Neurontin

(Gabapentin)

ApprovedSmall molecule

Gabapentin is used to treat nerve pain from shingles and to help control certain types of seizures. It's also commonly prescribed to help manage pain and other symptoms related to damaged nerves.[2] Neurontin is currently approved and in use across 100 indications[4].[1]

Neurontin is one of 1580 small molecule programs targeting Childhood Acute Lymphoblastic Leukemia. It is currently in Approved.

100

Indications

316

Total Trials

Active Trials

1,579

Competitors

FDA Applications

NDA/BLA/ANDA regulatory filings

Pipeline

Status by Indication[4][1]

Indication

Childhood Acute Lymphoblastic LeukemiaActive, not recruiting

Total Joint ArthroplastyActive, not recruiting

Intervertebral Disc DisplacementApproved

Premature BirthApproved

HIV InfectionApproved

DyspepsiaActive, not recruiting

Nicotine DependenceApproved

Neuropathic PainApproved

Low Back PainActive, not recruiting

Partial EpilepsyApproved

Childhood Acute Lymphoblastic LeukemiaPhase 2

Active, not recruiting

Total Joint ArthroplastyPhase 1

Active, not recruiting

Intervertebral Disc DisplacementApproved

Approved

Premature BirthApproved

Approved

HIV InfectionApproved

Approved

DyspepsiaPhase 3

Active, not recruiting

Nicotine DependenceApproved

Approved

Neuropathic PainApproved

Approved

Low Back PainPhase 2

Active, not recruiting

Partial EpilepsyApproved

Approved

Showing 10 of 94 indications

Competition

Competitive Landscape

2828 competitors in Breast Cancer

#DrugCompanyPhaseTrials

Neurontin

VViatris Specialty LLC

Approved

5 2

Tecentriq

Roche

Preclinical

36 3

Adriamycin

GGynecologic Oncology Group

Preclinical

87 4

Nolvadex

SSan Diego Pacific Oncology & Hematology Associates

Preclinical

78 5

Prolia

Amgen

Preclinical

14 6

Megace

Bristol-Myers Squibb

Preclinical

4 7

DATROWAY

Daiichi Sankyo

Preclinical

4 8

MS Contin

Merck & Co.

Preclinical

2 9

Zolymbus

AbbVie

Preclinical

1 10

Methylthioninium Chloride

PProvepharm SAS

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Timeline

Expected Milestones

Q3 2026

Post-ApprovalRecruiting

Recovery

NCT05302999

Q4 2026

Post-ApprovalRecruiting

Preoperative

NCT04860141

Phase 1/2Recruiting

Glioblastoma

NCT05664464

Phase 1/2Recruiting

Chronic Pain

NCT05156060

Q4 2027

Phase 2/3Not yet recruiting

Analgesic Efficacy

NCT07047040

Q4 2028

Phase 3Not yet recruiting

Neuropathic Pain

NCT02219373

Clinical

Trials by Indication[1]

Nausea and vomiting6 trials

Gabapentin in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT00880191·430 enrolled

Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting

Completed·MMedical University of South Carolina·N/A·NCT00886236·62 enrolled

Aprepitant Versus Gabapentin Prophylaxis for Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgeries

Completed·—·Phase 2/3·NCT02525848·150 enrolled

Show 3 more trials

Ondansetron and Gabapentin in Preventing Postoperative Nausea and Vomiting After Laparoscopic Sleeve Gastrectomy

Completed·TTanta University·Phase 3·NCT05620641·100 enrolled

Gabapentin in the Prevention of Nausea and Vomiting Induced by Chemotherapy

Completed·FFaculdade de Medicina do ABC·Phase 3·NCT01052844·80 enrolled

Gabapentin to Reduce Postoperative Nausea and Vomiting

Completed·KKhon Kaen University·Phase 4·NCT02944981·80 enrolled

Neuropathic Pain6 trials

Neuropathic Pain Management

Completed· Merck & Co. logo

Merck & Co.·Phase 3·NCT01263132·104 enrolled

Transporters for Organic Cations and Glycemic Control in Patients With Neuropathic Pain.

Completed·NNatalia Valadares de Moraes·Phase 4·NCT03047278·29 enrolled

Evaluation of Initiation Time on the Efficacy of Gabapentin in Treating Neuropathic Pain in SCI

Completed·MMetroHealth Medical Center·Phase 4·NCT04256603·27 enrolled

Show 3 more trials

Effects of Gabapentin in the Treatment of Neuropathic Pain on Driving Performance and Cognition

Terminated·UUMC Utrecht·Phase 4·NCT00189072·24 enrolled

Comparing Gabapentin and Amitriptyline for the Treatment of Neuropathic Pain in Children and Adolescents

Completed·TThe Hospital for Sick Children·Phase 3·NCT00312260·34 enrolled

Gabapentin and Oxcarbazepine for Chronic Neuropathic Pain in Children and Adolescents: A Clinical Effectiveness Study

Not yet recruiting·—·Phase 3·NCT02219373·60 enrolled

Hot flashes6 trials

Study of Gabapentin Extended Release (G-ER) in the Treatment of Vasomotor (Hot Flashes/Hot Flushes) Symptoms in Postmenopausal Women

Completed·DDepomed·Phase 2·NCT00511953·108 enrolled

Gabapentin for the Treatment of Hot Flashes in Menopausal Women

Completed·NNorth Toronto Primary Care Research Network·Phase 3·NCT00112138·200 enrolled

Study of Gabapentin Extended Release (G-ER) in the Treatment of Vasomotor (Hot Flashes/Hot Flushes) Symptoms in Postmenopausal Women

Completed·DDepomed·Phase 3·NCT00755417·541 enrolled

Show 3 more trials

Study of Gabapentin Extended Release (G-ER)in the Treatment of Vasomotor (Hot Flashes/Hot Flushes) Symptoms in Postmenopausal Women.

