Dibenzyline

(Phenoxybenzamine)

PreclinicalSmall molecule

AAdvanz Pharma

Dibenzyline is one of 6 small molecule programs targeting Cardiopulmonary Bypass. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

FDA Application

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[3][1]

Indication

Cardiopulmonary BypassTerminated

Cardiopulmonary BypassPreclinical

Terminated

Competition

Competitive Landscape

7 competitors in Cardiopulmonary Bypass

#DrugCompanyPhaseTrials

Nitric Oxide Gas

XXijing Hospital

Phase 3

1 2

Primacor

Sanofi

Preclinical

2 3

Versed

CConrado Roberto Hoffmann Filho

Preclinical

1 4

Aprotinin

Bayer

Preclinical

1 5

Dibenzyline

AAdvanz Pharma

Preclinical

1 6

Protamine Sulfate

LLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2027

Post-ApprovalRecruiting

Pheochromocytoma

NCT05702944

Clinical

Trials by Indication[1]

Pheochromocytoma2 trials

The Effect and Safety of Omitting Preoperative Alpha-adrenergic Blockade for Normotensive Pheochromocytoma

Recruiting·SSeoul National University Hospital·Phase 4·NCT05702944·24 enrolled

Preoperative Alpha Blockade for Pheochromocytoma

Completed·UUniversity of California, Los Angeles·Phase 3·NCT03176693·39 enrolled

Congenital Heart Disease1 trial

Parenteral Phenoxybenzamine During Congenital Heart Disease Surgery

Withdrawn·VVanderbilt University·Phase 2·NCT00770705

Cardiopulmonary Bypass1 trial

Use of Phenoxybenzamine [PBZ] IV to Assist High Flow Low Pressure Perfusion [HFLPP] on Cardio-pulmonary Bypass

Terminated·TThe Cleveland Clinic·N/A·NCT00620945·87 enrolled

Pediatric Patients1 trial

Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery

Completed·UUniversity of Arkansas·Phase 2·NCT00569855·785 enrolled

Unspecified1 trial

Phenoxybenzamine Versus Doxazosin in PCC Patients

Completed·UUniversity Medical Center Groningen·Phase 4·NCT01379898·134 enrolled

Regulatory

FDA Approval Timeline[4]

Jan 1, 1982

DIBENZYLINE

NDA NDA008708

Sources

References

[1]
ClinicalTrials.gov — 6 trial records for Phenoxybenzamine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Phenoxybenzamine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Phenoxybenzamine. EMBL-EBI & Wellcome Sanger Institute.
[4]
OpenFDA — FDA approval records (NDA NDA008708). U.S. Food & Drug Administration.
[5]
SEC EDGAR — Advanz Pharma company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: AAdvanz Pharma

Dibenzyline

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2027

Trials by Indication[1]

Pheochromocytoma2 trials

Congenital Heart Disease1 trial

Cardiopulmonary Bypass1 trial

Pediatric Patients1 trial

Unspecified1 trial

FDA Approval Timeline[4]

References

Drug Info

Quick Facts

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