lopinavir/ritonavir

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

Cardiovascular DiseaseAdultHIV-1 InfectionHepatitisHepatitis CFibrosisPilot Study

146 competitors in Cardiovascular Disease

#DrugCompanyPhaseTrials

1

Tivicay

GSK

Approved

12

Enbrel

IImmunex

Approved

13

Januvia

ZZydus Therapeutics Inc.

Approved

—4

Demadex

SSarfez Pharmaceuticals, Inc.

Approved

—5

Zithromax

PPfizer's Upjohn has merged with Mylan to form Viatris Inc.

Approved

—6

Colcrys

Jazz Pharmaceuticals

Phase 3

17

Cagrilintide

Novo Nordisk

Phase 3

18

Pelacarsen

Novartis

Phase 3

19

Berberine

XXijing Hospital of Digestive Diseases

Phase 3

110

Obicetrapib

NNewAmsterdam Pharma

Phase 3

1Show 43 more competitors

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

HIV9 trials

Cyclosporine A in Combination With Abacavir Sulfate, Lamivudine, and Zidovudine and Lopinavir/Ritonavir in HIV

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00084149·54 enrolled

Pharmacokinetic Study of Two HIV Protease Inhibitors in Patients

Terminated·UUniversity of Oklahoma·Phase 4·NCT00420355·19 enrolled

ABT-378/Ritonavir and Efavirenz in HIV-Infected Patients Who Have Taken More Than One Protease Inhibitor in the Past

Completed·VViRx·Phase 2·NCT00004582

Show 6 more trials

Dual Versus Triple Protease Inhibitor Combinations, Including Ritonavir, in HIV Infected People

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00028366·56 enrolled

A Study of Two Different Doses of ABT-378/Ritonavir in HIV-Infected Patients Who Have Taken Protease Inhibitors and Non-Nucleoside Reverse Transcriptase Inhibitors

Completed·AAbbott·Phase 3·NCT00038636·36 enrolled

Comparison of Two Dosing Regimens of GW433908/Ritonavir Versus Lopinavir/Ritonavir for 48 Weeks in HIV Patients Who Have Taken Protease Inhibitors and Experienced Virological Failure

Unknown status·GSK·Phase 3·NCT00025727·330 enrolled

Study of Anti-HIV Therapy Intensification

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00034086·22 enrolled

ABT-378/Ritonavir in Combination With Reverse Transcriptase Inhibitors in Antiretroviral Naïve HIV-Infected Subjects

Completed·AAbbott·Phase 1/2·NCT00004578·100 enrolled

A Study of ABT-378/Ritonavir Combination in HIV-Infected Patients Who Have Taken Protease Inhibitors

Completed·AAbbott·Phase 1·NCT00004580

COVID-199 trials

Efficacy of Pragmatic Same-day COVID-19 Ring Prophylaxis for Adult Individuals Exposed to SARS-CoV-2 in Switzerland

Completed·CCalmy Alexandra·Phase 3·NCT04364022·326 enrolled

the Investigation Into Beneficial Effects of High-dose Interferon Beta 1-a, Compared to Low-dose Interferon Beta 1-a in Moderate to Severe Covid-19

Unknown status·SShahid Beheshti University of Medical Sciences·Phase 2·NCT04521400·100 enrolled

Combination Therapies to Reduce Carriage of SARS-Cov-2 and Improve Outcome of COVID-19 in Ivory Coast: a Phase Randomized IIb Trial

Completed·AANRS, Emerging Infectious Diseases·Phase 2/3·NCT04466241·294 enrolled

Show 6 more trials

Lopinavir/Ritonavir for the Treatment of COVID-19 Positive Patients With Cancer and Immune Suppression in the Last Year

Withdrawn·OOHSU Knight Cancer Institute·Phase 2·NCT04455958

Comparison of Lopinavir/Ritonavir or Hydroxychloroquine in Patients With Mild Coronavirus Disease (COVID-19)