Completed·DDepomed·Phase 3·NCT00777023·565 enrolled

Breeze3:Study of Gabapentin Extended Release in the Treatment of Vasomotor Symptoms(Hot Flashes)in Postmenopausal Women

Completed·DDepomed·Phase 3·NCT01080300·600 enrolled

A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats

Active, not recruiting· Astellas logo

Astellas··NCT06049797·999 enrolled

Post Operative Pain6 trials

Oral Gabapentin Versus Placebo for Treatment of Postoperative Pain Following Photorefractive Keratectomy

Completed·WWalter Reed Army Medical Center·N/A·NCT00793910·106 enrolled

Gabapentin and Diclofenac Sodium Comparison for Post-Operative Pain Relief

Completed·MMuhammad Aamir Latif·N/A·NCT07267182·240 enrolled

Gabapentin for Relief of Immediate Postoperative Pain

Withdrawn·IIndiana University·Phase 1/2·NCT03750773

Show 3 more trials

Gabapentin Premedication to Reduce Postoperative Pain for Pediatric Tonsillectomy

Recruiting·CChildren's Healthcare of Atlanta·Phase 4·NCT03625011·50 enrolled

Persistent Postoperative Pain Incidence With Gabapentin Used

Completed·HHospital Italiano de Buenos Aires·Phase 4·NCT02693821·122 enrolled

A Single Preoperative Dose of Gabapentin to Decreases Postoperative Pain in Ambulatory Anal Surgeries

Completed·MMinia University·Phase 1·NCT05533684·50 enrolled

Treatment6 trials

Morphine Consumption in Joint Replacement Patients, With or Without Gabapentin Treatment

Completed·MMcMaster University·N/A·NCT01307202·101 enrolled

Efficacy of Gabapentin in Alcohol Dependency Treatment

Completed·—·Phase 3·NCT03274167·112 enrolled

Pain Reduction Caused by the Combined Treatment of Physiotherapy, Oral Gabapentin and Oral Ibuprofen Arginine.

Completed·UUniversidad Europea de Madrid·Phase 4·NCT06781489·129 enrolled

Show 3 more trials

Novel Topical Therapies for the Treatment of Genital Pain

Completed·UUniversity of Rochester·Phase 2/3·NCT02099006·9 enrolled

Treatment of Pendular Nystagmus in OPT

Completed·HHospices Civils de Lyon·Phase 4·NCT02466191·7 enrolled

Sphenopalatine Blockade Versus Clinical Treatment

Unknown status·UUniversity of Sao Paulo General Hospital·N/A·NCT04148846·45 enrolled

115 more indications

Postherpetic Neuralgia5 trials

Effect of Early Use of Oxycodone During the Acute Phase of Herpes Zoster on Preventing Postherpetic Neuralgia

Unknown status·SSecond Affiliated Hospital, School of Medicine, Zhejiang University·N/A·NCT03120962·140 enrolled

A Comparison of EpiCept™ NP-1 Topical Cream vs. Oral Gabapentin in Postherpetic Neuralgia (PHN)

Completed·EEpiCept Corporation·Phase 2·NCT00475904·360 enrolled

Safety and Efficacy of Gabapentin in Postherpetic Neuralgia

Completed·DDepomed·Phase 3·NCT00636636·452 enrolled

Show 2 more trials

Safety and Efficacy of Gabapentin in Postherpetic Neuralgia

Completed·DDepomed·Phase 3·NCT00335933·378 enrolled

Effectiveness of Warm Acupuncture in Patients with Postherpetic Neuralgia

Not yet recruiting·UUniversity of Medicine and Pharmacy at Ho Chi Minh City·N/A·NCT06893172·36 enrolled

Seizure4 trials

Comparative Study Of Pregabalin And Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00537940·482 enrolled

A Phase III Open-Label Study Of Gabapentin As Adjunctive Therapy In Japanese Pediatric Patients With Partial Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00603473·92 enrolled

Does Gabapentin and Lamotriginel Have Significantly Fewer Side-effects While Providing Equal or Better Seizure Control Than the Current Drug Choice, Carbamazepine, for the Treatment of Seizures in the Elderly.

Completed·UUS Department of Veterans Affairs·Phase 3·NCT00007670·720 enrolled

Show 1 more trial

A Phase III Open-Label Extension Study Of Gabapentin As Adjunctive Therapy In Japanese Pediatric Patients With Partial Seizures

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00620555·65 enrolled

Insomnia4 trials

A Study of Single-Dose Gabapentin in Transient Insomnia Induced by a Sleep Phase Advance

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00667108·784 enrolled

A 28-Day Polysomnographic Study of Gabapentin in Transient Insomnia Induced by a Sleep Phase Advance

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00163046·256 enrolled

A Polysomnographic Study Of Single-Dose Gabapentin In Transient Insomnia

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00674752·377 enrolled

Show 1 more trial

A Polysomnographic Study of Single-Dose Gabapentin in Transient Insomnia Induced by a Sleep Phase Advance

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 3·NCT00666770·309 enrolled

Pruritus4 trials

Gabapentin for Prophylaxis Intrathecal Morphine-Induced Pruritus

Completed·PPrince of Songkla University·N/A·NCT01236859·180 enrolled

Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis

Completed·TTanta University·Phase 4·NCT06466421·60 enrolled

Gabapentin - A Solution to Uremic Pruritus?

