Enbrel

(Etanercept)

ApprovedProtein / enzyme

Etanercept is used to reduce inflammation and treat autoimmune diseases like rheumatoid arthritis, psoriasis, and Crohn's disease by blocking a protein in the body that causes swelling and joint damage.[2] Enbrel is currently approved and in use across 83 indications[4].[1]

Enbrel is one of 1379 small molecule programs targeting Arthropathy. It is currently in Approved.

Indications

308

Total Trials

Active Trials

1,378

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

ArthropathyActive, not recruiting

CachexiaActive, not recruiting

Metabolic SyndromeActive, not recruiting

HIV InfectionActive, not recruiting

GranulomaActive, not recruiting

Cardiovascular DiseaseActive, not recruiting

Polymyalgia RheumaticaActive, not recruiting

Pemphigus VulgarisActive, not recruiting

Primary Systemic AmyloidosisActive, not recruiting

SAPHO SyndromeActive, not recruiting

ArthropathyApproved

Active, not recruiting

CachexiaPhase 3

Active, not recruiting

Metabolic SyndromePhase 2

Active, not recruiting

HIV InfectionPhase 1

Active, not recruiting

GranulomaPhase 2/Phase 3

Active, not recruiting

Cardiovascular DiseaseApproved

Active, not recruiting

Polymyalgia RheumaticaPhase 3

Active, not recruiting

Pemphigus VulgarisPhase 2

Active, not recruiting

Primary Systemic AmyloidosisPhase 2

Active, not recruiting

SAPHO SyndromePhase 2

Active, not recruiting

Showing 10 of 80 indications

Competition

Competitive Landscape

1050 competitors in Asthma

#DrugCompanyPhaseTrials

Enbrel

IImmunex

Approved

2 2

Veramyst

GSK

Preclinical

46 3

Singulair

AstraZeneca

Preclinical

17 4

Nucala

GGlaxo Dba Glaxosmithkline

Preclinical

35 5

Cinqair

Teva

Preclinical

13 6

Spiriva

Boehringer Ingelheim

Preclinical

8 7

Qvar

Chiesi Farmaceutici S.p.A.

Preclinical

8 8

Atrovent

Boehringer Ingelheim

Preclinical

5 9

Formoterol Fumarate

AstraZeneca

Preclinical

8 10

Symbicort

AstraZeneca

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Phase 2Recruiting

Tinnitus

NCT04066348

Q3 2027

Post-ApprovalRecruiting

Arthritis

NCT06707194

Q1 2029

Phase 3Recruiting

Rheumatoid Arthritis

NCT03414502

Q2 2030

Post-ApprovalNot yet recruiting

Atopic Dermatitis

NCT07352566

Clinical

Trials by Indication[1]

Rheumatoid Arthritis45 trials

Evaluation of EULAR-RAID Score in Rheumatoid Arthritis Patients

Completed· Pfizer logo

Pfizer·Phase 4·NCT00768053·108 enrolled

Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)?

Completed·AAssistance Publique Hopitaux De Marseille·Phase 3·NCT02164214·60 enrolled

A Multicenter Study to Compare the Efficacy and Safety of the Combination of Etanercept and Methotrexate in Treatment of Rheumatoid Arthritis

Withdrawn· Pfizer logo

Pfizer·Phase 4·NCT00783536

Show 42 more trials

Study Comparing Etanercept With Usual DMARD Therapy in Subjects With Rheumatoid Arthritis in the Asia Pacific Region

Completed· Pfizer logo

Pfizer·Phase 4·NCT00422227·300 enrolled

Optimal Management of Rheumatoid Arthritis Patients Requiring Biologic Therapy

Completed·UUniversity of Glasgow·Phase 4·NCT01021735·302 enrolled

Preference Between Two Autoinjectors in Patients With Rheumatoid Arthritis and Plaque Psoriasis Treated With Etanercept

Completed· Amgen logo

Amgen·Phase 4·NCT01875991·217 enrolled

Treatment for Subjects With Active Rheumatoid Arthritis (RA)

Completed· Amgen logo

Amgen·Phase 3·NCT00110903

Study to Evaluate the Ability of Subjects With Rheumatoid Arthritis or Psoriatic Arthritis to Effectively Use a Reusable Autoinjector to Self-inject Etanercept

Completed· Amgen logo

Amgen·Phase 3·NCT01901185·77 enrolled

Tofacitinib (Xeljanz) Special Investigation for Rheumatoid Arthritis

Completed· Pfizer logo

Pfizer··NCT01932372·9,968 enrolled

Remission Induction in Very Early Rheumatoid Arthritis

Unknown status·UUniversity Hospital Birmingham·Phase 4·NCT00523692·20 enrolled

Study of Etanercept Monotherapy vs Methotrexate Monotherapy for Maintenance of Rheumatoid Arthritis Remission

Completed· Amgen logo

Amgen·Phase 3·NCT02373813·371 enrolled

Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid Arthritis

Terminated· Amgen logo

Amgen·Phase 3·NCT00078806·19 enrolled

RABIOPRED - a Validation Study of Theranostic Test to PREDict Treatment Response of Anti-TNFα BIologicals in Rheumatoid Arthritis

Terminated·TTcLand Expression S.A.··NCT03016260·250 enrolled

Evaluating Etanercept Use in Patients With Moderate to Severe Rheumatoid Arthritis Who Have Lost Response to Adalimumab