Terminated·—·Phase 2·NCT04307693·65 enrolled

Ultra Low Doses of Therapy With Radiation Applicated to COVID-19

Suspended·FFundacion GenesisCare·N/A·NCT04394182·15 enrolled

Trial of Early Therapies During Non-hospitalized Outpatient Window for COVID-19

Completed·VVanderbilt University Medical Center·Phase 2·NCT04372628·452 enrolled

COVID-19 Ring-based Prevention Trial With Lopinavir/Ritonavir

Unknown status·UUnity Health Toronto·Phase 3·NCT04321174·123 enrolled

Austrian CoronaVirus Adaptive Clinical Trial (COVID-19)

Unknown status·MMedical University of Vienna·Phase 2/3·NCT04351724·500 enrolled

Treatment8 trials

Raltegravir vs. Lopinavir/Ritonavir, Both in Combination With Truvada, in HIV+ Treatment Naive Individuals

Terminated·GGeorge Washington University·Phase 4·NCT00632970·6 enrolled

Lopinavir/ Ritonavir, Ribavirin and IFN-beta Combination for nCoV Treatment

Completed·TThe University of Hong Kong·Phase 2·NCT04276688·127 enrolled

Effects of Treatment Changes on Fat Wasting in the Arms and Legs of HIV Patients

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00028314·150 enrolled

Show 5 more trials

A Study to Compare Two Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Previously Received Anti-HIV Treatment

Completed·AAbbott·Phase 3·NCT00004581·300 enrolled

Comparison of Treatment Simplification by LPV/r vs Current Treatment Continuation in HIV-Infected Patients

Completed·IInstitut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba·Phase 3·NCT00140751·186 enrolled

Treatment Options for Protease Inhibitor-exposed Children

Completed·—·Phase 3·NCT01146873·300 enrolled

Anti-HIV Treatment Interruptions in HIV Infected Adults in South Africa

Completed·TThe Wistar Institute·N/A·NCT00100646·30 enrolled

Evaluation of Two Anti-HIV Treatment Strategies in Resource-Limited South African Communities

Completed·CCIPRA SA·N/A·NCT00255840·812 enrolled

Drug6 trials

Drug Use Investigation of Kaletra

Completed·AAbbott··NCT01076972·1,184 enrolled

A Comparison of Two Anti-HIV Drug Regimens for Youth Who Have Failed Prior Therapy

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00102206·6 enrolled

Simplified Drug Regimens for HIV Patients in ACTG 388 or Patients Who Responded to A First Potent Combination Regimen

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00014937·240 enrolled

Show 3 more trials

Preventing Sexual Transmission of HIV With Anti-HIV Drugs

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00074581·3,526 enrolled

Study to Determine the Pharmacokinetic Behavior of Antiretroviral Drugs in Patients Infected by HIV

Completed·GGermans Trias i Pujol Hospital·Phase 1·NCT00307502·675 enrolled

A Study to Compare Anti-HIV Drugs Given Twice a Day or Once a Day, With or Without Direct Observation

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00036452·402 enrolled

Interaction5 trials

Drug Interaction Study of Darunavir/Ritonavir and Lopinavir/Ritonavir on GSK2248761 PK and CYP450 Probe Drugs

Completed·GSK·Phase 1·NCT00920088·24 enrolled

Drug Interaction Study of Lopinavir/Ritonavir and Gemfibrozil

Completed·NNational Institutes of Health Clinical Center (CC)·N/A·NCT00474201·15 enrolled

GSK1349572 Drug Interaction With Etravirine and Either Darunavir/Ritonavir or Lopinavir/Ritonavir

Completed·GSK·Phase 1·NCT00867152·17 enrolled

Show 2 more trials

Drug-drug Interaction Study Between Lopinavir/Ritonavir and Isavuconazole

Completed·Astellas·Phase 1·NCT01660477·68 enrolled

Drug-Drug Interaction of Lopinavir/Ritonavir on Pitavastatin

Completed·KKowa Research Institute, Inc.·Phase 4·NCT01057433·24 enrolled

52 more indications

Effectiveness5 trials

Safety and Effectiveness of Lopinavir/Ritonavir in Individuals Who Have Failed Prior HIV Therapy

Completed·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·N/A·NCT00357552·123 enrolled

The Effectiveness of Dual Therapy (Lopinavir/Ritonavir + LamivudinE) in Treatment-Experienced HIV Infected Patients in the Russian Federation