Unknown status·HHospital Authority, Hong Kong·N/A·NCT00577967·80 enrolled

Show 1 more trial

Comparison of Gabapentin With Doxepin in the Management of Uremic Pruritus

Completed·—·Phase 4·NCT03758079·14 enrolled

Diabetic Neuropathy4 trials

Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy

Completed·AAziende Chimiche Riunite Angelini Francesco S.p.A·Phase 2·NCT03749642·240 enrolled

A Study to Compare Safety and Efficacy of Tramadol Hydrochloride/Acetaminophen With Gabapentin in Participants With Diabetic Neuropathy

Completed· Johnson & Johnson logo

Johnson & Johnson·Phase 4·NCT00634543·162 enrolled

A Study on the Efficacy and Safety of Gabapentin in the Treatment of Patients With Painful Diabetic Neuropathy

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.·Phase 4·NCT00644748·95 enrolled

Show 1 more trial

Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy

Terminated·WWake Forest University·Phase 4·NCT00619983·22 enrolled

Agitation4 trials

Gabapentin Oral Solution in Decreasing Desflurane Associated Emergence Agitation

Unknown status·KKuwait Specialized Eye Center·N/A·NCT03347916·75 enrolled

The Effect of Oral Gabapentin on Emergence Agitation and Delirium in Adult Patients After Nasal Surgery.

Not yet recruiting·—·Phase 3·NCT06887998·63 enrolled

Dexmedetomidine Versus Gabapentin Premedication on the Emergence Agitation After Rhinoplasty

Completed·—·Phase 4·NCT05626998·153 enrolled

Show 1 more trial

Specific Interventions for Agitation in Alzheimer's Disease

Completed·UUS Department of Veterans Affairs·N/A·NCT00018291

Fasting Conditions4 trials

Bioequivalence Study of Gabapentin 800 mg Tablets Under Fasting Conditions

Completed·RRanbaxy Laboratories Limited·N/A·NCT00778401·28 enrolled

A Relative Bioavailability Study of Gabapentin 400 mg Capsules Under Non-fasting Conditions

Completed·AActavis Inc.·Phase 1·NCT00864305·18 enrolled

A Relative Bioavailability Study of Gabapentin 400 mg Capsules Under Fasting Conditions

Completed·AActavis Inc.·Phase 1·NCT00864058·30 enrolled

Show 1 more trial

Bioequivalence Study of Gabapentin 400 mg Capsules Under Fasting Conditions

Completed·RRanbaxy Laboratories Limited·N/A·NCT00778271·26 enrolled

Analgesic3 trials

Preanalgesic Effect of Gabapentin in Total Knee Repair

Completed·TTexas Health Resources·N/A·NCT00279487·24 enrolled

Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures

Withdrawn·MMassachusetts General Hospital·Phase 4·NCT02957097

MAST Trial: Multi-modal Analgesic Strategies in Trauma

Completed·TThe University of Texas Health Science Center, Houston·Phase 4·NCT03472469·1,561 enrolled

Breast Cancer3 trials

Gabapentin With or Without Antidepressants in Treating Hot Flashes in Women Who Have Had Breast Cancer or Have Concerns About Taking Hormone Therapy

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT00087399·118 enrolled

Prophylactic Gabapentin for Taxane-Induced Arthralgia and Myalgia Syndrome in Breast Cancer Patients Undergoing Adjuvant Chemotherapy

Unknown status·BBritish Columbia Cancer Agency·Phase 2/3·NCT03566394·46 enrolled

Tamoxifen in Women With Breast Cancer and in Women at High-Risk of Breast Cancer Who Are Receiving Venlafaxine, Citalopram, Escitalopram, Gabapentin, or Sertraline

Completed·MMayo Clinic··NCT00667121·88 enrolled

Pain3 trials

Pain Relief After Corneal Collagen Cross-Linking

Unknown status·—·Phase 1·NCT06212830·51 enrolled

Gabapentin and Neural Mobilization Pain Reduction Effect Compared to Only Gabapentine

Completed·UUniversidad Europea de Madrid·Phase 4·NCT06778798·72 enrolled

Gabapentin for Postop Pain After SSLF

Completed·UUniversity of North Carolina, Chapel Hill·Phase 4·NCT03123861·45 enrolled

Fibromyalgia3 trials

Fibromyalgia Treatment Trial With Gabapentin and Osteopathic Manipulative Medicine

Completed·—·Phase 3·NCT01107574·41 enrolled

Effect of Milnacipran / Gabapentin in Fibromyalgia

Unknown status·MMansoura University·N/A·NCT05384210·75 enrolled

Gabapentin in Fibromyalgia Trial (GIFT)

Completed·NNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)·Phase 2/3·NCT00057278·150 enrolled

Alcohol Withdrawal3 trials

Comparing the Treatment of Alcohol Withdrawal Syndrome Using Gabapentin Versus Lorazepam

Completed·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 2·NCT00229125·160 enrolled

Comparing Gabapentin and Lorazepam for Treating Alcohol Withdrawal

Completed·NNational Institute on Alcohol Abuse and Alcoholism (NIAAA)·Phase 2·NCT00011297·160 enrolled