Terminated· Amgen logo

Amgen·Phase 4·NCT01927757·90 enrolled

Safety and Tolerability of Rituxan With Methotrexate and Etanercept or Methotrexate and Adalimumab in Patients With Active Rheumatoid Arthritis

Terminated· Biogen logo

Biogen·Phase 2·NCT00298272·54 enrolled

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Measure Response to Etanercept in Rheumatoid Arthritis

Completed· Amgen logo

Amgen·Phase 1·NCT00361634·14 enrolled

Treatment of Early Aggressive Rheumatoid Arthritis (TEAR)

Completed·UUniversity of Alabama at Birmingham·Phase 4·NCT00259610·755 enrolled

Study Evaluating the Efficacy and Safety of Etanercept in Chinese Subjects With Rheumatoid Arthritis

Completed· Pfizer logo

Pfizer·Phase 3·NCT00443950·150 enrolled

Stopping TNF Alpha Inhibitors in Rheumatoid Arthritis

Unknown status·GGeorgetown University·Phase 4·NCT01793519·290 enrolled

Study Comparing Etanercept Plus Methotrexate to Either Etanercept or Methotrexate Alone in Rheumatoid Arthritis.

Completed· Pfizer logo

Pfizer·Phase 3·NCT00393471·615 enrolled

Study Conducted in Subjects With Rheumatoid Arthritis Who Have Moderate to Severe Disease Activity Despite Methotrexate Therapy With or Without Other Non Biologic Disease Modifying Antirheumatic Drugs (DMARDs)for at Least 12 Weeks Prior to Screening

Completed· Pfizer logo

Pfizer·Phase 4·NCT01578850·491 enrolled

Etanercept Plus Methotrexate Versus Methotrexate Alone in Children With Polyarticular Course Juvenile Rheumatoid Arthritis

Terminated· Amgen logo

Amgen·Phase 3·NCT03781375·25 enrolled

The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept

Completed·NNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)·Phase 2·NCT00034060·36 enrolled

Moderate Rheumatoid Arthritis (RA) With Etanercept (Enbrel)

Completed· Amgen logo

Amgen·Phase 4·NCT01313208·210 enrolled

Study Evaluating Enbrel In Adults With Active Rheumatoid Arthritis In Luxemburg

Completed· Pfizer logo

Pfizer··NCT00195338·25 enrolled

Circadian RA Study in Rheumatoid Arthritis Subjects

Withdrawn·UUniversity of California, Davis··NCT03178955

Study Evaluating Etanercept Plus Methotrexate in Early Rheumatoid Arthritis

Completed· Pfizer logo

Pfizer·Phase 4·NCT00913458·306 enrolled

SWITCH Clinical Trial for Patients With Rheumatoid Arthritis Who Have Failed an Initial TNF-blocking Drug.

Completed·JJulia Brown·Phase 4·NCT01295151·122 enrolled

Study Comparing Etanercept and Methotrexate vs. Methotrexate Alone in Rheumatoid Arthritis

Completed· Pfizer logo

Pfizer·Phase 4·NCT00195494·542 enrolled

An Open-Label Study to Assess the Rate of Failure of an Enbrel® (Etanercept) SureClick™ Auto-injector in Subjects With Rheumatoid Arthritis

Completed· Amgen logo

Amgen·Phase 4·NCT00346294·115 enrolled

Characterize Patients With Moderately Active Rheumatoid Arthritis (RA)

Completed· Pfizer logo

Pfizer··NCT01557322·1,754 enrolled

Rheumatoid Arthritis Treatment After First Anti-TNF INvestiGation

Terminated· Mario Negri Institute for Pharmacological Research logo

Mario Negri Institute for Pharmacological Research·Phase 4·NCT03100253·208 enrolled

Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response

Recruiting·UUniversity of Nebraska·Phase 3·NCT03414502·400 enrolled

An Observational Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis And Inadequate Response Or Intolerance to a First Anti-TNF Alpha Therapy

Completed· Roche logo

Roche··NCT01592292·90 enrolled

A 6-month Randomised, Double-blind, Open Arm Comparator, Phase IIb, With AZD9056, in Patients With Rheumatoid Arthritis (RA)

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00520572·385 enrolled

A Study of Immune Cells in Patients With Rheumatoid Arthritis During Different Types of Anti-TNF Alpha Treatments (Study P05521)

Withdrawn· Merck & Co. logo

Merck & Co.··NCT00724672

A Proof of Concept and Dose Ranging Study in Patients With Rheumatoid Arthritis

Completed· AstraZeneca logo

AstraZeneca·Phase 2·NCT00713544·373 enrolled

Study Comparing Etanercept in Combination With Methotrexate in Subjects With Rheumatoid Arthritis

Completed· Pfizer logo

Pfizer·Phase 4·NCT00565409·834 enrolled

Evaluating Efficacy and Safety of Etanercept 50 mg Twice Weekly (BIW) in Rheumatoid Arthritis (RA) Subjects Who Are Sub-Optimal Responders to Etanercept 50 mg Once Weekly (QW)

Completed· Amgen logo

Amgen·Phase 4·NCT00115219·200 enrolled

Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy

Completed·UUS Department of Veterans Affairs·N/A·NCT00405275·353 enrolled

Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA)

Completed·CCoherus Oncology, Inc.·Phase 3·NCT02115750·647 enrolled

Niclosamide With Etanercept in Rheumatoid Arthritis

Completed·FFaiq Gorial·Phase 1/2·NCT03160001·110 enrolled

A Study to Evaluate Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to DMARDs