Completed·AbbVie··NCT02581202·216 enrolled

Safety and Effectiveness of Lopinavir/Ritonavir in HIV Infected Infants

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT00038480·31 enrolled

Show 2 more trials

Comparing the Safety, Effectiveness, and Tolerability of Three Anti-HIV Drug Regimens for Treatment-Naive Patients

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00050895·775 enrolled

Effectiveness of ABT-378/Ritonavir Plus Lamivudine Plus Efavirenz Plus Tenofovir DF in HIV-Infected Patients

Completed·AAbbott·Phase 2·NCT00038220·40 enrolled

Children5 trials

Lopinavir/Ritonavir (Kaletra) PK in Children

Completed·EEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)·Phase 4·NCT00810108·12 enrolled

When to Start Anti-HIV Drugs in Children Infected With HIV (The PREDICT Study)

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00234091·300 enrolled

Safety of Saquinavir and High Doses of Lopinavir/Ritonavir in Children With HIV

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1/2·NCT00084058·26 enrolled

Show 2 more trials

Emtricitabine Given Once A Day With Other Anti-HIV Drugs in Children With HIV

Unknown status·TTriangle Pharmaceuticals·Phase 2·NCT00017992·100 enrolled

Pharmacokinetic Study of Two Generic Co-formulations of Lopinavir/Ritonavir for HIV Infected Children (SURF)

Completed·RRadboud University Medical Center·Phase 1·NCT00665951·12 enrolled

Malaria4 trials

Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women

Completed·UUniversity of California, San Francisco·Phase 3·NCT00993031·389 enrolled

HIV Protease Inhibitors for the Prevention of Malaria in Ugandan Children

Completed·UUniversity of California, San Francisco·Phase 3·NCT00978068·176 enrolled

Pharmacokinetic Interactions Between Antiretroviral Agents and Antimalarial Drug Combinations

Completed·FFran Aweeka·Phase 1·NCT00697892·38 enrolled

Show 1 more trial

Differences in Malaria Infection Levels in HIV-infected Infants and Children Receiving PI- and NNRTI-based HAART

Completed·IInternational Maternal Pediatric Adolescent AIDS Clinical Trials Group·Phase 1·NCT00719602·105 enrolled

HIV infection3 trials

Anti-HIV Drugs for Treating Infants Who Acquired HIV Infection at Birth

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00102960·377 enrolled

Antiretroviral Regimens Containing Raltegravir for Prophylaxis of Mother-to-child-transmission of HIV Infection

Terminated·FFundação Bahiana de Infectologia·Phase 2/3·NCT01854762·33 enrolled

Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission: A Phase I/II Proof of Concept Study

Recruiting·NNational Institute of Allergy and Infectious Diseases (NIAID)·Preclinical·NCT02140255·1,120 enrolled

Tuberculosis3 trials

Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)··NCT04518228·205 enrolled

Evaluating the Safety and Drug Interaction of PA-824, an Investigational Tuberculosis Medication, Together With Efavirenz, Ritonavir-Boosted Lopinavir, or Rifampin

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT01571414·52 enrolled

Optimal Dosing of 1st Line Antituberculosis and Antiretroviral Drugs in Children (a Pharmacokinetic Study)

Completed·UUniversity of Cape Town·Phase 4·NCT01637558·200 enrolled

Efficacy and Safety3 trials

Comparison of Efficacy and Safety of Infant Peri-exposure Prophylaxis With Lopinavir/Ritonavir Versus Lamivudine to Prevent HIV-1 Transmission by Breastfeeding

Completed·FFrench National Agency for Research on AIDS and Viral Hepatitis·Phase 3·NCT00640263·1,500 enrolled

Clinical Study to Evaluate the Efficacy and Safety of Lopinavir/Ritonavir Monotherapy Versus Darunavir/Ritonavir Monotherapies as Simplification Switching Strategies of PI/NNRTI-Triple Therapy Based-Regimens

Completed·GGermans Trias i Pujol Hospital·Phase 4·NCT00994344·73 enrolled

Efficacy and Safety of Kaletra Monotheraphy Compared to Kaletra Based Triple Therapy to Treat HIV in Antiretroviral Naїve Patients

Completed·AAbbott·Phase 3·NCT00234923·138 enrolled

Tics3 trials

The Influence of Ritonavir, Alone and in Combination With Lopinavir, on Fenofibric Acid Pharmacokinetics in Healthy Volunteers

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 1·NCT01148004·25 enrolled

Study Assessing the Effects of Darunavir/Ritonavir or Lopinavir/Ritonavir on the Pharmacokinetics of Daclatasvir in Healthy Participants

Completed·Bristol-Myers Squibb·Phase 1·NCT02159352·49 enrolled

Pharmacokinetics of Lopinavir/Ritonavir at Three Different Doses.