Gabapentin vs Chlordiazepoxide for Ambulatory Alcohol Withdrawal

Completed·VVA Salt Lake City Health Care System·Phase 4·NCT01573052·26 enrolled

Peripheral Neuropathy3 trials

Botulinum Toxin Type A in Diabetic Peripheral Neuropathy

Completed·—·Phase 4·NCT05296759·30 enrolled

Safety and Efficacy of Gabapentin in Diabetic Peripheral Neuropathy

Completed·DDepomed·Phase 2·NCT00712439·147 enrolled

Gabapentin in Treating Peripheral Neuropathy in Cancer Patients Undergoing Chemotherapy

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT00027963·100 enrolled

Total Knee Arthroplasty3 trials

Large Doses of Methylprednisolone Combined With Gabapentin in Total Knee Arthroplasty

Completed·JJagiellonian University·Phase 4·NCT04653415·160 enrolled

Dextromethorphan Use in Multimodal Analgesia Regimens for Total Knee Arthroplasty

Terminated·UUniversity of Southern California·Phase 4·NCT02987920·23 enrolled

Analgesic Effect of Gabapentin in Total Knee Arthroplasty (TKA)

Completed·HHvidovre University Hospital·Phase 4·NCT01507363·300 enrolled

Laparoscopic Cholecystectomy2 trials

Use of Preoperative Gabapentin in Patients Undergoing Laparoscopic Cholecystectomy

Unknown status·—··NCT03583892·60 enrolled

Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy

Unknown status·HHvidovre University Hospital·Phase 4·NCT00209885·60 enrolled

Fed2 trials

Bioequivalence Study of Gabapentin 800 mg Tablets Under Fed Conditions

Completed·RRanbaxy Laboratories Limited·N/A·NCT00778232·22 enrolled

Bioequivalence Study of Gabapentin 400 mg Capsules Under Fed Conditions

Completed·RRanbaxy Laboratories Limited·N/A·NCT00778765·24 enrolled

Spinal Fusion2 trials

Perioperative Use of Gabapentin To Decrease Narcotic Requirements in Spinal Fusion

Completed·MMedical College of Wisconsin·N/A·NCT00726999·63 enrolled

Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery

Completed·UUniversity of Puerto Rico·Phase 4·NCT05413902·100 enrolled

Chronic pain2 trials

Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer

Recruiting·NNatalie Lockney·Phase 1/2·NCT05156060·64 enrolled

Preoperative Gabapentin for Chronic Pain After Thoracotomy (GABATHOMIE).

Completed·UUniversity Hospital, Lille·Phase 3·NCT03158376·201 enrolled

Prevention2 trials

Gabapentin for Alcohol Relapse Prevention

Completed·MMedical University of South Carolina·Phase 2·NCT02349477·96 enrolled

Gabapentin Versus Trospium Chloride for Prevention of a Catheter-related Bladder Discomfort Inside the ICU

Completed·—·Phase 4·NCT06346522·120 enrolled

Hysterectomy2 trials

Optimal Multimodal Analgesia in Abdominal Hysterectomy

Unknown status·HHvidovre University Hospital·Phase 4·NCT00209872·60 enrolled

Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy

Completed·SState University of New York at Buffalo·Phase 3·NCT04429022·68 enrolled

Children2 trials

Efficacy of Gabapentin in Treating Pain in Children With SNI (Gabapentin Trial)

Recruiting·UUniversity of British Columbia·Phase 2·NCT04619862·5 enrolled

Study to Compare Gabapentin to Tramadol in Children With Chronic Neuropathic or Mixed Pain

Terminated·PPharmaceutical Research Management srl·Phase 3·NCT02722603·2 enrolled

Tinnitus2 trials

Effect of Gabapentin on Idiopathic Subjective Tinnitus

Unknown status·—·Phase 2·NCT00555776·70 enrolled

Gabapentin for the Treatment of Tinnitus

Terminated·WWashington University School of Medicine·Phase 2/3·NCT00317850·160 enrolled

Tonsillectomy2 trials

Effect of Gabapentin on Postoperative Opioid Analgesic Use and Pain in Adolescents Undergoing Tonsillectomy

Terminated·—·Phase 4·NCT05024825·17 enrolled

How Does Gabapentin Affects Post-operative Tonsillectomy Pain?

Completed·UUniversity of British Columbia·Phase 3·NCT00624455·28 enrolled

Prostate Cancer2 trials

Quality of Life Study Using Gabapentin Versus Venlafaxine in Treating Hot Flashes in Patients With Prostate Cancer

Terminated·UUniversity of Wisconsin, Madison·Phase 2·NCT01533753·5 enrolled

Gabapentin in Treating Hot Flashes in Patients With Prostate Cancer

Completed·AAlliance for Clinical Trials in Oncology·Phase 3·NCT00028574·223 enrolled

Abuse Potential2 trials

Study Evaluating the Abuse Potential of NEURONTIN® in Healthy Non-drug Dependent, Recreational Opioid Users

Completed·VViatris Specialty LLC·Phase 4·NCT05319756·54 enrolled

Evaluating the Abuse Potential of NEURONTIN® When Taken Orally in Healthy Non-drug Dependent Participants With Sedative Drug Abuse Experience

