Therapeutic Exchange Plasma

PreclinicalBiologic

Therapeutic Exchange Plasma is one of 5 biologic programs targeting Stage III Hepatocellular Carcinoma AJCC v8. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Stage III Hepatocellular Carcinoma AJCC V8Recruiting

Stage III Hepatocellular Carcinoma AJCC V8Preclinical

Recruiting

Competition

Competitive Landscape

4 competitors in Stage III Hepatocellular Carcinoma AJCC V8

#DrugCompanyPhaseTrials

Tecentriq

Roche

Preclinical

1 2

Avastin

Roche

Preclinical

1 3

Imfinzi

AstraZeneca

Preclinical

1 4

Pneumococcal 13-Valent Conjugate Vaccine

Sanofi

Preclinical

1 5

Therapeutic Exchange Plasma

LLisata Therapeutics, Inc.

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q1 2031

PreclinicalRecruiting

Stage III Hepatocellular Carcinoma AJCC V8

NCT03942328

Clinical

Trials by Indication[1]

Melanoma8 trials

Vaccine Therapy in Treating Patients With Stage IV or Recurrent Melanoma

Completed·LLisata Therapeutics, Inc.·Phase 1/2·NCT00012064·56 enrolled

Radiation Therapy, Plasma Exchange, and Immunotherapy (Pembrolizumab or Nivolumab) for the Treatment of Melanoma

Completed·MMayo Clinic·Phase 1·NCT04581382·18 enrolled

Dendritic Cell Therapy With Pembrolizumab for Metastatic or Unresectable Melanoma

Terminated·MMayo Clinic·Phase 1/2·NCT03325101·7 enrolled

Show 5 more trials

Vaccine Therapy Followed by Biological Therapy in Treating Patients With Stage III or Stage IV Melanoma

Terminated·UUniversity of Southern California·Phase 2·NCT00006113·25 enrolled

Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma

Unknown status·—·Phase 2·NCT00085397·40 enrolled

Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma

Completed·UUniversity Hospital Erlangen·Phase 1/2·NCT00053391·62 enrolled

Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma

Completed·—·Phase 1·NCT00085488

Vaccine Therapy in Treating Patients With Stage IV Melanoma

Unknown status·—·Phase 1/2·NCT00126685·30 enrolled

Breast Cancer4 trials

Paclitaxel, Cyclophosphamide & Doxorubicin, Autologous Dendritic Cells & Surgery in Stage II/III Breast Cancer (Women)

Completed·UUniversity of Nebraska·Phase 2·NCT00499083·17 enrolled

Platelet Rich Plasma for the Treatment of Genitourinary Syndrome of Menopause in Patients With Stage 0-III Breast Cancer

Completed·MMayo Clinic·Phase 1·NCT04535323·20 enrolled

Vaccine Therapy, Trastuzumab, and Vinorelbine in Treating Patients With Locally Recurrent or Metastatic Breast Cancer

Completed·UUNC Lineberger Comprehensive Cancer Center·Phase 2·NCT00266110·17 enrolled

Show 1 more trial

Vaccine Therapy, Trastuzumab, and Vinorelbine in Treating Women With Locally Recurrent or Metastatic Breast Cancer

Terminated·UUNC Lineberger Comprehensive Cancer Center·Phase 2·NCT00088985·56 enrolled

Metastatic Prostate Cancer3 trials

Vaccine Therapy in Treating Patients With Non-Metastatic Prostate Cancer

Terminated·MMayo Clinic·Phase 2·NCT00814892·2 enrolled

Vaccine Therapy in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

Unknown status·JJonsson Comprehensive Cancer Center·Phase 1·NCT00005992

Vaccine Therapy in Treating Patients With Metastatic Prostate Cancer

Terminated·—·Phase 1·NCT00010127·3 enrolled

Metastatic Melanoma3 trials

Vaccine Therapy in Treating Patients With Metastatic Melanoma

Completed·UUniversity of Southern California·Phase 2·NCT00334776·6 enrolled

Vaccine Therapy and GM-CSF in Treating Patients With Recurrent or Metastatic Melanoma

Completed·HHoag Memorial Hospital Presbyterian·Phase 2·NCT00436930·200 enrolled

Vaccine Therapy in Treating Patients With Metastatic Melanoma

Unknown status·BBaylor Health Care System·Phase 1·NCT00017355

Kidney Cancer3 trials

Vaccine Therapy in Treating Patients With Stage III or Stage IV Kidney Cancer

Completed·—·Phase 1·NCT00005816·15 enrolled

Autologous Dendritic Cells in Treating Patients With Metastatic Kidney Cancer

Completed·JJonsson Comprehensive Cancer Center·Phase 1·NCT01826877·12 enrolled

Vaccine Therapy With or Without Fludarabine in Treating Patients With Stage IV Kidney Cancer

