Sporanox

(Itraconazole)

ApprovedSmall molecule

Itraconazole is used to treat fungal infections caused by fungi and molds. It works by stopping the growth of fungal organisms that cause infections in various parts of the body.[2] Sporanox is currently approved and in use across 69 indications[4].[1]

Sporanox is one of 1352 small molecule programs targeting Coccidioidomycosis. It is currently in Approved.

Indications

396

Total Trials

Active Trials

1,351

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Patents

Pipeline

Status by Indication[4][1]

Indication

CoccidioidomycosisApproved

HIV InfectionApproved

Bacterial DiseaseApproved

BlastomycosisActive, not recruiting

MetastasisApproved

NeutropeniaActive, not recruiting

Cryptococcal MeningitisActive, not recruiting

Prostate AdenocarcinomaApproved

Hepatitis B Virus InfectionApproved

Vulvovaginal CandidiasisActive, not recruiting

CoccidioidomycosisApproved

Approved

HIV InfectionApproved

Approved

Bacterial DiseaseApproved

Approved

BlastomycosisApproved

Active, not recruiting

MetastasisApproved

Approved

NeutropeniaPreclinical

Active, not recruiting

Cryptococcal MeningitisPreclinical

Active, not recruiting

Prostate AdenocarcinomaApproved

Approved

Hepatitis B Virus InfectionApproved

Approved

Vulvovaginal CandidiasisPreclinical

Active, not recruiting

Showing 10 of 69 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Sporanox

SSebela Pharmaceuticals Development LLC

Approved

1 2

Methylthioninium Chloride

PProvepharm SAS

Preclinical

3 3

Spravato

WWim Janssens

Preclinical

2 4

Nubain

AAultman Health Foundation

Preclinical

1 5

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 6

Systemic Therapy

Bristol-Myers Squibb

Preclinical

1 7

Zoladex

Luye Pharma Group Ltd.

Preclinical

8 8

Neoadjuvant Treatment

SShanghai Zhongshan Hospital

Preclinical

1 9

Beta Blocker

WWeill Medical College of Cornell University

Preclinical

1 10

Perflutren Lipid Microcpheres

TThomas Jefferson University

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1Recruiting

Advanced Breast Cancer

NCT06710990

Phase 1Recruiting

Clinical Trial

NCT07435194

Phase 2Recruiting

Esophageal Cancer

NCT04018872

Q4 2026

N/ARecruiting

Sporotrichosis

NCT06300138

Q2 2028

Phase 1/2Recruiting

Advanced/metastatic Solid Tumors

NCT05914116

Q4 2028

Phase 1/2Recruiting

Acute Myeloid Leukemia

NCT04067336

Clinical

Trials by Indication[1]

Interaction40 trials

A Study to Evaluate Drug-Drug Interaction of TAK-788 With Itraconazole and Rifampin in Healthy Adult Participants

Completed· Takeda logo

Takeda·Phase 1·NCT03928327·24 enrolled

PK Study to Assess Drug-drug Interaction Between Sitravatinib and a P-gp Inducer and an Inhibitor.

Completed·MMirati Therapeutics Inc.·Phase 1·NCT05255276·36 enrolled

A Drug-Drug Interaction Study of the Effect of Rabeprazole, Itraconazole or Fluconazole on the Pharmacokinetics of Vismodegib

Completed· Roche logo

Roche·Phase 1·NCT01772290·92 enrolled

Show 37 more trials

A Study to Assess the Interaction Between ASP1707 and Itraconazole in Healthy Female Subjects

Completed· Astellas logo

Astellas·Phase 1·NCT02175407·14 enrolled

Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Itraconazole

Completed· Novartis logo

Novartis·Phase 1·NCT05084651·19 enrolled

Drug-drug Interaction (DDI) With a P-gp Inhibitor, Organic Anion Transporting Polypeptide OATP-inhibitor, Food Effect

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT03116893·15 enrolled

First in Human Study to Investigate the Safety and Tolerability, Pharmacokinetics, Itraconazole Drug-drug-interaction and Food Effect of BAY1817080

Completed· Bayer logo

Bayer·Phase 1·NCT02817100·88 enrolled

Drug-Drug Interaction of ASN51 With Fluvoxamine, Itraconazole and Paroxetine in Healthy Subjects

Completed·AAsceneuron S.A.·Phase 1·NCT06232109·50 enrolled

A Drug-Drug Interaction Study to Assess the Pharmacokinetics of DC-806 When Orally Administered Alone, When Coadministered With Itraconazole, and When Coadministered With Carbamazepine in Healthy Adult Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT05994807·33 enrolled

Drug-Drug Interaction (DDI) Study for TD-9855

Completed·TTheravance Biopharma·Phase 1·NCT03432793·41 enrolled

Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects

Not yet recruiting·JJemincare·Phase 1·NCT06348290·72 enrolled

A Drug-Drug Interaction Study Between GDC-0853 and Midazolam, Itraconazole, Rosuvastatin, and Simvastatin

Completed· Roche logo

Roche·Phase 1·NCT03174041·63 enrolled

Drug-Drug Interaction (DDI) Study for TPN171H

Completed·VVigonvita Life Sciences·Phase 1·NCT06090123·24 enrolled

Drug-drug Interaction Trial of AP31969 and Carbamazepine or Itraconazole

Not yet recruiting·AAcesion Pharma·Phase 1·NCT07449390·28 enrolled

A Drug Interaction Study of GDC-0032 Co-administered With Rifampin or Itraconazole in Healthy Volunteers

Completed· Roche logo

Roche·Phase 1·NCT01814709·32 enrolled

Drug-drug Interaction Study of SPH3127

Completed·SShanghai Pharmaceuticals Holding Co., Ltd·Phase 1/2·NCT05359055·40 enrolled

Drug-Drug Interaction Study of Casdatifan in Healthy Adult Participants (ARC-29)

Completed· Arcus Biosciences logo

Arcus Biosciences·Phase 1·NCT06919991·14 enrolled

Study to Assess Drug-Drug Interaction Between Itraconazole or Gemfibrozil and JNJ-56021927

Completed·AAragon Pharmaceuticals, Inc.·Phase 1·NCT02230033·45 enrolled

Study to Evaluate the Effect of a Known and Marketed Product, Itraconazole (Mycosis Treatment) on Lu AF11167 Entering the Body and Subsequently Elimination. The Study is a Drug-drug Interaction Study in Healthy Volunteers.

