Health Care System·Phase 1·NCT00003792

Cyclophosphamide and Fludarabine Followed by Vaccine Therapy, Gene-Modified White Blood Cell Infusions, and Aldesleukin in Treating Patients With Metastatic Melanoma

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 1·NCT00091104·136 enrolled

Cyclophosphamide and Fludarabine Followed By an Autologous Lymphocyte Infusion and Interleukin-2 in Treating Patients With Refractory or Recurrent Metastatic Melanoma

Terminated·NNational Institutes of Health Clinical Center (CC)·Phase 2·NCT00138229·6 enrolled

G-CSF3 trials

Plerixafor and Granulocyte Colony-stimulating Factor (G-CSF) With Busulfan, Fludarabine and Thymoglobulin

Completed·MM.D. Anderson Cancer Center·Phase 1/2·NCT00822770·47 enrolled

Evaluation of Pharmacokinetic and Pharmacodynamic Parameters of Filgrastim (G-CSF)Produced by Blausiegel Indústria e Comércio Ltda. Compared to Granulokine Produced by Produtos Roche Químicos e Farmacêuticos S/A.

Completed·AAzidus Brasil·Phase 1·NCT01549301·128 enrolled

Pharmacokinetic/Pharmacodynamic (PK/PD) Study Evaluating DA-3031 (PEG-G-CSF) to Filgrastim (Dong-A) in Healthy Volunteers

Completed·DDong-A ST Co., Ltd.·Phase 1·NCT00959777

Germ Cell Tumor3 trials

Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin

Completed·MMemorial Sloan Kettering Cancer Center·Phase 1/2·NCT00423852·26 enrolled

Combination Chemotherapy in Treating Children With Newly Diagnosed Malignant Germ Cell Tumors

Completed·CChildren's Oncology Group·N/A·NCT00066482·19 enrolled

Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors

Completed·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00432094·23 enrolled

Leukemia3 trials

T2007-002 Clofarabine, Etoposide, Cyclophosphamide in Relapsed Acute Myelogenous Leukemia (AML)

Terminated·TTherapeutic Advances in Childhood Leukemia Consortium·Phase 2·NCT00939653·6 enrolled

Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00005977·83 enrolled

Cyclophosphamide and Filgrastim Followed By SCT in Patients With Chronic or Accelerated Phase Myelogenous Leukemia

Terminated·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00005984·22 enrolled

Chemotherapy3 trials

Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor

Completed·CChildren's Oncology Group·Phase 3·NCT00304070·78 enrolled

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

Recruiting·CC17 Council·Phase 1·NCT06942039·15 enrolled

Chemotherapy and Monoclonal Antibody Therapy in Treating Patients With Advanced Myeloid Cancer

Completed·MMemorial Sloan Kettering Cancer Center·Phase 1/2·NCT00014495·32 enrolled

Endometrial Cancer3 trials

Doxorubicin Hydrochloride, Cisplatin, and Paclitaxel or Carboplatin and Paclitaxel in Treating Patients With Stage III-IV or Recurrent Endometrial Cancer

Completed·GGOG Foundation·Phase 3·NCT00063999·1,381 enrolled

Combination Chemotherapy With or Without G-CSF in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer

Completed·GGynecologic Oncology Group·Phase 3·NCT00003691·240 enrolled

Combination Chemotherapy Compared With Hormone Therapy in Treating Patients With Recurrent, Stage III, or Stage IV Endometrial Cancer

Terminated·GGynecologic Oncology Group·Phase 3·NCT00016341

Mantle Cell Lymphoma3 trials

S0213 Chemotherapy Plus Rituximab in Treating Patients With Mantle Cell Lymphoma

Completed·SSWOG Cancer Research Network·Phase 2·NCT00041132·56 enrolled

Rituximab, Cladribine, and Temsirolimus in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma

Completed·AAlliance for Clinical Trials in Oncology·Phase 1·NCT00787969·74 enrolled

Combination Chemotherapy and Rituximab in Treating Patients With Untreated Mantle Cell Lymphoma

