Neoadjuvant Chemotherapy

Phase 3Small molecule

Neoadjuvant Chemotherapy is one of 473 small molecule programs targeting Esophageal Squamous Cell Carcinoma. It is currently in Phase 3.

Indications

Total Trials

Active Trials

472

Competitors

Pipeline

Status by Indication[3][1]

Indication

Esophageal Squamous Cell CarcinomaActive, not recruiting

Esophageal CarcinomaActive, not recruiting

Nasopharyngeal CarcinomaActive, not recruiting

Hypopharyngeal CarcinomaActive, not recruiting

Lung CancerActive, not recruiting

OsteosarcomaActive, not recruiting

AdenocarcinomaActive, not recruiting

DeliriumActive, not recruiting

Intrahepatic CholangiocarcinomaActive, not recruiting

Breast CancerActive, not recruiting

Esophageal Squamous Cell CarcinomaPreclinical

Active, not recruiting

Esophageal CarcinomaPreclinical

Active, not recruiting

Nasopharyngeal CarcinomaPhase 3

Active, not recruiting

Hypopharyngeal CarcinomaPhase 3

Active, not recruiting

Lung CancerPhase 3

Active, not recruiting

OsteosarcomaPhase 1

Active, not recruiting

AdenocarcinomaPhase 2

Active, not recruiting

DeliriumPreclinical

Active, not recruiting

Intrahepatic CholangiocarcinomaPhase 2

Active, not recruiting

Breast CancerPhase 2

Active, not recruiting

Showing 10 of 20 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Neoadjuvant Chemotherapy

JJapan Clinical Oncology Group

Phase 3

12 2

Zinecard

CChildren's Oncology Group

Preclinical

2 3

Spravato

WWim Janssens

Preclinical

2 4

Feraheme

AAzurity Pharmaceuticals

Preclinical

1 5

Systemic Therapy

Bristol-Myers Squibb

Preclinical

1 6

Diuretic

RReprieve Cardiovascular, Inc

Preclinical

1 7

Perflutren Lipid Microcpheres

TThomas Jefferson University

Preclinical

2 8

Lipegfilgrastim

Merck & Co.

Preclinical

1 9

Ablavar

LLantheus Medical Imaging

Preclinical

2 10

Escitalopram Oxalate

TTorrent Pharmaceuticals Limited

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Recruiting

Esophageal Squamous Cell Carcinoma

NCT07054086

N/ARecruiting

Neoadjuvant Chemotherapy

NCT07202819

Phase 1Active, not recruiting

Breast Cancer

NCT03387553

Q4 2026

Phase 3Recruiting

Colon Cancer

NCT05194878

Phase 2Active, not recruiting

Hepatocellular Carcinoma

NCT06524466

Q2 2027

Phase 2Recruiting

Chemotherapy

NCT05507411

Clinical

Trials by Indication[1]

Breast Cancer12 trials

Neoadjuvant Chemotherapy in Combination With Toripalimab for HR+/HER2- Breast Cancer : a Randomized, Open-label, Parallel-controlled, Multi-center Phase III Study (NEOTORCH-BREAST04)

Recruiting·FFirst Affiliated Hospital of Zhejiang University·Phase 3·NCT06977893·194 enrolled

Neoadjuvant Therapy Combined With Trastuzumab Rezetecan and Toripalimab for HR+/HER2-low Breast Cancer (NEOTORCH-BREAST 08)

Recruiting·FFirst Affiliated Hospital of Zhejiang University·Phase 2·NCT07383818·111 enrolled

MRI in Evaluating Early Response to Chemotherapy in Women With Infiltrating Breast Cancer

Completed·IInstitut Bergonié·N/A·NCT00462696·16 enrolled

Show 9 more trials

Study of Neoadjuvant Chemotherapy of Breast Cancer

Unknown status·—·Phase 2·NCT00830544·54 enrolled

HER2 Directed Dendritic Cell Vaccine During Neoadjuvant Therapy of HER2+Breast Cancer

Active, not recruiting·HH. Lee Moffitt Cancer Center and Research Institute·Phase 1·NCT03387553·31 enrolled

Immune Tumor Stroma Factors and Pathologic Complete Response After Neoadjuvant Chemotherapy in Early Breast Cancer

Active, not recruiting·IInstitute of Oncology Ljubljana·N/A·NCT07407244·268 enrolled

Neoadjuvant Aromatase Inhibitor(AI) With Ovarian Suppression Versus Chemotherapy in Premenopausal Breast Cancer Patients