Completed· Lundbeck logo

Lundbeck·Phase 1·NCT02199431·20 enrolled

Drug to Drug Interaction Study of KBP-5074 in Healthy Subjects

Completed·KKBP Biosciences·Phase 1·NCT04606537·24 enrolled

Thorough ECG (Electrocardiogram) and Drug Interaction Study With Anetumab Ravtansine and Itraconazole

Completed· Bayer logo

Bayer·Phase 1·NCT02824042·63 enrolled

An Open-Label, 2 Treatment Period,Study To Study The Drug Interaction Between Repeated Doses Of Itraconazole And Single Dose Pharmacokinetics (PK) Of PF-06648671 In Healthy Adults.

Completed· Pfizer logo

Pfizer·Phase 1·NCT02883114·12 enrolled

Drug-drug Interaction Study with GLPG3667 and Itraconazole in Healthy Subjects

Completed·GGalapagos NV·Phase 1·NCT05272683·14 enrolled

A Study to Evaluate the Effect of Food on the Single-Dose Pharmacokinetics and a Drug-Drug Interaction Evaluation of Itraconazole and Carbamazepine on INCB123667 When Administered Orally to Healthy Adult Participants

Recruiting· Incyte logo

Incyte·Phase 1·NCT06909162·51 enrolled

Drug-drug Interaction Study With MDV3100 (ASP9785) and Gemfibrozil and Itraconazole

Completed· Astellas logo

Astellas·Phase 1·NCT01913379·41 enrolled

A Drug-Drug Interaction Study to Evaluate the Effect of Itraconazole on the Pharmacokinetic Profile of Etrumadenant in Healthy Adult Participants

Completed· Arcus Biosciences logo

Arcus Biosciences·Phase 1·NCT05154136·20 enrolled

A Study to Evaluate Potential Cytochrome P450 and Transporter Protein Interactions With CC-99677

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT04268394·48 enrolled

Drug-drug Interaction (DDI) Study to Assess ODM-201 as a Victim of CYP3A4 Inhibition or Induction

Completed· Bayer logo

Bayer·Phase 1·NCT03048110·15 enrolled

Drug Drug Interaction Trial With Strong CYP3A4 Inhibitor (Itraconazole) in CYP2C19 Extensive Metabolizers and Poor Metabolizers

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02248259·25 enrolled

An Interaction Study of LY3200882 in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT03792139·23 enrolled

A Drug-Drug Interaction Study of ALKS 5461 in Healthy Volunteers

Completed·AAlkermes, Inc.·Phase 1·NCT02272764·24 enrolled

Drug-Drug Interaction Study Between EDP-938, Itraconazole, Rifampin, and Quinidine in Healthy Subjects

Completed·EEnanta Pharmaceuticals, Inc·Phase 1·NCT03755778·72 enrolled

A Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Potential of CCX168 With Concomitant Medications

Completed· Amgen logo

Amgen·Phase 1·NCT06004947·32 enrolled

Drug-drug Interaction Between Belumosudil, Itraconazole, Rifampicin, Rabeprazole, and Omeprazole in Healthy Volunteers

Completed·KKadmon Corporation, LLC·Phase 1·NCT03530995·73 enrolled

Drug-drug Interaction Study of Ozanimod With Inhibitor or Inducer of CYP2C8 and/or CYP3A

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03624959·100 enrolled

A 3-Part, Open-Label, Drug-Drug Interaction Study of Concomitant Administration of E2609 With Itraconazole, Rifampin, Digoxin, or Donepezil

Completed· Eisai logo

Eisai·Phase 1·NCT02055703·195 enrolled

Drug-Drug Interaction Study Between EDP-514, Itraconazole, Carbamazepine, and Quinidine in Healthy Subjects

Completed·EEnanta Pharmaceuticals, Inc·Phase 1·NCT04783753·72 enrolled

Study to Assess Pharmacokinetic Drug-Drug Interaction Between Avatrombopag When Co-Administered With Fluconazole, Itraconazole, or Rifampin in Healthy Subjects

Completed· Eisai logo

Eisai·Phase 1·NCT02809768·48 enrolled

A Study to Assess the Drug Interaction Between MYK-224 and Itraconazole and Verapamil in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT05304533·45 enrolled

A Phase 1, Open-label Study Evaluating the Pharmacokinetics and Drug-drug Interaction of VX-993 in Healthy Adults

Completed· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 1·NCT06392659·42 enrolled

Tics26 trials

To Assess the Effect of Itraconazole and Fluconazole on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT02093728·26 enrolled

Assessment of the Safety, Tolerability and Pharmacokinetics of AV078 in Healthy Volunteers

Completed·AAeovian Pharmaceuticals, Inc.·Phase 1·NCT06205381·89 enrolled

Effect of Administration of Itraconazole on the Pharmacokinetics of S-309309 in Healthy Participants

Completed· Shionogi logo

Shionogi·Phase 1·NCT06106334·14 enrolled

Show 23 more trials

A Study to Investigate the Effect of Itraconazole and Rifampin on Pharmacokinetics (PK) of Vemurafenib at Steady State

Completed· Roche logo

Roche·Phase 1·NCT02608034·32 enrolled

Studies Evaluating the Effects of Itraconazole or Rifampicin on the Pharmacokinetics of TY-9591 Tablets in Healthy Subjects

Completed·TTYK Medicines, Inc·Phase 1·NCT06255951·48 enrolled

A Study to Assess the Pharmacokinetics of AZD6793 When Administered Alone and in Combination With Itraconazole in Healthy Participants.

