Isavuconazole

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Central Nervous System LymphomaAcute Myeloid Leukemia (AML)Primary Central Nervous System LymphomaMucormycosis

34 competitors in Central Nervous System Lymphoma

#DrugCompanyPhaseTrials

1

Rituxan

Roche

Approved

172

Idamycin

Pfizer

Approved

—3

Tepadina

Jazz Pharmaceuticals

Approved

—4

Brukinsa

BBeOne Medicines

Approved

15

Temodar

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Phase 3

66

Trexall

Jazz Pharmaceuticals

Phase 2

197

Nublexa

BBeijing InnoCare Pharma Tech Co., Ltd.

Phase 3

48

Cytosar

Teva

Phase 2

69

Gazyva

Roche

Phase 2

110

Fludara

Sanofi

Phase 2

1Show 19 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Interaction9 trials

Drug Interaction Study of Isavuconazole and Midazolam

Completed·Astellas·Phase 1·NCT01406171·24 enrolled

Drug Interaction Study of Isavuconazole and Warfarin in Healthy Male Subjects

Completed·Astellas·Phase 1·NCT01657825·20 enrolled

Drug Interaction Study of Multiple Doses of Isavuconazole and a Single Dose of Bupropion

Completed·Astellas·Phase 1·NCT01635972·24 enrolled

Show 6 more trials

Drug Interaction Study of Isavuconazole and Digoxin

Completed·Astellas·Phase 1·NCT01582412·24 enrolled

Drug-drug Interaction Study Between Lopinavir/Ritonavir and Isavuconazole

Completed·Astellas·Phase 1·NCT01660477·68 enrolled

Drug Interaction Study of Isavuconazole and Methadone

Completed·Astellas·Phase 1·NCT01582425·24 enrolled

Drug Interaction Study of Isavuconazole and Tacrolimus

Completed·Astellas·Phase 1·NCT01535547·24 enrolled

Drug Interaction Study of Isavuconazole and Cyclosporine

Completed·Astellas·Phase 1·NCT01494597·24 enrolled

Drug Interaction Study of Isavuconazole and Oral Contraceptive Containing Ethinyl Estradiol and Norethindrone

Completed·Astellas·Phase 1·NCT01597986·24 enrolled

Adult Subject4 trials

Drug Interaction Study of Multiple Doses of Isavuconazole and Single Dose of Dextromethorphan in Healthy Adult Subjects

Completed·Astellas·Phase 1·NCT01651325·24 enrolled

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Prednisone in Healthy Adult Subjects

Completed·Astellas·Phase 1·NCT01711827·21 enrolled

A Study to Assess the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Mycophenolate Mofetil in Healthy Adult Subjects

Completed·Astellas·Phase 1·NCT01711489·24 enrolled

Show 1 more trial

Drug Interaction Study of the Effect of Ketoconazole at Steady State on the Pharmacokinetics of a Single Dose of Isavuconazole in Healthy Adult Subjects

Completed·Astellas·Phase 1·NCT01657838·24 enrolled

Tics2 trials

A Study to Assess the Safety and Pharmacokinetics of Isavuconazole in Healthy Chinese Volunteers

Completed·Astellas·Phase 1·NCT01555918·36 enrolled

A Study to Evaluate the Effect of Multiple Doses of Esomeprazole on the Pharmacokinetics of Isavuconazole

Completed·Astellas·Phase 1·NCT02128893·24 enrolled

Aspergillosis2 trials

Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis

Completed·Astellas·Phase 3·NCT00412893·527 enrolled

Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi

Completed·Astellas·Phase 3·NCT00634049·149 enrolled

Elderly1 trial

Study of the Pharmacokinetics of Isavuconazole in Healthy Non-Elderly and Elderly Male and Female Subjects

Completed·Astellas·Phase 1·NCT01657890·28 enrolled

20 more indications

Drug Monitoring1 trial

Study on Theraputic Drug Monitoring and Phamacokinetics of Isavuconazole in Children

Recruiting·SShanghai Children's Medical Center·N/A·NCT06440915·200 enrolled

Mucormycosis1 trial

Amphotericin B Versus Isavuconazole for Mucormycosis: A Comparative Efficacy and Safety Study