Terminated·RRuijin Hospital·Phase 3·NCT02532400·21 enrolled

Combined Chemo-immunotherapy Plus SBRT in Neoadjuvant Treatment for Luminal Subtype Breast Cancer

Not yet recruiting·FFirst Affiliated Hospital of Wenzhou Medical University·Phase 2·NCT07254858·302 enrolled

Study of Preoperative Chemotherapy for Early Triple Negative or HER2-positive Operable Breast Cancer

Unknown status·CChinese Academy of Medical Sciences·Phase 2·NCT02934828·230 enrolled

Docetaxel, Carboplatin, and Capecitabine as Treatment for Patients With Locally Advanced or Inflammatory Breast Cancer Before Surgery

Unknown status·CCancer Research Network·Phase 2·NCT00251329·48 enrolled

Neoadjuvant Complete Response Customized Treatment Approach for Definitive Management of Breast Cancer

Not yet recruiting·OOhio State University Comprehensive Cancer Center·Preclinical·NCT07217990·84 enrolled

Neoadjuvant SBRT Followed by Nab-Paclitaxel Combined With Toripalimab in HR+/HER2- Breast Cancer: A Single-arm, Prospective Clinical Trial

Recruiting·XXijing Hospital·Phase 2·NCT06914440·27 enrolled

Neoadjuvant Chemotherapy6 trials

Outcome of Neoadjuvant Chemotherapy for Obstructive Colon Cancer

Not yet recruiting·TThe Catholic University of Korea·N/A·NCT04889820·204 enrolled

Neoadjuvant Chemotherapy Versus Surgery Alone in Patients With High-Grade UTUC

Completed·XXiangya Hospital of Central South University·Phase 2·NCT02876861·74 enrolled

Neoadjuvant Chemotherapy With Camrelizumab in Locally Advanced Esophageal Squamous Cell

Unknown status·FFudan University·Phase 2·NCT04520035·60 enrolled

Show 3 more trials

Neoadjuvant Chemotherapy for Obstructive Colon cancER First Treated by cOlostomy

Recruiting·UUniversity Hospital, Rouen·Phase 3·NCT06107920·232 enrolled

Effect of Neoadjuvant Chemotherapy on MRI Accuracy Before Cystectomy

Recruiting·—·N/A·NCT07202819·76 enrolled

Validity of Sentinel Lymphnode Biopsy After Neoadjuvant Chemotherapy Cancer Patients With Radiologically Positive Axillary Lymph Nodes

Completed·GGangnam Severance Hospital··NCT01622478·120 enrolled

Gastric Cancer5 trials

Neoadjuvant Chemoradiotherapy vs. Chemotherapy Followed by Radical Gastrectomy and Adjuvant Chemotherapy for Advanced Gastric Cancer

Completed·SSun Yat-sen University·Phase 3·NCT01815853·620 enrolled

Quality of Life in Advanced Gastric Cancer Patients Receiving Neoadjuvant Chemotherapy

Unknown status·PPeking University Cancer Hospital & Institute··NCT04408859·290 enrolled

AI Prediction of Gastric Cancer Response to Neoadjuvant Chemotherapy

Recruiting·CChinese Academy of Sciences··NCT06035250·200 enrolled

Show 2 more trials

A Comparison of Laparoscopic With Open Distal Gastrectomy in Advanced Gastric Cancer After Neoadjuvant Chemotherapy

Unknown status·PPeking University·Phase 2·NCT02404753·102 enrolled

Perioperative Chemotherapy Combined With HIPEC for High-risk Advanced Gastric Cancer

Unknown status·SSixth Affiliated Hospital, Sun Yat-sen University·Phase 3·NCT02960061·640 enrolled

Ovarian Cancer5 trials

Efficacy Study of Neoadjuvant Chemotherapy to Treat Advanced Ovarian Cancer

Completed·—·Phase 2·NCT01462149·43 enrolled

SUROVA - Surgery in Ovarian Cancer, Comparing Primary and Interval Cytoreductive Surgery

Unknown status·—··NCT06223763·5,000 enrolled

Efficacy of HIPEC as NACT and Postoperative Chemotherapy in the Treatment of Advanced-Stage Epithelial Ovarian Cancer

Unknown status·SShu-Zhong Cui·Phase 3·NCT03180177·263 enrolled

Show 2 more trials

Total Neoadjuvant 6 Cycles of Chemotherapy Versus 3 Cycles in Partial Responder Patients Diagnosed With Epithelial Ovarian Cancer