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00433537·77 enrolled

Stem Cell Transplant3 trials

Donor Stem Cell Transplant Followed By Donor White Blood Cell Infusions in Treating Young Patients With Hematologic Cancer

Terminated·UUniversity of California, San Francisco·N/A·NCT00301860·8 enrolled

Donor Stem Cell Transplant With No or Low-Intensity Chemotherapy Using Sirolimus and Treated Immune Cells to Treat Blood and Lymph Cancers

Terminated·NNational Cancer Institute (NCI)·Phase 2·NCT00074490·442 enrolled

Cyclophosphamide and/or Mycophenolate Mofetil With or Without Tacrolimus in Treating Patients Who Are Undergoing a Donor Bone Marrow or Peripheral Stem Cell Transplant for Hematologic Cancer

Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 1·NCT00255710·60 enrolled

Kidney Cancer2 trials

Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney Cancer

Completed·CChildren's Oncology Group·Phase 3·NCT00002611·3,031 enrolled

Combination Chemotherapy in Treating Patients With Advanced Bladder or Kidney Cancer

Completed·MMemorial Sloan Kettering Cancer Center·Phase 1·NCT00003342·30 enrolled

Hodgkin's Disease2 trials

Combination Chemotherapy With or Without Dexrazoxane in Treating Children With Hodgkin's Disease

Completed·CChildren's Oncology Group·Phase 3·NCT00005578·219 enrolled

Combination Chemotherapy and Radiation Therapy in Treating Children With Previously Untreated Stage II, Stage III, or Stage IV Hodgkin's Disease

Completed·CChildren's Oncology Group·Phase 2·NCT00004010·99 enrolled

Small Cell Lung Cancer2 trials

Topotecan, Paclitaxel, and Filgrastim in Treating Patients With Previously Untreated Extensive-Stage Small Cell Lung Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00004055·38 enrolled

Combination Chemotherapy and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 2·NCT00033696·65 enrolled

Neutropenia2 trials

Telpegfilgrastim vs Filgrastim for Secondary Prevention of Chemotherapy-Induced Neutropenia in Pediatric Solid Tumors

Not yet recruiting·—·Phase 2·NCT06926751·132 enrolled

G-CSF in Preventing Neutropenia in Patients With Solid Tumors Who Are Receiving Chemotherapy

Completed·CCentre Francois Baclesse·Phase 3·NCT00770172·140 enrolled

Hematologic Cancer2 trials

Chemotherapy and Total-Body Irradiation Followed by Donor Umbilical Cord Blood Transplant, Cyclosporine, and Mycophenolate Mofetil in Treating Patients With Hematologic Cancer

Completed·MMasonic Cancer Center, University of Minnesota·N/A·NCT00290641·68 enrolled

Combination Chemotherapy Plus Infusion of White Blood Cells in Treating Patients With Hematologic Cancer

Completed·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 1·NCT00003243

Rhabdomyosarcoma2 trials

Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma

Completed·CChildren's Oncology Group·Phase 3·NCT00003958·702 enrolled

Comparison of Chemotherapy Regimens in Treating Children With Relapsed or Progressive Rhabdomyosarcoma

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00025363·150 enrolled

Solid Tumors2 trials

MT2004-30: Tomotherapy for Solid Tumors

Terminated·MMasonic Cancer Center, University of Minnesota·Phase 1·NCT00623077·23 enrolled

Docetaxel in Treating Children With Recurrent Solid Tumors

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00002825·20 enrolled

Stage IV Ovarian Epithelial Cancer1 trial

High-Dose Chemotherapy Compared With Standard Chemotherapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer That Has Been Removed During Surgery

Completed·EEBMT Solid Tumors Working Party·Phase 3·NCT00004921

Soft Tissue Sarcoma1 trial

Combination Chemotherapy, Surgery, and Radiation Therapy in Treating Children With Advanced Soft Tissue Sarcoma