Unknown status·SSt. Luke's Medical Center·Phase 2·NCT00093522·28 enrolled

12 more indications

Acute Myeloid Leukemia2 trials

Vaccine Therapy in Treating Patients With Acute Myeloid Leukemia in Complete Remission

Completed·IInstitut Paoli-Calmettes·Phase 1·NCT00963521·10 enrolled

Vaccine Therapy in Treating Patients With Acute Myeloid Leukemia

Terminated·—·Phase 1·NCT00100971·9 enrolled

Non-Small Cell Lung Cancer2 trials

Vaccine Therapy in Treating Patients With Non-Small Cell Lung Cancer

Completed·RRoswell Park Cancer Institute·Phase 1·NCT00023985

Vaccine Therapy in Treating Patients Who Are Undergoing Surgery for Stage IB, Stage II, or Stage IIIA Non-Small Cell Lung Cancer

Terminated·JJonsson Comprehensive Cancer Center·Phase 1·NCT00098917·15 enrolled

Colorectal Cancer2 trials

Pembrolizumab and Autologous Dendritic Cells for the Treatment of Refractory Colorectal Cancer (CRC)

Withdrawn·RRoswell Park Cancer Institute·Phase 2·NCT05518032

Vaccine Therapy in Treating Patients With Liver or Lung Metastases From Colorectal Cancer

Completed·MMichael Morse, MD·Phase 2·NCT00103142·74 enrolled

Malignant Glioma2 trials

Vaccine Therapy in Treating Young Patients Who Are Undergoing Surgery for Malignant Glioma

Completed·JJonsson Comprehensive Cancer Center·Phase 1·NCT00107185·7 enrolled

Vaccine Therapy in Treating Patients With Malignant Glioma

Completed·JJonsson Comprehensive Cancer Center·Phase 1·NCT00068510·28 enrolled

Ovarian Cancer1 trial

p53 Vaccine for Ovarian Cancer

Terminated·NNational Cancer Institute (NCI)·Phase 2·NCT00001827·21 enrolled

Prostate Cancer1 trial

APC8015 and Bevacizumab in Treating Patients With Prostate Cancer

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00027599·25 enrolled

Transplantation1 trial

A Pilot Study of Autologous T-Cell Transplantation With Vaccine Driven Expansion of Anti-Tumor Effectors After Cytoreductive Therapy in Metastatic Pediatric Sarcomas

Completed·NNational Cancer Institute (NCI)·Phase 2·NCT00001566·42 enrolled

Ductal Carcinoma in Situ1 trial

Vaccine Therapy in Treating Patients Who Are Undergoing Surgery for Ductal Carcinoma In Situ of the Breast

Completed·—·Phase 1·NCT00107211·30 enrolled

Glioblastoma Multiforme1 trial

Vaccine Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Completed·GGary Archer Ph.D.·Phase 1·NCT00639639·42 enrolled

Biological Therapy1 trial

Biological Therapy in Treating Patients With Advanced Cancer

Completed·—·N/A·NCT00005956·3 enrolled

Metastatic Cancer1 trial

Denileukin Diftitox Followed by Vaccine Therapy in Treating Patients With Metastatic Cancer

Completed·HH. Kim Lyerly·Phase 1·NCT00128622·24 enrolled

Stage III Hepatocellular Carcinoma AJCC v81 trial

MC1641 Phase II Study Of Intratumoral Injection Of Autologous Dendritic Cells Combined With Immune Checkpoint Inhibition After High-Dose Conformal External Beam Radiotherapy In Patients With Unresectable Primary Liver Cancer

Recruiting·MMayo Clinic·Preclinical·NCT03942328·85 enrolled

Sources

References

[1]
ClinicalTrials.gov — 37 trial records for Therapeutic Exchange Plasma. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Therapeutic Exchange Plasma compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Therapeutic Exchange Plasma. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Lisata Therapeutics, Inc. company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Biologic[2]
Highest Phase: Preclinical[1]
Company: LLisata Therapeutics, Inc.

Therapeutic Exchange Plasma

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q1 2031

Trials by Indication[1]

Melanoma8 trials

Breast Cancer4 trials

Metastatic Prostate Cancer3 trials

Metastatic Melanoma3 trials

Kidney Cancer3 trials

Acute Myeloid Leukemia2 trials

Non-Small Cell Lung Cancer2 trials

Colorectal Cancer2 trials

Malignant Glioma2 trials

Ovarian Cancer1 trial

Prostate Cancer1 trial

Transplantation1 trial

Ductal Carcinoma in Situ1 trial

Glioblastoma Multiforme1 trial

Biological Therapy1 trial

Metastatic Cancer1 trial

Stage III Hepatocellular Carcinoma AJCC v81 trial

References

Drug Info

Quick Facts

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