PTM SEMA

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

TenofovirPre-Exposure Prophylaxis of HIV Infection

9 competitors in Tenofovir

#DrugCompanyPhaseTrials

1

Tybost

Gilead

Phase 3

62

B/F/TAF

Gilead

Phase 3

23

ISL/LEN

Gilead

Phase 3

14

F/TAF

Gilead

Phase 3

15

Cobicistat TOS

Gilead

Phase 3

16

Third Agent

Gilead

Phase 3

27

Lpv/r

Gilead

Phase 3

18

PTM SEMA

Gilead

Phase 3

19

Truvada

Gilead

Preclinical

3

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Cirrhosis1 trial

Study of Semaglutide, and Cilofexor/Firsocostat, Alone and in Combination, in Adults With Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)

Completed·Gilead·Phase 2·NCT04971785·457 enrolled

Tenofovir1 trial

Study to Compare an Oral Weekly Islatravir/Lenacapavir Regimen With Bictegravir/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed People With HIV-1

Active, not recruiting·Gilead·Phase 3·NCT06630286·609 enrolled

Ulcerative Colitis1 trial

Study to Evaluate the Efficacy and Safety of Filgotinib in the Induction and Maintenance of Remission in Adults With Moderately to Severely Active Ulcerative Colitis

Completed·Gilead·Phase 3·NCT02914522·1,351 enrolled

Pre-Exposure Prophylaxis of HIV Infection1 trial

A Phase 3, Double-Blinded, Multicenter, Randomized Study to Evaluate Safety and Efficacy of Twice Yearly Long-Acting Subcutaneous Lenacapavir, and Daily Oral Emtricitabine/Tenofovir Alafenamide for Pre-Exposure Prophylaxis in Adolescent Girls and Young Women at Risk of HIV Infection

Active, not recruiting·Gilead·Phase 3·NCT04994509·5,368 enrolled

HIV1 trial

PURPOSE-1: Lenacapavir PrEP for HIV Prevention

Completed·Gilead·Phase 3·NCT04925752·5,338 enrolled

Details

Drug Info

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