JNJ-80948543

Phase 1Small molecule

Johnson & Johnson

JNJ-80948543 is one of 8 small molecule programs targeting Lymphoma, Non-Hodgkin. It is currently in Phase 1.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Lymphoma, Non-HodgkinActive, not recruiting

Lymphoma, Non-HodgkinPhase 1

Active, not recruiting

Competition

Competitive Landscape

11 competitors in Lymphoma, Non-Hodgkin

#DrugCompanyPhaseTrials

Gazyva

Roche

Preclinical

1 2

COLUMVI

Roche

Preclinical

1 3

Actemra

CCelltrion

Preclinical

1 4

MK-1045

Merck & Co.

Preclinical

1 5

JNJ-87801493

Johnson & Johnson

Phase 1

2 6

JNJ-75348780

Johnson & Johnson

Phase 1

2 7

JNJ-80948543

Johnson & Johnson

Phase 1

3 8

Prizloncabtagene Autoleucel

Johnson & Johnson

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 1Active, not recruiting

Lymphoma, Non-Hodgkin

NCT06139406

Q1 2027

Phase 1Active, not recruiting

Lymphoma, Non-Hodgkin

NCT06660563

Q3 2027

Phase 1Active, not recruiting

Lymphoma, Non-Hodgkin

NCT05424822

Clinical

Trials by Indication[1]

Lymphoma, Non-Hodgkin3 trials

A Phase 1, First-in-human Study of JNJ-80948543, a T-cell Redirecting Antibody, in Participants With NHL and CLL

Active, not recruiting· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT05424822·167 enrolled

A Phase 1b Study of JNJ-80948543 in Combination With Other CD3 T-Cell Engagers (TCEs) in Participants With Relapsed/Refractory B-Cell Non-Hodgkin Lymphoid (R/R B-Cell NHL) Malignancies

Active, not recruiting· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT06660563·19 enrolled

A Phase 1, First-in-human Study of JNJ-87801493 in Combination With CD3 T-Cell Engagers in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoid Malignancies (NHLs)

Active, not recruiting· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT06139406·70 enrolled

Leukemia, Myeloid, Acute1 trial

An Open Label, Rollover Platform Study for Continued Study Treatment and Ongoing Safety Monitoring

Enrolling by invitation· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT06788509·120 enrolled

Sources

References

[1]
ClinicalTrials.gov — 4 trial records for JNJ-80948543. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — JNJ-80948543 compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for JNJ-80948543. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Johnson & Johnson company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 1[1]
Company: Johnson & Johnson

JNJ-80948543

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q1 2027

Q3 2027

Trials by Indication[1]

Lymphoma, Non-Hodgkin3 trials

Leukemia, Myeloid, Acute1 trial

References

Drug Info

Quick Facts

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