Completed·KKirby Institute·Phase 1·NCT00985543·22 enrolled

Antiretroviral Treatment2 trials

Trial About Hepatic Security of Antiretroviral Treatment Based on Kaletra Versus Nevirapine in Co-infected HIV/HCV Patients

Terminated·GGermans Trias i Pujol Hospital·Phase 4·NCT00661349·9 enrolled

Safety and Tolerability Study to Evaluate Lower Dose of GSK2248761 in Antiretroviral Treatment-Naive HIV-1 Infected Adults.

Completed·GSK·Phase 2·NCT00945282·8 enrolled

Liver2 trials

Strategies for Delivering Anti-HIV Therapy in South Africa

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00080522·813 enrolled

Safety of Lopinavir/Ritonavir (Kaletra) in HIV/HCV Co-infected Subjects vs Baseline Liver Biopsy Metavir Score

Completed·AbbVie·Phase 4·NCT00234975·86 enrolled

Pregnancy2 trials

Comparison of Three Anti-HIV Regimens to Prevent Nevirapine Resistance in Women Who Take Nevirapine During Pregnancy

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00099632·484 enrolled

Pharmacokinetics of the Tablet Formulation of Lopinavir/r as Standard and Increased Dosage During Pregnancy

Completed·OOswaldo Cruz Foundation·Phase 4·NCT00605098·60 enrolled

Outcome2 trials

Study of Adherence Effects and Clinical Outcomes of Kaletra Based HIV Antiviral Therapy

Terminated·AAbbott·Phase 4·NCT00234962·200 enrolled

Clinical, Virological and Safety Outcomes of a Lopinavir/Ritonavir-Based Regimen in HIV-1 Infected Patients in Routine Clinical Use in China

Completed·AAbbott··NCT01074931·98 enrolled

Monotherapy2 trials

Pilot Simplification Study to Lopinavir/Ritonavir 800/200 mg Monotherapy Regimen Once Daily

Completed·DDaniel Podzamczer·Phase 4·NCT01581853·21 enrolled

Evaluation of a Lopinavir/Ritonavir Monotherapy vs a Triple Therapy as Maintenance Regimens in HIV-1 Infected Patients

Completed·FFrench National Agency for Research on AIDS and Viral Hepatitis·Phase 2/3·NCT00946595·420 enrolled

Adult Subject2 trials

A Bioavailability Study of Rifabutin and Lopinavir/Ritonavir in Healthy Adult Subjects

Terminated·AAbbott·Phase 1·NCT00743470·15 enrolled

Drug Interaction Study Between Eltrombopag and Lopinavir/Ritonavir in Healthy Adult Subjects.

Completed·GSK·Phase 1·NCT00833378·40 enrolled

HIV-1 infection2 trials

Safety and Effectiveness of Short-Term Anti-HIV Drug Therapy for Recent HIV-1 Infection

Completed·UUniversity of Colorado, Denver·N/A·NCT00414518·16 enrolled

GEMINI Study - A Study of Saquinavir/Ritonavir in Treatment-Naive Patients With HIV-1 Infection

Completed·Roche·Phase 3·NCT00105079·337 enrolled

Drug Resistance2 trials

Using Drug Levels and Drug Resistance Testing to Select Effective Anti-HIV Drug Combinations in Patients With Drug-resistant HIV

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00027339·53 enrolled

Comparing Standard-Dose Versus Adjusted-Dose Lopinavir/Ritonavir Therapy in HIV-Infected Persons With Drug Resistance

