solithromycin

Phase 3Small molecule

MMelinta Therapeutics, Inc.

solithromycin is one of 115 small molecule programs targeting Gonorrhea. It is currently in Phase 3.

Indications

Total Trials

Active Trials

114

Competitors

Pipeline

Status by Indication[3][1]

Indication

GonorrheaActive, not recruiting

Bacterial PneumoniaActive, not recruiting

Chronic Obstructive Pulmonary DiseaseActive, not recruiting

CirrhosisActive, not recruiting

GonorrheaPhase 2

Active, not recruiting

Bacterial PneumoniaPhase 3

Active, not recruiting

Chronic Obstructive Pulmonary DiseasePhase 2

Active, not recruiting

CirrhosisPhase 2

Active, not recruiting

Competition

Competitive Landscape

557 competitors in Chronic Obstructive Pulmonary Disease

#DrugCompanyPhaseTrials

solithromycin

MMelinta Therapeutics, Inc.

Phase 3

1 2

Veramyst

GSK

Preclinical

26 3

Flovent

GSK

Preclinical

6 4

Spiriva

Boehringer Ingelheim

Preclinical

15 5

Aclidinium Bromide

AstraZeneca

Preclinical

21 6

Atrovent

Boehringer Ingelheim

Preclinical

5 7

Calciferol

Alnylam Pharmaceuticals

Preclinical

—8

Proventil

Mylan Pharmaceuticals Inc

Preclinical

3 9

Duragesic

CCephalon

Preclinical

2 10

Narcan

SScienture

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Bacterial Pneumonia3 trials

Safety and Efficacy of Solithromycin in Adolescents and Children With Community-Acquired Bacterial Pneumonia

Terminated·MMelinta Therapeutics, Inc.·Phase 2/3·NCT02605122·97 enrolled

Efficacy and Safety Study of Oral Solithromycin (CEM-101) Compared to Oral Moxifloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia

Completed·MMelinta Therapeutics, Inc.·Phase 3·NCT01756339·860 enrolled

Efficacy and Safety Study of Intravenous to Oral Solithromycin (CEM-101) Compared to Intravenous to Oral Moxifloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia

Completed·MMelinta Therapeutics, Inc.·Phase 3·NCT01968733·863 enrolled

Gonorrhea2 trials

Safety and Efficacy Study of Single-Dose Oral CEM-101 in Patients With Uncomplicated Urogenital Gonorrhea

Completed·MMelinta Therapeutics, Inc.·Phase 2·NCT01591447·60 enrolled

Efficacy and Safety Study of Oral Solithromycin Compared to Intramuscular Ceftriaxone Plus Oral Azithromycin in the Treatment of Patients With Gonorrhea

Completed·MMelinta Therapeutics, Inc.·Phase 3·NCT02210325·264 enrolled

Adolescent2 trials

Pharmacokinetics and Safety of Solithromycin Capsules in Adolescents

Completed·MMelinta Therapeutics, Inc.·Phase 1·NCT01966055·13 enrolled

Pharmacokinetics and Safety of Solithromycin in Adolescents and Children

Completed·MMelinta Therapeutics, Inc.·Phase 1·NCT02268279·84 enrolled

Chronic Obstructive Pulmonary Disease1 trial

A Study to Evaluate the Anti-inflammatory Effects of Solithromycin in Chronic Obstructive Pulmonary Disease

Terminated·IImperial College London·Phase 2·NCT02628769·6 enrolled

Tics1 trial

Genitourinary and Pharyngeal Pharmacokinetics of Solithromycin

Completed·NNational Institute of Allergy and Infectious Diseases (NIAID)·Phase 1·NCT02348424·28 enrolled

1 more indication

Cirrhosis1 trial

Safety and Efficacy of Solithromycin in the Treatment of Nonalcoholic Steatohepatitis Without Cirrhosis

Completed·MMelinta Therapeutics, Inc.·Phase 2·NCT02510599·10 enrolled

Sources

References

[1]
ClinicalTrials.gov — 10 trial records for solithromycin. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — solithromycin compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for solithromycin. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Melinta Therapeutics, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: MMelinta Therapeutics, Inc.

solithromycin

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Bacterial Pneumonia3 trials

Gonorrhea2 trials

Adolescent2 trials

Chronic Obstructive Pulmonary Disease1 trial

Tics1 trial

Cirrhosis1 trial

References

Drug Info

Quick Facts

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