COLUMVI

(Glofitamab)

Phase 3Monoclonal antibody

Glofitamab is used to treat certain types of blood cancers, specifically a form of lymphoma called diffuse large B-cell lymphoma. It works by helping the body's immune system recognize and destroy cancer cells.[1] COLUMVI is currently being investigated across 20 indications[3], with its most advanced program in Phase 3.[1]

COLUMVI is one of 162 biologic programs targeting Lymphoma. It is currently in Phase 3.

Indications

Total Trials

Active Trials

161

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

LymphomaActive, not recruiting

Mantle Cell LymphomaRecruiting

Diffuse Large B-Cell LymphomaRecruiting

DLBCLNot yet recruiting

Lymphoma, B-CellActive, not recruiting

B-Cell MalignancyRecruiting

B-Cell Non Hodgkin LymphomaActive, not recruiting

Diffuse Large B-Cell Lymphoma(dlbcl)Not yet recruiting

Large B-Cell Lymphoma (LBCL)Not yet recruiting

Lymphoma, Non-HodgkinActive, not recruiting

LymphomaPhase 3

Active, not recruiting

Mantle Cell LymphomaPhase 2

Recruiting

Diffuse Large B-Cell LymphomaPhase 3

Recruiting

DLBCLPhase 2

Not yet recruiting

Lymphoma, B-CellPhase 1

Active, not recruiting

B-Cell MalignancyPreclinical

Recruiting

B-Cell Non Hodgkin LymphomaPhase 1

Active, not recruiting

Diffuse Large B-Cell Lymphoma(dlbcl)Phase 2

Not yet recruiting

Large B-Cell Lymphoma (LBCL)Phase 2

Not yet recruiting

Lymphoma, Non-HodgkinPreclinical

Active, not recruiting

Showing 10 of 20 indications

Competition

Competitive Landscape

375 competitors in Lymphoma

#DrugCompanyPhaseTrials

COLUMVI

Roche

Phase 3

16 2

Zofran

Novartis

Preclinical

2 3

Norvir

AbbVie

Preclinical

1 4

Cabenuva

GSK

Preclinical

1 5

Emend

CCidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Preclinical

1 6

Kenalog

BBausch Health Americas, Inc.

Preclinical

1 7

Elitek

AAzienda U.S.L. 1 di Massa e Carrara

Preclinical

—8

Decadron

QQuince Therapeutics S.p.A.

Preclinical

—9

Solu-Medrol

MMassachusetts Eye and Ear Infirmary

Systemic Therapy

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2Recruiting

Non-Hodgkin Lymphoma,b Cell

NCT06534437

Phase 1Active, not recruiting

Lymphoma, B-Cell

NCT04161248

Q1 2027

PreclinicalRecruiting

Blastoid Variant Mantle Cell Lymphoma

NCT05861050

Phase 1Active, not recruiting

Lymphoma

NCT06624085

PreclinicalActive, not recruiting

Lymphoma, Non-Hodgkin

NCT04077723

Q3 2027

Phase 2Not yet recruiting

Relapsed/refractory Diffuse Large B-Cell Lymphoma

NCT07748364

Clinical

Trials by Indication[1]

Lymphoma16 trials

Bispecific Antibody-Based Salvage Therapy Followed by CAR-T ± ASCT in R/R Aggressive B-Cell Lymphoma

Recruiting·IInstitute of Hematology & Blood Diseases Hospital, China·Phase 2·NCT06996132·25 enrolled

A Study to Learn About the Effects of Two Study Medicines (Maplirpacept [PF-07901801] And Glofitamab) When Given Together In People With Relapsed Or Refractory Diffuse Large B Cell Lymphoma.