Not yet recruiting·—·Phase 3·NCT06980545·50 enrolled

Short-course HIPEC in Advanced Epithelial Ovarian Cancer

Completed·PProfessor Fernando Figueira Integral Medicine Institute·Phase 2·NCT02249013·15 enrolled

Cervical Cancer3 trials

Neoadjuvant Immunochemotherapy for Locally Advanced Cervical Cancer: a Prospective, Single-arm, Phase II Clinical Trial

Recruiting·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University·Phase 2·NCT07003620·34 enrolled

Node Positive Cervical Cancer Treated by Neoadjuvant Chemotherapy Plus Radical Surgery: a Single Center Experience

Terminated·AAzienda Policlinico Umberto I··NCT06752135·97 enrolled

Neoadjuvant Chemotherapy in Cervical Cancer

Completed·—·Phase 3·NCT05384366·33 enrolled

34 more indications

Chemotherapy2 trials

Feasibility Study of Deep Learning-based MDixon Quant for Quantitative Assessment of Chemotherapy-induced Fatty Liver

Recruiting·YYunnan Cancer Hospital·N/A·NCT06735118·120 enrolled

Watch and Wait for NeoAdjuvant Concurrent Radiochemotherapy Combined With Camrelizumab in Patients With Resectable ESCC

Recruiting·ZZhejiang Cancer Hospital·Phase 2·NCT05507411·100 enrolled

Esophageal Carcinoma2 trials

Neoadjuvant Chemotherapy or Chemoradiotherapy in Resectable Oesophageal Carcinoma（NewEC Study）

Completed·SSun Yat-Sen Memorial Hospital of Sun Yat-Sen University··NCT04027543·423 enrolled

Neo-adjuvant Immunochemotheray Versus Neo-adjuvant Chemotherapy for Resectable Esophageal Carcinoma

Recruiting·HHenan Cancer Hospital·Phase 3·NCT04280822·400 enrolled

Pancreatic Cancer2 trials

Neoadjuvant vs Upfront Surgery for Resectable Pancreatic Cancer and Periampullary Cancer

Recruiting·MMinia University·Phase 3·NCT07081360·262 enrolled

NEOadjuvant Gemcitabine/Oxaliplatin Plus Adjuvant Gemcitabine in Resectable PAncreatic Cancer

Completed·IInstitut Paoli-Calmettes·Phase 3·NCT01521702·2 enrolled

Locally Advanced Colon Cancer2 trials

Neoadjuvant Chemotherapy for the Treatment of Resectable Locally Advanced Colon Cancer

Unknown status·TThe First Affiliated Hospital with Nanjing Medical University·Phase 2/3·NCT02882269·400 enrolled

Neoadjuvant CAPEOX Versus Upfront Surgery for Locally Advanced Colon Cancer With Elevated CEA: A Single-Center, Open-Label, Randomized Controlled Trial

Not yet recruiting·SSun Yat-sen University·N/A·NCT07413146·100 enrolled

Esophageal Squamous Cell Carcinoma2 trials

Surufatinib in Combination With Neoadjuvant Chemo-immunotherapy and Concurrent Chemoradiotherapy for Patients With Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma

Recruiting·SSun Yat-sen University·Phase 2·NCT07086469·69 enrolled

Patient Derived Organoids (PDOs) to Observe the Clinical Consistency of Personalized Neoadjuvant Therapy for Resectable Esophageal Squamous Cell Carcinoma

Recruiting·SShanghai Zhongshan Hospital··NCT07054086·30 enrolled

Lung Cancer2 trials

Neoadjuvant Immunochemotherapy for Lung Cancer

Completed·SShanghai Zhongshan Hospital··NCT06023797·83 enrolled

Neoadjuvant or Adjuvant Chemotherapy in Patients With Operable Non-small-cell Lung Cancer

Completed·SSpanish Lung Cancer Group·Phase 3·NCT00913705·624 enrolled

Locally-advanced Rectal Cancer2 trials

Neoadjuvant Chemoradiotherapy Plus Sintilimab for MSS, Locally Advanced Rectal Cancer-

Withdrawn·SSun Yat-sen University·Phase 2·NCT06895577

Capecitabine + Irinotecan Followed by Combined Modality Capecitabine and Radiation in Locally Advanced Rectal Cancer

Terminated·—·Phase 2·NCT00216086·22 enrolled

Colorectal Cancer2 trials

Neoadjuvant Toripalimab With or Without Celecoxib in dMMR/MSI-H Colorectal Cancer

