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Other/Acute Liver Failure

Acute Liver Failure

14

Pipeline Programs↗

8

Active Trials↗

7

Companies Involved↗

Acute Liver Failure is an emerging landscape with 14 programs across 7 companies.

Intelligence

Pipeline Metrics

Competitive Density

44/100

Pipeline Velocity

11/100

Mech. Concentration

67/100

Completion Rate

56/100

Attrition Rate

18/100

Pipeline

Programs by Phase

Preclinical8

N-Acetyl-L-Cysteine

Peking University People's Hospital

Granulocyte Colony-Stimulating Factor

Sanofi

Therapeutic Plasma Excahnge

Institute of Liver and Biliary Sciences, India

Prophylactic Antibiotics

Institute of Liver and Biliary Sciences, India

N-Acetylcysteine (NAC) Treatment

The First Affiliated Hospital of Soochow University

Phase 11

Exosome

Paracrine Therapeutics Dermatology Pte. Ltd.

Phase 25

Equine Anti-Thymocyte Globulin

National Cancer Institute (NCI)

Prednisolone

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Diphenhydramine

Parkedale

Methylprednisolone

Pfizer

HMB002

King's College Hospital NHS Trust

Phase 3

No programs

Approved

No programs

Analysis

Modality Breakdown

91%

Small molecule

10 of 11 classified programs — the dominant modality here.

Small molecule leads; the ring shows all 11 classified programs, each share of the total. Modality classified for 100% of 14 pipeline programs.

Analysis

Trial Status

22

clinical trials

Completed5 · 23%

Unknown status4 · 18%

Active, not recruiting4 · 18%

Terminated2 · 9%

Recruiting2 · 9%

Withdrawn2 · 9%

Other3 · 14%

Clinical Trials

Trial Activity

22 trials

Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure

Recruiting·IInstitute of Liver and Biliary Sciences, India·N/A·NCT06831643·40 enrolled

Role of N-Acetylcysteine in Non-Acetaminophen-Induced Liver Failure

Recruiting·KKing Edward Medical University·Preclinical·NCT07765823·62 enrolled

Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure

Active, not recruiting·LLahore General Hospital·N/A·NCT06872372·62 enrolled

PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure

Active, not recruiting·TThird Affiliated Hospital, Sun Yat-Sen University·Phase 1·NCT07409259·20 enrolled

A Phase 2b, Double-Blind, Three Arm, Randomized, Placebo Controlled Trial With Restricted Response Adaptive Randomization Testing the Efficacy and Safety of High Dose Methylprednisolone or Equine Anti-Thymocyte Globulin as Treatment for Acute Liver Failure in Pediatric Patients

Active, not recruiting·National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 2·NCT04862221·44 enrolled

Identification of Outcome Biomarkers in Patients With Liver Failure.

Active, not recruiting·UUniversity of Edinburgh·N/A·NCT02833064·200 enrolled

Daily Versus Alternate Day Plasma Exchange in Wilson Disease With Acute Liver Failure in Children

Not yet recruiting·IInstitute of Liver and Biliary Sciences, India·N/A·NCT06698991·20 enrolled

Hepatocyte Microbeads for Acute Liver Failure

Not yet recruiting·KKing's College Hospital NHS Trust·Phase 1/2·NCT05491135·17 enrolled

Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure

Completed·VVital Therapies, Inc.·Phase 2·NCT00030225·19 enrolled

Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen

Completed·National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 3·NCT00004467·173 enrolled

High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver Failure

Completed·IInstitute of Liver and Biliary Sciences, India·N/A·NCT02718079·40 enrolled

N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure

Completed·UUniversity of Pittsburgh·Phase 3·NCT00248625·184 enrolled

Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury

Completed·—·Phase 2·NCT01548690·47 enrolled

Safety and Efficacy of the ELAD System (ELAD) to Treat Acute Liver Failure (ALF)

Terminated·VVital Therapies, Inc.·Phase 2·NCT01875874·8 enrolled

Study of N-Acetylcysteine in Acute Liver Failure (ALF)

Terminated·UUniversity of Texas Southwestern Medical Center·Phase 4·NCT00896025·255 enrolled

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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)