Active, not recruiting· Pfizer logo

Pfizer·Phase 1/2·NCT05896163·24 enrolled

A Study of Glofitamab in Combination With Rituximab or Obinutuzumab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP), or Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (CHP) in Participants With Non-Hodgkin Lymphomas or With DLBCL

Completed· Roche logo

Roche·Phase 1·NCT03467373·111 enrolled

Show 13 more trials

A Multicentre, Parallel Arm, Open-label Trial of Frontline R-CHOP/Pola-RCHP and Glofitamab in Younger, Higher Risk Patients With Diffuse Large B Cell Lymphoma (DLBCL)

Active, not recruiting·PPeter MacCallum Cancer Centre, Australia·Phase 1/2·NCT04914741·80 enrolled

Rituximab in Combination With Glofitamab and Polatuzumab Vedotin in Patients With Previously Untreated Aggressive B-cell Lymphoma Ineligible for R-CHOP

Active, not recruiting·IInstitut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest·Phase 2·NCT05798156·125 enrolled

A Study of Efficacy and Safety of Glofitamab in Combination With Salvage Therapy in a Real-world Setting in Chinese Adult Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma.

Recruiting·TThe First Affiliated Hospital of Soochow University··NCT06497452·50 enrolled

A Study Evaluating the Efficacy, Safety, and Pharmacokinetics of Glofitamab in Combination With Rituximab Plus Ifosfamide, Carboplatin Etoposide Phosphate in Participants With Relapsed/Refractory Transplant or CAR-T Therapy Eligible Diffuse B-Cell Lymphoma

Completed· Roche logo

Roche·Phase 1·NCT05364424·43 enrolled

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7443904 in Combination With Glofitamab in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma

Terminated· Roche logo

Roche·Phase 1·NCT05219513·53 enrolled

A Trial of Polatuzumab Vedotin, Obinutuzumab and Glofitamab As a Peri-CAR-T Cell Treatment Strategy in Large B-cell Lymphoma

Recruiting·UUniversity College, London·Phase 2·NCT06071871·99 enrolled

The Efficacy and Safety of Glofitamab in Combination With PD-1 Antibody and Lenalidomide in Patients With Relapsed/Refractory Large B-cell Lymphoma (LBCL) With TP53 Aberrations: A Prospective, Multicenter, Phase II Clinical Study

Recruiting·TThe First Affiliated Hospital with Nanjing Medical University·Phase 2·NCT07240194·24 enrolled

CAR T-cell Therapy in Combination With Glofitamab for Relapsed/Refractory Large B-Cell Lymphoma With High-Risk Prognostic Factors

Not yet recruiting·RRuijin Hospital·Phase 2·NCT06567366·45 enrolled

A Phase 2 Trial of Glofitamab for Minimal Residual Disease in Patients With Large B-cell Lymphoma

Withdrawn·MM.D. Anderson Cancer Center·Phase 2·NCT06670105

Phase 2 Study of Glofitamab and Gemcitabine and Oxaliplatin (Glofit-GemOx) Bridging to Lisocabtagene Maraleucel in Relapsed/Refractory Aggressive B-cell Lymphomas

Recruiting·MMassachusetts General Hospital·Phase 2·NCT07711483·56 enrolled

A Phase III, Open-Label, Multicenter Randomized Study Evaluating Glofitamab as a Single Agent Versus Investigator's Choice in Patients With Relapsed/Refractory Mantle Cell Lymphoma

Recruiting· Roche logo

Roche·Phase 3·NCT06084936·182 enrolled

A Phase Ib Study Evaluating the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in U.S. Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Active, not recruiting· Roche logo

Roche·Phase 1·NCT06624085·50 enrolled

A Phase II Study Evaluating the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Circulating Tumor (ct)DNA High-Risk Patients With Untreated Diffuse Large B-Cell Lymphoma

Active, not recruiting· Roche logo

Roche·Phase 2·NCT04980222·46 enrolled

Diffuse Large B-Cell Lymphoma10 trials

The Effectiveness and Safety of Glofitamab in Real-World Clinical Practice Among Chinese Adult Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma: A Prospective, Observational, Multicenter Study

