N-Acetylcysteine (NAC) Treatment

Phase 3Small molecule

TThe First Affiliated Hospital of Soochow University

N-Acetylcysteine (NAC) Treatment is one of 119 small molecule programs targeting Acute Liver Failure. It is currently in Phase 3.

Indications

Total Trials

Active Trials

118

Competitors

Pipeline

Status by Indication[3][1]

Indication

Acute Liver FailureActive, not recruiting

HepatitisNot yet recruiting

SepsisRecruiting

Thrombotic MicroangiopathyActive, not recruiting

Breast CancerRecruiting

Acute Liver FailurePreclinical

Active, not recruiting

HepatitisPhase 3

Not yet recruiting

SepsisPhase 3

Recruiting

Thrombotic MicroangiopathyPhase 3

Active, not recruiting

Breast CancerPhase 2

Recruiting

Competition

Competitive Landscape

702 competitors in Breast Cancer

#DrugCompanyPhaseTrials

N-Acetylcysteine (NAC) Treatment

TThe First Affiliated Hospital of Soochow University

Phase 3

1 2

Adenocard

Astellas

Preclinical

2 3

Voltaren

Novartis

Preclinical

1 4

Zolymbus

AbbVie

Preclinical

1 5

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

3 6

Duragesic-100

CCephalon

Preclinical

2 7

MS Contin

HHikma Pharmaceuticals LLC

Preclinical

2 8

Spravato

WWim Janssens

Preclinical

2 9

Duragesic

CCephalon

Preclinical

1 10

Tricor

JJagotec

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q4 2026

Phase 2/3Active, not recruiting

Thrombotic Microangiopathy

NCT07279610

Q1 2027

Phase 3Not yet recruiting

Hepatitis

NCT06956482

Q4 2027

Phase 2Recruiting

Breast Cancer

NCT07117630

Q3 2028

ApprovedRecruiting

Sepsis

NCT07273071

Clinical

Trials by Indication[1]

Parkinson's Disease1 trial

Randomized, Placebo-Controlled Trial of N-acetylcysteine In Parkinson's Disease Patients: A Pilot Study

Completed·—·Phase 2·NCT07093944·42 enrolled

Post-Traumatic Stress Disorder, PTSD1 trial

Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)

Completed·MMedical University of South Carolina·Phase 2·NCT02966873·182 enrolled

Thrombotic Microangiopathy1 trial

N-Acetylcysteine as Therapy for Transplantation- Associated Thrombotic Microangiopathy

Active, not recruiting·TThe First Affiliated Hospital of Soochow University·Phase 2/3·NCT07279610·44 enrolled

Hepatitis1 trial

PROlonged Corticosteroid Treatment or N-ACetylcysteine for Severe Alcoholic Hepatitis

Not yet recruiting·UUniversity Hospital, Lille·Phase 3·NCT06956482·477 enrolled

Acute Liver Failure1 trial

Role of N-Acetylcysteine in Non-Acetaminophen-Induced Acute Liver Failure

Active, not recruiting·LLahore General Hospital·N/A·NCT06872372·62 enrolled

2 more indications

Sepsis1 trial

A Randomized, Placebo-controlled, Blinded, Parallel-group Clinical Trial to Assess the Efficacy of N-acetylcysteine in Adults With Acute Infections or Sepsis and Evidence of Liver Dysfunction: the IMPACT-NAC Trial

Recruiting·TTheis S. Itenov·Approved·NCT07273071·360 enrolled

Breast Cancer1 trial

An Open-Label, Bayesian Adaptive Phase II Clinical Study in HR+/HER2- Advanced Breast Cancer After Progression on Standard Therapy

Recruiting·FFudan University·Phase 2·NCT07117630·60 enrolled

Sources

References

[1]
ClinicalTrials.gov — 7 trial records for N-Acetylcysteine (NAC) Treatment. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — N-Acetylcysteine (NAC) Treatment compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for N-Acetylcysteine (NAC) Treatment. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — The First Affiliated Hospital of Soochow University company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Phase 3[1]
Company: TThe First Affiliated Hospital of Soochow University

N-Acetylcysteine (NAC) Treatment

Status by Indication[3][1]

Competitive Landscape

Expected Milestones

Q4 2026

Q1 2027

Q4 2027

Q3 2028

Trials by Indication[1]

Parkinson's Disease1 trial

Post-Traumatic Stress Disorder, PTSD1 trial

Thrombotic Microangiopathy1 trial

Hepatitis1 trial

Acute Liver Failure1 trial

Sepsis1 trial

Breast Cancer1 trial

References

Drug Info

Quick Facts

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