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00046033·118 enrolled

Women2 trials

Differences in Blood Levels of Lopinavir/Ritonavir in HIV Infected Men and Women

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00102986·116 enrolled

NNRTI vs PI Regimens for HIV Infected Women After They Have Taken Nevirapine to Prevent Mother-To-Child HIV Transmission

Completed·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·Phase 3·NCT00089505·745 enrolled

Pneumonia2 trials

Darunavir/Cobicistat vs. Lopinavir/Ritonavir in COVID-19 Pneumonia in Qatar

Completed·HHamad Medical Corporation··NCT04425382·400 enrolled

A Prospective/Retrospective,Randomized Controlled Clinical Study of Antiviral Therapy in the 2019-nCoV Pneumonia

Unknown status·TTongji Hospital·Phase 4·NCT04255017·400 enrolled

Safety and Efficacy1 trial

Safety and Efficacy of Kaletra in ARV Therapy Experienced Patients

Completed·AbbVie·Phase 4·NCT00648999·207 enrolled

Infections1 trial

When to Start Anti-HIV Drugs in Patients With Opportunistic Infections

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT00055120·283 enrolled

Tenofovir1 trial

Study of Lopinavir, Ritonavir, Tenofovir and Emtricitabine in HIV-Infected Antiretroviral Naïve Subjects

Completed·AAbbott·Phase 3·NCT00043966·200 enrolled

Hepatitis C1 trial

Effects of Anti-HIV Therapy on Treatment for Hepatitis C in HCV/HIV Infected Adults

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00100581·2 enrolled

Itching1 trial

Metabolic Effects of Switching Kaletra to Boosted Reyataz

Completed·MMassachusetts General Hospital·N/A·NCT00413153·15 enrolled

Child1 trial

Comparison of Anti-HIV Drug Combinations to Prevent Mother-to-Child Transmission of HIV

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00086359·19 enrolled

Tenofovir Disoproxil Fumarate1 trial

Study Comparing Lopinavir/Ritonavir (LPV/r) + Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) With a Nucleoside Sparing Regimen Consisting of Lopinavir/Ritonavir + Raltegravir (RAL)

Completed·AAbbott·Phase 3·NCT00711009·206 enrolled

Plasmodium Falciparum1 trial

Comparing PI-Based to a nNRTI-based ART for Clearance of Plasmodium Falciparum Parasitemia in HIV-Infected

Completed·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·Phase 1/2·NCT01632891·52 enrolled

Immune System1 trial

Effects of Two Anti-HIV Drug Combinations on the Immune Systems of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00004855·55 enrolled

Drug Therapy1 trial

A Phase III Study Comparing Two Different Anti-HIV Drug Combinations in HIV-Positive Patients Without Previous Anti-HIV Drug Therapy

Completed·AAbbott·Phase 3·NCT00004583·660 enrolled

Pilot Study1 trial

Pilot Study of Effect of Kaletra on CD4 Response in HIV Positive (+) Patients With Viral Suppression KIMBO Study

Terminated·UUniversity of Maryland, Baltimore·N/A·NCT00344487·3 enrolled

Pregnant Women1 trial

Special Investigation of Kaletra in Pregnant Women

Completed·AAbbott··NCT01076985·24 enrolled

Hepatitis1 trial

Long-term Effectiveness and Safety in Hepatitis-co-infected Patients

Completed·AAbbott··NCT01153269·33 enrolled

Fasting Conditions1 trial

Bioequivalence Study of Lopinavir/Ritonavir 200/50 mg Film Tablet (World Medicine Ilac, Turkey) Under Fasting Conditions

Completed·WWorld Medicine ILAC SAN. ve TIC. A.S.·Phase 1·NCT04386876·30 enrolled

Adolescent1 trial

IMPAACT P1058A: Pharmacokinetic Effects of New Antiretroviral Drugs on Children, Adolescents and Young Adults

Completed·IInternational Maternal Pediatric Adolescent AIDS Clinical Trials Group··NCT00977756·168 enrolled

Fibrosis1 trial

Effect of a Change in HIV Therapy on Liver Steatosis, Inflammation, and Fibrosis

Withdrawn·NNational Institute of Allergy and Infectious Diseases (NIAID)·N/A·NCT00023218