Not yet recruiting·RRuijin Hospital··NCT06656234·200 enrolled

A Study to Evaluate Glofitamab as Single Agent Administered After Pretreatment With Obinutuzumab in Chinese Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Completed· Roche logo

Roche·Phase 1·NCT04657302·30 enrolled

Glofitamab in Relapsed or Refractory Diffuse Large B-cell Lymphoma After CD19 Chimeric Antigen Receptor T-cell Therapy

Active, not recruiting·SSamsung Medical Center·Phase 2·NCT06552572·30 enrolled

Show 7 more trials

Efficacy and Safety of Glofitamab Combined With GemOxin the Treatment of Refractory Diffuse Large B-Cell Lymphoma

Active, not recruiting·—·Phase 2·NCT07480850·40 enrolled

A Phase II Study of Glofitamab Plus Polatuzumab-R-CHP for Patients With High-risk Diffuse Large B-cell Lymphoma

Recruiting·JJennifer Crombie, MD·Phase 2·NCT05800366·41 enrolled

A Study Evaluating the Safety and Efficacy of Glofitamab or Mosunetuzumab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma and High-Grade Large B-Cell Lymphoma

Completed· Roche logo

Roche·Phase 1·NCT04313608·23 enrolled

Efficacy and Safety of Glofitamab, Polatuzumab Vedotin and Zanubrutinib in the First-line Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma (DLBCL): A Single-center, Single-arm, Prospective, Phase II Trial

Recruiting·SShanghai Zhongshan Hospital·Phase 2·NCT07012980·38 enrolled

Evaluating Effectiveness and Safety of Glofitamab Based Second-Line Therapy in Chinese Adult Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma: A Prospective, Observational, Multicenter, Cohort Study

Recruiting· Roche logo

Roche··NCT07200375·300 enrolled

A Phase III, Open-Label, Multicenter, Randomized Study Evaluating the Efficacy and Safety of Glofitamab in Combination With Gemcitabine Plus Oxaliplatin Versus Rituximab in Combination With Gemcitabine and Oxaliplatin in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Active, not recruiting· Roche logo

Roche·Phase 3·NCT04408638·270 enrolled

TPG: a Phase 2 Trial of Polatuzumab Vedotin, Glofitamab, and Tafasitamab as Chemotherapy-sparing First-line Therapy for Diffuse Large B-cell Lymphoma and High-grade B-cell Lymphoma

Not yet recruiting·BBrown University·Phase 2·NCT07502872·30 enrolled

Mantle Cell Lymphoma8 trials

A Study of Glofitamab and Lenalidomide in People With Mantle Cell Lymphoma

Recruiting·MMemorial Sloan Kettering Cancer Center·Phase 1·NCT06192888·39 enrolled

Glofitamab Combined With Lenalidomide in High Risk Patients With Relapsed or Refractory Mantle Cell Lymphoma

Recruiting·PPeking University Third Hospital·Phase 2·NCT07460362·43 enrolled

A Phase 2 Trial of GlOfitamab anD pIrtobrutinib in Mantle Cell Lymphoma Patients With Prior BTK Inhibitor Exposure.

Recruiting·AAustralasian Leukaemia and Lymphoma Group·Phase 2·NCT05833763·42 enrolled

Show 5 more trials

Glofitamab Plus Ibrutinib With Obinutuzumab for the Treatment of Patients With Mantle Cell Lymphoma, IGNITE MCL Trial

Recruiting·OOHSU Knight Cancer Institute·Phase 1/2·NCT06357676·27 enrolled

A Prospective, Single-Center Study Evaluating the Efficacy and Safety of Glofitamab Combined With Orelabrutinib and Bortezomib in Patients With High-Risk Mantle Cell Lymphoma

Not yet recruiting·RRuijin Hospital·Phase 2·NCT06656221·29 enrolled

A Phase 2 Study of Glofitamab With Acalabrutinib in Patients With Relapsed/Refractory Mantle Cell Lymphoma

