VivoSeq
Neurology

Cluster Headache

26

Pipeline Programs↗

8

Active Trials↗

17

Companies Involved↗

Cluster headache is an emerging landscape with 26 programs across 17 companies. The most active players are Novartis, Amgen, Eleusis Therapeutics. 3 therapies are approved with 9 more in late-stage development.

Intelligence

Pipeline Metrics

Competitive Density

51/100

Pipeline Velocity

19/100

Mech. Concentration

19/100

Completion Rate

71/100

Attrition Rate

21/100

Competition

Competitive Landscape

Bubble size = clinical trials

Approved
Phase 3
Phase 2
Phase 1
Preclinical

Key Players

Top Companies Companies ranked by the number of pipeline programs they run for this disease.

Novartis logo

Novartis

1 program

Phase 2Amgen logo

Amgen

1 program

Phase 2E

Eleusis Therapeutics

1 program

Phase 2COMPASS Pathways logo

COMPASS Pathways

1 program

Phase 2Eli Lilly logo

Eli Lilly

1 program

Phase 3Lundbeck logo

Lundbeck

1 program

Phase 3

Pipeline

Programs by Phase

Analysis

Modality Breakdown

82%

Small molecule

28 of 34 classified programs — the dominant modality here.

18%ALL OTHERSMonoclonal antibody515%Peptide13%

Small molecule leads; the ring shows all 34 classified programs, each share of the total. Modality classified for 100% of 34 pipeline programs.

Analysis

Trial Status

43

clinical trials

Completed22 · 51%
Terminated9 · 21%
Recruiting6 · 14%
Unknown status4 · 9%
Not yet recruiting1 · 2%
Active, not recruiting1 · 2%

Clinical Trials

Trial Activity

43 trials

Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headache
Recruiting·UUniversity Hospital, Basel, Switzerland·Phase 2·NCT03781128·30 enrolled
LSD to Improve Cluster Headache Impact Trial
Recruiting·RRadboud University Medical Center·Phase 2·NCT05477459·65 enrolled
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache
Recruiting·NNorwegian University of Science and Technology·Phase 3·NCT03944876·112 enrolled
Ketamine + Magnesium for Chronic Cluster Headache (KETALGIA)
Recruiting·UUniversity Hospital, Clermont-Ferrand·Phase 4·NCT04814381·90 enrolled
A Monocentric, Single-arm, Single-blind Withdrawal First-in-human Study to Assess the Initial Safety, Tolerability, and Effectiveness of the ONSS Bilateral Occipital Nerve Field Stimulation System for the Prophylactic Treatment of Chronic Cluster Headache in Difficult-to-treat Subjects.
Recruiting·MMan and Science, SA·Preclinical·NCT07677137·10 enrolled
Yogabased Movements Weekly (Online Live or Face to Face) for Primary Headaches
Recruiting·KKarolinska Institutet·Preclinical·NCT07348783·80 enrolled
Yogabaserade övningar Som Kompletterande Behandling Vid migrän Och/Eller klusterhuvudvärk YOURHEAD - a Pilot Study
Active, not recruiting·KKarolinska Institutet·Preclinical·NCT07292090·20 enrolled
Efficacy, Safety and Tolerability of Low Sodium Oxybate for Nocturnal Cluster Headache Attacks
Not yet recruiting·LLeiden University Medical Center·Phase 2·NCT06950281·52 enrolled
A Phase III Study of Civamide Nasal Solution (Zucapsaicin) for the Treatment of Episodic Cluster Headache
Completed·WWinston Laboratories·Phase 3·NCT00033839·60 enrolled
Cluster Headache Cortivazol Injection (CHCI)
Completed·AAssistance Publique - Hôpitaux de Paris·Phase 2/3·NCT00804895·43 enrolled
A 1-year Trial to Inform About Long-term Exposure to Eptinezumab in Participants With Chronic Cluster Headache (cCH)
Completed·Lundbeck logoLundbeck·Phase 3·NCT05064397·131 enrolled
A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache
Completed·Eli Lilly logoEli Lilly·Phase 3·NCT02797951·165 enrolled
Intranasal Civamide for Episodic Cluster Headache
Completed·WWinston Laboratories·Phase 3·NCT00069082·2 enrolled
Study Of Sumatriptan Succinate Injection Kit In Patients With Migraine or Cluster Headache In Japan
Completed·GSK logoGSK·Phase 3·NCT00356603·75 enrolled
A Study Of Galcanezumab In Participants With Episodic Cluster Headache
Completed·Eli Lilly logoEli Lilly·Phase 3·NCT02397473·109 enrolled
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Data sources: ClinicalTrials.gov (NIH) · OpenFDA (FDA) · ChEMBL (EMBL-EBI) · Open Targets (EBI/Sanger) · MedlinePlus (NIH) · PubMed (NIH) · SEC EDGAR (SEC)