Completed·CChildren's Oncology Group·Phase 2·NCT00002804·43 enrolled

Multiple Sclerosis1 trial

Phase I Pilot Study of Total-Body Irradiation, Anti-Thymocyte Globulin and Cyclophosphamide Followed By Syngeneic or Autologous Peripheral Blood Stem Cell Transplantation in Patients With Multiple Sclerosis

Completed·FFred Hutchinson Cancer Center·Phase 1·NCT00014755·35 enrolled

Ewing's Sarcoma1 trial

Vinblastine, Celecoxib, and Combination Chemotherapy in Treating Patients With Newly-Diagnosed Metastatic Ewing's Sarcoma Family of Tumors

Completed·CChildren's Oncology Group·Phase 2·NCT00061893·38 enrolled

Advanced Cancer1 trial

Rebeccamycin Analog and Cisplatin With or Without Filgrastim in Treating Patients With Advanced Cancer

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00004189·40 enrolled

Bile Duct Cancer1 trial

Liposomal Doxorubicin in Treating Patients With Liver or Bile Duct Cancer

Unknown status·—·Phase 2·NCT00003296·26 enrolled

Completed·RRecardio, Inc.·Phase 2·NCT03486080·49 enrolled

Malignant Brain Tumors1 trial

Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors

Terminated·OOHSU Knight Cancer Institute·Phase 1·NCT00238173·2 enrolled

Ewing sarcoma1 trial

Two Regimens of Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed Localized Ewing Sarcoma Family of Tumors

Completed·CChildren's Oncology Group·N/A·NCT00618813·35 enrolled

Non-Small Cell Lung Cancer1 trial

Amifostine in Treating Patients With Stage II or Stage III Non-small Cell Lung Cancer

Completed· Radiation Therapy Oncology Group logo

Radiation Therapy Oncology Group·Phase 3·NCT00003313·243 enrolled

Central Nervous System Lymphoma1 trial

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Central Nervous System Lymphoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00003632·30 enrolled

Metastatic Cancer1 trial

Gene-Modified Lymphocytes, High-Dose Aldesleukin, and Vaccine Therapy in Treating Patients With Progressive or Recurrent Metastatic Cancer

Terminated·NNational Institutes of Health Clinical Center (CC)·Phase 2·NCT00704938·3 enrolled

Ovarian Cancer1 trial

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Epithelial Ovarian Cancer or Primary Peritoneal Cancer

Completed·UUniversity of Chicago·Phase 1/2·NCT00003136·11 enrolled

Myelofibrosis1 trial

Combination Chemotherapy, Total Body Irradiation, and Donor Blood Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis

Completed·MM.D. Anderson Cancer Center·Phase 1·NCT03426969·3 enrolled

Hematologic Malignancies1 trial

Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Terminated·FFred Hutchinson Cancer Center·N/A·NCT01076270·1 enrolled

Acute Respiratory Failure1 trial

Heparin Binding Protein in Patients With Acute Respiratory Failure Treated With GCSF (Filgrastim)

Completed·HHelsinki University Central Hospital·Phase 2/3·NCT01713309·59 enrolled

mCRPC1 trial

LEE011 (Ribociclib) in Combination With Docetaxel Plus Prednisone in mCRPC

Completed·RRahul Aggarwal·Phase 1/2·NCT02494921·43 enrolled

Refractory Solid Tumors1 trial

Oblimersen Plus Combination Chemotherapy and Dexrazoxane in Treating Children and Adolescents With Relapsed or Refractory Solid Tumors

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00039481·15 enrolled

Glioblastoma Multiforme1 trial

Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Glioblastoma Multiforme or Brain Stem Tumors

Completed·NNYU Langone Health·Phase 2·NCT00002619·60 enrolled

Sickle Cell Disease1 trial

Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

Active, not recruiting·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT02105766·56 enrolled

Safety and Efficacy1 trial

Multicenter Study of Safety and Efficacy Nivolumab at the Fixed Dose 40 mg (Nivo40) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed PMBL

Recruiting·NNational Research Center for Hematology, Russia·Phase 3·NCT06188676·100 enrolled