Completed·VViatris Specialty LLC·Phase 4·NCT04570436·52 enrolled

Pregabalin2 trials

Pregabalin vs. Gabapentin on Reducing Opioid Usage

Completed·—·Phase 4·NCT04705480·109 enrolled

Comparison of Pregabalin Versus Gabapentin as Pre-emptive Analgesic

Completed·MMuhammad Aamir Latif·N/A·NCT07389551·142 enrolled

Postoperative Pain Control2 trials

Gabapentin as Adjunctive Treatment for Postoperative Pain Control

Completed·IIndiana University·Phase 1·NCT02490345·13 enrolled

Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy

Terminated·LLoma Linda University·N/A·NCT00954187·8 enrolled

Perioperative Analgesia2 trials

Perioperative Analgesia Using Gabapentin in Head and Neck Cancer Surgery

Terminated·UUniversity of California, Davis·Phase 3·NCT03682367·8 enrolled

Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery

Terminated·—·Phase 3·NCT04176419·30 enrolled

Sinus Surgery1 trial

Preoperative Gabapentin Versus Bisoprolol for Hemodynamic Optimization During Sinus Surgery

Completed·ZZagazig University·Phase 4·NCT03850093·63 enrolled

Shoulder Arthroplasty1 trial

Opioid-Free Shoulder Arthroplasty

Completed·OOrthoCarolina Research Institute, Inc.·Phase 4·NCT03540030·86 enrolled

Premedication1 trial

The Effects of Gabapentin Premedication on Neurosurgery

Completed·—·N/A·NCT02306278·122 enrolled

Alcohol1 trial

Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics

Completed·MMedical University of South Carolina·Phase 2·NCT03220776·54 enrolled

Post-surgical1 trial

Gabapentin and Chronic Post Surgical Pain

Withdrawn·EEmory University·Phase 3·NCT03867240

Pain Control1 trial

Nonopioid Pain Control Regimen After Arthroscopic Hip Procedures

Recruiting·MMayo Clinic·Phase 4·NCT05076110·188 enrolled

Head and Neck1 trial

Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients

Completed·WWashington University School of Medicine·Phase 4·NCT02926573·123 enrolled

Randomized1 trial

Morphine COnsumption in Joint Replacement Patients, With and Without GaBapentin Treatment, a RandomIzed ControlLEd Study

Completed·HHamilton Health Sciences Corporation·N/A·NCT00889148·103 enrolled

Rib Fracture1 trial

Efficacy of Gabapentin vs. Placebo for Adjuvant Pain Control Following Acute Rib Fractures

Completed·—·Phase 1·NCT02856750·100 enrolled

Tachycardia1 trial

Gabapentin Treatment of Postural Tachycardia Syndrome (PoTS)

Completed·MMedstar Health Research Institute·N/A·NCT04345432·10 enrolled

Opioid-induced Hyperalgesia1 trial

Dextromethorphan, Gabapentin, and Oxycodone to Treat Opioid-Induced Hyperalgesia

Completed·NNational Institute on Drug Abuse (NIDA)·N/A·NCT00218374·60 enrolled

Vulvodynia1 trial

A Trial of Gabapentin in Vulvodynia: Biological Correlates of Response

Completed·UUniversity of Tennessee·N/A·NCT01301001·230 enrolled

Epidural Analgesia1 trial

The Effect of Gabapentin on Thoracic Epidural Analgesia Following Thoracotomy

Completed·UUniversity of Aarhus·Phase 3·NCT01116583·104 enrolled

Perioperative Pain Control1 trial

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

Unknown status·UUniversity of Illinois College of Medicine at Peoria·Phase 4·NCT02958566·80 enrolled

Acupuncture1 trial

Effect of Acupuncture and Pain Medication on Radicular Pain Using QST

Completed·MMassachusetts General Hospital·N/A·NCT01678586·56 enrolled

Chest pain1 trial

Efficacy of Gabapentin in the Treatment of Chest Pain and Paresthesia in Patients With Sternotomy

Completed·—·Phase 4·NCT00800527·110 enrolled

Bladder Cancer1 trial

Gabapentin in Reducing the Need for Pain Medication in Patients With Bladder Cancer Undergoing Radical Cystectomy

Completed·UUniversity of Washington·Phase 2/3·NCT02355886·25 enrolled

Chronic Pelvic Pain1 trial

Oral Gabapentin in Management of Chronic Pelvic Pain in Females: A Randomised Placebo-controlled Study.

Unknown status·—·Phase 3·NCT02918760·64 enrolled

Cognitive Change1 trial

Cognitive Changes With Gabapentin Treatment

Terminated·WWashington University School of Medicine··NCT04106011·3 enrolled

Randomized Controlled Trial1 trial

Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial

Completed·UUniversity of California, Davis·Phase 4·NCT03080493·121 enrolled

Muscle Cramp1 trial

Gabapentin in Treatment of Muscle Cramps in Patients With Liver Cirrhosis

Unknown status·TTanta University·Phase 3·NCT02642484·200 enrolled

Chronic1 trial

Impact of Polymorphisms of OCT2 and OCTN1 on the Kinetic Disposition of Gabapentin in Patients Undergoing Chronic Use

Completed·SSão Paulo State University·Phase 4·NCT02977208·66 enrolled

Drug1 trial

Drug Use Investigation Of Gabapentin

Completed·PPfizer's Upjohn has merged with Mylan to form Viatris Inc.··NCT00567268·1,273 enrolled

Delirium1 trial

Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain

Completed·UUniversity of California, San Francisco·Phase 3·NCT00221338·750 enrolled

Kidney Transplant1 trial

Enhanced Recovery After Surgery (ERAS) in Live Donor Kidney Transplant Recipients

Enrolling by invitation·—·Phase 4·NCT06997016·60 enrolled

Post-thoracotomy Pain1 trial

Does Peri-Operative Gabapentin Reduce Chronic Post-Thoracotomy Pain?