Completed· Astellas logo

Astellas·Phase 3·NCT02308163·509 enrolled

A Study Evaluating 10 mg and 25 mg Doses of Etanercept in Patients With Rheumatoid Arthritis

Completed· Pfizer logo

Pfizer·Phase 3·NCT00484237·80 enrolled

Switching Anti-TNF-Alpha Agents in Rheumatoid Arthritis (RA)

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 4·NCT00796705·13 enrolled

Psoriasis33 trials

Study to Assess the Immunogenicity and Safety of Etanercept Produced Using a Modified Process in Patients With Plaque Psoriasis

Completed· Amgen logo

Amgen·Phase 4·NCT02274792·132 enrolled

A Study of Tildrakizumab in Pediatric Subjects With Chronic Plaque Psoriasis

Active, not recruiting· Sun Pharmaceutical Industries Limited logo

Sun Pharmaceutical Industries Limited·Phase 2/3·NCT03997786·135 enrolled

Etanercept With Tacrolimus for Psoriasis

Completed·UUniversity of Medicine and Dentistry of New Jersey·Phase 2·NCT00134394·20 enrolled

Show 30 more trials

An Observational Monocentric Study Investigating the Association Between Trough Serum Levels of Etanercept, Antibodies Towards Etanercept and Its Effectiveness in Psoriasis Patients

Completed·UUniversitaire Ziekenhuizen KU Leuven··NCT02322580·56 enrolled

Moderate to Severe Plaque Psoriasis With Scalp Involvement

Completed· Amgen logo

Amgen·Phase 4·NCT00791765·124 enrolled

Canadian Assessment of Patient Outcomes and Effectiveness of Etanercept (Enbrel) in Psoriasis

Completed· Amgen logo

Amgen·Phase 4·NCT00332332·246 enrolled

An Evaluation of Etanercept in the Treatment of Subjects With Psoriasis

Completed· Amgen logo

Amgen·Phase 3·NCT00111111

Etanercept Therapy for Nails Psoriasis Monitoring With Noninvasive Imaging

Unknown status·OOptiSkin Medical·Phase 4·NCT05135312·10 enrolled

Study to Help Understand the Action of the Drug Etanercept for the Adult Patient With Psoriasis

Completed·RRockefeller University·Phase 3·NCT00116181·30 enrolled

Trial of an Injectable Biologic and U0279 as Combination Therapy for Severe Plaque-Type Psoriasis

Withdrawn· GSK logo

GSK·Phase 4·NCT00832364

Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Chronic Plaque Psoriasis (PsO)

Completed·CCoherus Oncology, Inc.·Phase 3·NCT02134210·521 enrolled

Efficacy and Safety of Etanercept 50 mg Once Weekly Plus As Needed Topical Agent in Moderate to Severe Plaque Psoriasis

Completed· Amgen logo

Amgen·Phase 3·NCT01313221·310 enrolled

Utilization of Narrow Band Ultraviolet B (UVB) Light Therapy and Etanercept for the Treatment of Psoriasis

Completed· Amgen logo

Amgen·Phase 4·NCT00110981·86 enrolled

Evaluation of Etanercept in Patients With Plaque Psoriasis After Stopping Ciclosporin Therapy

Completed· Pfizer logo

Pfizer·Phase 4·NCT00581555·120 enrolled

Study Evaluating Etanercept and Methotrexate in Plaque Psoriasis

Completed· Pfizer logo

Pfizer·Phase 4·NCT00161655·60 enrolled

Comparative Effectiveness of Psoriasis Treatments on Systemic Inflammation

Completed·UUniversity Hospitals Cleveland Medical Center··NCT02330380·26 enrolled

The Safety & Efficacy of Etanercept in Psoriasis Patients Who Have Not Responded to Adalimumab

Completed·DDermatrials Research·Phase 4·NCT00833729·10 enrolled

Study Comparing 2 Different Strategies For Management of Subjects With Plaque Psoriasis Who Have Responded to Etanercept

Completed· Pfizer logo

Pfizer·Phase 4·NCT00992394·174 enrolled

Efficacy and Safety Study of Certolizumab Pegol (CZP) Versus Active Comparator and Placebo in Subjects With Plaque Psoriasis (PSO)

Completed· UCB logo

UCB·Phase 3·NCT02346240·559 enrolled

Psoriasis Inflammation and Systemic Co Morbidities

Completed·RRockefeller University·N/A·NCT01170715·29 enrolled

Phase 3b Safety and Efficacy Study of Apremilast to Treat Moderate to Severe Plaque-plaque Psoriasis

Completed· Amgen logo

Amgen·Phase 3·NCT01690299·250 enrolled

Effects of Etanercept on Nail Psoriasis and Plaque Psoriasis

Completed· Pfizer logo

Pfizer·Phase 4·NCT00581100·136 enrolled

Study of Etanercept in the Treatment of Psoriasis in Adult Subjects

Completed· Amgen logo

Amgen·Phase 3·NCT00121615·391 enrolled

Economic Evaluation of Systemic Treatments for Moderate-to-severe Psoriasis

Completed·JJochen Schmitt.··NCT01812954·1 enrolled

Effects of Treatment With Biological Agents on Vascular and Cardiac Function in Psoriasis

Unknown status·UUniversity of Athens·Phase 4·NCT02144857·200 enrolled

Study Evaluating Safety of Etanercept in Treatment of Patients With Moderate to Severe Psoriasiswith Etanercept

