Agitation

107

Pipeline Programs↗

31

Active Trials↗

38

Companies Involved↗

Agitation is a highly competitive landscape with 107 programs across 38 companies. The most active players are Neumora Therapeutics, Inc., AFT Pharmaceuticals, Ltd., Milestone Pharmaceuticals Inc.. 30 therapies are approved with 28 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

72/100

Pipeline Velocity

37/100

Mech. Concentration

10/100

Completion Rate

83/100

Attrition Rate

11/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved

Phase 3

Phase 2

Phase 1

Preclinical

Key Players

Top Companies

Neumora Therapeutics, Inc.

1 program

AFT Pharmaceuticals, Ltd.

1 program

Milestone Pharmaceuticals Inc.

1 program

Merck & Co.

2 programs

Teikoku Pharma USA, Inc.

3 programs

BioXcel Therapeutics Inc

2 programs

Pipeline

Programs by Phase

Analysis

Trial Status

189

clinical trials

Completed105 · 56%

Unknown status32 · 17%

Recruiting18 · 10%

Terminated16 · 8%

Not yet recruiting9 · 5%

Withdrawn5 · 3%

Other4 · 2%

Clinical Trials

Trial Activity

189 trials

Nabilone for Agitation Blinded Intervention Trial

Recruiting·SSunnybrook Health Sciences Centre·Phase 3·NCT04516057·112 enrolled

The PREVENT AGITATION Trial II - Children ≤1 Year

Recruiting·—·Phase 2/3·NCT05091242·336 enrolled

MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children

Recruiting·—·Phase 3·NCT05541276·400 enrolled

Oral Melatonin Versus Nebulized Dexmedetomidine on Emergence Agitation in Children Undergoing Adenotonsillectomy

Recruiting·TTanta University·N/A·NCT07345715·96 enrolled

Efficacy of Remifentanil in Preventing Emergence Agitation

Recruiting·SSaglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital·N/A·NCT06539013·99 enrolled

Prevention of Emergence Agitation in Rhinoplasty With Subanesthetic Propofol and Single-Dose Dexmedetomidine: A Prospective Double-Blind Clinical Study

Recruiting·YYuzuncu Yil University·N/A·NCT07144007·80 enrolled

Effect of Preoperative Oral Magnesium on Emergence Agitation

Recruiting·TTanta University·N/A·NCT07082894·120 enrolled

Dexmedetomidine and Agitation After Nasal Surgery

Recruiting·FFayoum University Hospital·N/A·NCT06867302·50 enrolled

The Effect of Dexmedetomidine on Agitation During Weaning From Mechanical Ventilation

Recruiting·SSohag University·N/A·NCT07066605·62 enrolled

Masupirdine for the Treatment of Agitation in Dementia of the Alzheimer's Type

Recruiting·SSuven Life Sciences Limited·Phase 3·NCT05397639·375 enrolled

Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease

Recruiting· Bristol-Myers Squibb logo

Bristol-Myers Squibb·Phase 2·NCT06808984·120 enrolled

A Study of ONO-2020 in Patients With Agitation Associated With Alzheimer's Disease Dementia

Recruiting· Ono Pharmaceutical Co. Ltd logo

Ono Pharmaceutical Co. Ltd·Phase 2·NCT06803823·90 enrolled

A Single Bolus of Dexmedetomidine Versus Normal Saline in Postoperative Agitation

Recruiting·—·Phase 3·NCT04928391·60 enrolled

Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Alzheimer's Disease Dementia

Recruiting·EExciva GmbH·Phase 2/3·NCT07284472·300 enrolled

Clinical Trial on Agitation in Alzheimer's Dementia

Recruiting·—·Phase 2·NCT05543681·164 enrolled

Page 1 of 13

Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)