Withdrawn·UUniversity of Kansas Medical Center·Phase 3·NCT00934193

Anxiety1 trial

Does Postoperative Gabapentin Reduce Pain, Opioid Consumption and Anxiety and Have a Positive Effect on Health Related Quality of Life After Radical Prostatectomy?

Completed·SSunnybrook Health Sciences Centre·Phase 4·NCT00982800·60 enrolled

Cannabis Dependence1 trial

Gabapentin Treatment of Cannabis Dependence

Completed·TThe Scripps Research Institute·Phase 2·NCT00395044·50 enrolled

Cannabis Use Disorder1 trial

Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders

Recruiting·MMedical University of South Carolina·Phase 2·NCT05064319·68 enrolled

Total Knee Replacement1 trial

Pain Control With Total Knee Replacement

Completed·TTexas Tech University Health Sciences Center·Phase 4·NCT01680549·50 enrolled

Oral Mucositis1 trial

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

Recruiting·AAlliance for Clinical Trials in Oncology·Phase 3·NCT06992427·228 enrolled

Concentration1 trial

Plasma Gabapentin Concentration During and Following Cardiac Bypass

Completed·QQueen's University·Phase 4·NCT01022736·16 enrolled

Completed·SSt. Jude Children's Research Hospital·Phase 2·NCT01954927·90 enrolled

After Cardiac Surgery1 trial

Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery

Completed·RRigshospitalet, Denmark·Phase 4·NCT01966172·180 enrolled

Scoliosis1 trial

Analgesic Effects of Gabapentin After Scoliosis Surgery in Children

Completed·TThe Hospital for Sick Children·Phase 3·NCT00684112·35 enrolled

Thoracic Surgery1 trial

Pain Control in Children and Adolescent After Thoracic Surgery: The Effect of Gabapentin

Completed·NNational Institute for Tuberculosis and Lung Diseases, Poland·Phase 4·NCT03393702·104 enrolled

Pain Management1 trial

Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty

Completed·UUniversity of Alabama at Birmingham·Phase 4·NCT03859024·48 enrolled

Autism Spectrum Disorder1 trial

Study of Neuroimaging Biomarkers of Social Cognition Deficits in Adolescents (Age 13-17) With Autism Spectrum Disorder and Effects of Gabapentin

Completed·UUniversity of Massachusetts, Worcester·Phase 1·NCT03589898·19 enrolled

Opioid Dependence1 trial

Improving Treatment Outcomes for Prescription Opioid Dependence

Completed·UUniversity of Arkansas·Phase 2/3·NCT02543944·117 enrolled

Concussion1 trial

Gabapentin's Effects on Insomnia in Patients With Recent Concussion

Completed·SState University of New York at Buffalo·Phase 1·NCT01421264·21 enrolled

Dilation and Evacuation1 trial

Gabapentin for Pain Management During Dilation and Evacuation

Completed·MMedstar Health Research Institute·Phase 4·NCT03635905·130 enrolled

Analgesic Efficacy1 trial

Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin

Not yet recruiting·—·Phase 2/3·NCT07047040·86 enrolled

Multiple Sclerosis1 trial

Treatment of Pendular Nystagmus With Gabapentin and Memantine in Patients With Multiple Sclerosis

Completed·HHospices Civils de Lyon·Phase 2·NCT01744444·10 enrolled

Tracheal Intubation1 trial

Oral Amantadine Versus Gabapentin to Attenuate the Response to Laryngoscopy and Tracheal Intubation

Completed·GGhada Mohammed AboelFadl·Phase 2/3·NCT03172234·90 enrolled

Methylprednisolone1 trial

Efficacy of Methylprednisolone for Pain Control After ACL Repair

Recruiting·SSt. Louis University·Phase 4·NCT07158476·90 enrolled

Carpal Tunnel Syndrome1 trial

Oral Gabapentin and Median Nerve Mobilization in the Treatment of Carpal Tunnel Syndrome

Completed·UUniversidad Europea de Madrid·Phase 4·NCT04285281·126 enrolled

Cesarean Section1 trial

The Effectiveness of Gabapentin for Post-operative Pain Following Cesarean Section

Completed·SSamuel Lunenfeld Research Institute, Mount Sinai Hospital·N/A·NCT01094925·126 enrolled

Hernia1 trial

Short-term Effectiveness of Gabapentin Versus Placebo in Acute Lumbosacral Radiculalgia by Herniation Disc (GRADE)

Unknown status·LLille Catholic University·Phase 4·NCT04865042·144 enrolled

Surgery1 trial

Management of Pain Associated With Failed Back Surgery Syndrome

Completed·—·Phase 4·NCT05324761·60 enrolled

Spinal Anesthesia1 trial

The Effect of Gabapentin on Spinal Anesthesia Duration

Completed·—·Phase 1·NCT05659810·50 enrolled

Preoperative1 trial

Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.

