Levcromakalim

PreclinicalSmall molecule

DDanish Headache Center

Levcromakalim is one of 56 small molecule programs targeting Migraine Without Aura. It is currently in Preclinical.

Indications

Total Trials

Active Trials

Competitors

Pipeline

Status by Indication[3][1]

Indication

Migraine Without AuraActive, not recruiting

MigraineActive, not recruiting

Cluster HeadacheActive, not recruiting

Migraine With AuraActive, not recruiting

Migraine Without AuraPreclinical

Active, not recruiting

MigrainePreclinical

Active, not recruiting

Cluster HeadachePreclinical

Active, not recruiting

Migraine With AuraPreclinical

Active, not recruiting

Competition

Competitive Landscape

105 competitors in Migraine

#DrugCompanyPhaseTrials

Zonegran

AAzurity Pharmaceuticals

Phase 3

3 2

Avicel

SSanthera Pharmaceuticals

Phase 3

2 3

Magnesium

SSpherium Biomed

Phase 3

3 4

Triptans

Pfizer

Phase 3

2 5

Flunarizine

AAspartes Pharmaceuticals, Inc.

Phase 3

9 6

BAT7104

Teva

Phase 3

1 7

Tizanidine Hydrochloride

EElan Pharmaceuticals

Phase 3

1 8

Bayer Aspirin

Bayer

Preclinical

2 9

Cervidil

Pfizer

Preclinical

1 10

Cymbalta

Jazz Pharmaceuticals

Preclinical

Ranked by pipeline maturity and clinical activity. Current drug highlighted in teal.

Clinical

Trials by Indication[1]

Migraine3 trials

Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab

Completed·DDanish Headache Center·N/A·NCT05889442·16 enrolled

The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.

Unknown status·DDanish Headache Center·N/A·NCT05565001·20 enrolled

Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine

Completed·DDanish Headache Center·N/A·NCT05211050·24 enrolled

Migraine With Aura2 trials

Migraine Inducing Effect of Levcromakalim in Patients With Migraine With Aura

Completed·DDanish Headache Center·N/A·NCT04905654·35 enrolled

Headache Inducing Effect of Levcromakalim in Migraine With Aura Patients

Completed·DDanish Headache Center·N/A·NCT04012047·17 enrolled

Headache2 trials

Headache Inducing Effect of Cromakalim in Migraine Patients

Completed·DDanish Headache Center·N/A·NCT03228355·16 enrolled

Hypersensitivity to Opening of ATP-Sensitive Potassium Channels in Post-Traumatic Headache

Completed·DDanish Headache Center·N/A·NCT05243953·21 enrolled

Double-blind2 trials

The Effect of Levcromakalim Infusion on the Cranial Arteries Over Several Hours Using a High Resolution MRA Technique in a Randomized, Double-blind Placebo-controlled Design in Healthy Volunteers.

Completed·DDanish Headache Center·N/A·NCT03609008·20 enrolled

The Hemodynamics Effect of Glibenclamide on Levcromakalim Assessed by High Resolution Magnetic Resonance Angiography (MRA) Technique in a Randomized Double-blind Cross-over Placebo-controlled Study With Healthy Volunteers

Unknown status·DDanish Headache Center·N/A·NCT03886922·15 enrolled

Migraine Without Aura1 trial

Effect of Ivabradine on Levcromakalim-Induced Symptoms in Individuals With Migraine Without Aura (ILIM)

Completed·DDanish Headache Center·N/A·NCT04853797·37 enrolled

2 more indications

Cluster headache1 trial

The Effects of Levcromakalim in Patients With Cluster Headache

Completed·DDanish Headache Center·N/A·NCT05093582·41 enrolled

Unspecified1 trial

Peripheral Nociceptive Effects of Levcromakalim

Completed·DDanish Headache Center·N/A·NCT03726242·20 enrolled

Sources

References

[1]
ClinicalTrials.gov — 12 trial records for Levcromakalim. U.S. National Library of Medicine, National Institutes of Health.
[2]
ChEMBL — Levcromakalim compound record. European Bioinformatics Institute (EMBL-EBI).
[3]
Open Targets Platform — Drug–disease associations for Levcromakalim. EMBL-EBI & Wellcome Sanger Institute.
[4]
SEC EDGAR — Danish Headache Center company filings. U.S. Securities and Exchange Commission.

Details

Drug Info

Quick Facts

Modality: Small molecule[2]
Highest Phase: Preclinical[1]
Company: DDanish Headache Center

Levcromakalim

Status by Indication[3][1]

Competitive Landscape

Trials by Indication[1]

Migraine3 trials

Migraine With Aura2 trials

Headache2 trials

Double-blind2 trials

Migraine Without Aura1 trial

Cluster headache1 trial

Unspecified1 trial

References

Drug Info

Quick Facts

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