Recruiting·CCity of Hope Medical Center·Phase 2·NCT06054776·40 enrolled

A Multicenter Phase 2 Study of Glofitamab With Pirtobrutinib for Relapsed or Refractory Mantle Cell Lymphoma

Recruiting·UUniversity of California, San Francisco·Phase 2·NCT06252675·30 enrolled

A Phase II, Multicenter Study of GlOfitamab in Patients With Mantle Cell Lymphoma and inaDequate Response or Relapse Following CAR T-cell Therapy (GOLD)

Recruiting·FFondazione Italiana Linfomi - ETS·Phase 2·NCT07453095·41 enrolled

DLBCL3 trials

Feasibility Trial of Glofitamab in a Response Adapted Approach Incorporating Interim FDG PET and ctDNA to Optimize Primary Therapy of DLBCL (GRAIL)

Recruiting·UUniversity Health Network, Toronto·Phase 2·NCT06050694·40 enrolled

Glofitamab in Chinese Patients With R/R DLBCL

Recruiting·PPeking Union Medical College Hospital··NCT06481826·20 enrolled

Glofitamab Combined With CAR-T Therapy in R/R DLBCL

Not yet recruiting·RRuijin Hospital·Phase 2·NCT07326371·24 enrolled

Non-Hodgkins Lymphoma2 trials

An Open-Label, Multi-Center, Phase IB/II Study of Glofitamab and Atezolizumab or Polatuzumab Vedotin (Plus a Single Pre-Treatment Dose of Obinutuzumab) in Adult Patients With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma

Completed· Roche logo

Roche·Preclinical·NCT03533283·211 enrolled

A Multicenter, Open-label, Phase I/II Study to Evaluate the Safety, Efficacy, Tolerability and Pharmacokinetics of Escalating Doses of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab Administered After a Fixed, Single Dose Pre-treatment of Obinutuzumab (Gazyva®/Gazyvaro™) in Patients With Relapsed/Refractory B-cell Non-hodgkin's Lymphoma

Active, not recruiting· Roche logo

Roche·Preclinical·NCT03075696·940 enrolled

30 more indications

Diffuse Large B-cell Lymphoma(DLBCL)2 trials

Optimizing Frontline Therapy for DLBCL in Older Adults: A GLOfitamab-based, Response-adapted, Window-stYle Study (GLORY)

Recruiting·MMemorial Sloan Kettering Cancer Center·Phase 2·NCT06765317·42 enrolled

An Open-Label, Multicenter, Randomized Study Evaluating the Efficacy and Safety of Glofitamab in Combination With Gemcitabine Plus Oxaliplatin Versus Standard of Care in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Not yet recruiting·TThe First Affiliated Hospital of Soochow University·Phase 2·NCT07599423·96 enrolled

Large B-cell Lymphoma2 trials

Phase II Study of Dual Targeting of CD19 and CD20 Antigens Using Sequential CD19-directed CAR-T Cells Followed by Mosunetuzumab or Glofitamab in Relapsed or Refractory Diffuse Large B-cell or Transformed Follicular Lymphomas

Active, not recruiting·AAbramson Cancer Center at Penn Medicine·Phase 2·NCT04889716·23 enrolled

A Phase III, Multicenter, Randomized, Open-Label Study Comparing the Efficacy and Safety of Glofitamab (RO7082859) in Combination With Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (Pola-R-CHP) Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma

Active, not recruiting· Roche logo

Roche·Phase 3·NCT06047080·1,130 enrolled

Large B-Cell Lymphoma (LBCL)2 trials

A Single-Center, Single-Arm, Open-Label, Phase II Clinical Trial of Sonrotoclax, Glofitamab, Gemcitabine and Oxaliplatin in Patients With Relapsed/Refractory Large B-Cell Lymphoma

Not yet recruiting·TThe First Affiliated Hospital of Soochow University·Phase 2·NCT07774234·39 enrolled

