VivoSeq
Other

Sedation

210

Pipeline Programs↗

75

Active Trials↗

38

Companies Involved↗

Sedation is a highly competitive landscape with 210 programs across 38 companies. The most active players are Nobilis Therapeutics Inc., Melt Pharmaceuticals, Homeostasis Therapeutics, LLC. 81 therapies are approved with 34 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

82/100

Pipeline Velocity

58/100

Mech. Concentration

19/100

Completion Rate

85/100

Attrition Rate

10/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

N

Nobilis Therapeutics Inc.

1 program

Phase 1M

Melt Pharmaceuticals

1 program

Phase 1H

Homeostasis Therapeutics, LLC

1 program

Phase 1S

Sichuan Haisco Pharmaceutical Group Co., Ltd

3 programs

Phase 2A

ACADIA Pharmaceuticals Inc.

1 program

Phase 2F

Fujian Shengdi Pharmaceutical Co., Ltd.

1 program

Phase 2

Pipeline

Programs by Phase

Preclinical68

Clonidine

Boehringer Ingelheim

Fentanyl

Cephalon

Desflurane

Baxter Healthcare Corporation

Rocuronium

Fresenius Kabi Oncology Ltd.

Active Comparator

Moderna

Phase 18

Ketamine-Midazolam

Soroka University Medical Center

Xenon

Nobilis Therapeutics Inc.

Ketamine/ Propofol

Zagazig University

Midazolam Alone

Melt Pharmaceuticals

Pentobarbital

University of California, Los Angeles

Phase 219

Pimavanserin

ACADIA Pharmaceuticals Inc.

HSK3486

Sichuan Haisco Pharmaceutical Group Co., Ltd

Bupivacain

Istanbul University

Quetiapine

Engelhard Arzneimittel GmbH & Co.KG

Remimazolam Tosilate

Fujian Shengdi Pharmaceutical Co., Ltd.

Phase 334

Dexmedetomidine Hydrochloride

Pfizer

Lorazepam

Bausch Health Americas, Inc.

Sevoflurane

AbbVie

Bupivacaine

Innocoll

Magnesium Sulfate

Fresenius Kabi Oncology Ltd.

Approved81

Atropine

Fresenius Kabi Oncology Ltd.

Propofol

Fresenius Kabi Oncology Ltd.

Ketamine

Aultman Health Foundation

Remimazolam Besylate

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Dexmedetomidine

McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.

Analysis

Trial Status

582

clinical trials

Completed334 · 57%
Unknown status112 · 19%
Recruiting45 · 8%
Terminated40 · 7%
Not yet recruiting22 · 4%
Withdrawn17 · 3%
Other12 · 2%

Clinical Trials

Trial Activity

582 trials

Propofol Sedation vs. Anaesthetist Guided Anaesthesia in Oocyte Pickup
Recruiting·WWunschbaby Institut Feichtinger·N/A·NCT05741814·100 enrolled
Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation
Recruiting·—·Phase 2/3·NCT04195256·400 enrolled
A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy
Recruiting·—·Phase 4·NCT07456111·90 enrolled
Evaluation of the Safety of Inhaled Sedation With Isoflurane in Head Trauma Patients
Recruiting·UUniversity Hospital, Grenoble·N/A·NCT06311604·30 enrolled
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
Recruiting·SSecond Affiliated Hospital of Wenzhou Medical University·Phase 4·NCT06853431·80 enrolled
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Recruiting·VVanderbilt University Medical Center·Phase 3·NCT04801589·372 enrolled
Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation
Recruiting·SSohag University·N/A·NCT06756594·100 enrolled
Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With EVT on Long-term Prognosis in Patients With AIS (PPDET)
Recruiting·—·Phase 4·NCT04916197·368 enrolled
Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
Recruiting·RRomanian Society for Enteral and Parenteral Nutrition·Phase 3·NCT07113483·120 enrolled
Sedation Efficacy and Safety of Remazolam Besylate in Ventilated Surgical Critically Ill Patients
Recruiting·—·Phase 4·NCT06575530·306 enrolled
The Study is Being Conducted to Evaluate the Efficacy and Safety of Dexmedetomidine Hydrochloride Microneedles for Preoperative Sedation in Children
Recruiting·GGuangzhou Novaken Pharm Co., Ltd.·Phase 2·NCT07168720·64 enrolled
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness
Recruiting·—·N/A·NCT05823454·200 enrolled
Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants
Recruiting·AAssistance Publique - Hôpitaux de Paris·Phase 3·NCT06878703·380 enrolled
A Comparative Study of Eleveld and Schnider Pharmacokinetic Models for Target-Controlled Infusion of Propofol in Sedation of Mechanically Ventilated ICU Patients
Recruiting·HHacettepe University·N/A·NCT07239687·84 enrolled
Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy
Recruiting·PPost Graduate Institute of Medical Education and Research, Chandigarh·Phase 3·NCT07184801·56 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)