Recurrent Ovarian Epithelial Cancer1 trial

Radiolabeled Monoclonal Antibody Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory or Recurrent Ovarian Epithelial Cancer

Completed·—·Phase 1/2·NCT00004177·15 enrolled

Brain Tumors1 trial

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Completed·SSt. Jude Children's Research Hospital·Phase 1·NCT03434262·68 enrolled

Hematological Diseases1 trial

Myeloablative Umbilical Cord Blood Transplantation in Hematological Diseases

Completed·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00309842·213 enrolled

Acute Leukemia1 trial

Ex Vivo Expansion of Mafosfamide Purged CD34+ Cells in Patients With Acute Leukemia

Terminated·SSidney Kimmel Comprehensive Cancer Center at Johns Hopkins·Phase 1·NCT00245115·7 enrolled

Hematological Malignancies1 trial

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

Recruiting·FFred Hutchinson Cancer Center·Phase 2·NCT04195633·60 enrolled

Myelodysplastic Syndromes1 trial

Erythropoietin (EPO)+/- Filgrastim (G-CSF) vs. Supportive Therapy Alone for Patients With Myelodysplastic Syndromes

Completed·EEastern Cooperative Oncology Group·Phase 3·NCT00003138·118 enrolled

Transplantation1 trial

Clinical And Economic Impact Of Upfront Plerixafor In Autologous Transplantation

Completed·UUniversity of Florida·Phase 2·NCT01339572·72 enrolled

Myeloid Neoplasm1 trial

Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients With Relapsed or Refractory High-Grade Myeloid Neoplasms

Completed·UUniversity of Washington·Phase 2·NCT02756572·30 enrolled

Stem Cell1 trial

Efficacy of Biosimilar Filgrastim on the Mobilization of Hematopoietic Stem Cell CD34+ (Cluster of Differentiation 34) and on the Kinetic Engraftment

Unknown status·AAzienda Ospedaliera San Giovanni Battista··NCT02806791·300 enrolled

Temozolomide1 trial

Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors

Completed·NNational Cancer Institute (NCI)·Phase 1·NCT00052780·72 enrolled

Uterine Leiomyosarcoma1 trial

Gemcitabine Hydrochloride and Docetaxel Followed by Doxorubicin Hydrochloride or Observation in Treating Patients With High-Risk Uterine Leiomyosarcoma Previously Removed by Surgery

Terminated·GGynecologic Oncology Group·Phase 3·NCT01533207·38 enrolled

Recurrent Head and Neck Cancer1 trial

Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer That Cannot Be Removed By Surgery

Terminated· Radiation Therapy Oncology Group logo

Radiation Therapy Oncology Group·Phase 3·NCT00113399·15 enrolled

Ischemic stroke1 trial

AXIS 2: AX200 for the Treatment of Ischemic Stroke

Completed·SSygnis Bioscience GmbH & Co KG·Phase 2·NCT00927836·328 enrolled

Recurrent or Refractory Solid Tumors1 trial

Chemotherapy Plus Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Solid Tumors

Completed·FFred Hutchinson Cancer Center·Phase 1·NCT00003899

Pompe Disease1 trial

Clinical Specimen Collection From Pompe Disease Patients

Unknown status·—··NCT04476550·12 enrolled

Central Nervous System Cancer1 trial

Chemotherapy and Stem Cell Transplantation in Treating Children With Central Nervous System Cancer

Completed·RRoswell Park Cancer Institute·Phase 1·NCT00053118·1 enrolled

Ependymoma1 trial

Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma

Completed·CChildren's Oncology Group·Phase 2·NCT00027846·378 enrolled

Pemphigus1 trial

Phase II Study of High-Dose Cyclophosphamide in Patients With Refractory Pemphigus