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT06494644·17 enrolled

A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP3700 in Healthy Male Subjects

Completed· Astellas logo

Astellas·Phase 1·NCT02155504·44 enrolled

A Study to Investigate the Effect of CYP3A Inhibition on the Pharmacokinetics of RO7017773 in Healthy Participants

Completed· Roche logo

Roche·Phase 1·NCT03774576·14 enrolled

A Study to Assess the Pharmacokinetics of AZD4831 When Administered Alone and in Combination With Itraconazole

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT05236543·21 enrolled

A Study to Evaluate Effect of Itraconazole on the Pharmacokinetics of Cobimetinib in Healthy Participants

Completed· Roche logo

Roche·Phase 1·NCT01929876·16 enrolled

A Study to Investigate the Effect of Itraconazole on the Pharmacokinetics of Debio 1450 in Healthy Subjects

Completed·DDebiopharm International SA·Phase 1·NCT03209648·20 enrolled

A Study to Determine the Effects of Itraconazole on the Pharmacokinetics (PK) of DS-8500 in Healthy Subjects

Completed· Daiichi Sankyo logo

Daiichi Sankyo·Phase 1·NCT02790671·26 enrolled

A Study To Evaluate The Effect Of Itraconazole On Pharmacokinetics Of PF-06463922 In Healthy Volunteers

Completed· Pfizer logo

Pfizer·Phase 1·NCT02838264·16 enrolled

A Study to Evaluate the Effect of the Potent CYP3A4 Inhibitor Itraconazole on the Pharmacokinetics (PK) of TAK-906 in Healthy Participants

Completed· Takeda logo

Takeda·Phase 1·NCT03161405·12 enrolled

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) Given by Mouth in Healthy Volunteers

Completed· Roche logo

Roche·Phase 1·NCT02633709·33 enrolled

A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of PC14586 in Healthy Participants

Completed·PPMV Pharmaceuticals, Inc·Phase 1·NCT06362642·12 enrolled

Effect of Itraconazole on the Pharmacokinetics of BIIB074

Completed· Biogen logo

Biogen·Phase 1·NCT02698267·16 enrolled

A Study to Assess the Pharmacokinetics of Camizestrant (AZD9833) When Administered Alone and in Combination With Itraconazole

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT05551897·14 enrolled

A Study to Evaluate the Effect of Co-administration of Itraconazole or Diltiazem on the Pharmacokinetics of BMS-986177 in Healthy Subjects

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02807909·28 enrolled

A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics (PK) of Nemiralisib

Completed· GSK logo

GSK·Phase 1·NCT03398421·20 enrolled

A Study to Evaluate the Relative Bioavailability of STI-1558 and the Effect of Itraconazole and Rifampin on the Pharmacokinetics of STI-1558

Completed·ZZhejiang ACEA Pharmaceutical Co. Ltd.·Phase 1·NCT05685719·37 enrolled

Study to Investigate Effects of Repeated Administration of Itraconazole on Pharmacokinetics of JNJ-42847922 in Healthy Male Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02455856·16 enrolled

A Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SY-5007 in Healthy Subjects

Not yet recruiting·SShouyao Holdings (Beijing) Co. LTD·Phase 1·NCT06332053·28 enrolled

Study to Evaluate the Effects of Itraconazole and Rifampin on the Pharmacokinetics of ASC40 in Healthy Subjects

Completed·AAscletis Pharmaceuticals Co., Ltd.·Phase 1·NCT04843449·24 enrolled

A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of JNJ-42165279 in Healthy Male Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02065739·16 enrolled

Study Evaluating the Effects of Food, Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of CC-122

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT03340662·81 enrolled

Adult13 trials

A Study to Evaluate the Effect of Multiple Doses of Itraconazole, Phenytoin, and Paroxetine on the Single-Dose Pharmacokinetics of Poziotinib in Healthy Adult Participants

Completed· Spectrum Pharmaceuticals, Inc logo

Spectrum Pharmaceuticals, Inc·Phase 1·NCT04981704·74 enrolled

A Study to Assess the Effects of Itraconazole and Rifampicin on the Single-Dose Pharmacokinetics of JNJ-53718678 in Healthy Adults

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT02729467·33 enrolled

Study to Evaluate the Effect of Multiple Doses of Itraconazole and Rifampin on the Single-Dose Pharmacokinetics of Mitapivat Sulfate (AG-348) in Healthy Adult Participants

Completed·AAgios Pharmaceuticals, Inc.·Phase 1·NCT03991312·28 enrolled

Show 10 more trials

A Study to Evaluate the Effect of Itraconazole on JNJ-56136379 in Healthy Adult Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT03945539·16 enrolled

A Study to Assess LY4100511 (DC-853) in Healthy Adult Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT06345794·50 enrolled

A Study to Assess the Effects of Itraconazole and Etravirine on JNJ-64417184 in Healthy Adult Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT04208373·32 enrolled

A Study of the Effect of Itraconazole and Phenytoin on Calderasib (MK-1084) in Healthy Adults (MK-1084-008)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT06719557·28 enrolled

A Study of the Safety, Tolerability, and Pharmacokinetics of Orally Administered Venglustat and Itraconazole in Healthy Adult Male Participants

Completed· Sanofi logo

Sanofi·Phase 1·NCT06421714·8 enrolled

A Study of Soticlestat With Itraconazole and Mefenamic Acid in Healthy Adults

Completed· Takeda logo

Takeda·Phase 1·NCT05064449·28 enrolled

A Study to Evaluate the Effect of Itraconazole and Rifampin on the Drug Levels of AR-LDD (BMS-986365) in Healthy Adult Male Participants

Recruiting· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT07242781·42 enrolled

A Study to Learn if the Study Medicines Called Itraconazole and Cyclosporine Change How the Body Processes the Other Study Medicine Called Danuglipron in Healthy Adults.