Completed· Pfizer logo

Pfizer·Phase 4·NCT00581165·500 enrolled

Evaluating the Safety of Etanercept in the Treatment of Psoriasis in Adult Subjects

Completed· Amgen logo

Amgen·Phase 3·NCT00111436·912 enrolled

Safety and Efficacy of Etanercept in Patients With Psoriasis

Unknown status·—·N/A·NCT02258282·80 enrolled

Study Comparing the Efficacy and Safety of ABT-874 to Etanercept and Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis

Completed· AbbVie logo

AbbVie·Phase 3·NCT00710580·350 enrolled

Evaluating the Safety of Etanercept 50 mg Twice Weekly in Subjects With Psoriasis

Completed· Amgen logo

Amgen·Phase 3·NCT00111449·600 enrolled

Observational Safety Study of Etanercept (Enbrel) for Treatment of Psoriasis

Completed· Amgen logo

Amgen··NCT00322439·2,511 enrolled

Open Label Study Etanercept's Maintenance Dose in Obese Patients With Moderate to Severe Plaque Type Psoriasis

Completed·UUniversity of California, San Francisco·N/A·NCT00800982·30 enrolled

Study Evaluating the Efficacy and Safety of Etanercept and Acitretin in Korean Patient With Moderate to Severe Psoriasis

Completed· Pfizer logo

Pfizer·Phase 4·NCT00936065·60 enrolled

Ankylosing Spondylitis13 trials

Study To Evaluate The Impact Of Early Initiation Of Biological Treatment With Ankylosing Spondylitis

Completed· Pfizer logo

Pfizer··NCT04507763·763 enrolled

Effects of Etanercept on the Heart, Veins and Thickness of Certain Major Arteries In Ankylosing Spondylitis Patients

Terminated· Pfizer logo

Pfizer·Phase 4·NCT00910273·34 enrolled

An Open-Label, Multicentre, Long-Term Extension Study of Etanercept in Ankylosing Spondylitis

Completed· Pfizer logo

Pfizer·Phase 3·NCT00421980·84 enrolled

Show 10 more trials

Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study

Unknown status·—·Phase 4·NCT02489760·30 enrolled

Study Investigating Enbrel Treatment for Ankylosing Spondylitis

Completed· Pfizer logo

Pfizer··NCT00195416·526 enrolled

Etanercept (Enbrel) in Ankylosing Spondylitis

Unknown status·—·Phase 2·NCT01289743·24 enrolled

16.0040 Ankylosing Spondylitis Study

Completed· Amgen logo

Amgen·Phase 3·NCT00356356·257 enrolled

Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis

Completed· Pfizer logo

Pfizer·Phase 4·NCT00247962·566 enrolled

A Pilot Study of MSCs Iufusion and Etanercept to Treat Ankylosing Spondylitis

Unknown status·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2/3·NCT02809781·250 enrolled

Study Comparing Etanercept 50 mg Once Weekly to 25 mg Twice Weekly in Patients With Ankylosing Spondylitis

Completed· Pfizer logo

Pfizer·Phase 3·NCT00418548·350 enrolled

Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

Unknown status·JJagiellonian University·Phase 4·NCT02132234·100 enrolled

Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis

Completed· Pfizer logo

Pfizer··NCT00544557·1,715 enrolled

Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study

Completed·SSun Yat-sen University·Phase 4·NCT02915354·35 enrolled

Psoriatic Arthritis8 trials

Double-blind, Randomized, Placebo-controlled Phase 3 Study of Etanercept in the Treatment of Psoriatic Arthritis and Psoriasis

Completed· Amgen logo

Amgen·Phase 3·NCT00317499·205 enrolled

Study Evaluating the Safety and Efficacy of Etanercept in Patients With Psoriatic Arthritis Treated by Rheumatologists

Completed· Pfizer logo

Pfizer··NCT00293722·1,308 enrolled

Study Evaluating the Safety and Efficacy of Etanercept in Patients With Psoriatic Arthritis Treated by Dermatologists

Completed· Pfizer logo

Pfizer··NCT00293709·129 enrolled

Show 5 more trials

Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis

Completed· Amgen logo

Amgen·Phase 3·NCT02376790·851 enrolled

Impact of Tapering Immunosuppressants on Maintaining Minimal Disease Activity in Adult Subjects With Psoriatic Arthritis

Unknown status·UUniversity of Erlangen-Nürnberg Medical School·Phase 3·NCT04610476·270 enrolled

Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis

Completed· Pfizer logo

Pfizer·Phase 4·NCT00245960·752 enrolled

Tumor Necrosis Factors (TNF)-α Blockade for Psoriatic Arthritis

Completed·—·Phase 4·NCT00432406·40 enrolled

REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Etanercept (Enbrel®)

Completed· Amgen logo

Amgen·Phase 4·NCT00127842·110 enrolled

Arthritis7 trials

Pharmacokinetics and Pharmacodynamics of Biologic Drugs in Obese Patients With Arthritis

Withdrawn·—·Phase 1·NCT04585711

Study Comparing Etanercept (ETN) Against a Placebo for Etanercept on a Background Nonsteroidal Anti Inflammatory Drug (NSAIDs) in the Treatment of Early Spondyloarthritis (SpA) Patients Who do Not Have X-ray Structural Changes