Completed·JJohns Hopkins University·Phase 2·NCT00010413·35 enrolled

Peripheral Blood Stem Cell Transplantation1 trial

The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation

Recruiting·NNational Cancer Institute (NCI)·Phase 1/2·NCT05436418·260 enrolled

Liposomal Doxorubicin1 trial

Comparison of Liposomal Doxorubicin Used Alone or in Combination With Bleomycin Plus Vincristine in the Treatment of Kaposi's Sarcoma in Patients With AIDS

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00001059·120 enrolled

Relapse1 trial

Epigenetic Reprogramming in Relapse AML

Terminated·MMichael Burke·Phase 1·NCT02412475·3 enrolled

Colorectal Cancer1 trial

Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver and/or Lung

Completed·NNational Cancer Institute, France·Phase 2·NCT00557102·24 enrolled

Radiation Therapy1 trial

Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT

Completed·—·Phase 2·NCT00084838·25 enrolled

Metastatic Prostate Cancer1 trial

A Phase I/II Study of Azacitidine, Docetaxel, and Prednisone for Metastatic Prostate Cancer Patients

Terminated·UUniversity of Miami·Phase 1/2·NCT00503984·22 enrolled

Esophageal Adenocarcinoma1 trial

Neoadjuvant Intra-tumoral RP2 and FLOT in Gastroesophageal Adenocarcinoma

Not yet recruiting·—·Phase 2·NCT07059611·34 enrolled

Advanced Malignancies1 trial

Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies

Recruiting·UUniversity of California, Irvine·Phase 1/2·NCT07064018·67 enrolled

Myeloid Leukemia1 trial

G-CSF in Stimulating Peripheral Stem Cells for Autologous Stem Cell Transplant in Treating Patients With Chronic Phase Chronic Myeloid Leukemia in Complete Remission

Completed·HHerbert Irving Comprehensive Cancer Center·Phase 1·NCT00233961·20 enrolled

Premature ovarian insufficiency1 trial

Filgrastim for Premature Ovarian Insufficiency

Completed·SSouth Valley University·Phase 4·NCT02783937·10 enrolled

Juvenile Myelomonocytic Leukemia1 trial

Cytosine Arabinoside and Mitoxantrone for Patients With Juvenile Myelomonocytic Leukemia Receiving Repeat Stem Cell Transplantation

Terminated·MMasonic Cancer Center, University of Minnesota·Phase 1/2·NCT00609739·1 enrolled

Primitive Neuroectodermal Tumor1 trial

Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma

Completed·—·Phase 2·NCT00006258

Graft Versus Host Disease1 trial

Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT03434730·46 enrolled

Fibrosarcoma1 trial

Surgery and/or Chemotherapy in Treating Children With Infantile, Congenital, or Childhood Fibrosarcoma

Terminated·CChildren's Oncology Group·Phase 2·NCT00072280·7 enrolled

Locally Advanced Head and Neck Cancer1 trial

Combination Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer

Terminated·MMasonic Cancer Center, University of Minnesota·Phase 2·NCT00352118·4 enrolled

Osteosarcoma1 trial

Combination Chemotherapy and Surgery in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT00003776

Stomach Cancer1 trial

Comparison of Combination Chemotherapy Regimens in Treating Patients With Advanced Stomach Cancer

Completed·EEastern Cooperative Oncology Group·Phase 2·NCT00003172

Myelodysplastic Syndrome1 trial

HLA-haploidentical Hematopoietic Stem Cell Transplantation for Children and Adolescents With Acute Leukemia, Myelodysplastic Syndrome and Solid Tumors

Unknown status·—·Phase 1/2·NCT01509300·10 enrolled

Bone Marrow Failure Syndrome1 trial

Phase II Pilot Study of Granulocyte Colony-Stimulating Factor for Inherited Bone Marrow Failure Syndromes

Completed·NNational Center for Research Resources (NCRR)·Phase 2·NCT00004787·20 enrolled

Drug1 trial

Severe Bullous Drug Eruption and Filgrastim

Recruiting·HHospices Civils de Lyon·Phase 2/3·NCT04651439·42 enrolled

Newly Diagnosed1 trial

Decitabine With GCLAM for Adults With Newly Diagnosed, Relapsed, or Refractory AML or High-Risk MDS