Completed· Pfizer logo

Pfizer·Phase 1·NCT06541678·16 enrolled

A Study to Evaluate the Effect of Fluconazole and Itraconazole on Erdafitinib Pharmacokinetics in Healthy Adult Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT03135106·54 enrolled

A Study to Learn About How Itraconazole Affects the Blood Level of Study Medicine (PF-07817883) in Healthy Adults.

Completed· Pfizer logo

Pfizer·Phase 1·NCT05822440·12 enrolled

ART8 trials

A Study to Evaluate the Effects of Itraconazole on MK-1708 in Healthy Participants (MK-1708-003)

Completed· Merck & Co. logo

Merck & Co.·Phase 1·NCT06586606·12 enrolled

A Study of LY2623091 in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT02300259·48 enrolled

Effect of Phenytoin or Itraconazole on How BGB-16673 is Absorbed and Removed From the Body in Healthy Participants

Completed· BeiGene logo

BeiGene·Phase 1·NCT06906809·37 enrolled

Show 5 more trials

A Study of Effects of Itraconazole and Rifampin on Selpercatinib (LY3527723) in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT05338489·24 enrolled

A Study of LY3509754 in Healthy Non-Japanese and Japanese Participants

Terminated· Eli Lilly logo

Eli Lilly·Phase 1·NCT04586920·104 enrolled

A Study to Evaluate the Effect of Co-administration of Itraconazole or Diltiazem on the Single-dose of Danicamtiv in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT05162222·30 enrolled

Study of the Effects of Itraconazole and Rifampin on LOXO-305 in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT05134337·27 enrolled

A Study of LY3323795 in Healthy Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT02989389·42 enrolled

Drug Interactions5 trials

A Study to Investigate the Drug-drug Interactions (DDIs) of SKLB1028 With Itraconazole, Gemfibrozil or Rifampicin in Healthy Subjects

Unknown status· CSPC ZhongQi Pharmaceutical Technology Co., Ltd. logo

CSPC ZhongQi Pharmaceutical Technology Co., Ltd.·Phase 1·NCT05069870·42 enrolled

A Study to Evaluate Potential Drug Interactions Between ALXN2080 and Itraconazole, Fluconazole & Carbamazepine in Healthy Adults

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT06173596·60 enrolled

A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects

Completed·AAllist Pharmaceuticals, Inc.·Phase 1·NCT06162169·66 enrolled

Show 2 more trials

Assess the Drug Interactions of BBT-877 and Midazolam, Itraconazole, and Esomeprazole in Healthy Adult Subjects

Completed·BBridge Biotherapeutics, Inc.·Phase 1·NCT04138836·48 enrolled

A Study to Evaluate the Drug-drug Interactions (DDIs) of GP681 With Rosuvastatin, Digoxin, Itraconazole, Oseltamivir in Chinese Healthy Volunteers

Completed·JJiangxi Qingfeng Pharmaceutical Co. Ltd.·Phase 1·NCT05789342·54 enrolled

70 more indications

Esophageal Cancer4 trials

Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer

Recruiting·—·Phase 2·NCT04018872·78 enrolled

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

Recruiting·VVA Office of Research and Development·Phase 2·NCT05563766·78 enrolled

CCRT With Itraconazole in Locally Advanced Squamous Esophageal Cancer

Unknown status·HHangzhou Cancer Hospital·Phase 2·NCT04481100·38 enrolled

Show 1 more trial

Itraconazole as a Targeted Therapy for Inhibiting Hedgehog Pathway Signaling in Esophageal Cancer Patients

Unknown status·—·Phase 1·NCT02749513·18 enrolled

ESS4 trials

Study to Assess Blood Levels of Itraconazole During a Two-Week Period

Completed· GSK logo

GSK·Phase 1·NCT00695071·16 enrolled

A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060

Recruiting· Pfizer logo

Pfizer·Phase 1·NCT07160738·28 enrolled

A Study to Assess How Itraconazole Affects the Uptake and Elimination of Capivasertib in the Body

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT04712396·11 enrolled

Show 1 more trial

Evaluation and Validation of Metabolic Markers for the Assessment of CYP3A Activity and Prediction of DDI

Completed·SSeoul National University Hospital·Phase 1·NCT02328443·24 enrolled

Efficacy and Safety3 trials

A Study to Compare Efficacy and Safety of Mycamine® and Itraconazole for Preventing Fungal Infections

Completed· Astellas logo

Astellas·Phase 3·NCT00794703·288 enrolled

An Efficacy and Safety Study of Itraconazole Sequential Therapy (Intravenous Injection Followed by Oral Solution) in Invasive Pulmonary Fungal Infections

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 4·NCT01823289·71 enrolled

Efficacy and Safety of Terbinafine and Itraconazole

Unknown status·—·Phase 2/3·NCT05881980·150 enrolled

Prostate Cancer3 trials

Study of Itraconazole in Castrate-resistant Prostate Cancer (CRPC) Post-chemotherapy

Terminated·SStanford University·Phase 2·NCT01450683·4 enrolled

A Study of Extending Relugolix Dosing Intervals Through Addition of Itraconazole or Ritonavir in Prostate Cancer Patients