Completed· Pfizer logo

Pfizer·Phase 3·NCT01258738·225 enrolled

Extension Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis

Completed· Pfizer logo

Pfizer·Phase 3·NCT01421069·109 enrolled

Show 4 more trials

A Study to Evaluate the NSAIDS Sparing Effect of Etanercept in Subjects With Axial Spondyloarthritis

Completed· Pfizer logo

Pfizer·Phase 4·NCT01298531·90 enrolled

STep-up and Step-down Therapeutic Strategies in Childhood ARthritiS

Recruiting·IIstituto Giannina Gaslini·Phase 3·NCT03728478·260 enrolled

Effect and Safety of Benzathine Penicillin Combined With Etanercept on Spondyloarthritis

Recruiting·NNanfang Hospital, Southern Medical University·Phase 4·NCT06707194·340 enrolled

Etanercept (Enbrel) in Undifferentiated Spondyloarthritis

Unknown status·—·Phase 2·NCT01289730·8 enrolled

65 more indications

Treatment5 trials

Study to Evaluate the Efficacy of Etanercept Treatment in Adults Who Failed Therapy With Apremilast

Completed· Amgen logo

Amgen·Phase 4·NCT02749370·80 enrolled

Treatments Against RA and Effect on FDG-PET/CT

Completed·—·Phase 4·NCT02374021·159 enrolled

Treatment Tapering in JIA With Inactive Disease

Completed·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT02840175·62 enrolled

Show 2 more trials

Etanercept for Treatment of Hidradenitis

Completed·UUniversity of Pennsylvania·Phase 2·NCT00107991·15 enrolled

An Open-label Study to Evaluate the Efficacy of Re-treatment for Patients With a History of Etanercept Use

Unknown status·FFlorida Academic Dermatology Centers·Phase 4·NCT01132235·20 enrolled

Type 1 Diabetes5 trials

Stem Cell Mobilization (Plerixafor) and Immunologic Reset in Type 1 Diabetes (T1DM)

Completed·UUniversity of Alberta·Phase 1/2·NCT03182426·22 enrolled

Peritransplant Deoxyspergualin in Islet Transplantation in Type 1 Diabetes

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00434850·14 enrolled

Etanercept in New Onset Type 1 Diabetes

Completed·SState University of New York at Buffalo·Phase 1/2·NCT00730392·18 enrolled

Show 2 more trials

Islet Transplantation in Type 1 Diabetes

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00434811·48 enrolled

EDCR Study - Etanercept Diamyd Combination Regimen -Open Trial to Evaluate Safety in Children With Type 1 Diabetes

Completed·JJohnny Ludvigsson·Phase 2·NCT02464033·20 enrolled

Metabolic Syndrome4 trials

Study of TNF-Antagonism in Metabolic Syndrome

Completed·MMassachusetts General Hospital·N/A·NCT00409318·56 enrolled

Effects of TNF-alpha Antagonism (Etanercept) in Patients With the Metabolic Syndrome and Psoriasis

Terminated·MMassachusetts General Hospital·N/A·NCT00477191·18 enrolled

Study of TNF-Antagonism in the Metabolic Syndrome (II)

Completed·MMassachusetts General Hospital·N/A·NCT00413400·40 enrolled

Show 1 more trial

Effects of Tumor Necrosis Factor (TNF)-Alpha Antagonism in Patients With Metabolic Syndrome

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2/3·NCT00111956·56 enrolled

Kidney Transplant3 trials

Islet After Kidney Transplant for Type 1 Diabetes

Withdrawn·VVirginia Commonwealth University·Phase 1/2·NCT00784966

Study of Islet Transplantation in Type 1 Diabetic Kidney Transplant Recipients

Completed·MMassachusetts General Hospital·Phase 1/2·NCT00888628·7 enrolled

Efficacy of Islet After Kidney Transplantation

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 3·NCT00468117·24 enrolled

Remission3 trials

COBRA-Slim With or Without Fast Access to TNF Blockade for Remission Induction in Early RA

Completed·PP. Verschueren·Phase 4·NCT03649061·276 enrolled

Study With Etanercept Focusing on Remission and Predictability of Remission in Real Life Clinical Practice

Completed· Pfizer logo

Pfizer··NCT02202837·157 enrolled

Defining Remission With Etanercept in AS in Real Life Clinical Practice

Completed· Pfizer logo

Pfizer··NCT02202850·84 enrolled

Alzheimer's Disease2 trials

TNF-Alpha Inhibition for Treatment of Alzheimer's Disease

Completed·TTobinick, Edward Lewis, M.D.·Phase 1·NCT00203320·30 enrolled

TNF-Alpha Inhibition for Treatment of Alzheimer's Disease

Completed·TTobinick, Edward Lewis, M.D.·Phase 1·NCT00203359·15 enrolled

Hidradenitis Suppurativa2 trials

Etanercept in Hidradenitis Suppurativa

Completed·UUniversity of Athens·Phase 2·NCT00329823·10 enrolled

Treatment of Hidradenitis Suppurativa Using Etanercept

Completed·PPenn State University··NCT00949546·20 enrolled

Tics2 trials

Effects of Denosumab on the Pharmacokinetics of Etanercept

Terminated· Amgen logo

Amgen·Phase 1·NCT01294397·19 enrolled

Pharmacokinetics, Safety, and Tolerability Study of the Autoinjector and Pre-filled Syringe of SB4 in Healthy Male Subjects