A Study to Evaluate the Efficacy and Safety of an AI-Driven Treatment Strategy Versus ZR2 in Older Treatment-naive Patients With Large B-cell Lymphoma (LBCL)

Not yet recruiting·RRuijin Hospital·Phase 2·NCT07717177·112 enrolled

High Risk1 trial

Phase 2 Study of BTKi-Rituximab Induction Followed by Glofitamab Consolidation in High Risk Untreated MCL Patients - WINDOW-4 Study

Not yet recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT07257055·30 enrolled

B-cell Lymphoma1 trial

A Phase 2 Study of Axicabtagene Ciloleucel and Glofitamab as Second-Line Therapy for Relapsed or Refractory Patients With Large B Cell Lymphoma

Recruiting·MM.D. Anderson Cancer Center·Phase 2·NCT06213311·40 enrolled

Recurrent Mantle Cell Lymphoma1 trial

A Phase II Study of Glofitamab for Relapsed/Refractory Mantle Cell Lymphoma in Patients Previously Treated With CD19-Directed CAR T-Cell Therapy

Recruiting·NNational Cancer Institute (NCI)·Phase 2·NCT07003295·20 enrolled

Diffuse Large B Cell Lymphoma Refractory1 trial

A Phase II,Open Label, Single Arm, Multicenter Study Investigating the Efficacy and Safety of Glofitamab When Used as a Bridge to and/or Consolidation Post-transplant for Patients With Relapsed/Refractory B-cell Lymphomas Transformed Low Grade B Cell Lymphoma) Fit and Eligible for ASCT

Recruiting·AAmerican University of Beirut Medical Center·Phase 2·NCT07387848·40 enrolled

AIDS-Related Diffuse Large B-cell Lymphoma1 trial

A Feasibility Study of Glofitamab Plus Chemoimmunotherapy in Newly Diagnosed HIV-Associated Large B-Cell Lymphoma

Recruiting·NNational Cancer Institute (NCI)·Phase 1·NCT07649304·15 enrolled

Blastoid Variant Mantle Cell Lymphoma1 trial

Phase 1/2 Study of the Combination of Glofitamab, Venetoclax and Lenalidomide in Patients With Newly Diagnosed High Risk Mantle Cell Lymphoma

Recruiting·CCity of Hope Medical Center·Preclinical·NCT05861050·50 enrolled

PCNSL1 trial

A Multicenter, Open-Label, Single-Arm, Prospective Clinical Study of Glofitamab Combined With Gemcitabine and Oxaliplatin in Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) and Secondary Central Nervous System Lymphoma (SCNSL)

Not yet recruiting·TThe First Affiliated Hospital with Nanjing Medical University·Phase 2·NCT07888621·40 enrolled

Chronic Lymphocytic Leukemia1 trial

A Phase 2 Study of Glofitamab as Monotherapy or in Combination With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation

Recruiting·CChristine Ryan·Phase 2·NCT06043674·70 enrolled

Aggressive B-Cell Non-Hodgkin Lymphoma1 trial

A Non-Randomized Prospective Single-Center Open-Label Study With Two Parallel Therapeutic Cohorts to Evaluate the Efficacy and Safety of a CD20×CD3 Bispecific Antibody in Combination With GemOx or Polatuzumab Vedotin as Holding/Bridging Therapy in Patients With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin Lymphomas Before CAR T-Cell Therapy

Recruiting·NNational Research Center for Hematology, Russia·Phase 2·NCT07883135·40 enrolled

B-cell non-Hodgkins lymphoma1 trial

A Phase II, Open-Label, Multicenter Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab Monotherapy and Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Patients With Relapsed/Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma

Recruiting· Roche logo

Roche·Phase 2·NCT06806033·130 enrolled

Mature B-Cell Non-Hodgkin Lymphoma1 trial

A Phase I/II, Open-Label, Single-Arm, Two-Part Trial to Evaluate Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity of Glofitamab in Monotherapy and in Combination With Chemoimmunotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Mature B-Cell Non-Hodgkin Lymphoma