Terminated·UUniversity of Chicago·Phase 1·NCT05679388·60 enrolled

Itraconazole in Treating Patients With Biochemically Relapsed Prostate Cancer

Completed·UUniversity of California, San Francisco·Phase 2·NCT01787331·21 enrolled

Histoplasmosis3 trials

Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis

Completed·NNational Center for Research Resources (NCRR)·Phase 1/2·NCT00004811·7 enrolled

A Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDS

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00000992·30 enrolled

A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 3·NCT00002159·60 enrolled

Cystic Fibrosis2 trials

An Exploratory Study to Assess Multiple Doses of Omalizumab in Patients With Cystic Fibrosis Complicated by Acute Bronchopulmonary Aspergillosis (ABPA)

Terminated· Novartis logo

Novartis·Phase 4·NCT00787917·14 enrolled

Evaluation of VX-828 in Healthy Participants and in Participants With Cystic Fibrosis

Recruiting· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 1·NCT06154447·255 enrolled

Acute Myeloid Leukemia2 trials

First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia

Recruiting·KKura Oncology, Inc.·Phase 1/2·NCT04067336·263 enrolled

AMG 176 First in Human Trial in Participants With Relapsed or Refractory Multiple Myeloma and Participants With Relapsed or Refractory Acute Myeloid Leukemia

Terminated· Amgen logo

Amgen·Phase 1·NCT02675452·141 enrolled

Oral2 trials

Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single Oral Dose of BI 1026706 in Healthy Male Subjects

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02513446·16 enrolled

Effect of Cytochrome P 450 3A4 Inhibition by Itraconazole on the Single Oral Dose Pharmacokinetics of Cilobradine

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT02264041·25 enrolled

Single Ascending Dose2 trials

Single Ascending Dose, First-in-Human Study on Safety, Tolerability and Pharmacokinetics of BAY1161116

Terminated· Bayer logo

Bayer·Phase 1·NCT03119077·32 enrolled

First-in-human: Single Ascending Dose, Food Effect, Drug-drug Interaction, Multiple Ascending Dose, Proof of Pharmacology

Completed· Astellas logo

Astellas·Phase 1·NCT02420782·116 enrolled

Fungal Infection2 trials

A Study of Itraconazole in the Management of Superficial Fungal Infections in India

Terminated· Johnson & Johnson logo

Johnson & Johnson·Phase 4·NCT03923010·40 enrolled

A Study of Treatments for Fungal Infections of the Mouth and Throat in HIV-Infected Patients Who Have Had Success With Itraconazole But Not With Fluconazole

Completed· Johnson & Johnson logo

Johnson & Johnson·N/A·NCT00002341

Drug2 trials

A Study to Evaluate the Effect of Fluconazole, Bupropion, or Itraconazole on the Drug Levels and Safety of BMS-986235

Withdrawn· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT04464577

A Study to Assess the Effect of Itraconazole, Phenytoin and Gemfibrozil on the Drug Levels of BMS-986166 in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT04956627·15 enrolled

Phase 12 trials

A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT03843060·14 enrolled

Phase 1 Study to Investigate Effect of Rifampin and Itraconazole on the Pharmacokinetics of BGB-3111 in Healthy Subjects

Completed· BeiGene logo

BeiGene·Phase 1·NCT03301181·40 enrolled

Lymphoma2 trials

A Safety and Efficacy Study of CC-90011 in Participants With Relapsed and/or Refractory Solid Tumors and Non-Hodgkin's Lymphomas

Terminated· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT02875223·75 enrolled

A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics of Alisertib in Participants With Advanced Solid Tumors or Relapsed/Refractory Lymphoma

Completed· Takeda logo

Takeda·Phase 1·NCT02259010·24 enrolled

Patients With Advanced Solid Tumors2 trials

A Study to Evaluate the Effect of Itraconazole and Rifampin on the Pharmacokinetics of Talazoparib in Patients With Advanced Solid Tumors

Completed· Pfizer logo

Pfizer·Phase 1·NCT03077607·36 enrolled

The Effect of Tesetaxel on the QTc Interval and the Effect of Food, Itraconazole, and Rifampin on Tesetaxel Pharmacokinetics in Patients With Advanced Solid Tumors

Terminated·OOdonate Therapeutics, Inc.·Phase 1·NCT04312282·93 enrolled

CAR2 trials

A Study to Assess the Effect of Multiple Doses of Itraconazole, Gemfibrozil, or Carbamazepine on BMS-986278 in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT05932303·47 enrolled

Study of the Effects of Itraconazole and Carbamazepine on LY3410738 in Healthy Participants

Terminated· Eli Lilly logo

Eli Lilly·Phase 1·NCT05205447·27 enrolled

Single Dose2 trials

A Single-center, Randomized, Open-label, Parallel-design Clinical Study to Evaluate the Pharmacokinetic Effects of Itraconazole, Fluconazole or Efavirenz on a Single Dose of Clifutinib in Healthy Participants

Not yet recruiting· Sunshine Lake Pharma Co., Ltd. logo

Sunshine Lake Pharma Co., Ltd.·Phase 1·NCT07341672·80 enrolled

A Study of the Effect of Multiple Doses of Itraconazole and Fluoxetine on the Pharmacokinetics of a Single Dose of RO5285119 in Healthy Subjects

Completed· Roche logo

Roche·Phase 1·NCT01967979·28 enrolled

Tinea Capitis1 trial

Efficacy Comparison of Itraconazole Pulse Therapy and Terbinafine Therapy in Treatment of Tinea Capitis in Children.