Completed·SSamsung Bioepis Co., Ltd.·Phase 1·NCT03193203·50 enrolled

Drug2 trials

A Drug Use Investigation of ENBREL for Post-marketing Surveillance (PMS) for RA and PsA

Completed· Pfizer logo

Pfizer··NCT00195403·1,014 enrolled

Study Evaluating Enbrel Drug Levels in Healthy Male Chinese Subjects

Completed· Pfizer logo

Pfizer·Phase 1·NCT00705042·60 enrolled

Pneumonia2 trials

Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell Transplant

Completed·CChildren's Oncology Group·Phase 2·NCT00309907·39 enrolled

Effectiveness of Etanercept for Idiopathic Pneumonia Syndrome Following Stem Cell Transplantation (BMT CTN 0403)

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 3·NCT00421174·37 enrolled

Efficacy2 trials

Safety, Tolerability, Pharmacokinetics, and Efficacy of Acapatamab in Subjects With mCRPC

Terminated· Amgen logo

Amgen·Phase 1·NCT03792841·212 enrolled

Study To Evaluate The Efficacy And Long-Term Adherence Of Spondyloarthropathies(SpA) Patients On Enbrel

Completed· Pfizer logo

Pfizer··NCT04507776·763 enrolled

Necrosis2 trials

Human Tumor Necrosis Factor Alpha (TNFa)-Induced Pre-B Cell Bone Marrow Emigrants

Withdrawn·UUniversity of Pittsburgh·Phase 4·NCT01009879

A Pilot Study to Examine the Feasibility and Effect of Tumor Necrosis Factor (TNF) Inhibition on HIV Disease

Completed·UUniversity of Wisconsin, Madison·N/A·NCT00205231·25 enrolled

Acute Graft Versus Host Disease2 trials

The Use of Etanercept (Enbrel®) in the Treatment of Acute Graft-Versus-Host Disease

Completed·UUniversity of Michigan Rogel Cancer Center·Phase 2·NCT00141713·40 enrolled

Treatment for Acute Graft-Versus-Host Disease (BMT CTN 0302)

Completed·NNational Heart, Lung, and Blood Institute (NHLBI)·Phase 2·NCT00224874·180 enrolled

Myelodysplastic Syndromes2 trials

Arsenic Trioxide and Etanercept in Treating Patients With Myelodysplastic Syndromes

Completed·FFred Hutchinson Cancer Center·Phase 1/2·NCT00093366·32 enrolled

Azacitidine and Etanercept in Treating Patients With Myelodysplastic Syndromes

Completed·FFred Hutchinson Cancer Center·Phase 1/2·NCT00118287·32 enrolled

Unknown status·TTehran University of Medical Sciences·N/A·NCT00931957·80 enrolled

Function1 trial

Functional Implications of TNF

Completed·NNational Institute of Environmental Health Sciences (NIEHS)··NCT00729131·10 enrolled

Age1 trial

NATIENS: Optimal Management and Mechanisms of SJS/TEN

Completed·VVanderbilt University Medical Center·Phase 3·NCT02987257·2 enrolled

Asthma1 trial

TNF Alpha in Refractory Asthma

Completed·UUniversity Hospitals, Leicester·N/A·NCT00276029·10 enrolled

Inguinal hernia1 trial

Preoperative Etanercept Before Inguinal Hernia Surgery

Completed·JJohns Hopkins University·N/A·NCT00825344·77 enrolled

Complication1 trial

Study of Etanercept for the Prevention of Complications Resulting From Hematopoietic Stem Cell Transplantation (HSCT)

Completed·UUniversity of Michigan Rogel Cancer Center·Phase 2·NCT00141739·100 enrolled

Langerhans Cell Histiocytosis1 trial

Treatment of Resistant Langerhans Cell Histiocytosis With ENBREL

Completed·—·Phase 2·NCT00048373·20 enrolled

Injury1 trial

Evaluation of Efficacy and Mechanisms of an Antiinflammatory Intervention for Chemotherapy Related Mucosal Injury

Terminated·NNational Institute of Nursing Research (NINR)·Phase 2·NCT00031551·27 enrolled

Myocardial Infarction1 trial

Etanercept Treating Patient With Acute ST Segment Elevated Myocardial Infarction

Unknown status·XXijing Hospital·Phase 4·NCT01372930·200 enrolled

Temporomandibular Disorders1 trial

Study of Etanercept and Celecoxib to Treat Temporomandibular Disorders (Painful Joint Conditions)

Completed·NNational Institute of Dental and Craniofacial Research (NIDCR)·Phase 2·NCT00001955·150 enrolled

Autoimmune Disease1 trial

Organization of Teratology Information Services (OTIS) Autoimmune Diseases in Pregnancy Project

Completed· Amgen logo

Amgen··NCT00116272·830 enrolled

Sjogren's Syndrome1 trial

Etanercept Therapy for Sjogren's Syndrome

Completed·NNational Institute of Dental and Craniofacial Research (NIDCR)·Phase 2·NCT00001954·28 enrolled

Juvenile Myelomonocytic Leukemia1 trial

Etanercept (Enbrel) for Juvenile Myelomonocytic Leukemia

Terminated·MM.D. Anderson Cancer Center·Phase 2·NCT00509600·1 enrolled

Palmoplantar Pustulosis1 trial

A Placebo-Controlled Double-Blind Study on the Safety and Efficacy of Etanercept in Palmoplantar Pustulosis

