rt-PA

Pipeline

Status by Indication[3][1]

Competition

Competitive Landscape

2 competitors in Thrombectomy

#DrugCompanyPhaseTrials

1

Tnkase

Roche

Phase 3

32

rt-PA

Boehringer Ingelheim

Phase 1

1

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Clinical

Trials by Indication[1]

Stroke5 trials

1-year Clinical Outcomes in Recombinant Tissue Plasminogen Activator (Rt-PA) Treated Chinese Acute Ischaemic Stroke (AIS) Patients

Completed·Boehringer Ingelheim··NCT05395338·12,551 enrolled

Alteplase Treatment in Elderly Acute Ischaemic Stroke (AIS) Patients

Completed·Boehringer Ingelheim··NCT05401149·3,058 enrolled

rhPro-UK in Acute Ischaemic Stroke Within 4.5 Hours of Stroke Onset Trial 2(PROST-2)

Completed·TTasly Biopharmaceuticals Co., Ltd.·Phase 3·NCT05700591·1,552 enrolled

Show 2 more trials

Randomized Controlled Trial of Argatroban With Tissue Plasminogen Activator (tPA) for Acute Stroke

Terminated·—·Phase 2·NCT01464788·90 enrolled

A Multicenter Randomized Controlled Trial Comparing Tissue Plasminogen Activator With Dual Antiplatelet Therapy for Patients With Hyperacute Single Perforating Artery Infarction

Recruiting·NNippon Medical School·Approved·NCT07111559·500 enrolled

Ischemic stroke4 trials

Argatroban Plus R-tPA for Acute Ischemic Stroke

Completed·GGeneral Hospital of Shenyang Military Region·Phase 4·NCT03740958·808 enrolled

Study of the Combination Therapy of Rt-PA and Eptifibatide to Treat Acute Ischemic Stroke

Completed·UUniversity of Cincinnati·Phase 2·NCT00894803·126 enrolled

Alteplase in Elderly Acute Ischemic Stroke (AIS) Patients During Hospitalization

Completed·Boehringer Ingelheim··NCT05395351·113,035 enrolled

Show 1 more trial

Local Versus Systemic Thrombolysis for Acute Ischemic Stroke (SYNTHESIS)

Completed·NNiguarda Hospital·Phase 3·NCT00540527·54 enrolled

Tenecteplase1 trial

Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion

Withdrawn·UUniversity Hospital Center of Martinique·Phase 2·NCT02338466

Thromboembolism1 trial

Low Dosage of rt-PA in the Treatment of Pulmonary Thromboembolism in China

Completed·—·Phase 4·NCT00781378·118 enrolled

Posterior Circulation1 trial

Argatroban Plus r-tPA for Posterior Circulation Infarction（AR-PCI）

Terminated·HHui-Sheng Chen·Phase 4·NCT03506009·3 enrolled

6 more indications

Cerebrovascular Event1 trial

Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅱ

Completed·—·Phase 3·NCT04797013·1,430 enrolled

Thrombectomy1 trial

Study on Hibernation-like Therapy Based on Mechanical Thrombectomy

Recruiting·—·Phase 1·NCT06663631·32 enrolled

Phase II1 trial

Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III

Completed·JJohns Hopkins University·Phase 3·NCT01827046·499 enrolled

Acute Myocardial Infarction1 trial

Trial to Compare the Efficacy and Safety of a Single Bolus of TNK-tPA (Tenecteplase, Metalyse®) With Accelerated Infusion of Rt-PA (Alteplase, Actilyse®) in Asian Patients With Acute Myocardial Infarction

Completed·Boehringer Ingelheim·Phase 3·NCT00148460·270 enrolled

Hemodialysis1 trial

Prolonged Hemodialysis Catheter Survival With Copolymer Coating and Rt-PA

Unknown status·—·Phase 4·NCT01670474·240 enrolled

Unspecified1 trial

Dose-effect Relationship of Rt-PA on ICH Evacuation

Unknown status·TTongji Hospital·Phase 2·NCT02472574·108 enrolled

Details

Drug Info

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