Completed·MMuhammad Aamir Latif·N/A·NCT07068256·164 enrolled

HIV infection1 trial

Study of Itraconazole in Patients With Advanced HIV Infection

Completed· Johnson & Johnson logo

Johnson & Johnson·N/A·NCT00002370·36 enrolled

Arsenic Trioxide1 trial

Arsenic Trioxide and Itraconazole in Treating Patients With Advanced Basal Cell Cancer

Withdrawn·JJean Yuh Tang·Phase 1·NCT02699723

Hematopoietic Stem Cell Transplant1 trial

Voriconazole Versus Itraconazole In Primary Prophylaxis Of Invasive Fungal Infection (IFI) In Subjects With Allogeneic Hematopoietic Stem Cell Transplants (HSCT)

Completed· Pfizer logo

Pfizer·Phase 3·NCT00289991·489 enrolled

Advanced Cancer1 trial

A Study in People With Advanced Cancer to Test Whether the Amount of BI 907828 in the Blood is Influenced by Taking an OATP Inhibitor or a CYP3 Inhibitor

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT05372367·33 enrolled

Allergic Bronchopulmonary Aspergillosis1 trial

A Randomized Trial of Prednisolone, Itraconazole, or Their Combination in Allergic Bronchopulmonary Aspergillosis

Recruiting·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT06174922·300 enrolled

Bone Marrow Transplantation1 trial

Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation

Completed·FFred Hutchinson Cancer Center·Phase 3·NCT00003883·578 enrolled

TIA1 trial

A Phase I Study to Assess PK of AZD7986 Alone & With Verapamil, Itraconazole or Diltiazem in Healthy Subjects

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT02653872·15 enrolled

Ciprofloxacin1 trial

Evaluate the Effects of Itraconazole and Ciprofloxacin on Single-Dose PK of Pracinostat in Healthy Nonsmoking Subjects

Completed·HHelsinn Healthcare SA·Phase 1·NCT02118909·32 enrolled

Growth1 trial

A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer

Completed· Pfizer logo

Pfizer·Phase 1·NCT00585195·596 enrolled

Aspergillosis1 trial

Chronic Pulmonary Aspergillosis and Ambisome Aerosol with Itraconazole

Recruiting·PPoitiers University Hospital·Phase 3·NCT03656081·224 enrolled

Trial1 trial

A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of Praliciguat (IW-1973) in Healthy Volunteers

Completed·CCyclerion Therapeutics·Phase 1·NCT03499106·24 enrolled

Advanced Breast Cancer1 trial

Investigation of Drug-drug Interaction of Ritonavir and Itraconazole on the Pharmacokinetics of SHR-A1811 in Subjects With HER2-expressing Advanced Breast Cancer

Recruiting·JJiangsu HengRui Medicine Co., Ltd.·Phase 1·NCT06710990·32 enrolled

NAFLD1 trial

DDI Study of ASC41 in HV and the PK, Safety and Tolerability in Subjects With NAFLD.

Completed·GGannex Pharma Co., Ltd.·Phase 1·NCT04845646·24 enrolled

Graft Versus Host Disease1 trial

Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients

Terminated·SSamsung Medical Center·Phase 4·NCT01282879·36 enrolled

Onychomycosis1 trial

Comparative Study Between Pulse Therapy With Oral Itraconazole Versus Continuous Oral Terbinafine Therapy for Treatment of Onychomycosis

Completed·—·Phase 1·NCT05578950·100 enrolled

Statin1 trial

A Study to Assess the Drug Levels of CC-92480 After Coadministration With Rifampin and Itraconazole, and the Drug Levels of Digoxin and Rosuvastatin After Coadministration With CC-92480 in Healthy Participants

Completed· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 1·NCT05389722·24 enrolled

Pediatric Cancer1 trial

Pharmacokinetics of Itraconazole in Pediatric Cancer Patients

Completed·SSeoul National University Hospital·Phase 1·NCT01409018·6 enrolled

Wound Healing1 trial

Assessment of Mechanisms of Improved Wound Healing

Completed·TThe University of Texas Medical Branch, Galveston·Phase 2/3·NCT00673309·644 enrolled

Autologous Hematopoietic Stem Cell Transplantation1 trial

Efficacy of Prophylactic Itraconazole in High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation

Completed·SSamsung Medical Center·Phase 4·NCT00336531·100 enrolled

Allogeneic Hematopoietic Stem Cell Transplantation1 trial

Voriconazole Compared With Itraconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Completed·JJonsson Comprehensive Cancer Center·N/A·NCT00079222

Myelodysplastic Syndrome1 trial

PKC412 in Participants With Acute Myeloid Leukemia or With Myelodysplastic Syndrome (CPKC412A2104 Core); and PKC412 in Participants With Acute Myeloid Leukemia or With Myelodysplastic Syndrome With Either Wild Type or Mutated FMS-like Tyrosine Kinase 3 (FLT3) (CPKC412A2104E1 and CPKC412A2104E2)

Completed· Novartis logo

Novartis·Phase 1/2·NCT00045942·144 enrolled

Adult Subject1 trial

A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects

Completed· Vertex Pharmaceuticals logo

Vertex Pharmaceuticals·Phase 1·NCT01768663·80 enrolled

Advanced Solid Malignancies1 trial

Drug-drug Interaction Study With AZD5305 and Itraconazole in Patients With Advanced Solid Malignancies

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT05573724·16 enrolled

Pityriasis Versicolor1 trial

Comparison of Efficacy of Oral Fluconazole Versus Oral Itraconazole in the Treatment of Pityriasis Versicolor

Recruiting·KKhyber Teaching Hospital·Phase 4·NCT06922344·106 enrolled

Alzheimer's Disease1 trial

A Study of LY3202626 in Healthy Participants and Participants With Alzheimer's Disease

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT02323334·94 enrolled

Overweight or Obese1 trial

A Drug-Drug Interaction Study to Examine the Impact of Itraconazole and Cyclosporine on PF-07081532 Pharmacokinetics in Overweight or Obese Adults