Completed·IInnovaderm Research Inc.·Phase 3·NCT00353119·15 enrolled

Clinical Trial1 trial

An Observational, Retrospective, Multicenter, National Study for the Monitoring of Subjects Who Participated in the LoadET Clinical Trial

Completed· Pfizer logo

Pfizer··NCT01793285·85 enrolled

Pancreatic Adenocarcinoma1 trial

Etanercept and Gemcitabine in Patients With Advanced, Chemotherapy Naive Pancreatic Adenocarcinoma

Completed·OOhio State University Comprehensive Cancer Center·Phase 1/2·NCT00201838·38 enrolled

Renal Transplant1 trial

Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant

Completed·MMassachusetts General Hospital·Phase 2·NCT02464878·2 enrolled

Glucocorticoid1 trial

TNF and Glucocorticoid Antagonist for GWI Associated Multi-symptom Disease Homeostasis Reset

Active, not recruiting·NNova Southeastern University·Phase 1·NCT04254627·20 enrolled

Graft Versus Host Disease1 trial

Addition of Etanercept and Extracorporeal Photopheresis (ECP) to Standard Graft-Versus-Host Disease (GVHD) Prophylaxis in Stem Cell Transplant

Completed·UUniversity of Michigan Rogel Cancer Center·Phase 2·NCT00639717·48 enrolled

ISS1 trial

Swiss Dermatology Network of Targeted Therapies (SDNTT)

Recruiting·SSwiss Dermatology Network for Targeted Therapies··NCT01706692·1,121 enrolled

Resistance1 trial

The Immunological Basis for Treatment Resistance to Anti-TNF Treatments

Completed·UUniversity of Michigan·Phase 4·NCT01971346·50 enrolled

Synovitis1 trial

Evaluation of The Efficacy And Safety of Intra-Articular Etanercept in Patients With Refractory Knee Joint Synovitis

Completed·UUniversity of Padova·Phase 2·NCT00678782·31 enrolled

Lichen Planus1 trial

Use of Etanercept in the Treatment of Moderate to Severe Lichen Planus

Terminated·SStanford University·Phase 2·NCT00285779·27 enrolled

Atopic Dermatitis1 trial

Utilization of a Microdevice for Psoriasis and Atopic Dermatitis

Not yet recruiting·UUniversity of California, San Francisco·Phase 4·NCT07352566·10 enrolled

Chronic Fatigue Syndrome1 trial

Tumor Necrosis Factor-alpha Inhibition Using Etanercept in Chronic Fatigue Syndrome

Terminated·HHaukeland University Hospital·Phase 2·NCT01730495·4 enrolled

Corticosteroids1 trial

Capability of Tofacitinib or Etanercept to Accelerate Tapering of NSAID and Treat-to-target Guided De-escalation of Corticosteroids in RA Patients

Completed·—·Phase 4·NCT04485325·92 enrolled

Idiopathic Pulmonary Fibrosis1 trial

Study Evaluating the Safety and Efficacy of Etanercept in Patients With Idiopathic Pulmonary Fibrosis

Completed· Pfizer logo

Pfizer·Phase 2·NCT00063869·88 enrolled

Pilot Study1 trial

Pilot Study Evaluating The Efficacy Of Etanercept In Acute Gout

Terminated·RRutgers, The State University of New Jersey·Phase 4·NCT03636373·5 enrolled

Lupus Nephritis1 trial

Etanercept for the Treatment of Lupus Nephritis

Terminated·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 2·NCT00447265·1 enrolled

Spondylarthropathies1 trial

TNFalfa Blocking Treatment of Spondylarthropathies

Completed·HHvidovre University Hospital·Phase 4·NCT00133315·50 enrolled

Radiculopathy1 trial

A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy

Completed·JJohns Hopkins University·Phase 2/3·NCT00733096·84 enrolled

Methotrexate1 trial

Study Evaluating Efficacy / Safety of Etanercept + Methotrexate Compared to Usual Treatment in Moderate RA Subjects

Terminated· Pfizer logo

Pfizer·Phase 4·NCT00706797·141 enrolled

Anorexia1 trial

Etanercept in Treating Cancer-Related Cachexia and Anorexia in Patients With Advanced Cancer

Completed·MMayo Clinic·Phase 3·NCT00046904

ART1 trial

A Study of Nipocalimab With Co-administration of Etanercept or Hydroxychloroquine in Healthy Participants

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 1·NCT04973566·48 enrolled

Double-blind1 trial

TNF-alpha Antagonists for AECOPD: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

Completed·OOttawa Hospital Research Institute·Phase 2/3·NCT00789997·81 enrolled

Chronic Lymphocytic Leukemia1 trial

Etanercept and Rituximab in Patients With Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

Completed·JJohn Byrd·Phase 1/2·NCT00201682·36 enrolled

Myelodysplastic Syndrome1 trial

Biological Therapy in Treating Patients With Myelodysplastic Syndrome

Completed·FFred Hutchinson Cancer Center·Phase 2·NCT00005853

Safety and Efficacy1 trial

Safety and Efficacy Study of the Effect of Etanercept in Hemodialysis Patients

Terminated·—·Phase 2·NCT00293202·10 enrolled

Dermatomyositis1 trial

Understanding the Pathogenesis and Treatment of Childhood Onset Dermatomyositis

Terminated·—·Phase 2/3·NCT00035958·75 enrolled

Cardiovascular Disease1 trial

A Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors

Completed· Roche logo

Roche·Phase 4·NCT01331837·3,080 enrolled

Mild to Moderate Alzheimer's Disease1 trial

Short Term Efficacy and Safety of Perispinal Administration of Etanercept in Mild to Moderate Alzheimer's Disease