Completed·FFred Hutchinson Cancer Center·Phase 1/2·NCT02921061·28 enrolled

B-cell acute lymphoblastic leukemia1 trial

Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia

Completed·CChildren's Oncology Group·Phase 3·NCT00381680·275 enrolled

Unspecified3 trials

Anti-NY ESO-1 mTCR Peripheral Blood Lymphocytes

Terminated·—·Phase 1·NCT02774291·3 enrolled

Ruxolitinib in Combination With Autotransplant

Withdrawn·MMarina Kremyanskaya·N/A·NCT02469974

High-dose ICE With Amifostine

Completed·—·Phase 2·NCT00003657·24 enrolled

Sources

References

[1]
ClinicalTrials.gov — 819 trial records for filgrastim. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Neupogen drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — filgrastim compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for filgrastim. EMBL-EBI & Wellcome Sanger Institute.
[5]
SEC EDGAR — Eastern Cooperative Oncology Group company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Granulocyte Colony Stimulating Factor Receptor Agonist[3]
Modality: Protein / enzyme[3]
Highest Phase: Approved[1]
Company: EEastern Cooperative Oncology Group

Neupogen

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q3 2027

Q4 2027

Q2 2028

Trials by Indication[1]

Lymphoma23 trials

Breast Cancer19 trials

Multiple Myeloma10 trials

Stem Cell Transplantation9 trials

Bone Marrow Transplantation7 trials

Acute Myeloid Leukemia6 trials

Neuroblastoma5 trials

Acute Lymphoblastic Leukemia5 trials

Primary Systemic Amyloidosis4 trials

Chronic Lymphocytic Leukemia4 trials

Chronic Myelogenous Leukemia4 trials

Metastatic Melanoma3 trials

G-CSF3 trials

Germ Cell Tumor3 trials

Leukemia3 trials

Chemotherapy3 trials

Endometrial Cancer3 trials

Mantle Cell Lymphoma3 trials

Stem Cell Transplant3 trials

Kidney Cancer2 trials

Hodgkin's Disease2 trials

Small Cell Lung Cancer2 trials

Neutropenia2 trials

Hematologic Cancer2 trials

Rhabdomyosarcoma2 trials

Solid Tumors2 trials

Stage IV Ovarian Epithelial Cancer1 trial

Soft Tissue Sarcoma1 trial

Multiple Sclerosis1 trial

Ewing's Sarcoma1 trial

Advanced Cancer1 trial

Bile Duct Cancer1 trial

Metastatic Colorectal Cancer1 trial

Refractory AML1 trial

Myocardial Infarction1 trial

Malignant Brain Tumors1 trial

Ewing sarcoma1 trial

Non-Small Cell Lung Cancer1 trial

Central Nervous System Lymphoma1 trial

Metastatic Cancer1 trial

Ovarian Cancer1 trial

Myelofibrosis1 trial

Hematologic Malignancies1 trial

Acute Respiratory Failure1 trial

mCRPC1 trial

Refractory Solid Tumors1 trial

Glioblastoma Multiforme1 trial

Sickle Cell Disease1 trial

Safety and Efficacy1 trial

Recurrent Ovarian Epithelial Cancer1 trial

Brain Tumors1 trial

Hematological Diseases1 trial

Acute Leukemia1 trial

Hematological Malignancies1 trial

Myelodysplastic Syndromes1 trial

Transplantation1 trial

Myeloid Neoplasm1 trial

Stem Cell1 trial

Temozolomide1 trial

Uterine Leiomyosarcoma1 trial

Recurrent Head and Neck Cancer1 trial

Ischemic stroke1 trial

Recurrent or Refractory Solid Tumors1 trial

Pompe Disease1 trial

Central Nervous System Cancer1 trial

Ependymoma1 trial

Pemphigus1 trial

Peripheral Blood Stem Cell Transplantation1 trial

Liposomal Doxorubicin1 trial

Relapse1 trial

Colorectal Cancer1 trial