Completed· Pfizer logo

Pfizer·Phase 1·NCT05745701·16 enrolled

Immunocompromised1 trial

The Relationship of Defeverscence and Itraconazole Plasma Level Study in Immunocompromised Participants

Completed· Johnson & Johnson logo

Johnson & Johnson··NCT01021683·203 enrolled

Cancer1 trial

Topical Itraconazole in Treating Patients With Basal Cell Cancer

Completed·JJean Yuh Tang·Phase 1·NCT02735356·9 enrolled

Vulvovaginal Candidiasis1 trial

Monthly Itraconazole Versus Classic Homeopathy for Treatment of Recurrent Vulvovaginal Candidiasis (RVVC)

Completed·MMedical University of Vienna·N/A·NCT00895453·144 enrolled

Formulation Bridging1 trial

Food-effect, Drug-Drug Interaction (DDI), and Formulation Bridging Study

Completed·TTheravance Biopharma·Phase 1·NCT03555617·36 enrolled

Celecoxib1 trial

ATRA, Celecoxib, and Itraconazole as Maintenance

Completed·UUniversity of Iowa·Phase 1·NCT02401295·1 enrolled

Completed· Roche logo

Roche·Phase 1·NCT06809608·36 enrolled

Breast Cancer1 trial

A Pilot Trial of Itraconazole Pharmacokinetics in Patients With Metastatic Breast Cancer

Completed·IIndiana University·N/A·NCT00798135·13 enrolled

Concentration1 trial

A Study to Evaluate the Effect of Itraconazole on the Concentration of GSK3923868 in the Blood in Healthy Participants

Completed· GSK logo

GSK·Phase 1·NCT06597500·20 enrolled

Advanced/Metastatic Solid Tumors1 trial

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

Recruiting·DDualityBio Inc.·Phase 1/2·NCT05914116·862 enrolled

Glioblastoma1 trial

A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Recurrent Glioblastoma

Completed·UUniversity of Ulm·Phase 1/2·NCT02770378·10 enrolled

Hematological Diseases1 trial

Micafungin Versus Intravenous Itraconazole as Empirical Antifungal Therapy for Febrile Neutropenic Patients With Hematological Diseases

Completed·YYonsei University·Phase 2·NCT01344681·153 enrolled

Opioid Use Disorder1 trial

Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).

Terminated· AstraZeneca logo

AstraZeneca·Phase 1·NCT06406400·15 enrolled

Candidiasis1 trial

An Open Study of the Effect of Itraconazole Oral Solution for the Treatment of Fluconazole Refractory Oropharyngeal Candidiasis in HIV-Positive Subjects.

Completed· Johnson & Johnson logo

Johnson & Johnson·N/A·NCT00002133

Female1 trial

A Study of LY3484356 in Healthy Female Participants

Completed· Eli Lilly logo

Eli Lilly·Phase 1·NCT04840888·82 enrolled

Clinical Trial1 trial

A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazolam Levels (MK-2828-007)

Recruiting· Merck & Co. logo

Merck & Co.·Phase 1·NCT07435194·28 enrolled

Sporotrichosis1 trial

Antifungal Agents and Infrared Thermotherapy Alone or in Combination in the Treatment of Sporotrichosis

Recruiting·FFirst Hospital of China Medical University·N/A·NCT06300138·150 enrolled

Basal Cell Carcinoma1 trial

Topical Itraconazole in the Treatment of Basal Cell Carcinoma

Completed·JJohns Hopkins University·Phase 1·NCT02120677·5 enrolled

Postmenopausal Women1 trial

Study Evaluating Effects of Multiple-Dose Administration of Itraconazole on the Single Dose Pharmacokinetics of Conjugated Estrogens/Bazedoxifene in Non-Obese and Obese Postmenopausal Women

Completed· Pfizer logo

Pfizer·Phase 1·NCT02100553·24 enrolled

Hepatitis C1 trial

Single and Multiple Dose Study of Uprifosbuvir (MK-3682/IDX21437) in Healthy and Hepatitis C Virus (HCV)-Infected Participants (MK-3682-001)

Completed· Merck & Co. logo

Merck & Co.·Phase 1/2·NCT01974687·178 enrolled

Women1 trial

Study That Evaluates the Effect of CYP3A4 Inhibition on Lu AG06466 in Healthy Men and Women

Completed· Lundbeck logo

Lundbeck·Phase 1·NCT04405323·16 enrolled

Prospective1 trial

A Prospective Study on Optimizing Treatment for ABPA

Unknown status·SShanghai Zhongshan Hospital·N/A·NCT05129033·100 enrolled

Surufatinib1 trial

A Study to Assess the Effect of a Strong CYP3A Inhibitor, on Surufatinib in Healthy Subjects

Completed·HHutchison Medipharma Limited·Phase 1·NCT04372407·13 enrolled

Cryptococcal Meningitis1 trial

Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis

Completed·IInterMune·Phase 2·NCT00012467·60 enrolled

Non-Hodgkins Lymphoma1 trial

COPANLISIB (BAY80-6946) Drug-drug Interaction and Cardiovascular Safety Study in Advanced Solid Tumor and Non-Hodgkin's Lymphoma Patients

Completed· Bayer logo

Bayer·Phase 1·NCT02253420·51 enrolled

Unspecified16 trials

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 894416 in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT03722173·14 enrolled

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1358894 in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT03843151·16 enrolled

HMPL-523 CYP3A/P-gp Inhibitor and CYP Inducer Study

Completed·HHutchmed·Phase 1·NCT05720767·28 enrolled

Show 13 more trials

A Study to Evaluate the Effect of a Potent Cytochrome P450 (CYP) 3A Inhibitor on Ipatasertib

