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Physostigmine

PreclinicalSmall molecule

2

Indications

9

Total Trials

0

Active Trials

0

Competitors

Pipeline

Status by Indication[3][1]

Indication

Tobacco SmokingCompleted

Tobacco SmokingPreclinical

Completed

Clinical

Trials by Indication[1]

Sedation2 trials

Phamacological Reversal of Airway Instability During Sedation

Completed·UUniversity of Rochester·N/A·NCT01171118·10 enrolled

The Effect of Physostigmine on Cognitive Functioning in the Immediate Period After Sedation for Colonoscopy

Unknown status·RRabin Medical Center·N/A·NCT01121497·160 enrolled

General Anesthesia1 trial

Physostigmine After General Anesthesia

Unknown status·—·N/A·NCT00850850·50 enrolled

Insulin resistance1 trial

Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve Activity

Completed· AstraZeneca logo

AstraZeneca·Phase 1·NCT00689208·12 enrolled

Opioid Analgesia1 trial

Pilot Study of Physostigmine-Enhanced Opioid Analgesia

Completed·MMedical University of Graz·Phase 3·NCT01394445·20 enrolled

Tobacco Smoking1 trial

Acetylcholine, Tobacco Smoking, Genes and Nicotinic Receptors

Completed·YYale University·N/A·NCT02008292·80 enrolled

3 more indications

Adolescent1 trial

Treatment of Adolescent Antimuscarinic (Anticholinergic) Toxidrome

Completed·UUniversity of Colorado, Denver·Phase 4·NCT03090620·19 enrolled

Delirium1 trial

Evaluation if Physostigmine Reduces Symptoms in Patients Who Has Developed a Delirium in Intensive Care After a Surgery

Unknown status·PPD Dr. Bertram Scheller·Phase 3·NCT02216266·120 enrolled

Unspecified1 trial

Anticholium® Per Se

Completed·UUniversity Hospital Heidelberg·N/A·NCT03013322·20 enrolled

Sources

References

[1]
ClinicalTrials.gov — 9 trial records for Physostigmine. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Physostigmine compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Physostigmine. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — AstraZeneca company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: AstraZeneca

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