VivoSeq
Neurology

Delirium

134

Pipeline Programs↗

68

Active Trials↗

41

Companies Involved↗

Delirium is a highly competitive landscape with 134 programs across 41 companies. The most active players are Fresenius, Nobilis Therapeutics Inc., Retrophin. 58 therapies are approved with 24 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

77/100

Pipeline Velocity

45/100

Mech. Concentration

7/100

Completion Rate

72/100

Attrition Rate

14/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

F

Fresenius

1 program

Phase 1N

Nobilis Therapeutics Inc.

1 program

Phase 2R

Retrophin

1 program

Phase 2Sanofi logo

Sanofi

1 program

Phase 2Idorsia Pharmaceuticals Ltd. logo

Idorsia Pharmaceuticals Ltd.

1 program

Phase 2T

Triax

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical36

Sugammadex

Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Remifentanil

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Ramelteon

Takeda

Thiamine

Universiti Kebangsaan Malaysia Medical Centre

Desflurane

Baxter Healthcare Corporation

Phase 16

Dexmedetomidine Hydrochloride

Pfizer

Remimazolam Intervention

Assiut University

S-Ketamine

Peking University First Hospital

Propofol Alone

Washington University School of Medicine

Ketone Supplementation

Vanderbilt University Medical Center

Phase 210

Xenon

Nobilis Therapeutics Inc.

Olanzapine

MODAG GmbH

Oxytocin

Retrophin

Ziprasidone

Pfizer

Duloxetine

Alnylam Pharmaceuticals

Phase 324

Guanfacine

Promius Pharma, LLC

Melatonin

Neurim Pharmaceuticals Ltd.

Lorazepam

Bausch Health Americas, Inc.

Gabapentin

Viatris Specialty LLC

Liraglutide

Novo Nordisk

Approved58

Dexamethasone

Aspen Global Incorporated

Propofol

Fresenius Kabi Oncology Ltd.

Fentanyl

Cephalon

Acetaminophen

Kenvue Brands

Suvorexant

Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Analysis

Modality Breakdown

99%

Small molecule

162 of 163 classified programs — the dominant modality here.

1%ALL OTHERSPeptide1<1%

Small molecule leads; the ring shows all 163 classified programs, each share of the total. Modality classified for 98% of 168 pipeline programs.

Analysis

Trial Status

261

clinical trials

Completed100 · 38%
Unknown status55 · 21%
Recruiting37 · 14%
Terminated23 · 9%
Not yet recruiting19 · 7%
Withdrawn14 · 5%
Other13 · 5%

Clinical Trials

Trial Activity

261 trials

Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence Delirium
Recruiting·KKasr El Aini Hospital·Phase 4·NCT07427446·50 enrolled
Effect of Remimazolam and Propofol on Postoperative Delirium
Recruiting·IInje University·N/A·NCT05514405·82 enrolled
Delirium Reduction With Ramelteon
Recruiting·—·Phase 4·NCT05069428·506 enrolled
Melatonin for Treatment of Delirium in Critically Ill Adult Patients
Recruiting·CCiusss de L'Est de l'Île de Montréal·Phase 2·NCT05713877·30 enrolled
Effect of Nasal Spray Dexmedetomidine on Emergence Delirium Prevention in Total Hip Replacement
Recruiting·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·Phase 4·NCT06579001·264 enrolled
Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries
Recruiting·TTanta University·N/A·NCT07108764·100 enrolled
Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery
Recruiting·WWashington University School of Medicine·Phase 3·NCT06969287·46 enrolled
HALO Trial: Haloperidol vs Olanzapine in Hyperactive Delirium in Palliative Care Patients; A Multi-Centre, Randomised-Controlled Trial
Recruiting·TTan Tock Seng Hospital·Phase 3·NCT04833023·72 enrolled
Clonidine to Prevent Delirium After Electroconvulsive Therapy.
Recruiting·IInsel Gruppe AG, University Hospital Bern·Phase 4·NCT04828226·130 enrolled
Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic Surgery
Recruiting·—·Phase 2·NCT07443085·75 enrolled
Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery
Recruiting·SSir Ganga Ram Hospital·N/A·NCT04707794·270 enrolled
The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium
Recruiting·MMedical University of Vienna·Phase 4·NCT05990790·1,332 enrolled
Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients
Recruiting·—·N/A·NCT05168280·420 enrolled
Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery
Recruiting·TThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School·Phase 3·NCT06361238·260 enrolled
Intraoperative Midazolam on Delirium Outcome of Elderly Patients
Recruiting·—·Phase 1·NCT06963112·612 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)