Completed·LLife Extension Foundation Inc.·Phase 1·NCT01716637·12 enrolled

Kawasaki Disease1 trial

A Randomized, Double Blind, Placebo Controlled Study of Etanercept in Children With Kawasaki Disease

Completed·MMichael Portman·Phase 2·NCT00841789·205 enrolled

Hypothermia1 trial

Limitation of Ischemic Injury of a Kidney Stored in Machine Perfusion in Hypothermia - Evaluation of the Impact on Kidney Allograft Function

Completed·MMedical University of Warsaw·Phase 2·NCT01731457·94 enrolled

Stem Cell Transplant1 trial

Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant

Completed·UUniversity of Michigan Rogel Cancer Center·Phase 2·NCT00141726·34 enrolled

Discoid Lupus Erythematosus1 trial

Targeted Therapy Using Intradermal Injection of Etanercept for Remission Induction in Discoid Lupus Erythematosus

Completed·UUniversity of Leeds·Phase 2·NCT02656082·25 enrolled

Tinnitus1 trial

TNF-α Treatment of Blast-Induced Tinnitus

Recruiting·WWayne State University·Phase 2·NCT04066348·88 enrolled

Osteomyelitis1 trial

CHronic Nonbacterial Osteomyelitis International Registry

Recruiting·SSeattle Children's Hospital··NCT04725422·2,000 enrolled

Randomized Controlled Trial1 trial

TNF-alpha Inhibition in CRPS: A Randomized Controlled Trial

Withdrawn·SStanford University·N/A·NCT02031211

Unspecified4 trials

Very Early Versus Delayed Etanercept in Patients With RA

Completed·UUniversity of Leeds·Phase 4·NCT02433184·120 enrolled

Open Label, Dose-Regimen Study Evaluating Etanercept 50 mg Once-Weekly In Japanese Subjects With RA

Completed· Pfizer logo

Pfizer·Phase 3·NCT00418717·42 enrolled

Understanding GWI: Integrative Modeling

Unknown status·SSouth Florida Veterans Affairs Foundation for Research and Education·Phase 1·NCT04255498·20 enrolled

Show 1 more trial

Pharmacokinetic, Safety and Tolerability Study of Altebrel in Healthy Male Subjects

Completed·AAryoGen Pharmed Co.·Phase 1·NCT03273088·34 enrolled

Regulatory

FDA Approval Timeline[5]

Nov 2, 1998

ENBREL

BLA BLA103795

Sources

References

[1]
ClinicalTrials.gov — 308 trial records for Etanercept. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Enbrel drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Etanercept compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Etanercept. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (BLA BLA103795). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Immunex company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: TNF-Alpha Inhibitor[3]
Modality: Protein / enzyme[3]
Highest Phase: Approved[1]
Company: IImmunex

Enbrel

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q3 2027

Q1 2029

Q2 2030

Trials by Indication[1]

Rheumatoid Arthritis45 trials

Psoriasis33 trials

Ankylosing Spondylitis13 trials

Psoriatic Arthritis8 trials

Arthritis7 trials

Treatment5 trials

Type 1 Diabetes5 trials

Metabolic Syndrome4 trials

Kidney Transplant3 trials

Remission3 trials

Alzheimer's Disease2 trials

Hidradenitis Suppurativa2 trials

Tics2 trials

Drug2 trials

Pneumonia2 trials

Efficacy2 trials

Necrosis2 trials

Acute Graft Versus Host Disease2 trials

Myelodysplastic Syndromes2 trials

Osteoarthritis2 trials

Granuloma2 trials

Behcet's Disease1 trial

Function1 trial

Age1 trial

Asthma1 trial

Inguinal hernia1 trial

Complication1 trial

Langerhans Cell Histiocytosis1 trial

Injury1 trial

Myocardial Infarction1 trial

Temporomandibular Disorders1 trial

Autoimmune Disease1 trial

Sjogren's Syndrome1 trial

Juvenile Myelomonocytic Leukemia1 trial

Palmoplantar Pustulosis1 trial

Clinical Trial1 trial

Pancreatic Adenocarcinoma1 trial

Renal Transplant1 trial

Glucocorticoid1 trial

Graft Versus Host Disease1 trial

ISS1 trial

Resistance1 trial

Synovitis1 trial

Lichen Planus1 trial

Atopic Dermatitis1 trial

Chronic Fatigue Syndrome1 trial

Corticosteroids1 trial

Idiopathic Pulmonary Fibrosis1 trial

Pilot Study1 trial

Lupus Nephritis1 trial

Spondylarthropathies1 trial

Radiculopathy1 trial

Methotrexate1 trial

Anorexia1 trial

ART1 trial

Double-blind1 trial

Chronic Lymphocytic Leukemia1 trial

Myelodysplastic Syndrome1 trial

Safety and Efficacy1 trial

Dermatomyositis1 trial

Cardiovascular Disease1 trial

Mild to Moderate Alzheimer's Disease1 trial

Kawasaki Disease1 trial

Hypothermia1 trial

Stem Cell Transplant1 trial

Discoid Lupus Erythematosus1 trial

Tinnitus1 trial

Osteomyelitis1 trial

Randomized Controlled Trial1 trial

Unspecified4 trials

FDA Approval Timeline[5]