Completed· Roche logo

Roche·Phase 1·NCT03222310·15 enrolled

A Study in Healthy Male Volunteers to Look at How the Test Medicine GLPG1690 is Taken up by the Body When Doses of Itraconazole and Voriconazole Are Given to Healthy Volunteers

Completed·GGalapagos NV·Phase 1·NCT03515382·18 enrolled

A Study to Evaluate the Effects of Phenytoin and Itraconazole on Sonrotoclax (BGB-11417) in Healthy Volunteers

Completed· BeiGene logo

BeiGene·Phase 1·NCT06543043·30 enrolled

A Study in Healthy Men to Test Whether Itraconazole Influences the Amount of BI 1584862 in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT06041438·14 enrolled

A Study in Healthy People to Test How Itraconazole Influences the Amount of BI 3031185 in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT07211425·14 enrolled

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 730357 in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT03782987·14 enrolled

Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic Study of GSK2881078 and Study to Evaluate the Effect of CYP3A4 Inhibition on PK of GSK2881078

Completed· GSK logo

GSK·Phase 1·NCT02567773·108 enrolled

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 474121 in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT04716894·14 enrolled

Study in Healthy Subjects to Determine the Effect of an Inhibitor on Exposure to Relacorilant and Its Metabolites

Completed·CCorcept Therapeutics·Phase 1·NCT03512548·52 enrolled

A Study in Healthy Men to Test How Itraconazole Influences the Amount of Zongertinib (BI 1810631) in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT05833139·16 enrolled

A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 1323495 in the Blood

Completed· Boehringer Ingelheim logo

Boehringer Ingelheim·Phase 1·NCT04011241·14 enrolled

A Study of Empirical Antifungal Therapy With Itraconazole

Completed· Johnson & Johnson logo

Johnson & Johnson··NCT01706562·138 enrolled

A Pharmacokinetic Study of the Effect of Itraconazole Exposure to Orvepitant in Healthy Volunteers

Completed·NNerre Therapeutics Ltd.·Phase 1·NCT03535662·16 enrolled

Regulatory

FDA Approval Timeline[5]

Sep 11, 1992

SPORANOX

NDA NDA020083

Feb 21, 1997

SPORANOX

NDA NDA020657

Mar 30, 1999

SPORANOX

NDA NDA020966

Apr 29, 2010

ONMEL

NDA NDA022484

Dec 11, 2018

TOLSURA

NDA NDA208901

Sources

References

[1]
ClinicalTrials.gov — 396 trial records for Itraconazole. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Sporanox drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Itraconazole compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Itraconazole. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA208901). U.S. Food & Drug Administration.
[6]
FDA Orange Book — Patent and exclusivity data for Sporanox. U.S. Food & Drug Administration.
[7]
SEC EDGAR — Sebela Pharmaceuticals Development LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Cytochrome P450 51 Inhibitor[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: SSebela Pharmaceuticals Development LLC

Patent Landscape[6]

Patent Cliff

Oct 3, 2028

Earliest patent expiration — generic entry possible after this date

Patent #Expires

8486456Oct 3, 2028

10463740Jun 21, 2033

9713642Jun 21, 2033

10806792Jun 21, 2033

8921374Jun 21, 2033

1 more patents

9272046Jun 21, 2033

Sporanox

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q2 2028

Q4 2028

Trials by Indication[1]

Interaction40 trials

Tics26 trials

Adult13 trials

ART8 trials

Drug Interactions5 trials

Esophageal Cancer4 trials

ESS4 trials

Efficacy and Safety3 trials

Prostate Cancer3 trials

Histoplasmosis3 trials

Cystic Fibrosis2 trials

Acute Myeloid Leukemia2 trials

Oral2 trials

Single Ascending Dose2 trials

Fungal Infection2 trials

Drug2 trials

Phase 12 trials

Lymphoma2 trials

Patients With Advanced Solid Tumors2 trials

CAR2 trials

Single Dose2 trials

Tinea Capitis1 trial

HIV infection1 trial

Arsenic Trioxide1 trial

Hematopoietic Stem Cell Transplant1 trial

Advanced Cancer1 trial

Allergic Bronchopulmonary Aspergillosis1 trial

Bone Marrow Transplantation1 trial

TIA1 trial

Ciprofloxacin1 trial

Growth1 trial

Aspergillosis1 trial

Trial1 trial

Advanced Breast Cancer1 trial

NAFLD1 trial

Graft Versus Host Disease1 trial

Onychomycosis1 trial

Statin1 trial

Pediatric Cancer1 trial

Wound Healing1 trial

Autologous Hematopoietic Stem Cell Transplantation1 trial

Allogeneic Hematopoietic Stem Cell Transplantation1 trial

Myelodysplastic Syndrome1 trial

Adult Subject1 trial

Advanced Solid Malignancies1 trial

Pityriasis Versicolor1 trial

Alzheimer's Disease1 trial

Overweight or Obese1 trial

Immunocompromised1 trial

Cancer1 trial

Vulvovaginal Candidiasis1 trial

Formulation Bridging1 trial

Celecoxib1 trial

Chronic Granulomatous Disease1 trial

Chronic Rhinosinusitis With Nasal Polyps1 trial

Medication1 trial

Breast Cancer1 trial

Concentration1 trial

Advanced/Metastatic Solid Tumors1 trial

Glioblastoma1 trial

Hematological Diseases1 trial

Opioid Use Disorder1 trial

Candidiasis1 trial

Female1 trial

Clinical Trial1 trial

Sporotrichosis1 trial

Basal Cell Carcinoma1 trial

Postmenopausal Women1 trial

Hepatitis C1 trial

Women1 trial

Prospective1 trial