Recruiting· Roche logo

Roche·Preclinical·NCT05533775·65 enrolled

Aggressive Non-Hodgkin Lymphoma1 trial

A Pilot Study to Estimate the Safety and Tolerability of the Combination of Polatuzumab Vedotin, With or Without Glofitamab, With Dose Adjusted Rituximab, Etoposide, Cyclophosphamide, and Doxorubicin (PERCH) for Upfront Treatment of Aggressive B-Cell Non-Hodgkin Lymphomas

Active, not recruiting·UUniversity of Washington·Preclinical·NCT04231877·56 enrolled

Follicular Lymphoma1 trial

A Phase 2 Study of Glofitamab and Obinutuzumab for First-line Treatment of Follicular Lymphoma and Marginal Zone Lymphoma

Active, not recruiting·RReid Merryman, MD·Phase 2·NCT05783596·47 enrolled

Non-hodgkin Lymphoma,B Cell1 trial

An Open Label, Phase 2 Clinical Trial of MEN1703 as Monotherapy and in Combination With Glofitamab in Patients With Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma

Recruiting·RRyvu Therapeutics SA·Phase 2·NCT06534437·178 enrolled

B-cell Malignancy1 trial

A Phase 1b/2, Open-Label, Master Protocol Study of BTK-Degrader BGB-16673 in Combination With Other Agents in Patients With Relapsed or Refractory B-Cell Malignancies

Recruiting·BBeOne Medicines·Preclinical·NCT06634589·80 enrolled

Non Hodgkin Lymphoma (NHL)1 trial

A Phase 1 First in Human Study of ARV-393 in Adult Participants With Advanced Non-Hodgkin's Lymphoma

Recruiting·AArvinas Inc.·Phase 1·NCT06393738·329 enrolled

Ann Arbor Stage II Mantle Cell Lymphoma1 trial

A Phase I Study of Glofitamab With Alternating R-CHOP/R-DHAP in Previously Untreated Mantle Cell Lymphoma

Not yet recruiting·NNational Cancer Institute (NCI)·Phase 1·NCT07444710·16 enrolled

Lymphoma, Non-Hodgkin1 trial

An Open-Label, Phase I/II Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa (RO7227166, A CD19 Targeted 4-1BB Ligand) in Combination With Obinutuzumab and in Combination With Glofitamab Following a Pre-treatment Dose of Obinutuzumab Administered in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma

Active, not recruiting· Roche logo

Roche·Preclinical·NCT04077723·498 enrolled

Recurrent Burkitt Lymphoma1 trial

A Randomized Phase 2/3 Study the Bispecific Antibody (BsAb), Glofitamab, Plus Chemoimmunotherapy in Newly Diagnosed and Relapsed Burkitt and High-Grade (Double Hit) B-Cell Lymphomas With MYC and BCL2 Rearrangements

Not yet recruiting·NNational Cancer Institute (NCI)·Preclinical·NCT07724457·271 enrolled

Relapsed/Refractory Diffuse Large B-cell Lymphoma1 trial

Phase II Trial of Glofitamab in B-NHL Using Mid-Therapy Intratumoral Transcriptomics

Not yet recruiting·JJoshua Brody·Phase 2·NCT07748364·16 enrolled

Diffuse Large B-Cell Lymphoma-Recurrent1 trial

An Open-label, Single-arm, Single-center, Phase II Clinical Trial of Glofitamab Combination With Chidamide in Patients With Recurrent and Refractory Diffuse Large B-Cell Lymphoma

Recruiting·TTianjin Medical University Cancer Institute and Hospital·Phase 2·NCT06570447·22 enrolled