Recruiting·SSun Yat-sen University·Phase 2·NCT03926338·270 enrolled

An Exploratory Study of Sequential Transarterial Chemoembolization With Lipiodol and Neoadjuvant Chemotherapy in the Treatment of Initial Unresectable Colorectal Cancer (CRC)

Unknown status·GGang Wu·Phase 2·NCT05340231·100 enrolled

Bladder Cancer2 trials

Neoadjuvant Chemotherapy in Non Muscle Invasive T1b Bladder Cancer

Unknown status·—··NCT04245618·50 enrolled

Neoadjuvant Chemotherapy for Locally Advanced Gall Bladder Cancer : a Randomized Control Trial (NEOGB)

Recruiting·RRajiv Gandhi Cancer Institute & Research Center, India·Phase 3·NCT06712420·114 enrolled

Squamous Cell Carcinoma2 trials

RCT on the Combined Modality Treatment of Squamous Cell Carcinoma of the Esophagus

Terminated·MMinistry of Scientific Research and Information Technology, Poland·Phase 3·NCT00559351·84 enrolled

Short Course Neoadjuvant Chemo-radiotherapy Plus Toripalimab for Locally Advanced Resectble Squamous Cell Carcinoma of Esophagus

Unknown status·JJiangsu Cancer Institute & Hospital·Phase 2·NCT05424432·63 enrolled

Chemoradiotherapy1 trial

Adjuvant ChemoRadiotherapy Prior to Surgery in Stage IVa Oral Cancers

Completed·—·Phase 1·NCT03923998·8 enrolled

Neoadjuvant Therapy1 trial

Iparomlimab and Tuvonralimab Combined With Paclitaxel and Cisplatin as Neoadjuvant Therapy for CC

Recruiting·OObstetrics & Gynecology Hospital of Fudan University·Phase 2·NCT06878222·35 enrolled

Intrahepatic Cholangiocarcinoma1 trial

Neoadjuvant Therapy for Resectable Intrahepatic Cholangiocarcinoma With High Predict Risk of Lymph Node Metastasis

Unknown status·—·Phase 2·NCT04523402·100 enrolled

Trial1 trial

EUS-RFA PANCARDINAL-1 Trial

Recruiting·TThe University of Texas Health Science Center, Houston·Phase 2·NCT04990609·60 enrolled

Neoadjuvant1 trial

Neoadjuvant HAIC and PD-1 Plus Adjuvant PD-1 for High-risk Recurrent HCC

Recruiting·SSun Yat-sen University·Phase 2·NCT06467799·39 enrolled

Nasopharyngeal Carcinoma1 trial

A Multicenter Trial Comparing Multi-course Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma

Unknown status·SSun Yat-sen University·Phase 3·NCT00705627·400 enrolled

Immunochemotherapy1 trial

Neoadjuvant Immunochemotherapy vs Chemoradiotherapy in ESCC

Completed·YYongtao Han·N/A·NCT07236320·200 enrolled

Pathological Complete Response1 trial

A Clinical Study Based on FAPI-PET/CT Technology to Predict Pathological Complete Response After Neoadjuvant Chemoradiotherapy for MSS Rectal Cancer

Completed·SSun Yat-sen University·Phase 2·NCT06608537·52 enrolled

Colon Cancer1 trial

Neoadjuvant FOLFOXIRI Versus Immediate Surgery for Stage II and III Colon Cancers

Recruiting·SSun Yat-sen University·Phase 3·NCT05194878·840 enrolled

Hepatocellular Carcinoma1 trial

Neoadjuvant SBRT Combined With Lenvatinib and Pucotenlimab for Resectable Hepatocellular Carcinoma

Active, not recruiting·SSun Yat-sen University·Phase 2·NCT06524466·35 enrolled

Neoadjuvant Treatment1 trial

Neoadjuvant Treatment Real-world Clinical Outcomes in NSCLC

Recruiting·—··NCT05974007·1,500 enrolled

Peritoneal Carcinoma1 trial

Trial of Chemotherapy in Ovarian, Fallopian Tube and Peritoneal Carcinoma

Completed·RRachel Miller·Phase 2·NCT01519869·28 enrolled

Osteosarcoma1 trial

A Phase I Clinical Trial of Neoadjuvant Chemotherapy With/Without SPIONs/SMF for Patients With Osteosarcoma

Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 1·NCT04316091·60 enrolled

Hypopharyngeal Carcinoma1 trial

Comparing Neoadjuvant Chemotherapy Combined With PD-1 Inhibitor Versus Neoadjuvant Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Carcinoma