Single Dose1 trial

Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV

Completed·IInternational Maternal Pediatric Adolescent AIDS Clinical Trials Group·Phase 2·NCT00307151·452 enrolled

HCV Coinfection1 trial

Treatment of HIV/HCV Coinfection With Peg-IFN and Ribavirin in Patients Receiving ART Monotherapy With Lopinavir/r

Completed·FFundacion SEIMC-GESIDA·Phase 4·NCT00866021·68 enrolled

Pediatric1 trial

A Phase II/III Trial of Lopinavir/Ritonavir Dosed According to the WHO Pediatric Weight Band Dosing Guidelines

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2/3·NCT01172535·97 enrolled

Advanced1 trial

Antiretroviral Therapy for Advanced HIV Disease in South Africa

Completed·NNational Institutes of Health Clinical Center (CC)·Phase 4·NCT00342355·1,771 enrolled

Newborns1 trial

Antiretroviral Regime for Viral Eradication in Newborns

Completed·NNational Center for Women and Children's Health, China CDC·Phase 4·NCT02712801·600 enrolled

Drug Interactions1 trial

Drug Interactions Between Lopinavir/Ritonavir and Oral or Patch Contraceptives in HIV Infected Women

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00125983·32 enrolled

Prevention1 trial

Trizivir Vs. Kaletra and Combivir for the Prevention of Mother-to-Child Transmission of HIV

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00270296·730 enrolled

Toxicities1 trial

Lopinavir/Ritonavir in Combination With Saquinavir Mesylate or Lamivudine/Zidovudine to Explore Metabolic Toxicities in Antiretroviral HIV-Infected Subjects

Completed·AAbbott·Phase 2·NCT00043953·30 enrolled

Aging1 trial

A Study of HIV-Disease Development in Aging

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00006144·90 enrolled

ESS1 trial

Roll-Over Protocol To Provide Atv And/Or Truvada For Extended Access

Completed·Bristol-Myers Squibb·Phase 3·NCT01003990·710 enrolled

Cardiovascular Disease1 trial

Effect of the HIV Protease Inhibitors Atazanavir and Lopinavir/Ritonavir on Cardiovascular Disease Risk Factors

Completed·IIndiana University·N/A·NCT00720590·30 enrolled

Medication1 trial

Nine Month Course of Anti-HIV Medications for People Recently Infected With HIV

Terminated·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·Phase 2·NCT00090779·130 enrolled

AIN1 trial

Atazanavir Versus Lopinavir/Ritonavir (LPV/RTV) in Patients Who Have Not Had Success With Protease Inhibitor-Containing HAART Regimen(s)

Completed·Bristol-Myers Squibb·Phase 3·NCT00028301

Combination Therapy1 trial

Study of Options for Second-Line Effective Combination Therapy (SELECT)

Completed·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·Phase 3·NCT01352715·515 enrolled

Phase II1 trial

A Phase IIIb Study Comparing Two Boosted Protease Inhibitor-based HAART Regimens in HIV-infected Patients Experiencing Their First Virologic Failure While Receiving an NNRTI-containing HAART Regimen

Completed·Bristol-Myers Squibb·Phase 3·NCT00135395·200 enrolled

Adult1 trial

Determining the Effects of Observed and Self-Administered Drug Regimens in HIV Infected Adults

Completed·AAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections·N/A·NCT00608569·529 enrolled

Resistance1 trial

Reducing the Incidence of Nevirapine Resistance Mutations in Pregnant HIV Infected Women Who Receive Anti-HIV Drugs Prior to and After Giving Birth

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00109590·175 enrolled

Corona Virus Infection1 trial

Multi-centre, Adaptive, Randomized Trial of the Safety and Efficacy of Treatments of COVID-19 in Hospitalized Adults

Completed·IInstitut National de la Santé Et de la Recherche Médicale, France·Phase 3·NCT04315948·1,552 enrolled

Unspecified2 trials

Evaluation of Kaletra Therapy Over the Long-term

Completed·AAbbott··NCT01083810·284 enrolled

Lopinavir Capsules to Kaletra or Invirase Tablets

Completed·RRoyal Free Hampstead NHS Trust·Phase 4·NCT00438152·53 enrolled

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