Active, not recruiting·QQiu Ye··NCT07191756·150 enrolled

Metformin1 trial

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Metformin

Completed·Astellas·Phase 1·NCT01884558·24 enrolled

Adult1 trial

A Study to Evaluate the Effect of Pharmacokinetics (PK) of Acalabrutinib and Its Active Metabolite (ACP-5862) When Administered Alone and With Moderate CYP3A4 Inhibitors Fluconazole or Isavuconazole in Healthy Adult Participants

Completed·AAcerta Pharma BV·Phase 1·NCT05140096·30 enrolled

Myelodysplastic Syndrome1 trial

Isavuconazole in Preventing Invasive Fungal Infections in Adult Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome and Neutropenia

Completed·MM.D. Anderson Cancer Center·Phase 2·NCT03019939·65 enrolled

Renal Impairment1 trial

Study of the Effect of Renal Impairment on the Pharmacokinetics of Isavuconazole.

Completed·Astellas·Phase 1·NCT01555866·49 enrolled

Candidemia1 trial

Isavuconazole (BAL8557) in the Treatment of Candidemia and Other Invasive Candida Infections

Completed·Astellas·Phase 3·NCT00413218·450 enrolled

Cardiac Repolarization1 trial

Study of the Effect of Repeat Doses of Isavuconazole on Cardiac Repolarization

Completed·Astellas·Phase 1·NCT01565720·161 enrolled

Single Dose1 trial

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Sirolimus in Healthy Subjects

Completed·Astellas·Phase 1·NCT01809860·22 enrolled

Chemotherapy1 trial

Safety, Efficacy and Pharmacokinetics of an Antifungal in Patients Undergoing Chemotherapy

Completed·Basilea Pharmaceutica·Phase 2/3·NCT00413439·18 enrolled

LAM1 trial

Cresemba® in Treating Chinese Patients With IFD Caused by Aspergillus Species or Other Filamentous Fungi

Completed·Pfizer·Phase 4·NCT05630976·70 enrolled

Atorvastatin1 trial

Drug Interaction Study of Multiple Doses of Isavuconazole and Single Dose of Atorvastatin

Completed·Astellas·Phase 1·NCT01635946·24 enrolled

Methotrexate1 trial

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Methotrexate

Completed·Astellas·Phase 1·NCT01884636·24 enrolled

Caffeine1 trial

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Repaglinide and Caffeine

Completed·Astellas·Phase 1·NCT02128321·24 enrolled

CAR1 trial

A Study to Understand How the Use of Paxlovid Affected the Healthcare Use in People With Pre-existing Conditions.

Completed·Pfizer··NCT04550936·307 enrolled

Hematopoietic Stem Cell Transplant1 trial

Fungal Prophylaxis With Isavuconazole for Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant (HCT)

Completed·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT03149055·99 enrolled

Central Nervous System Lymphoma1 trial

A Study of Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, and Rituximab (TEDDI-R) in Aggressive B-cell Lymphomas With Secondary Involvement of the Central Nervous System (CNS)

Active, not recruiting·NNational Cancer Institute (NCI)·Phase 2·NCT03964090·48 enrolled

Primary Central Nervous System Lymphoma1 trial

Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, Rituximab (TEDDI-R) in Primary CNS Lymphoma

Active, not recruiting·NNational Cancer Institute (NCI)·Phase 1·NCT02203526·68 enrolled

Acute Myeloid Leukemia (AML)1 trial

Phase 1b Study of Monzosertib In Patients With Relapsed Or Refractory Acute Myeloid Leukemia Or High-Risk Myelodysplastic Syndrome

Not yet recruiting·MM.D. Anderson Cancer Center·Phase 1·NCT07780565·42 enrolled

Invasive Fungal Infections1 trial

Therapeutic Drug Monitoring of Isavuconazole in Solid Organ and Hematopoietic Stem Cell Transplant Recipients: A Single-Center Retrospective Cohort Study of Plasma Trough Exposure, Its Determinants, and Hepatic Safety

Completed·ZZhibin Xu··NCT07716878·110 enrolled

Details

Drug Info

Related News