Recruiting·LLoma Linda University·Phase 4·NCT04860141·98 enrolled

Alcohol Dependence1 trial

Gabapentin Treatment of Alcohol Dependence

Completed·TThe Scripps Research Institute·Phase 2·NCT00391716·150 enrolled

Restless Leg Syndrome1 trial

Blinded, Randomized Study of Gabapentin (Neurontin®) and Gabapentin Enacarbil (Horizant™) in Restless Leg Syndrome

Terminated·TTheresa Zesiewicz, MD·Phase 4·NCT02117076·5 enrolled

Laparoscopic Sleeve Gastrectomy1 trial

Effect of Gabapentin on Kidney Function Following Laparoscopic Sleeve Gastrectomy(LSG)

Completed·TTanta University·Phase 4·NCT06254183·90 enrolled

Alopecia1 trial

Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia

Completed·UUniversity of Minnesota·Phase 1·NCT03346668·5 enrolled

Shoulder pain1 trial

Effects of Preoperative Gabapentin Versus Pregabalin on Shoulder Pain After Laparoscopic Cholecystectomy

Completed·—·Phase 4·NCT03241875·90 enrolled

Critically Ill1 trial

Impact of Gabapentin on Slow Wave Sleep in Adult Critically Ill Patient

Completed·MMahidol University·N/A·NCT04818450·60 enrolled

Overactive Bladder1 trial

Efficacy and Safety of Gabapentin in Treating Overactive Bladder

Completed·MMichael E. Chua·Phase 2/3·NCT01486706·94 enrolled

Benzodiazepine Abuse1 trial

Gabapentin Treatment of Benzodiazepine Abuse in Methadone Maintenance Patients

Completed·NNew York State Psychiatric Institute·Phase 2·NCT00420771·19 enrolled

Opioid Consumption1 trial

Gabapentin Regimens and Their Effects on Opioid Consumption

Completed·—·Phase 4·NCT03334903·77 enrolled

Cataract1 trial

Effect of Gabapentin on Pain of the Second Cataract Surgery

Unknown status·SSeoul National University Hospital·Phase 4·NCT02127853·70 enrolled

Abdominal Surgery1 trial

Preemptive Oral Gabapentin 600 mg in Reducing Morphine Requirement After Non Obstetric Lower Abdominal Surgery

Completed·IIndonesia University·Phase 1/2·NCT04434430·72 enrolled

Prospective1 trial

Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain

Unknown status·DDoron Aframian·Phase 4·NCT02339662·50 enrolled

Head and Neck Cancer1 trial

Study of Efficacy and Safety of Gabapentin to Reduce the Need for Strong Opioid Use in Head and Neck Cancer Patients.

Withdrawn·UUniversity Hospital, Ghent·Phase 3·NCT03747562

Trial1 trial

Gabapentin for the Reduction of Opiate Use Following Pulmonary Resection (GROUP Trial)

Withdrawn·MM.D. Anderson Cancer Center·Phase 3·NCT05100160

Effectiveness1 trial

Effectiveness of Ropinirole and Gabapentin for the Treatment of RLS in Patients on Maintenance HD

Terminated·UUniversity of Alberta·Phase 2·NCT03708237·3 enrolled

Vasomotor Symptoms1 trial

Vasomotor Symptoms and Cardiovascular Control

Withdrawn·—·N/A·NCT02202707

Perioperative Pain Management1 trial

Gabapentin as an Adjunct to Paracervical Block for Perioperative Pain Management

Completed·EEmory University·Phase 4·NCT02944656·114 enrolled

Childhood Acute Lymphoblastic Leukemia1 trial

Therapeutic Interventions For Pain Induced By Vincristine Treatment For Childhood Acute Lymphoblastic Leukemia (ALL)

Completed·SSt. Jude Children's Research Hospital·Phase 2·NCT01506453·51 enrolled

Liver Disease1 trial

Gabapentin to Treat Itch in Patients With Liver Disease

Completed·NNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)·Phase 3·NCT00058890·15 enrolled

Anterior Cruciate Ligament Reconstruction1 trial

Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction

Completed·HHenry Ford Health System·Phase 2/3·NCT03818932·90 enrolled

Recovery1 trial

Feasibility of Early Gabapentin as an Intervention for Neurorecovery

Recruiting·MMetroHealth Medical Center·Phase 4·NCT05302999·42 enrolled

Abortion1 trial

Gabapentin for Perioperative Pain Relief in Surgical Abortion

Completed·UUniversity of Nevada, Las Vegas·Phase 1·NCT04292171·219 enrolled

Dyspepsia1 trial

Gabapentin in Functional Dyspepsia Refractory to Proton Pump Inhibition

Withdrawn·559th Medical Wing·Phase 3·NCT01052896

Single Dose1 trial

Comparative Randomized, Single Dose, Two-way Crossover Open-label Study to Determine the Bioequivalence of Gabapentin From Nerpentin 600 mg (Test ) F.C.T (Aman Pharma ,Egypt.) and Gabapentin From Neurontin 300 mg (Referance ) H.G.C. ( Pfizer Egypt)

Completed·PPharma Guide CRO·N/A·NCT04805827·34 enrolled

Advanced1 trial

Decreasing Narcotics in Advanced Pelvic Surgery

Completed·HHartford Hospital·Phase 4·NCT02110719·138 enrolled

Complex Regional Pain Syndrome1 trial

Treatment of Complex Regional Pain Syndrome With Once Daily Gastric-Retentive Gabapentin (Gralise)

Terminated·MMassachusetts General Hospital·N/A·NCT01623271·5 enrolled

Post-cesarean Pain1 trial

Gabapentin in the Post-cesarean Pain Management of Buprenorphine Patient

Withdrawn·VVanderbilt University Medical Center·Phase 4·NCT03335436

Opioid Use1 trial

Gabapentin Reduces Opioid Use Postoperatively ("GROUP Study")