Not yet recruiting·FFudan University·Phase 3·NCT06957938·168 enrolled

Concurrent Chemoradiotherapy1 trial

Neoadjuvant Chemo-immunotherapy Followed by Concurrent Chemoradiotherapy and Immunotherapy in LACC

Not yet recruiting·RRenJi Hospital·Phase 2·NCT06916117·30 enrolled

Adenocarcinoma1 trial

Endoscopic Ultrasound Radiofrequency Ablation and Immunotherapy Pembrolizumab for Locally Advanced Unresectable and Metastatic Pancreatic Duct Adenocarcinoma

Recruiting·TThe University of Texas Health Science Center, Houston·Phase 2·NCT06831136·24 enrolled

Cytoreductive Surgery1 trial

OVCA-NAC-P2: Study of Chemotherapy Followed by Cytoreductive Surgery for Ovarian, Tubal and Peritoneal Cancers: JCOG0206

Completed·JJapan Clinical Oncology Group·Phase 2·NCT00112086·56 enrolled

Prospective1 trial

CNCMT：a Multi-center, Prospective, Single-arm Study

Enrolling by invitation·UUnknown Sponsor·N/A·NCT06714084·20 enrolled

Observational Study1 trial

Observational Study on Rectal Cancer to Verify if Response After Chemo-radiotherapy Can be Predicted With a Particular Blood Test.

Terminated·DDimitri Christoforidis··NCT03699410·25 enrolled

Lymph Node Dissection1 trial

Partial Cystectomy & Extended Pelvic Lymph Node Dissection With SOC Perioperative Systemic Therapy

Recruiting·—·Phase 2·NCT06290687·40 enrolled

Small Cell Lung Cancer1 trial

Neoadjuvant Therapy Combined With Radical Surgery for the Treatment of Small Cell Lung Cancer (SCLC) in II and IIIA Stage

Unknown status·PPeng Zhang·N/A·NCT03523234·300 enrolled

Efficacy and Safety1 trial

Association Between Microbiome and the Efficacy and Safety of PD-1/PD-L1 Blockade in Resectable NSCLC

Not yet recruiting·—··NCT06613308·20 enrolled

Delirium1 trial

Effect of Neoadjuvant Anti-PD-1 Immunotherapy on Perioperative Analgesia and Postoperative Delirium

Completed·TTianjin Medical University Cancer Institute and Hospital··NCT05273827·81 enrolled

Epithelial Ovarian Cancer1 trial

The Feasibility, Safety, and Clinical Outcomes of Fasting During Neoadjuvant Chemotherapy in Patients With Epithelial Ovarian Cancer

Recruiting·CCase Comprehensive Cancer Center·Preclinical·NCT06386887·20 enrolled

Sources

References

[1]
ClinicalTrials.gov — 75 trial records for Neoadjuvant Chemotherapy. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Neoadjuvant Chemotherapy compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Neoadjuvant Chemotherapy. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Japan Clinical Oncology Group company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: JJapan Clinical Oncology Group

Neoadjuvant Chemotherapy

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q2 2027

Trials by Indication[1]

Breast Cancer12 trials

Neoadjuvant Chemotherapy6 trials

Gastric Cancer5 trials

Ovarian Cancer5 trials

Cervical Cancer3 trials

Chemotherapy2 trials

Esophageal Carcinoma2 trials

Pancreatic Cancer2 trials

Locally Advanced Colon Cancer2 trials

Esophageal Squamous Cell Carcinoma2 trials

Lung Cancer2 trials

Locally-advanced Rectal Cancer2 trials

Colorectal Cancer2 trials

Bladder Cancer2 trials

Squamous Cell Carcinoma2 trials

Chemoradiotherapy1 trial

Neoadjuvant Therapy1 trial

Intrahepatic Cholangiocarcinoma1 trial

Trial1 trial

Neoadjuvant1 trial

Nasopharyngeal Carcinoma1 trial

Immunochemotherapy1 trial

Pathological Complete Response1 trial

Colon Cancer1 trial

Hepatocellular Carcinoma1 trial

Neoadjuvant Treatment1 trial

Peritoneal Carcinoma1 trial

Osteosarcoma1 trial

Hypopharyngeal Carcinoma1 trial

Concurrent Chemoradiotherapy1 trial

Adenocarcinoma1 trial

Cytoreductive Surgery1 trial

Prospective1 trial

Observational Study1 trial

Lymph Node Dissection1 trial

Small Cell Lung Cancer1 trial

Efficacy and Safety1 trial

Delirium1 trial

Epithelial Ovarian Cancer1 trial

References

Drug Info

Quick Facts

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