B-cell Non Hodgkin Lymphoma1 trial

A Phase 1b Open-Label Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

Active, not recruiting·AADC Therapeutics S.A.·Phase 1·NCT04970901·154 enrolled

Refractory B-Cell Non-Hodgkin Lymphoma1 trial

A Real-World Study on the Efficacy and Safety of Bispecific Antibody in the Treatment of Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Not yet recruiting·YYanyan Liu··NCT07695896·200 enrolled

Lymphoma, Mantle-Cell1 trial

A Phase II, Multicenter, Open-label Study Evaluating Glofitamab in Combination With Venetoclax Plus Zanubrutinib or Venetoclax Alone in Subjects With Untreated or Relapsed/Refractory High-risk Mantle-cell Lymphoma

Recruiting·TThe Lymphoma Academic Research Organisation·Phase 2·NCT06558604·100 enrolled

Primary Central Nervous System Lymphoma1 trial

A Phase 1b Study of Glofitamab in CNS Lymphoma

Suspended·CCity of Hope Medical Center·Phase 1·NCT06922604·20 enrolled

Lymphoma, B-Cell1 trial

A Phase I Master Protocol of Novel Combination Therapy for Patients With Relapsed or Refractory Aggressive B-Cell Lymphoma

Active, not recruiting·CCanadian Cancer Trials Group·Phase 1·NCT04161248·40 enrolled

Unspecified1 trial

Glofitamab in Real Life

Recruiting·TThe Lymphoma Academic Research Organisation··NCT06994169·250 enrolled

Regulatory

FDA Approval Timeline[4]

Jun 15, 2023

COLUMVI

BLA BLA761309

Sources

References

[1]
ClinicalTrials.gov — 72 trial records for Glofitamab. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Glofitamab compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Glofitamab. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (BLA BLA761309). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Roche company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: B-Lymphocyte Antigen CD20 Binding Agent; T Cell Surface Glycoprotein CD3 Binding Agent[2]
Modality: Monoclonal antibody[2]
Highest Phase: Phase 3[1]
Company: Roche

COLUMVI

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q3 2027

Trials by Indication[1]

Lymphoma16 trials

Diffuse Large B-Cell Lymphoma10 trials

Mantle Cell Lymphoma8 trials

DLBCL3 trials

Non-Hodgkins Lymphoma2 trials

Diffuse Large B-cell Lymphoma(DLBCL)2 trials

Large B-cell Lymphoma2 trials

Large B-Cell Lymphoma (LBCL)2 trials

High Risk1 trial

B-cell Lymphoma1 trial

Recurrent Mantle Cell Lymphoma1 trial

Diffuse Large B Cell Lymphoma Refractory1 trial

AIDS-Related Diffuse Large B-cell Lymphoma1 trial

Blastoid Variant Mantle Cell Lymphoma1 trial

PCNSL1 trial

Chronic Lymphocytic Leukemia1 trial

Aggressive B-Cell Non-Hodgkin Lymphoma1 trial

B-cell non-Hodgkins lymphoma1 trial

Mature B-Cell Non-Hodgkin Lymphoma1 trial

Aggressive Non-Hodgkin Lymphoma1 trial

Follicular Lymphoma1 trial

Non-hodgkin Lymphoma,B Cell1 trial

B-cell Malignancy1 trial

Non Hodgkin Lymphoma (NHL)1 trial

Ann Arbor Stage II Mantle Cell Lymphoma1 trial

Lymphoma, Non-Hodgkin1 trial

Recurrent Burkitt Lymphoma1 trial

Relapsed/Refractory Diffuse Large B-cell Lymphoma1 trial

Diffuse Large B-Cell Lymphoma-Recurrent1 trial

B-cell Non Hodgkin Lymphoma1 trial

Refractory B-Cell Non-Hodgkin Lymphoma1 trial

Lymphoma, Mantle-Cell1 trial

Primary Central Nervous System Lymphoma1 trial

Lymphoma, B-Cell1 trial

Unspecified1 trial

FDA Approval Timeline[4]

References

Drug Info

Quick Facts

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