Unknown status·MMount Sinai Hospital, Canada·Phase 3·NCT02999724·44 enrolled

Cocaine-dependent1 trial

Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans

Completed·UUniversity of Arkansas·Phase 2·NCT00654953·102 enrolled

Glioblastoma1 trial

Glutamate Inhibitors in Glioblastoma

Recruiting·UUniversity of Zurich·Phase 1/2·NCT05664464·120 enrolled

Oropharyngeal Cancer1 trial

Gabapentin for the Reduction of Radiation Therapy Induced Pain During the Treatment of Oropharyngeal Cancer

Completed·HHenry Ford Health System·Phase 3·NCT03269344·65 enrolled

Tremor1 trial

Gabapentin for the Treatment of Neuroleptic-Induced Tremor

Terminated·MMinneapolis Veterans Affairs Medical Center·Phase 3·NCT00533455·40 enrolled

Unspecified6 trials

Pharmacovigilance in Gerontopsychiatric Patients

Terminated·HHannover Medical School·Phase 3·NCT02374567·407 enrolled

A Study on Ketoprofen Lysine Salt (KLS) + Gabapentin (GABA) vs KLS to Investigate Their Pharmacodynamic in Healthy Males

Completed·DDompé Farmaceutici S.p.A·Phase 1·NCT04802967·141 enrolled

Influence of Intestinal Transporter Genetic Variants on the Bioavailability of Gabapentin

Completed·UUniversity of California, San Francisco·N/A·NCT00187707·30 enrolled

Show 3 more trials

Bioequivalence Study of 300 mg Gabapentin

Completed· GSK logo

GSK·Phase 1·NCT01738893·26 enrolled

Perioperative Administration of Gabapentin for Reducing Inhalational Anesthetic Consumption

Unknown status·—·Phase 1·NCT05301205·96 enrolled

Preventive Approach Using Venlafaxine

Unknown status·MMit Ghamr Oncology Center·Phase 4·NCT05875610·60 enrolled

Regulatory

FDA Approval Timeline[5]

Dec 30, 1993

NEURONTIN

NDA NDA020235

Oct 9, 1998

NEURONTIN

NDA NDA020882

Mar 2, 2000

NEURONTIN

NDA NDA021129

Jan 28, 2011

GRALISE

NDA NDA022544

Sources

References

[1]
ClinicalTrials.gov — 316 trial records for Gabapentin. U.S. National Library of Medicine, National Institutes of Health.
[2]
MedlinePlus Drug Information — Neurontin drug information. U.S. National Library of Medicine, National Institutes of Health.
[3]
ChEMBL — Gabapentin compound record. European Bioinformatics Institute (EMBL-EBI).
[4]
Open Targets Platform — Drug–disease associations for Gabapentin. EMBL-EBI & Wellcome Sanger Institute.
[5]
OpenFDA — FDA approval records (NDA NDA022544). U.S. Food & Drug Administration.
[6]
SEC EDGAR — Viatris Specialty LLC company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Mechanism of Action: Voltage-Gated Calcium Channel Modulator[3]
Modality: Small molecule[3]
Highest Phase: Approved[1]
Company: VViatris Specialty LLC

Neurontin

Status by Indication[4][1]

Competitive Landscape

Expected Milestones

Q3 2026

Q4 2026

Q4 2027

Q4 2028

Trials by Indication[1]

Nausea and vomiting6 trials

Neuropathic Pain6 trials

Hot flashes6 trials

Post Operative Pain6 trials

Treatment6 trials

Postherpetic Neuralgia5 trials

Seizure4 trials

Insomnia4 trials

Pruritus4 trials

Diabetic Neuropathy4 trials

Agitation4 trials

Fasting Conditions4 trials

Analgesic3 trials

Breast Cancer3 trials

Pain3 trials

Fibromyalgia3 trials

Alcohol Withdrawal3 trials

Peripheral Neuropathy3 trials

Total Knee Arthroplasty3 trials

Laparoscopic Cholecystectomy2 trials

Fed2 trials

Spinal Fusion2 trials

Chronic pain2 trials

Prevention2 trials

Hysterectomy2 trials

Children2 trials

Tinnitus2 trials

Tonsillectomy2 trials

Prostate Cancer2 trials

Abuse Potential2 trials

Pregabalin2 trials

Postoperative Pain Control2 trials

Perioperative Analgesia2 trials

Sinus Surgery1 trial

Shoulder Arthroplasty1 trial

Premedication1 trial

Alcohol1 trial

Post-surgical1 trial

Pain Control1 trial

Head and Neck1 trial

Randomized1 trial

Rib Fracture1 trial

Tachycardia1 trial

Opioid-induced Hyperalgesia1 trial

Vulvodynia1 trial

Epidural Analgesia1 trial

Perioperative Pain Control1 trial

Acupuncture1 trial

Chest pain1 trial

Bladder Cancer1 trial

Chronic Pelvic Pain1 trial

Cognitive Change1 trial

Randomized Controlled Trial1 trial

Muscle Cramp1 trial

Chronic1 trial

Drug1 trial

Delirium1 trial

Kidney Transplant1 trial

Post-thoracotomy Pain1 trial

Anxiety1 trial

Cannabis Dependence1 trial

Cannabis Use Disorder1 trial

Total Knee Replacement1 trial

Oral Mucositis1 trial

Concentration1 trial

Prostatectomy1 trial

Sleep1 trial

Interaction1 trial

Sickle Cell Disease1 trial

After Cardiac Surgery1 trial

Scoliosis1 trial